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Nameof Dosage/ Indication
Contrain Mechanism Side
Nursing
drugs preparation dication ofaction effects
consideration
/ route
Phenobarbitals IV(Adultsand Anticonvul Hypersen- Producesall CNS: Monitor
Children1 -santin sitivity; levelsof hangove respiratory
Classification mo): 15–18 tonic Comatose CNS r, status,pulse,
Therapeutic: mg/kg ina clonic patientsor depression. delirium andBPand
anticonvulsan singleor (grand thosewith Depresses , signsand
ts,sedatives divideddose, mal), pre-existi thesensory depressi symptomsof
Pharmacologic: maximum partial, ng CNS cortex, on, angioedema
barbiturates loadingdose and depression; decreases drows (swellingof
20 mg/kg. febrile Severe motor iness, lips,face,
IV,PO(Adults seizuresin respiratory activity,and excita throat,
andChildren children. disease alters tion, dyspnea)
12 yr):1–3 Preoperat with cerebellar lethargy, frequentlyin
mg/kg/day as ive dyspneaor function. vertigo. patients
a single dose sedative obstruction Inhibits Resp: receiving
or 2 divided and in ; transmis-sio respirat phenobarbital
doses. other Uncontrolle ninthe ory IV.
situationsin d severe nervous depres Equipment
which pain; systemand sionIV, for
sedation Known raisesthe LARYN resuscitation
may be alcohol seizure GOSPA andartificial
required. intolerance threshold. SM, ventilation
Hypnotic (elixir Capableof bronc shouldbe
(short-ter only); inducing hospa readily
m). Lactation: (speeding sm. available.
Unlabeled Discontin up)enzymes CV: Respiratory
Use: ue drug intheliver IV— Depression is
Preventio or that hypote dose
n/treatme bottlefeed. metabolize nsion. dependent.
ntof drugs, GI:
hyperbilir bilirubin, constip
ubinemia andother ation,
in compounds. diarrhe
neonates. Therapeutic a,
Effects: nausea,
Anticonvuls vomiting
antactivity. .
Sedation. Derm:
photos
ensitivi
ty,
rashes,
urticaria
.
Local:
phlebitis
at
IVsite.
MS:
arthralgi
a,
myalgia,
neuralgi
a.
Misc:
hypers
ensitivi
ty
reactio
ns
includi
ng
ANGIOE
DEMA
and
SERUM
SICKNE
SS,
physical
dependen
ce,
psychologi
cal
dependenc
e.
Phenytoins
IM Treatment Contraindi Limits Mostlisted Monitor
administrati /preventio catedin: seizure arefor closelyfor
Classificati on isnot nof Hypersens propagati chronicuse notable
on recommend tonic-clonic itivity; on by of changesin
Therapeuti ed dueto (grandmal) Hypersens altering phenytoin behavior
c: erratic seizures itivityto ion CNS: that could
antiarrhyth absorption and propylene transport. SUICIDAL indicate
mic(group and painon complex glycol Mayalso THOUGH the
IB), injection. partial (phenytoin decrease TS, emergenc
anticonvuls Oral route seizures. injection synaptic ataxia, e
ants shouldbe Unlabeled only); transmissio agitation, or
Pharmacol used Use:Asan Alcohol n. confusion, worsening
ogic: whenever antiarrhyth intolerance Antiarrh dizziness, ofsuicidal
hydantoins possible. mic, (phenytoin ythmic drowsine thoughts
particularly injection properties ss, or
for and liquid asaresult dysarthri behavior
ventricular only); of a, or
arrhythmias Sinus shortening dyskinesia, depression.
associated bradycard theaction extrapyra
withdigoxin ia, potential mid al
toxicity, sinoatrial and syndrome,
prolonged block,2nd decreasing headache,
QT interval, or3rd automatic insomnia,
and degree ity. weakness.
surgical heart Therapeu EENT:
repair of block,or tic diplopia,
congenital Stokes Effects: nystagmus.
heart Adams Diminish CV:
diseases in syndrome ed hypotensi
children. (phenytoin seizure on (q
Manageme injection activity. withIV
nt of only); Terminati phenytoin),
neuropathic Concurrent on of tachycardi
pain, useof ventricular a. GI:
including delavirdine. arrhythm gingival
trigeminal ias. hyperplas
neuralgia. ia,
nausea,
constipatio
n,
drug-induc
ed
hepatitis,
vomiting.
Der m:
STEVENS
JOHNSON
SYNDRO
ME,
TOXIC
EPIDERMAL
NECROLYS
IS,
hypertrich
osis,rash,
exfoliative
dermatitis,
pruritus,
purple
glove
syndrome.
Hemat:
AGRANUL
OC
YTOSIS,
APLASTIC
ANEMIA,
leukopenia,
megalobl
astic
anemia,
thromboc
ytopenia.
MS:
osteomala
cia,
osteoporos
is. Misc:
fever,
lymphad
eno
pathy
Diazepam Status Adjunctin Contraindi Depresses CNS: Monitor
Epilepticus/ the catedin: theCNS, dizziness, BP, pulse,
Classificati Acute manageme Hypersens probably drowsine and
on Seizure nt of: itivity; by ss, respiratory
Therapeuti ActivityIV Anxiety Cross potentiati lethargy, rateprior
c: (Adults):5– Disorder, sensitivity ng GABA, depression, to and
antianxiety 10 mg,may Athetosis, withother an hangover, periodically
agents, repeat q10– Anxiety benzodiaz inhibitory ataxia, throughout
anticonvuls 15minto a relief prior epines neurotrans slurred therapy
ants, totalof30 tocardio may mitter. speech, and
sedative/hy mg,may version occur; Produces headache, frequentl
pn otics, repeat (injection), Comatose skeletal paradoxical y
skeletal regimen Stiffman patients; muscle excitation. duringIV
muscle again in2–4 Syndrome, Myasthe relaxation EENT: therapy.
relaxants hr(IM route Preoperati nia by blurred
(centrally maybe used ve gravis; inhibiting vision.
acting) ifIVroute sedation, Severe spinal Resp:
Pharmacol unavailable); Conscious pulmonary polysynap RESPIRATO
ogic: largerdoses sedation impairme tic RY
benzodiaze maybe (provides nt; Sleep afferent DEPRESSIO
pines required.IM, light apnea; pathways. N. CV:
IV (Children anesthesia Severe Hasan hypotensi
5yr): 0.05– and hepatic anticonvu on (IV
0.3 anterogra dysfunctio lsant only).GI:
mg/kg/dose de n; property constipatio
givenover3– amnesia). Pre-existin dueto n,
5 minq15– Treatment g CNS enhanced diarrhea
30 of status depression; presynap (maybe
mintoa epilepticus/ Uncontroll tic causedby
total dose un ed severe inhibition propylene
of10mg, controlled pain; . glycol
repeatq2– seizures Angle-closu Therapeu contentin
4 (injection). re tic oral
hr. Skeletal glaucoma; Effects: solution),
muscle Some Reliefof
relaxant. products anxiety.
