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J Stomatol Oral Maxillofac Surg 118 (2017) 40–44

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Review

Implication of general anaesthetic and sedation techniques in


temporomandibular joint disorders – a systematic review
J. Talaván-Serna a,*, J.M. Montiel-Company b, C. Bellot-Arcı́s b, J.M. Almerich-Silla b
a
Department of Anaesthesiology and Reanimation, Ontinyent General Hospital, Avda. Francisco Cerdà, 3, 46870 Valencia, Spain
b
Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, C/Gascó Oliag No. 10, 46010 Valencia, Spain

A R T I C L E I N F O A B S T R A C T

Article history: The purpose of this study was to conduct a systematic review of the literature on temporomandibular
Received 15 September 2016 joint damage directly related to general anaesthesia and sedation. We searched MEDLINE, SCOPUS and
Accepted 12 December 2016 the COCHRANE Library for titles and abstracts containing terms related to the subject. The search
Available online 3 February 2017
delimiters were analytical and descriptive studies with abstracts in Spanish, German, English or French,
with no time limit. The search was updated in January 2015. Of the 398 articles found, 89 were duplicates
Keywords: and only 28 were of interest. Of these, 23 (82.14%) were case and case series reports, 4 (14.28%) were
Mandibular
longitudinal studies and 1 (3.57%) was a cross-sectional study. General anaesthesia and sedation are risk
Joint
Sedation
factors for temporomandibular joint damage because of the drop in muscle tone caused by the drugs
Anaesthesia employed and because of airway management manoeuvres involving the joint. Joint complications have
Disorders been described with spontaneous ventilation as well as with ventilation assisted by a face or laryngeal
mask and with intubation. They are more frequent in women and/or patients with previous
temporomandibular problems. Proper assessment is required both before and after anaesthesia or
sedation in order to foresee and avoid or minimize temporomandibular complications. The data should
be treated with caution, as the evidence of case and case series reports is not of a high standard and the
small number of analytical studies is not entirely comparable. General anaesthesia and sedation
techniques can influence the onset of temporomandibular joint disorders. More studies are needed to
provide better clinical evidence.
C 2016 Elsevier Masson SAS. All rights reserved.

1. Introduction under general anaesthetic can predispose to greater joint


mobilisation [11,12], which can lead to more complications than
Many types of anaesthetic- and sedation-related temporoman- those already involved in mobilisation for airway control. Prior TMJ
dibular joint (TMJ) damage or disorder have been described. They dysfunction or certain systemic conditions can favour the
range from slight discomfort and joint sounds [1,2] to headaches development of new onset TMJ problems or the exacerbation of
and even to severe impairment of joint movement and malocclu- existing manifestations when general anaesthetic techniques are
sion problems [3–5] that interfere seriously with stomatognathic applied to the patient [13,14].
system function. However, the ultimate aetiology of such events is Additionally, there is widespread unawareness of the different
largely unknown [6,7], although it has been suggested that factors manifestations of TMJ damage that can appear after using
related to anaesthetic techniques may be involved [4,8], since anaesthetic techniques or in relation to the various airway control
airway management entails mobilising the mouth and TMJ system techniques [6,7].
[9,10] while the patient is unconscious and partially or totally In view of the foregoing, the aim of this study was to conduct a
unable to make defensive movements. While manoeuvring the systematic review of the literature concerning damage to the
joint, complications may arise. In the same way, loss of muscle tone temporomandibular joint directly related to different general
due to the unconsciousness and muscular relaxation of a patient anaesthesia and sedation methods, in order to acquire a better
understanding of the factors involved.

