2/14/2013 ow do ston ndnere terminals of raul formed aactory receptor nero find thi cret targets nei? ‘The vomeronasal onan (YNO} 2 species detector of pheromones Cell and molecular physiology of muscle contraction ‘Types of muscle tama Saath 0 eyees Light microscopy of skeletal muscle fibers tects ick, dost = Then drow uw2/14/2013 mur Gl fused thon a mltne G ‘aati ebm neal by 4 Meheon ‘Action poten seta mci and carne mc = ce ann Functional componentof a striated muscle cell “Ttubules ae invaginations ofthe plasma membrane Us 7 tral snacomore Seetcaeserees riley 122/14/2013 eet softhe el Proteins of the Z-disk (as of 2009) Dinca co oct heal (hind42 calcu) “wut 7 shal een — Flin tac ¢ | See M ‘A myosin the lament ade of several myosin molecules) 5 time Actin flamers in mace are decorated wth dependent eulatry moles > ata (Gioroet) cerpertittenenm I sats iS DIN vo ath ‘Acnmein irons cca tre bse as ce eo EK tee ‘The fll pecan aly cer nthe presence of SB etme > Co EM “Tre pow iis ro SES ten man isin eve, uncer ative cre prevent olin Gage mjesin *bieces > “Teper. yes aun wot 132/14/2013 Movement of mosis eroups are hey to force generation xctation-contracton coup ‘potential n a striated muscle ead to contraction? Inveducngtwo new ypesofchannels ater ® Shep auttiowe tT em ee2/14/2013 labens ‘action gotuat sl laste longer SF (Cott cena um on Sletl muscle contract reponte to 3 Sing ation potential ~=twth sy open Responses of shleta muscle to repeoted simulation OO axe comp ‘eationship between muse esion ni ‘mulation frequency 4 Revising requation of he force of muscle contraction 152/14/2013 AX eae a 3B Pee ee Ce vpyosia. “Spectnad so much lett V Sear = Muscle fatique: Loss of contraction de to ‘igh frequency repeated simulation rw an of Ca? tw Sorcopiasa retiolam 16Con ces between slow (type I) and fast (type) twitch skeletal muscle fiber verre ean ee dab BS Que as. et 2/14/2013 Properties of smooth muscle eens as rvtinu. oh Tnigsin gk Ova ‘erhontion ot in ht iin oth me ‘ecu estan wth an ES Sacer + etn dependent but diferent from striated muscle cells, rl: cng teponn nm mir Regulation of smooth muscle contraction: Stil Ca™- Calcium mobilization and phosphol Signaling cascades: liberation of, and DAG 72/14/2013 AA: [suger i c Oak Sources of Ca"to trigger smooth muscle contraction Mobilization of intracellular stores eee Soares of ato wee smooth muce oration “tector epee lon cana onthe race Soe ao s4- on me _ cf ont (TRPChannels: Receptoroperated channels of parecer ere cae oa — olya shes wy Baad eo, Mot types of smooth musce cells can fe atlon poten. mearoncrctn 2 ONE Ea vi ‘sep ‘Aci potrtilsin smooth rc cau Inge 2a 4 182/14/2013 Many smooth muscle cells have pacemaker activity (specially intestinal smooth muscle) Hany aan, 2 annie es cates mca ‘Common mechanisms fr inhibition of smooth muscle aut conro.ction > all assing topethur fused The hem bmn CLS aH oes commbnicdes, (omer eet les doorlinattn, iy leis eS 192/14/2013 peas byw am BOE @ ee 1 mre et con cnc ® Heart and Crcuatry Physiology ia Nevers Sustom needad Ute C= deny Sea ae EOS Tasae ae 2 Essential cardiac physiology: The pump(s) Patho blood flow trough the heart 20‘Major divisions