Sedation.
Manageme contain Amnesia. nausea,
nt ofthe alcohol, Skeletal vomiting,
symptoms propylene muscle weight
of alcohol glycol,or relaxation. gain.
withdrawal. tartrazine Decreased Derm:
Unlabeled andshould seizure rashes.
Use: be avoided activity. Local: pain
Anxiety in patients (IM),
associated with phlebitis
withacute known (IV), and
myocardial hypersensi venous
infarction, tivityor thrombosis.
insomnia intoleranc Misc:
e;OB:qrisk physical
of dependenc
congenital e,
malforma psychologic
tions; al
Pedi: dependenc
Children6 e,
mo(for tolerance.
oral;
safetynot
establishe
d);
Lactation:
Recomme
nd to
discontinue
drugor
bottle-feed.
Carbamez PO(Adults): Treatment Hypersens Decreases CNS: Monitor
apine Anticonvulsa of itivity; synaptic SUICIDAL closelyfor
nt—200mg tonic-cloni Bone transmissio THOUGH notable
Classificati twice daily c, marrow n in the TS, changesin
on (tablets) or mixed,and suppressio CNS by ataxia, behavior
Therapeuti 100mg4 complex n; affecting drowsine that could
c: timesdaily partial Concomita sodium ss, indicate
anticonvuls (suspension) seizures. nt use or channels fatigue, the
ants, ;qby200 Manageme use in psychosis, emergenc
mood mg/day q7 nt ofpain within14 neurons. sedation, e
stabilizers daysuntil in daysof Therapeu vertigo. or
therapeutic trigeminal MAO tic EENT: worsening
levelsare neuralgiaor inhibitors; Effects: blurred ofsuicidal
achieved diabetic Concurrent Prevention vision, thoughts
(rangeis neuropathy. useof of corneal or
600–1200 Equetro nefazodon seizures. opacities, behavior
mg/dayin only: e; OB: Reliefof nystagmus. or
divideddoses Acute Use only painin Resp: depression.
q 6–8hr; mania and ifpotential trigeminal pneumonit
notto mixed benefits neuralgia. is. CV:HF, Seizures:
exceed1 mania. outweigh Decreased edema, Assess
g/day in12– Unlabeled riskstothe mania. hypertens frequency,
15-yr Use:Other fetus; ion, location,
olds. formsof additional hypotension, duration,
Extended neurogenic vitaminK and
release pain. duringlast characteris
productsare weeksof ticsof
giventwice seizure
activity.
daily(XR, pregnancy syncope. Trigeminal
CR). hasbeen GI: Neuralgia:
Antineuralgi recomme hepatitis, Assessfor
c—100mg nded; liver facialpain
twice Lactation: enzymes, (location,
dailyor50 Discontinu pancreatit intensity,
mg 4times e drugor is, weight duration).
daily bottlefeed. gain. GU: Askpatient
(suspension hesitancy, toidentify
);qbyupto urinary stimulithat
200 retention. may
mg/dayuntil Derm: precipitate
painis STEVENS facialpain
relieved, JOHNSON (hotorcold
then SYNDRO foods,
maintenance ME, bedclothes,
doseof200– TOXIC touching
1200mg/day EPIDERMAL face).
in divided NECROLYS
doses (usual IS, nail
range, shedding,
400–800 photosens
mg/day). itivity,
rash,
urticaria.F
andE:
syndrome
of
inappropri
ate
antidiureti
c hormone
(SIADH),
hypernatre
mia.
Hemat:
AGRANUL
OC
YTOSIS,
APLASTIC
ANEMIA,
THROMB
OCY
TOPENIA,
eosinophil
ia,
leukopeni
a,
lymphade
no pathy.
Misc:
chills,
fever,
multi-orga
n
hypersensi
tivity
reactions.
Valproicacid
PO(Adults Monothera Hypersens Increase CNS: Seizures:
and py and itivity; levelsof SUICIDAL Assess
Classificati Children adjunctive Hepatic GABA,an THOUGH location,
on therapyfor impairmen inhibitory TS, duration,and
Therapeuti 10yr):Single t; agitation,
c: Known/su
spe
anticonvuls agent simpleand ctedurea neurotrans dizziness, characteris
ants, therapy complex cycle mitterin headache, ticsof
vascular (complex absence disorders the CNS. insomnia, seizure
headache partial seizures. (mayresult Therapeu sedation, activity.
suppressants seizures)— Monothera infatal tic confusion, Institute
Initialdose py and hyperamm Effects: depression. seizure
of 10–15 adjunctive onemic Suppressi CV: precautions
mg/kg/dayin therapyfor encephal on of peripheral .
1–4divided complex opathy); seizure edema.
doses;qby5– partial Mitochond activity. EENT: Migraine
10mg/kg/ seizures. rial Decreased visual Prophyla
day weekly Adjunctive disorders manic disturbanc xis:
until therapyfor causedby episodes. es. GI: Monitor
therapeutic patients mutations Decreased HEPATOT frequency
response with in frequency OXICITY, and
achieved multiple mitochond of PANCREAT intensity
(not to seizure rialDNA migraine ITI S, of
exceed60 types, polymerase headach abdominal migraine
mg/kg/day); including gamma es. pain, headaches
whendaily absence (qrisk for anorexia,
dose seizures. potentially diarrhea,
exceeds 250 Divalproex fatal indigestion,
mg,givein sodium hepatotox nausea,
divided only: icity); vomiting,
doses. Manic Pedi: constipati
Polytherapy episodes Children2 on,qap
(complex associated yr with petite.
partial withbipolar suspected Derm:
seizures)— disorder. mitochond alopecia,
Initialdose Prevention rial rashes.
of 10–15 of disorder Endo:
mg/kg/day;q migraine causedby weight
by 5–10 headache. mutations gain.
mg/kg/day in leukopenia
weeklyuntil mitochond ,
therapeutic rialDNA thromboc
response polymerase ytopenia.
achieved gamma Metab:
(not to (qrisk for HYPERAMM
exceed60 potentially ONEMIA.
mg/kg/day); fatal Neuro:
whendaily hepatotox HYPOTHER
dosage icity);OB: MIA,
exceeds 250 Pregnancy tremor,
mg,givein (for ataxia
divideddoses migraines
only).