2. Methods
* Corresponding author. Unidad Docente de Preventiva, Departamento de
Estomatologı́a, Facultad de Medicina y Odontologı́a, Universidad de Valencia, C/
Gascó Oliag No. 10, 46010 Valencia, Spain. We reviewed the bibliography systematically in accordance
E-mail address: jutaser@alumni.uv.es (J. Talaván-Serna). with the PRISMA (Preferred Reporting Items for Systematic

http://dx.doi.org/10.1016/j.jormas.2016.12.002
2468-7855/ C 2016 Elsevier Masson SAS. All rights reserved.
J. Talaván-Serna et al. / J Stomatol Oral Maxillofac Surg 118 (2017) 40–44 41

Reviews and Meta-Analyses) recommendations [15] and the the information given in the abstract was insufficient for definite
CONSORT criteria [16]. inclusion or exclusion, they reviewed the full article before taking
the final decision.
2.1. Study selection criteria
2.3. Data extraction
The selection criteria for inclusion in the review were: articles,
articles in press and reviews; studies conducted in adults. The The variables recorded for comparison of the studies were:
types of study included were: systematic reviews and meta- author(s), publication year, demographic data (gender and age),
analyses, randomised controlled trials (RCTs), cohort studies and sample size, study type and disorder described (Table 1).
case-control studies, both prospective and retrospective, and case
and case series reports. All those that investigated the involvement 3. Results
of general anaesthetic and sedation techniques in temporoman-
dibular joint disorders were accepted. The database search found 302 articles in Medline, 84 in Scopus
and 12 in Cochrane Library Plus, totalling 398 articles. The
2.2. Search strategy and screening of articles 89 duplicates were excluded. A critical reading of the title and
abstract led to excluding 279 articles that did not answer the
To identify the relevant studies, irrespective of language and research question, leaving a total of 30 articles. On reading the full
with no time limit, we conducted detailed electronic searches in text, a further 2 were excluded because they did not answer the
the Medline, Scopus and Cochrane Library databases, updating research question, resulting in a total of 28 articles.
them on 20 January 2015. Of these 28 articles, 23 were case and case series reports (Table
The search equations were formed from the following terms: 1), four were longitudinal studies and one was a cross-sectional
temporomandibular, temporomandibular joint, TMJ, temporo- study (Table 2). The case and case series reports assessed
mandibular disease, TMD, temporal, mandibular, intubation, 28 patients: 19 female (67.8%) and 9 male (32.14%). By anaesthetic
laryngoscopy, laryngoscope, extubation, anaesthesia, anesthesia, procedure, a general anaesthetic was applied in 27 cases (96.42%)
anaesthetic, anesthetic, induction, dislocation, jaw, perioperative, and sedation techniques in one case (3.57%). By disorder,
laryngeal mask, LMA, joint, propofol, ketamine and midazolam, 21 patients presented dislocation of one or both condyles
using all the possible combinations of these words. (75.0%), six patients (21.4%) had disc dislocation with locking
Two separate reviewers independently assessed the titles and and one case (3.5%) showed TMJ condyle resorption. The mean age
abstracts of all the articles. If they disagreed they attempted to was 40.89 years (female: 37.3, range 18–66 years, male: 48.5,
reach a consensus, failing which they consulted a third reviewer. If range 22–81 years) (Table 1).

Table 1
Distribution of case and case series reports.

Author (year) [reference] n Age Gender Anaesthetic When disorder occurred TMJ disorder
(F/M) technique

