LIVER

FIBROSIS
CONTENTS

1 LIVER DISEASES CAUSE FIBROSIS

2 CASE STUDY
 1
LIVER DISEASES
CAUSE FIBROSIS
 Hepatitis
Hepatitis is the inflammation of liver cells characterized
by the presence of inflammatory cells caused mainly by
viruses (Hepatitis B virus) or poisons (e.g. alcohol),
autoimmunity (Autoimmune hepatitis) or hereditary
conditions.

• The condition can be self-limiting (healing on its own)

or can progress to fibrosis (scarring).
• When scarring becomes extensive, it is called
cirrhosis, and this is a very serious condition usually
leads to necrosis.
 Non-Alcoholic Fatty Liver Disease
(NAFLD)
Fatty liver is the accumulation of large amounts of
neutral fat (TAG) in liver cells

Fatty liver is associated with obesity and may lead to a

hepatitis (steatohepatitis, Steato: means fat) and/or
cirrhosis.

Non-Alcoholic steatohepatitis (NASH) is the most

extreme form of NAFLD, which is regarded as a major
cause of cirrhosis of the liver.
 Fibrosis
• Fibrosis is the excessive accumulation of
extracellular matrix proteins including
collagen that occurs in most types of
chronic liver diseases.

• If the fibrosis is treated at this stage, even

though there is damage to the liver, the
organ can repair itself over time
( reversible ).
 Cirrhosis
Cirrhosis is a consequence of chronic liver disease
characterized by replacement of liver tissue by a scar tissue
and regenerative nodules leading to loss of liver function.

Cirrhosis is most commonly caused by :

alcoholism, hepatitis B, hepatitis C viruses, and fatty liver, but
has many other possible causes.

Cirrhosis is generally irreversible, and treatment usually

focuses on preventing progression and complications.

In advanced stages of cirrhosis the only option is a liver

transplant
 2
CASE STUDY
A 16-year-old boy visited the hospital with uncomfortable
symptom in gastrointestinal function such as mild abdominal
pain, diarrhea, as well as frequent fatigue since 12 months ago.

He has visited frequently the nurse's office at school because

of abdominal pain after entering high school.

Based on the diagnosis of irritable bowel syndrome (IBS), the

irregular medications were given to treat only IBS, but the long-
term symptoms became worse.

The boy neither drank alcoholic beverages nor smoked

cigarettes earlier, but still prefers to eat fast foods and oily
snack.
After visiting the hospital, the patient had been examined
several medical examinations.

Found no abnormality in abdominal X-ray and

colonoscopy, but noticed the moderate fatty liver with
fibrous tissue in ultrasonography and elevated serum level
of alanine aminotransferase (ALT) by
100 IU/L. ( Normal Range from 7 to 55 IU/L )

He complained physical lethargy and less motivation for

everything including school life, with sudden and frequent
abdominal pain at middle abdominal area.
The patient was a little fatty body (body mass index,
BMI 26.0), but has a shape of central obesity as thin
four limbs and tummy fat.

The genomic analysis using his salivary contents

was examined , and then the body's genome
showed the vulnerable feature for fat and glucose
metabolic problem
 MANAGEMENT
The patient was administrated with an herbal drug,
Chungganplus twice per day.
 MANAGEMENT
physical exercise and diet management were
strongly recommended, and thus he had
joined a boxing gym and regularly did the
practice three times weekly.

He had reduced body weight about 3 kg

during 6 months and the general symptoms
including abdominal pain as well as blood
chemistry (ALT by 41 IU/L) were improved.
 OUR TEAM
Amira Wadie Ramzy

Heba Ali Bahgat

Youmna Mohammed Ibrahim

Manar Ragab Shoeib

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