Furosemide PO(Adults): Edemadue Hypersens Inhibits CNS: MonitorBP
20–80 to heart itivity; the blurred andpulse
Classificati mg/day asa failure, Cross reabsorpt vision, beforeand
on singledose hepatic sensitivity io n of dizziness, during
Therapeuti initially,may impairment with sodium headache, administratio
c: repeatin6–8 or renal thiazidesand and vertigo.
diuretics disease. chloride
fromthe
Pharmacol hr;mayq Hypertension. sulfonamid loopof EENT: n.Monitor
ogic:loop dose by20– es may Henleand hearing frequency
diuretics 40mgq 6–8 occur; distal loss, of
hruntil Hepatic renal tinnitus. prescripti
desired comaor tubule. CV: on refills
response. anuria; Increases hypotensio to
Maintenance Some renal n. GI: determine
doses may liquid excretion anorexia, compliance
be given products of water, constipatio inpatients
once or may sodium, n, treatedfor
twicedaily contain chloride, diarrhea, hypertens
(dosesupto alcohol, magnesiu dry ion.
2.5g /day avoidin m, mouth,
have been patients potassiu dyspepsia,
usedin with m, liver
patientswith alcohol and enzymes,
HForrenal intolerance. calcium. nausea,
disease). Effectiven pancreatit
Hypertensio ess is,
n—40twice persistsin vomiting.
daily initially impaired GU:qBUN,
(when renal excessive
addedto function. urination,
regimen,pdo Therapeu nephrocal
se ofName tic cinosis.
/bks_53161_ Effects: Derm:
de Diuresis ERYTHEMA
glins_md_dis and MULTIFO
k/ subseque RME,
furosemide nt STEVENS
02/25/2014 mobilizati JOHNSON
10:00AM on of SYNDRO
Plate # excess ME,
0-Composite fluid TOXIC
pg 2 # 2 (edema, EPIDERMAL
2015 pleural NECROLYSI
F.A.Davis effusions). S,
Company Decreased photosens
CONTINUED BP. itiv ity,
PDFPage pruritis,
#22 other rash,
antihyperten urticaria.
sivesby Endo:
50%); hyperchol
adjust est
further erolemia,
dosing hyperglyce
based mia,
on hypertrigl
response;Hy yce
per ridemia,
calcemia—1 hyperurice
20 mg/day mia.Fand
in 1– 3 E:
doses. dehydratio
n,
hypocalce
mia,
hypochlor
emia,
hypokalem
ia,
hypomagn
esemia,
hyponatr
emia,
hypovolem
ia,
metabolic
alkalosis.
Hemat:
APLASTIC
ANEMIA,
AGRANUL
OC
YTOSIS,
hemolytic
anemia,
leukopenia,
thromboc
ytopenia.
MS:
muscle
cramps.
Neuro:
paresthes
ia. Misc:
fever.
Aspirin
Adult: Torelieve Historyof Major Hypersensi Monitor
PO/PR painoflow hypersensi actions tivity for loss
350–650 to tivityto appearto (urticaria, of
mg moderate salicylates be bro toleranceto
q4h(max:4 intensity. including associated nchospasm aspirin.
g/d) Also for methyl primarily , The
Child: various salicylate with anaphylact reactionis
PO/PR inflammato (oil of inhibiting ics hock no
10–15mg/kg ry wintergree the (laryngeal immunolog
in4 –6h conditions, n); formation edema). ic;
(max:3.6 suchas sensitivity of Dizz symptoms
g/d) acute to other prostaglan iness, usually
rheumatic NSAIDs; dins confusion, occur 15
fever, patients involved drowsiness. min to 3 h
Systemic with inthe after
Lupus, "aspirin production ingestion:
rheumatoid triad" of profuse
arthritis, (aspirin inflamma rhinorrhea,
osteoarthrit sensitivity, tio n, erythema,
is, bursitis, nasal pain, and nausea,
and polyps, fever. vomiting,
calcific asthma); Anti intestinal
tendonitis, chronic inflamm cramps,
and to rhinitis; atory and
reduce chronic action: diarrhea.
feverin urticaria; Inhibits Lab tests:
selected historyof prostagla frequent
febrile GI ndi n PT and
conditions. ulceration, synthesis. IRNwith
Usedto bleeding, As an concurrent
reduce or other anti anticoagula
recurrence problems; inflamma nt therapy;
of TIA hypoprot tory more
dueto hro agent, frequent
fibrin mbinemi aspirin fasting
platelet a,
appearsto blood
emboliand beinvolved glucose
riskof
vitaminK in levelswith
stroke in deficiency, enhancing diabetes.
men;to hemophil antigen
prevent ia, or removal Monitorthe
recurrence other and in diabetic
of MI;as bleeding reducing child
prophylaxis disorders; thespread carefully
againstMI CHF.Do of for needto
in men not use inflamma adjust
with aspirin tio n in insulin
unstable during ground dose.
angina. pregnancy substance Childrenon
(category s. These highdoses
D), anti- of aspirin
especially inflamma are
in third tory particularly
trimester; actions proneto
lactation; also hypoglyce
or in contribute mia
premature, to
neonates, analgesic
or effects.
children Ana
under2y, lgesic
except action:
under Principally
adviceand peripheral
supervision with
of
limited
physician. action in
Donotuse the CNS,
in children possibly
or on the
teenagers hypothala
with mus;
chickenpox resultsin
or
reliefof
influenza- mildto
like moderate
illnesses pain.
becauseof Antip
possible yretic
association action:I n
withReye's additionto
syndrome. inhibiting
prostagla
ndi n
synthesis,
aspirin
lowers
body
temperatu
re in
feverby
indirectly
causing
centrally
mediated
peripheral
vasodilati
on and
sweating
.A
ntiplatel
et
action.