Avidan (2002) [20] 1 26 F S Induction CD


Diagnosis: Postoperative
Bellman and Babu (1978) [11] 1 18 F GA Induction (pre-intubation) CD
Gambling and Ross (1988) [19] 1 30 F GA Induction (pre-intubation) CD
Gould and Banes (1995) [9] 2 34 F GA Induction (pre-intubation) in one case. DDL
24 F Not specified in the other case
Diagnosis: post-extubation (postoperative)
Iguchi et al. (2004) [26] 1 43 F GA Induction (pre-intubation) DDL
Knibbe et al. (1989) [3] 3 27 F GA Not specified DDL
31 M Diagnosis: postoperative DDL
81 M CD
Mareque-Bueno et al. (2013) [5] 1 52 F GA Not specified CR
Diagnosis: postoperative (late)
Michot et al. (2010) [24] 1 42 F GA Eduction (removal of laryngeal mask) CD
Oofuvong (2005) [10] 1 30 F GA Induction of anaesthesia (intubation) CD
Patel (1979) [12] 1 55 M GA Induction CD
Pillai and Konia (2013) [22] 1 66 F GA Not specified CD
Diagnosis: postoperative
Quessard et al. (2008) [7] 1 49 M GA Not specified CD
Diagnosis: postoperative
Rastogi et al. (1997) [4] 2 36 F GA Not specified CD
35 M Diagnosis: post-extubation (postoperative)
Rattan and Arora (2006) [30] 1 22 M GA Not specified CD
Diagnosis: post-ICU (late)
Roze des Ordons and Townsend (2008) [29] 1 39 F GA Induction (pre-intubation) DDL
Sia et al. (2008) [6] 2 64 M GA Induction (intubation/insertion of laryngeal mask) CD
60 F
Small et al. (2004) [28] 1 40 F GA Induction of anaesthesia (pre-intubation) CD
Schwartz (2000) [8] 1 69 M GA Postoperative CD
Sosis and Lazar (1987) [25] 1 27 F GA Induction (intubation) CD
Sriganesh et al. (2005) [14] 1 34 F GA Induction (intubation) CD
Ting J. (2006) [21] 1 45 F GA Not specified CD
Diagnosis: after removal of laryngeal mask (postoperative)
Unnikrishnan et al. (2006) [27] 1 31 M GA Induction CD
Wang et al. (2009) [23] 1 35 F GA. Extubation (eduction of anaesthesia) CD

F: female; M: male; GA: general anaesthesia; S: sedation; CD: condyle dislocation; DDL: disc dislocation and locking; CR: condylar resorption.
42 J. Talaván-Serna et al. / J Stomatol Oral Maxillofac Surg 118 (2017) 40–44

Table 2
Analytical articles.

Author/year [reference] n Mean age Gender Anaesthetic Results


(years) (F/M) technique

Rodrigues et al. (2009) [2] 100 44 M: 34% GA with 8% disc displacement (female to male ratio 7:1)
F: 66% intubation 19% joint sounds (female to male ratio 4:1)
Martin et al. (2007) [1] 122 53.4 M: 43.3% GA with Advanced age, female gender and low interincisal distance are risk
F: 56.7% intubation factors for TMJ pain
Greater risk if prior TMJ disorder
No relationship between intubation time and TMJ symptoms
Lipp et al. (1987) [18] 100 42.2 (GA) – GA with 66% of the patients who underwent general anaesthesia presented
46.8 (LRA) intubation/LRA up to 35% reduction of maximum mouth opening
Agró et al. (2015) [13] 68 50.6 M: 58.8 GA with 13% presented some type of TMJ dysfunction prior to surgery.
F: 41.2 intubation Of these, 44% worsened after intubation
5% of patients developed new onset TMJ dysfunction
Domino et al. (1999) [17] 4460 claims – M: 85% GA Of the 27 claims, 11 were for joint dislocation and 16 for isolated pain
(27 TMJ-related) F: 15% 30% presented discomfort due to previous joint disorders

F: female; M: male; GA: general anaesthesia; LRA: locoregional anaesthesia.

