CHAPTER 4: Hemostasis, Surgical Bleeding and Transfusion

Learning Objectives: At the end of this chapter, the student will be able to:

I. Identify the important events involved in hemostasis following a vascular injury

a. Vasoconstriction
b. Platelet activation
c. Coagulation cascade
i. Intrinsic pathway
ii. Extrinsic pathway

II. Classify bleeding disorders based on platelet structure and function

a. Congenital Coagulation factor deficiency
i. Factor III deficiency (Hemophilia A, Von Willebrand’s Disease)
ii. Factor IX deficiency
iii. Factor XI deficiency
b. Congenital Defects in platelet function
i. Thrombasthenia
ii. Bernard-Soulier syndrome
iii. Storage pool deficiency
c. Acquired Quantitative Platelet defects
i. Idiopathic thrombocytopenia
ii. Heparin-induced thrombocytopenia
iii. Disseminated intravascular coagulation
iv. Thrombocytiopenic purpura
v. Haemolytic uremic syndrome
d. Acquired Qualitative platelet defects

III. Recognize the importance of hemostasis and transfusion in surgery

a. coagulopathy in trauma
b. local hemostatic agents
c. indications of transfusion
d. complications of transfusion
 and transfusion

TABLE OF SPECIFICATION
Topic/Course Title: 2 – Systemic Response to Injury & Metabolic Support
No. of Hours Taught: 6
Type of Exam: Short Quiz, Long Exam
Faculty-In -Charge:  Dr Dy

LEVELS / SKILLS
Remembering Understanding Thinking
(Comprehension/ (Analysis/Synthesis/ TOTAL
(Knowledge)
Application) Evaluation)
SUBTOPICS
Item Item Item
No. No. No.
Placement Placement Placement No. of
of % of % of % %
or Question or Question or Question Items
Items Items Items
No. No. No.
Local detection
CNS regulation  2  1,3
Gene expression
Inflammatory cells 2 4,5
Endothelial cells
Surgical metabolism
Energy metabolism 1 2
Energy requirement
Nutrition 5 6,7,8,9,10
TOTAL