Mannitol IV(Adults): IV: Contraindi Increases CNS: Monitor
Edema, Adjunct catedin: the confusion, vital signs,
Classificati oliguric inthe Hypersens osmotic headache. urine
on renal treatment itivity; pressure EENT: output,
Therapeuti failure—50– of: Acute Anuria; of the blurred CVP, and
c: diuretics 100gasa Dehydratio glomerul vision, pulmonary
oliguric
Pharmacol 5–25% n; Active ar rhinitis.CV: artery
renal
ogic: solution;may intracranial filtrate, transient pressures
failure,
osmotic precedewith bleeding; thereby volume (PAP)
diuretics a testdose
Edema,
Severe inhibiting expansion, before
of0.2 g /kg Increased pulmonary reabsorp and
chestpain,
over3–5 intracrani edemaor tionof HF, hourly
min. al or congestion. water pulmonary throughout
Reduction of intraocular Use and edema, administra
intracranial/ pressure, Cautiously electrolyt tachycard tion.
intraocular Toxic in: OB, es. ia.GI: Assess
pressure— overdose. Lactation, Causes nausea, patientfor
0.25–2g /kg GU Safetynot excretion thirst, signsand
as 15–25% irrigant established) of: Water, vomiting. symptoms
solutionover During . Sodium, GU:renal of
30–60min transurethr Potassium, failure, dehydratio
(500mg/kg al Chloride, urinary n
maybe procedure Calcium, retention.F (decreased
sufficientin s Phosphor andE: skinturgor,
smallor us, dehydratio fever,dry
(2.5–5%
debilitated Magnesiu n, skinand
solution
patients).Di m, Urea, hyperkale mucous
only).
uresisin Uric mia, membran
drug acid. hypernatre es, thirst)
intoxication Therapeu mia, or
s— 50– 200 tic hypokalem signsof
g as a 5– Effects: ia, fluid
25% Mobilizati hyponatre overload
solution on of mia.Local: (increased
titratedto excess phlebitisat CVP,
maintain fluidin IVsite. dyspnea,
urine flow oliguric rales/crac
of100– renal kles,and
500mL/hr failure or edema).
edema.
Reduction
of
intraocular
or
intracran
ial
pressure.
Increased
urinary
excretion
of toxic
materials.
Decreased
hemolysis
when
used as
an
irrigant
after
transuret
hral
prostatic
resection
Sumatriptan PO(Adults): Subcut, Hypersensi Actsasa Alladverse Assesspain
25 mg PO, tiv ity; selective reactions location,
Classificati initially;if Intranasal Ischemic agonistof are less intensity,
on responseis , heart 5-HT1at common duration,
Therapeuti inadequate Transderm disease specific afteroral and
c: vascular at2 hr,upto orsigns vascular administra associated
al: Acute
headache 100 and serotonin tionCNS: symptoms
treatment
suppressa mgmaybe symptoms receptor dizziness, (photopho
of
nts given(initial of sites, vertigo, bia,
Pharmacol
migraine
dosesof25– ischemic causing anxiety, phonopho
ogi c: 50 mgmay
attacks. heart vasoconst drowsine bia,
5-HT1 be Subcut: disease, ric tion
in ss, nausea,
agonists more Acute Prinzmeta large fatigue, vomiting)
effective treatment l’s angina, intracrani feelingof during
than 25 mg). of cluster or al heaviness, migraine
If headache headache uncontroll arteries. feelingof attack.
recurs,doses episodes. ed Therapeu tightness,
maybe hypertensi tic headache,
repeatedq2 on ; Stroke Effects: malaise,
hr (notto or Reliefof strange
exceed 300 transient acute feeling,
mg/day).If ischemic attacksof tight
POtherapyis attack; migraine. feelingin
tofollowsub Peripheral head,
cutinjection, vascular weakness.
additional disease EENT:alter
PO (including, ati ons in
sumatripta butnot vision,
n limitedto, nasalsinus
maybetaken ischemic discomfort,
q 2hr(notto bowel throat
exceed Sub disease); discomfort.
cut (Adults): Concurrent
6 mg; may MAO
repeat inhibitor
after1hr(not
toexceed12 therapy; CV:MI,
mgin24hr). Hemiplegic angina,
Intranasal orbasilar chest
(Adults):Singl migraine; pressure,
e doseof5, Concurrent chest
10, or20mg useof tightness,
inone (within 24 coronary
nostril;may hr) vasospasm,
be repeated ergotamin ECG
in2 e changes,
hr,notto containing transient
exceed40 or hypertens
mg/24hror ergot-type ion.
treatmentof drugsor GI:abdomi
5 other5HT1 nal
episodes/m agonists; discomfort,
o. Severe dysphagia.
Transdermal hepatic Derm:
(Adults): impairme tingling,
Apply one nt; Geri: warm
patch;may Excessive sensation,
berepeated risk of burning
in 2hr,not cardiovasc sensation,
to ular contact
exceed2 complicati dermatitis
patches/24hr. ons. (patch
only),
cool
sensation,
flushing.
Local:
injection
site
reaction.M
S: jaw
discomfort,
muscle
cramps,
myalgia,
neck pain,
neck
stiffness.
Neuro:
numbness.
Dihydroer IM,Subcut Vascular Peripheral Vasocon CNS: Assess
gotamine (Adults):1 headaches vascular striction dizziness. frequency,
mg; may including: disease; of EENT: location,
Classificati repeatin1 Migraine, Ischemic dilated rhinitis.CV: duration,
on hrtoatotal Cluster heart blood MYOCARDI and
Therapeuti of 3mg(not headaches disease; vesselsby AL characteris
c: vascular to Uncontroll stimulati INFARCTIO tics(pain,
headache exceed3 ed ng alpha N, nausea,
suppressa mg/ dayor hypertensi adrenergic hypertensi and
nts 6 on;Severe and on,angina vomiting,
Pharmacol mg/wk).IM, renal or serotonergic pectoris, visual
ogic:ergot Subcut liver arterial disturbances)
(Children6yr):
alkaloids 0.5mg;may disease; (5-HT) spasm, ofchronic
be repeated Malnutriti receptors. intermitte headaches.
in1 on; Known Larger nt During
hr.IV alcohol doses claudicatio acute
(Adults): intolerance may n. GI: attack,
0.5mg;may (injection produce abdominal assess
repeatin1 only);OB: alpha pain, type,
hr (notto Pregnancy; adrenergic nausea, location,
exceed 2 Lactation: blockade vomiting, and
mg/dayor6 Lactation; and altered intensity
mg/wk).For Concurrent vasodilati taste, of
chronic useofCYP on. diarrhea, painbefore
intractable 3A4 Therapeu polydipsia. and60min
enzyme tic MS: after
inhibitors Effects: extremity administra
(macrolide Constricti stiffness, tion.
anti on of muscle
infectives dilated pain, stiff
and carotid neck,
protease arterybed stiff
inhibitors). with shoulders.