of the cardiac cycle 2/14/2013 Soe epee hn ese Dele eprint wrote ‘Coordination of the heart beat « Comenearpe sane tebe > Properties of pacemaker ells in the SA node = > Net corte ee ee hyper etanaion chard ae HEN channels: essential for cardiac pacemaker activity ents ehomat mzI ss Acyar ne wo i ax Tut ort 7 Bo na maUstll FAYE System of conducting fbersin heart om _ cee “ate a ‘ears ad me heart oF damage Hoy recoverbivm Aiseanu b/w action virgin — eA0! wt sane 2.2/14/2013 Speed faction potentias daring the care ee (on beat), > dusivadives Finan buat % Lowy QT syndrom > cudduar dyakh wtf aie ds Conk ob Cardiac output | SoM 22 so ii hf2/14/2013 Control of Stroke Volume 1. Cardiac output I. ten =a ae oe hone 1. comralof srake volume (57) semen ye ane it oe sinh Grew mich resistor eS / Hol vee Gerben Lb Tre Control of Stroke Volume 2. ja _Cnorepnepid rene rent corrasonta ha if a — Control of Stroke Volume 3. Complex relationship between hear at and cardiac outout acrtator anton hase FSHONS CHE UAE 23- ; g \w Wo < Ww gy 2/14/2013 pater dusts Ira to mero spn @ Heart failure =e fa a rice a a leah cre eminem ea ak, os me Sore ofthe carnal symptoms of congestive eat fare (P“E™ meee : ‘wlend aa wep Essential vascular physiology: The tubes Pressures vary alot in ifferet parts ofthe cardiovascular system cw wieght ie tamer diomatl ak A ae i 77 bia { sopestdsinersts hes cmpenens_ PSSM Vv ~ re the, CXchans Wagpery, Pressrow, and restance: Fi ow intubes = dak hewe any Siren Use — Ab others Wave syncoth musi ExcegEQPNOY, ew, foubd > Qs (BHR2/14/2013 01 char Yeon. _— ( ee aye 252/14/2013 Exchange of materials across a capillary wall Poa ame oT Sauce whew fave iaustnual ail 40 capo, How are blood vessels regulated? 2. Exec contls Cav} vem ete he scene + sos tn =e ‘han Qumgrore erg ‘Veins andthe systemic circulation ee eat (Sanne “THipve Chand of Stree sensi ea NAHM REY Foleo endethelal ayer in rlnaton of esclarsmoath muse 26ndothelom-drved NO and smooth mule relation 2/14/2013 Mechanisms of NO reaation of vse smooth mule Integrating cardiovascular function — regulation of systemic arterial pressure sae pre reste SSP tc oe ae ena 27ry > nse eh NDR ey Te 2/14/2013 a @ Le v Saal mare oe Aon ea Suroreceptor fle: fallin hear ate evoked by sete Trceasein blood presure mcroi artery PR = inmlaty HearRae Baroreceptor activation of medullary neurons FES mcesc BP.2/14/2013 ttectors: activation of baroreceptors inhibits activity of sympatheticnerves shutdows too Wig 8.P —> s\yt-down frecaymnctenene eran ea (iehetmanagen each toming og on) ok aot pepe ees Fh pcre re tae te em scenes crac out ee rt) Vp ad The Setpoint” or arterial blood [eco sevation of baroreceptors increases aetvty. TR+ Porasympathehic—> HRoe Ral ed Saree yf wie 292/14/2013 oreseptere = Fer shore tem SL gar ere ot pene oan eee aE oe ‘ea ace er eoaiod cys Dita SLen © saat tanta aes eae ‘iene vcntinecesnt oe “se cect pr, rata > Be aiintrinsicay how current classifications of blood pressure in adults = om = tins eeion ons PAE et scosronn ses pat trie Primary (idiopathic) hypertension perme agin er i en Oe BO aomvasewre Pa, co who api ‘Acute cardiovascul Ses ot eeeEnd of Section 2 ¥ 2/14/2013 31