Of the analytical studies, [17] examined the ASA Closed Claims as yawning) were enough to dislocate the condyle. In the same
Project, which records the data from 35 health insurers in the USA, way, Unnikrishnan et al. [27] described a case of condyle
to identify anaesthesia-related claims and collect information on dislocation associated with yawning during the induction of
airway lesions associated with general anaesthesia, the patients’ anaesthesia in a tracheostomy tube wearer. In these cases,
clinical manifestations and airway characteristics and the type of moreover, neuromuscular blocking drugs had not yet been
surgery. Agrò et al. [13] examined clinical manifestations in administered. Similarly, Gambling et al. [19] published an
68 patients before and after tracheal intubation in order to assess analogous case of condyle dislocation after anaesthesia had been
TMJ disorders and/or dysfunctions. Similarly, Martin et al. [1] induced with hypnotic and neuromuscular blocking drugs but
conducted a study in 122 patients who had undergone tracheal prior to intubation manoeuvres. As in the previous cases, joint
intubation in relation to different types of surgery. They assessed reduction under sedation was required after this early diagnosis of
pre- and postoperative TMJ-related clinical manifestations in order condyle subluxation.
to investigate the risk factors associated with TMJ dysfunction Other manoeuvres associated with invasive airway manage-
following intubation. Lipp et al. [18] described a controlled ment which do not require excessive opening, such as intubation
prospective study in which 50 patients underwent surgery with with a fibrescope or lighted stylet, have also been described as
general anaesthesia and orotracheal intubation and another possible joint dislocation triggers. Rastogi et al. [4] described a
50 with locoregional anaesthesia (control group), and all were case of TMJ condyle dislocation following intubation with a
examined postoperatively to assess possible intubation-related fibrescope and the administration of general anaesthesia with
TMJ damage. Rodrigues et al. [2] conducted a prospective study of neuromuscular blocking drugs. The same authors also reported
100 patients with no previous TMJ disorder, assessing disturbances a case of condyle dislocation in a patient with orotracheal
to this joint following tracheal intubation for different types of intubation with a lighted stylet following induction of anaes-
surgery. They recorded the patients’ clinical and demographic thesia with hypnotic and neuromuscular blocking drugs. Direct
variables postoperatively in order to study new onset development laryngoscopy manoeuvres had not been performed in either
of joint disorders following intubation. of these two cases, but their mouths were sufficiently open to
carry out the airway management procedure. Following the
4. Discussion intervention, their respective joints were repositioned under
sedation.
It would appear to have been established that forcing mouth Although most dislocations occur during intubation manoeu-
opening can cause TMJ complications [3,19–22], the most frequent vres while inducing anaesthesia, Wang et al. [23] reported a case of
in this joint being anterior dislocation [10,22,23], although the TMJ condyle dislocation in a 35-year-old patient in relation to excessive
accounts for only 3% of joint dislocations in the entire body oral opening during orotracheal extubation.
[22]. However, there is little information on the incidence of this Cases of mandibular dislocation during laryngeal mask inser-
peri-anaesthesia complication [4,7,24]. The symptoms of TMJ tion have also begun to be reported, even in patients with no
dislocation can range from a serious acute clinical picture with previous history of TMJ disorders [6,21,24]. The reason is that head
severe pre-auricular pain and inability to close the mouth to a tilt and chin lift manoeuvres tend to be used to position these
subacute picture of less obvious pain and partial mouth closure, airways, causing passive wide opening of the mouth, which
but both are associated with difficulty in speaking and present a together with the low muscle tone induced by the general
depression in the pre-auricular area on palpation [22]. In contrast, anaesthesia predisposes to joint dislocation [6].
subluxation involves spontaneous reduction of the joint [8]. Several Other studies report disc dislocation with locking but no
authors [3,7,8,10,11,14,22,25] mentioned TMJ condyle (sub)luxa- condyle dislocation. Gould et al. [9] described two such cases. In
tions related to orotracheal intubation manoeuvres under general one, the jaw locked even before laryngoscopy manoeuvres had
anaesthetic with hypnotic and neuromuscular blocking drugs. In begun. Small et al. [28] and Roze des Ordons et al. [29] described
these cases, the mere drop in muscle tone and loss of defensive similar cases. In the case reported by Small et al. [28], the disk
reflexes caused by general anaesthesia, together with laryngo- dislocation reduced spontaneously. In these cases, difficult airway
scope traction for intubation, were sufficient for this phenomenon management situations arose that required special intubation
to occur [10–12,21,26,27]. techniques. Knibbe et al. [3] and Iguchi et al. [26] also reported
Patel et al. [12] and Avidan et al. [20] referred to cases of TMJ cases of disk displacement with locking.
dislocation following the induction of anaesthesia before invasive Cases of condyle resorption in which malocclusion and facial
airway control had been effected: a few spontaneous actions (such deviation developed several months after performing difficult
J. Talaván-Serna et al. / J Stomatol Oral Maxillofac Surg 118 (2017) 40–44 43