Use resolution Neuro:leg
Cautiously ofvascular weakness,
in: headache. numbness
Illnesses or tingling
associated in
with fingersor
peripheral toes.Misc:
vascular fatigue.
pathology
suchas
diabetes
mellitus;
Concurrent
administra
tionof
other
vasoconstr
icting
agents;
Pedi:
Children6
yr.(safety
not
established)
.
Acetamino Children12 PO,Rect: Previous Inhibits CNS: ●Assess
phen yr. should Treatment hypersensi the agitation amount,
not of:Mild tiv ity; synthesis (qin frequency,
Classificati receive pain,
Products of children) andtypeof
on Fever. IV containing prostagla (IV), drugs
Therapeuti 5POor alcohol, ndi ns anxiety taken in
Treatment
c: rectal aspartame, that may (IV), patients
of:Mildto
antipyretic doses/24 saccharin, serveas headache self
moderate
s, hr. sugar,or mediators (IV),fatigue medicati
nonopioid without tartrazine ofpain (IV), ng,
analgesics notifying and insomnia especially
physicianor fever, (IV).Resp:
primarilyin
otherhealth pain, (FDC theCNS. atelectasis withOTC
care Moderate yellow Haveno (qin drugs.
professional. to severe dye#5) significant children) Prolonged
Nodosage pain shouldbe anti (IV), useof
adjustment with avoidedin inflamma dyspnea acetamino
needed opioid patients tor y (IV).CV: ph en
when analgesic who have propertie hypertensi increases
converting hypersensi s orGI on (IV), theriskof
s,
betweenIV tivityor toxicity. hypotensi adverse
Fever.
and PO intolerance Therapeu on (IV). renal
acetaminoph tothese tic GI: effects.For
en inadults compoun Effects: HEPATOT short-term
and ds; Analgesia. OXICITY use,
children 50 Severe Antipyresis (qDOSES), combined
kg. PO hepatic . constipatio dosesof
(Adults and impairme n (qin acetamino
Children nt/active children) phenand
liver (IV),qliver salicylates
12yr):325– disease. enzymes, shouldnot
650mgq6 nausea exceedthe
hr or1g (IV), recomme
3–4 vomiting nded
timesdailyor (IV). Fand doseof
1300mgq8 E: eitherdrug
hr (notto hypokale given
exceed 3g mia (IV). alone.
or2g /24hr GU: Donot
inpatients renal exceed
with failure maximum
hepatic/renal (high daily dose
impairment). doses/chr of
onicuse). acetamino
Hemat: ph en
neutropen when
ia, considering
pancytope allroutes
nia . MS: of adm
muscle
spasms
(IV),
trismus
(IV). Derm:
ACUTE
GENERALIZ
ED
EXANTHE
MATOUS
PUSTULO
SIS,
STEVENS
JOHNSON
SYNDRO
ME,
TOXIC
EPIDERMAL
NECROLYS
IS, rash,
urticaria
Lactulose PO(Adults): Treatment Patientson Increases Belching, Assess
30– 45
mL 3– of chronic low water cramps, patientf or
Classificati 4 times/day; constipatio galactose content distention, abdominal
on may be given n. Adjunct diets.Use and flatulence, distention,
Therapeuti q1–2 in softens
c: the
laxatives hrinitiallyto the Cautiously stool. diarrhea. presenceof
Pharmacol induce manageme in: Lowers Endo: bowel
ogic: laxation. PO nt of Diabetes the pH hyperglyce sounds,
osmotic (Infants): portal mellitus; ofthe mia and
2.5–10mL systemic Excessive colon, (diabetic normal
dailyin3–4 (hepatic) or which patients). patternof
divideddoses encephalo prolonge inhibits bowel
(unlabeled). d the function.●
pathy
PO (Children use(may diffusion Assess
(PSE).
and leadto of color,
Adolescents): dependen ammonia consistenc
40–90mL ce);OB, fromthe y, and
daily in3–4 Lactation: coloninto amount
divided Safety theblood, ofstool
doses not thereby produced.
(unlabeled). established. reducing ● PSE:
Rect blood Assess
(Adults): ammonia mental
300mL levels. status
diluted and Therapeu (orientatio
administered tic n, levelof
as a Effects: consciousn
retention Reliefof ess)
enema q 4– constipati beforeand
6 hr. on . periodicall
Decrease y
d blood throughout
ammonia courseof
levelswith therapy.
improved
mental
statusin
PSE.
Thorazine PO(Adults): Second-lin Hypersens Altersthe CNS: Assess
Psychoses— e itivity; effectsof NEUROLE mental
Therapeuti 10–25mg treatment Hypersens dopamine PTIC status
c:a 2–4 times for itivityto in the MALIGNA (orientatio
ntiemetics, daily; schizophre sulfites CNS. NT n, mood,
antipsychoti mayevery niaand (injectable Has SYNDROM behavior)
cs 3–4 days ); Cross significant E, priorto
psychoses
Pharmacolo (usual sensitivity anticholi sedation, and
after
gic: doseis200 withother ner extrapyra periodica
failure
phenothiaz mg/day;up phenothia gic/alpha midal lly
ines with
to 1 zine’s adrenergic reactions, during
atypical
g/day). may blocking tardive therapy.
Nauseaand
antipsycho occur; activity. dyskinesia.
vomiting—1
tics.
Angle Therapeu EENT:
0–25mgq4 Hyper closure tic blurred
hras excitable, glaucoma; Effects: vision,dry
needed. combative Bone Diminish eyes,and
Preoperative behavior marrow ed lens
sedation—25 in depression; signs/sy opacities.
–50mg2–3 children. Severe mpt oms CV:
hr before Nausea liver/card of hypotensio
surgery. and iov psychosis. n (qwith
Hiccups/porp vomiting. ascular Reliefof IM,
hyria—25– Intractable disease; nausea/v IV),
50mg 3–4 hiccups. Concurrent om tachycardi
times Preoperati pimozide iting/intra a. GI:
daily.PO ve ctable
sedation.
