fx 0.

6
CLcr 10
Clcr noraml 120
Intevalo IR
Intervalo normal 6

ClCr pcte/Clcr fisio 0.08333333 IR 9.90909091

ClCr pcte/Clcr fisio-1 -0.91666667
-0.55

t 1/2 12 h Kg L
intervalo 3h 1 7
D 300 m 70 490
Vd 5-9 L/kg (7)
Cp max
Cp min ke=0,693/t1/2
ke 0.05775 Cp=D/Vd
Cp a 1 ° dosis 0.40816327 KeT 0.462
R 0.63002234 R= e-ket
1-R 0.36997766
1/1-R 2.7028659
Cp max 1.10321057
R/1-R 1.7028659
Cp min 0.6950473
 Datos
Vd 5 L/kg
K 0.15 h
Cp pico 4h
F 85 %
d1 500 mg
d2 500 mg
d3 1000 mg
t1 9 am
t2 2 pm
t3 9 pm

Cp min
Ke*t1 3.6 ket 24h 3.6
Ke*t2 2.85 e-Ket24 0.02732372
Ke*t3 1.8 1- e-Ket24 0.97267628
e-Ket1 0.02732372 Vd*1-e-Ket24 4.86338139
e-Ket2 0.05784432 F/Vd*1-e-Ket24 0.17477552
e-Ket3 0.16529889 Cp min 36.3328432
d1*e-KeT1 13.6618612
d2*e-KeT2 28.9221604
d3*e-KeT3 165.298888
suma 207.88291
Cp max

Ket1 2.4 keT24 3.6

Ket2 1.65 e-Ket24 0.02732372
Ket3 0.6 1- e-Ket24 0.97267628
e-Ket1 0.09071795 Vd*1-e-Ket24 4.86338139
e-Ket2 0.19204991 1/Vd*1-e-Ket24 0.20561826
e-Ket3 0.54881164 Cp max 141.916809
d1*e-KeT1 45.3589766
d2*e-KeT2 96.0249543
d3*e-KeT3 548.811636
Suma 690.195567