orotracheal intubations have also been described. These could be minor TMJ incidents following intubation in a series of
related to infectious, autoimmune, endocrine, cardiovascular, 50 patients.
metabolic or traumatic factors [5]. Domino et al. [17] found that 10% of the claims for airway
Consequently, it could be argued that temporomandibular trauma (27 out of 266) were for TMJ damage, in all cases associated
dysfunction following laryngoscopy and intubation or the inser- with ordinary tracheal intubation in ASA I–II patients. Out of this
tion of a laryngeal mask does not imply failings in these total, 85% of the claims were made by women and 96% by persons
techniques, as the structure of the TMJ and the wide range of aged under 60 years. Of the 27 TMJ trauma claims, 11 were for joint
movements it can perform [23] make this joint quite susceptible to dislocation and 16 were for pain. 30% of the cases had a previous
instability and it may even dislocate when no external force has history of TMJ disorders.
been applied [25,27]. At all events, spontaneous dislocation of the Certain conditions, such as some autoimmune diseases that
temporomandibular joint and TMJ disorders arising as a result of affect joints; diseases that cause hyperlaxity and fragile connective
general anaesthesia have not yet been clarified sufficiently [6] and tissues; malocclusion problems; retrognathism; algodystrophic
probably have a multifactorial origin. TMJ syndromes; a previous history of joint dislocation favoured by
It would be advisable to assess TMJ status preoperatively in flatness of the articular eminence; muscle hypotonia; or even
order to plan the intubation accordingly [1–4,7,10,13,28], as psychogenic factors, can favour TMJ disorder development in the
recommended by the American Society of Anesthesiology [22], and course of airway control manoeuvres during anaesthesia, as the
to proceed cautiously [6] during induction and intubation, loss of muscle tone is combined with forced manoeuvres with a
checking the occlusion in the event of any suspicion of joint susceptible joint [4,6–8,13,14,19,22,23,25,27,28]. However, it
dislocation [30]. The patient should also be warned of the risk of would also appear that not achieving adequate neuromuscular
such complications, which could even be triggered de novo relaxation could make laryngoscopy manoeuvres more difficult
following airway manipulation in the context of general anaes- and oblige the anaesthetist to increase the force applied to the
thesia [2–4]. In severe cases, postponement of surgery might even adjacent tissues and to the TMJ itself, predisposing this joint to
be considered until the TMJ disorder has been resolved [3]. greater damage [9]. Moreover, slow induction of general anaes-
It would also be advisable for the anaesthetist to be conscious of thesia is also a risk factor for TMJ disorders [7,24] as it makes it
these complications [19], to be as careful as possible [6], to check necessary to extend the duration of airway control manoeuvres,
during the application of anaesthesia and perianaesthetically that which are one of the risk factors for joint disorders. In the same
TMJ disorders are absent, and to be able to diagnose and treat them way, a difficult airway adds to the difficulties and using more
[3,7,10,14,25,30], especially in the case of dislocation, where aggressive manoeuvres increases the risk of joint dislocation
delayed diagnosis can lead to greater difficulty in correcting the [3,8,28].
problem [6,20]. The main limitation of this review is that few studies have been
Diagnosing TMJ complications in patients with intubation can published on TMJ disorders related to general anaesthetic and
be complex, owing to communication difficulties as a result of the sedation techniques and most of those published are case or case
general anaesthesia, analgesic medication prescribed perioperati- series reports of isolated instances encountered while applying
vely, which can mask TMJ pain, and a lack of familiarity with joint these procedures. This means that the evidence they provide is of a