Acute
(Children): intermitte use. hiccups. constipatio
Psychoses/n nt Decreased n, dry
auseaand porphyria symptoms mouth,
vomiting—0. . of anorexia,
55 mg/kg Unlabeled porphyria. hepatitis,
(15 Use: ileus,
mg/m2) Vascular priapism.
q4–6 hras headache. GU:
needed. urinary
Bipolar
Preoperativ retention.
disorder.
e Derm:
sedation—0. photosens
55 mg/kg itivity,
(15 pigment
mg/m2) changes,
2–3 hr rash.Endo:
before galactorrhe
surgery a,
amenorrhe
a.Hemat:
AGRANUL
OC
YTOSIS,
leukopenia.
Metab:
hyperther
mia.Misc:
allergic
reactions.
Demerol PO,IM, Moderate Hypersens Bindsto CNS: Monitor
Subcut or severe itivity; opiate SEIZURES, patientson
Classificati (Adults): pain Hypersens receptors confusion, chronicor
on Analgesia— (aloneor itivityto in the sedation, high-dose
Therapeuti 50 mgq with bisulfites CNS. dysphoria, therapyfor
c: opioid 3-4hr; nonopioid (some Altersthe euphoria, CNS
analgesics maybeqas injectable perception floating stimulation
agents).
Pharmacol needed(not products); ofand feeling, (restlessne
Anesthesia
ogic: to exceed Recent response hallucinati ss,
adjunct.
opioid 600 (within14 to on s, irritability,
Analgesic
agonists mg/24hr). days)MAO painful headache, seizures)
during
Analgesia inhibitor stimuli, unusual due to
during
labor. therapy; while dreams. accumulati
labor—50– Preoperati Severe producing EENT: on of
100mgIM ve respiratory blurred normepe
generaliz
orsubcut sedation.U insufficienc ed CNS vision, ridine
when nlabeled y; OB: depressio diplopia, metabolite.
contractions Use: Chronic n. miosis. Riskof
become Rigors. usemay Therapeu Resp: toxicity
regular;may pose risk tic respirator increases
repeatq1–3 tothe Effects: y withdoses
hr. fetus Decrease depression. 600mg /24
Preoperative including in CV: hr,chronic
sedation—5 possible severity hypotensi administra
0–100mg addiction; of on, tion(2
IMor Lactation: pain. bradycardi days),
subcut30– Excretedin a. GI: andrenal
90 min constipatio
before n, nausea,
anesthesia.
breastmilk vomiting.G impairment
andcan U: urinary
cause retention.
respiratory Derm:
depression flushing,
in the sweating.
infant. Misc:
allergic
reactions
including
ANAPHYL
AXIS,
physical
dependenc
e,
psychologic
al
dependenc
e,
tolerance
Propofol IV(Adults Induction Hypersens Short-acti Adverse ●When
Undergoing of itivityto ng Reactions/ usingfor
Classificati Neurosurgi general propofol, hypnotic. Side ICU
on cal anesthesia soybean Mechani Effects sedation,
Therapeuti Procedures in children oil, egg sm of CNS: wake-up
c: general ): lecithin, actionis dizziness, and
3yr. and
anesthetics Induction— or unknown. headache. assessmen
adults.
20 mgq10 glycerol; Produces Resp: t
Maintenan
sec OB: amnesia. APNEA, ofCNS
ce of Crosses
until Haveno cough.CV: function
induction balanced placenta; analgesic bradycardi shouldbe
achieved (1– anesthesia maycause propertie a, donedaily
2 mg/kg whenused neonatal s. hypotensi during
total).Mainte withother depression; Therapeu on, maintenan
na agentsin Lactation: tic hypertensi ce to
nce—100– children2 Enters Effects: on.GI: determine
200 months breast Induction abdominal minimum
mcg/kg/min and milk; and cramping, dose
adults. effects on mainten hiccups, required
Initiation newborn anceof nausea, for
and unknown. anesthesia. vomiting. sedation.
maintenanc Derm: Maintaina
e of
flushing. lightlevel
monitored Local: of
anesthesia burning, sedation
care pain, during
(MAC). stinging, these
coldness, assessmen
Sedation
numbness, ts; donot
of
tinglingat discontinu
intubated, IV site. e. Abrupt
mechanical MS: discontinua
ly involuntary tionmay
ventilated muscle cause
patientsin movement rapid
intensive s, awakening
careunits perioperati with
(ICUs) ve anxiety,
myoclonia. agitation,
GU: and
resistance
to
mechanic
al
discolorati ventilation.
on of
urine
(green).Mi
sc:
PROPOFOL
INFUSION
SYNDRO
ME,
fever.
Dexameth PO(Adults): Used Active In Adverse Assessfor
asone Suppression systemical untreated pharmac reactions/ signsof
test—1mg ly and infections ologic sid e adrenal
Classificati at 11PM locally (maybe doses, effects are insufficien
on or0.5 inawide used in suppress much cy
Therapeuti mgq6hrfor varietyof patients es more (hypotensi
c:anti 48hr.IV being inflamma common on ,
chronic
inflammato (Children): treated for tionand withhigh weight
diseases
ries Chemothera tuberculo the dose/long loss,
(steroidal)
including:
py induced us normal term weakness,
Inflamma
emesis—5– meningiti immune therapy nausea,
tory,
20 mg s); response. CNS: vomiting,
given15–
Allergic, Known Have depression, anorexia,
30min Hematolo alcoholor numerous euphoria, lethargy,
before gic , bisulfite intense hallucinati confusion,
treatment. Endocrine hypersensi metabolic ons, restlessne
Cerebral , tivityor effects headache, ss) before
edema— Neoplasti intolerance (see qin and
Loadingdose c, (some Adverse tracranial periodically
1–2mg/kg Dermatol products Reactions pressure during
followedby ogic, contain andSide (children therapy
1–1.5mg/ Autoimmu these and Effects). only),
kg/day ne should Suppress insomnia,
dividedq4– disorders, beavoided es personality
6 hrfor5 in adrenal changes,
Manageme
days susceptible function psychoses,
nt of
(notto patients); at restlessne
cerebral
exceed 16 Lactation: chronic ss. EENT:
edema, dosesof
mg/day); Avoid cataracts,q
thentaper
Diagnostic chronic 0.75 int
over 1–6 agentin use mg/day. raocular
wk. adrenal Has pressure.
Bacterial disorders. negligible CV:
meningitis— Unlabeled mineralo hypertensi
0.6 Use:Short corticoid on,
mg/kg/day term activity. edema.GI:
divided q 6 administrat Therapeu PEPTIC
hr x 4 days ionto tic ULCERATIO
(start at high-risk Effects: N,
timeoffirst mothers Suppressi anorexia,
antibiotic before on of nausea,qa
dose). deliveryto inflamma ppetite,
prevent tionand vomiting.D
respiratory modificati er
distress on ofthe m:acne,pw
syndrome normal ound
in the
immune healing,
newborn. response. ecchymos
Adjunctive es,
manageme hirsutism,
nt of
petechiae.
nausea Endo:adrenal
and suppressio
vomiting n,
from hyperglyce
chemother mi a. F and
ap y.
E:
Treatment amenorrhe
ofairway a,
hypokalemi
edema
a,
prior to
alkalosis.
extubation.
Hemat:
Usedin THROMBOE
neonates MBOLISM,
with thrombop
bronchopu hle bitis.
lmonary Metab:
dysplasia weight
to gain. MS:
facilitate muscle
ventilator wasting,
weaning osteoporos
is,
avascular
necrosisof
joints,
muscle
pain.Misc:
cus
hingoid
appearan
ce(moon
face,
buffalo
hump),
qsusceptib
ilityto
infection.
Dantrolene PO PO: No Acts CNS: Muscle
(Adults):Spa Treatment contraindi directly drowsine Spasticity:
Classificati sticity—25 of cationsto on ss, Assess
on mg spasticity IV skeletal muscle neuromus
Therapeuti oncedaily associated formin muscle, weakness, cul ar
c: skeletal for7 days, treatment causing confusion, status and
with:
muscle then25 mg of relaxation dizziness, muscle
Spinal
relaxants 2times hyperther by headache, spasticity
cord
(directacting) dailyfor7 mia ; decreasing insomnia, before
injury,
days, then Lactation: calcium malaise, initiating
Stroke,
50mg3 Lactation; release nervousne and
timesdaily Cerebral Situations from ss. EENT: periodicall
for 7days, palsy, in which sarcoplas excessive y
then Multiple spasticityis mic lacrimati during
100mg3 sclerosis. usedto reticulum on, visual therapyto
times daily; Prophylaxi maintain inmuscle disturbanc determine
mayqto s of postureor cells. es. Resp: response.
100mg4 malignant balance. Prevents pleural
times daily, hyperther intense effusions,
if mia.IV catabolic respiratory
needed. Emergenc process depression.
Prevention y associated CV:changes
of treatment with
malignant of malignant
hyperthermia malignant
—4–8 hyperthermia
mg/kg/ day
in3–4
divided .
hyperthe inBP,heart
doses for Unlabele rmia. failure,
1–2days d Use: Therapeu tachycardi
before Manageme tic a. GI:
procedure, nt of Effects: HEPATOT
last dose3– neuroleptic Reduction OXICITY,
4hr. malignant ofmuscle diarrhea,
preop.Post spasticity. anorexia,
syndrome.
hyperther Prevention cramps,
mic crisisf of dysphagia,
malignant GI
hyperther bleeding,
mia. nausea,
vomiting.
GU:
crystalluria,
dysuria,
frequency,
erectile
dysfunction
,
incontinen
ce,
nocturia.
Derm:
pruritus,
sweating,
urticaria.
Hemat:
anemia,
aplastic
anemia,
eosinophil
ia,
leukopeni
a,
thromboc
yto penia.
Local:
irritation
at
IVsite,
phlebitis.
MS:
myalgia.
Misc:
ANAPHYL
AXIS,
chills,
drooling,
fever.
Penicillin 250mg Treatment :Previous Bindto CNS: Assessfor
400,000 of awide hypersensi bacterial SEIZURES. infection
Classificati units. PO varietyof tivityto cell wall, GI: (vitalsigns;
on (Adultsand infections penicillin’s resulting diarrhea, appearan
Therapeuti Children12 including: (cross in cell epigastric ce of
c: yr.):Most sensitivity death. distress, wound,
anti-infecti infections— Therapeutic nausea, sputum,
ve
Pharmacol
ogi
c:penicillin’s 125–500 Pneumoc existswith Effects: vomiting, urine,and
mgq 6–8 occal cephalosp Bacterici pseudom stool;
hr. pneumonia orin’sand dal em WBC) at
Rheumatic , other action branous beginning
fever Streptococ beta-lacta against colitis.GU: ofand
prevention— cal m suscepti interstitial during
125–250 antibiotics) ble nephritis. therapy
pharyngitis
mgq 12hr. ; Some bacteria. Derm:rash,
, Syphilis,
PO products Spectrum: urticaria.
Gonorrhea
(Children12 may Active Hemat:
strains. contain
yr.):Lyme against: eosinophil
Treatment tartrazine ia,
disease—50 Most
of andshould leukopeni
mg/kg/day gram
enterococc be avoided positive a.
in4 divided
doses i in patients organisms, Misc:
(unlabeled); infections with including allergic
prevention (requires known many reactions
of the hypersensi streptoco including
Streptococc additionof tivity.Use cci ANAPHYLA
us an Cautiously (Streptoc XISand
pneumonia aminoglyc in: Severe occus SERUM
sepsisin oside). renal pneumon SICKNESS,
childrenwith Prevention insufficienc iae, superinfec
sicklecell of y (dosage groupA tion.
disease— rheumatic reduction beta
125 mg fever. recomme hemolytic
twicedaily Should not nded); streptoco
OB: cci),
beused as
Although staphylo
asingle
safetynot cocci
agentto establishe (non–
treat d, has penicillin
anthrax. been ase
Unlabeled used -producin
Use: safely; g
Treatment Lactation strains)
of Lyme : and
disease. Safetynot Bacillus
Prevention establishe anthracis,
of d; Geri: Some
recurrent Consider gram
Streptoco bodymass, negative
ccal age-related organisms,
pneumonia pin suchas
e renal/hep Neisseria
septicemia atic meningiti
in children
/cardiac dis and
with function, N.
sickle-cell concurrent gonorrhea
disease. diseases (only
and drug penicillin
therapy. suscepti
ble
strains),
Some
anaerobic
bacteria
and
spirochete
s
including
Borellia
burgdorferi.