dislocation among healthcare staff [22]. As a result, the condition is low standard. A higher standard of evidence was provided by some
often not diagnosed until the patient recovers full consciousness authors [1,2,13,17,18], although the fact that their number is very
and is able to communicate the feeling of pain and the inability to small and the variables analysed by each of them were highly
move the mouth [4,6,23]. Prolonged unconsciousness, such as may disparate makes them difficult to analyse with a view to arriving at
occur in intensive care patients, can therefore entail a considerable definite conclusions.
delay in diagnosis. For instance, Rattan and Arora [30] describe the Despite the few studies found, we may conclude that intubation
case of a 22-year-old man whose prolonged orotracheal intubation can cause TMJ disorders, although their percentage is small. The
was followed by late diagnosis of TMJ condyle dislocation, which most frequent is condyle dislocation followed by disc locking. A
required surgical reduction as closed reduction was no longer record of TMJ problems is a risk factor for postoperative joint
possible. On occasion, the diagnosis may be still tardier, even complications. More studies of higher evidence quality need to be
occurring weeks or months after the patient’s postoperative conducted on TMJ disorders in relation to general anaesthetic and
discharge [3]. sedation procedures.
According to Martin et al. [1], the patient’s ability to open
the mouth preoperatively is correlated with the Mallampati Contributions
score, although the latter is not a good predictor of TMJ
dysfunction. They also consider that low interincisal distance, Conception and design of study: J. Talaván-Serna, J.M. Montiel-
female gender and increasing age are correlated with TMJ pain Company.
following intubation and that previously experience of TMJ Acquisition of data: J. Talaván-Serna, J.M. Montiel-Company,
symptoms is the best predictive factor for post-intubation C. Bellot-Arcis, J.M. Almerich-Silla.
symptoms, even up to two weeks after this procedure. A greater Analysis and/or interpretation of data: J. Talaván-Serna, J.M.
or lesser duration of intubation appears not to be related to TMJ Montiel-Company, C. Bellot-Arcis.
symptoms [1]. Drafting the manuscript: J. Talaván-Serna, J.M. Montiel-
It seems to have been established that TMJ dysfunction can be Company, C. Bellot-Arcis.
aggravated by intubation manoeuvres. For instance, Agrò et al. Revising the manuscript critically for important intellectual
[13] reported that up to 13% of the population presents symptoms, content: J. Talaván-Serna, J.M. Montiel-Company, C. Bellot-Arcis.
which suggest TMJ dysfunction prior to general anaesthesia, and Approval of the version of the manuscript to be published:
the symptoms of 44% of these worsened following intubation. J. Talaván-Serna, J.M. Montiel-Company C. Bellot-Arcis, J.M.
Moreover, up to 5% of patients developed new onset TMJ Almerich-Silla.
dysfunction. In the prospective study conducted by Gould et al.
[9], 35 of the 15 patients who underwent intubation presented Disclosure of interest
TMJ disorders, albeit temporary, and two cases presented disc
displacement with locking. Lipp et al. [18] reported up to 66% of The authors declare that they have no competing interest.
44 J. Talaván-Serna et al. / J Stomatol Oral Maxillofac Surg 118 (2017) 40–44

[15] Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The
Acknowledgements
PRISMA statement for reporting systematic reviews and meta-analyses of
studies that evaluate health care interventions: explanation and elaboration.
Mary Georgina Hardinge translated the manuscript into PLoS Med 2009;21(6):e1000100 [Epub 2009 Jul 21].
[16] Schulz KF, Altman DG, Moher D, CONSORT Group. CONSORT 2010 statement:
English.
updated guidelines for reporting parallel group randomised trials. BMC Med
2010;24(8):18. doi:10.1186/1741-7015-8-18.
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