Ceftriaxone IM,IV Treatment Hypersens Bindsto CNS: Observe
(Adults): of:Skin itivityto the SEIZURES patientfor
Classificati Most and skin cephalosp bacterial (high signsand
on infections structure orins; cell wall doses). symptoms
Therapeuti —1–2g infections, Serious membra GI: of
c: every12– hypersensi ne, PSEUDOME anaphylaxi
Boneand
anti-infecti 24hr tivityto causing MBRANO s
joint
ve Gonorrhea— penicillin’s; cell US (rash,
infections,
Pharmacol 250mgIM Pedi: death. COLITIS, pruritus,
ogic:third Complicat
(singledose). Neonates Therapeu diarrhea, laryngeal
generation ed and
Meningitis— tic cholelithias edema,
cephalospo uncomplic Effects:
2g every12 28days is, wheezing).
rin’s hr. ated (use in Bacterici gallbladder Discontinu
Perioperativ urinary hyperbilir dal sludging. e thedrug
e tract ubinemic action Derm: and notify
prophylaxis infections, neonates against rashes, health
—1 g0.5–2 Uncompli maylead suscepti urticaria. care
hr cated to ble Hemat: profession
before gynecolog kernicteru bacteria. bleeding, al
surgery ical s); Pedi: Spectrum: eosinophil immediat
(single infections Neonates Similarto ia, ely if
dose). including that of hemolytic these
IM,IV gonorrhea, 28days second anemia, symptoms
(Children): Lower requiring generatio leukopenia, occur.
Most respiratory calcium n thromboc Keep
infections— tract containing cephalos ytosis. epinephri
50–75 IV porins, Local: ne,an
infections,
mg/kg/day solutions but painatIM antihista
Intra
(notto (q activity site, mine,
exceed 2
abdominal riskof and
against phlebitisatI
g/day) infections, precipitati staphylo resuscitati
V
divided Septicemia on cocciis on
site.Misc:al
every 12– , formation) less, lergic equipment
24hr. Meningitis, . while reactions closebyin
Meningitis— Otitis activity including theevent
100 media. against ANAPHYL of an
mg/kg/day Perioperati gram AXIS, anaphylac
(notto ve negative superinfec tic
exceed 4 prophylaxi pathogens tion. reaction.
g/day) s. is greater,
divided evenfor
every 12– organisms
24hror resistant
Uncomplicat to first-
ed and
gonorrhea— second
125mgIM generati
(singledose). on
Acuteotitis agents.
media—50 Notableis
mg/kg(not increased
to exceed1 action
g)IM single against:
dose. Acinetob
acter,
Enteroba
cter,
Haemophilu
s
influenza
e
(includin
g-
lactamase
producing
strains),
Haemop
hilus
parainflu
enzae,
Escheric
hia coli,
Klebsiella
pneumoni
ae,
Morganell
a
morganii,
Neisseria,
Proteus,
Providen
cia,
Serratia,
Mo
raxella
catarrhal
is. Has
some
activity
against
anaerobe
s,
including
Bac
teroides
fragilis.
Not
active
against
methicillin
resistant
staphylo
coccior
enterococci.
Corticoste PO(Adults): Manageme Active In Adverse Assess
roids 25–300 nt of untreated pharmac reactions/ patientfor
mg/dayin adrenocor infections ologic sid e signsof
Classificati divided tical (maybe doses, effects are adrenal
on doses used in suppress much insufficien
insufficien
Therapeuti every12– patients es more cy
cy ;
c: anti 24 being inflamma common (hypotensi
chronic
inflammato hr.PO treated for tionand withhigh on ,
ries use in
(Children): tuberculo the dose/long weight
(steroidal) other loss,
Adrenocortic us normal term
Pharmacol al situations meningiti immune therapy weakness,
ogic: insufficiency is limited s); response. CNS: nausea,
corticoster —0.7 becauseof Lactation: Have depression, vomiting,
oids mg/kg/day mineraloco Avoid numerous euphoria, anorexia,
(20–25 rticoid chronic intense headache, lethargy,
mg/m2 / activity. use. metabolic qin confusion,
day)in tracranial
divideddoses
every8hr. Replaceme effects pressure restlessne
Otheruses— nt therapy (see (children ss) before
2.5–10 in Adverse only), and
mg/kg/day adrenal Reactions personality periodically
(75–300 insuffi andSide changes, during
mg/m2/ ciency. Effects). psychoses, therapy.
day) in Suppress restlessne
divided es ss. EENT:
dosesevery adrenal cataracts,q
6–8hr. function int
at raocular
chronic pressure.
dosesof CV:
20 hypertensi
mg/day. on.GI:
Replaces PEPTIC
endogeno ULCERATIO
us N,
cortisolin anorexia,
deficiency nausea,
states. vomiting.
Also has Derm:
potent acne,pwou
mineralo nd
corticoid healing,
(sodium ecchymos
retaining) es,
activity. fragility,
Therapeu hirsutism,
tic petechiae.
Effects: Endo:
Suppressi adrenal
on of suppressio
inflamma n,
tionand hyperglyce
modificati mi a. F and
on ofthe E:
normal fluid
immune retention
response. (long-term
Replace high
men t doses),
therapy hypokalemi
in a,
adrenal hypokalemi
insufficie c alkalosis.
ncy. Hemat:
THROMBOE
MBOLISM,
thrombop
hle
bitis.Meta
b: weight
gain,
weight
loss.MS:a
vascular
necrosisof
joints,
muscle
wasting,
osteoporos
is, muscle
pain. Misc:
cushingoid
appearan
ce
(moon
face,
buffalo
hump),qs
usc
eptibility
to
infection.
Riluzole PO(Adults): Treatment Severe Action CNS: Assess
50 mgq12 of patients hypersensi may be dizziness, patientfor
Classificati hr. with tivity. related weakness, aggravati
on amyotroph to: headache. on
Therapeuti ic lateral Inhibition Resp: reaction
c: agents of decreased causing
sclerosis
for glutamate lung worsening
(ALS).
amyotrop release, function, of ALS
hic lateral Inactivati hypersensi symptoms
sclerosis on of tivity (unusual
sodium pneumonit tiredness
channels is, and or
or, interstitial weakness
Interferen lung ,
ce with disease. spasticity,
neurotrans CV: diarrhea,
mitter hypertens nausea,
bindingat ion, vomiting).
receptor peripheral May
sites. edema.GI: require
Therapeu HEPATITIS, dose
tic abdominal reduction.
Effects: pain,
Extended nausea,
survivalor anorexia,
timeto diarrhea,
tracheosto dyspepsia,
myinALS flatulence,
patients. liver
enzymes,
vomiting.
Hemat:
neutrope
nia.
Metab:
weight
loss. MS:
arthralgia,
backpain.
Neuro:
circumoral
paresthesia.
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