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https://doi.org/10.1038/s41371-020-0384-7
ARTICLE
Abstract
Hypertension is a major risk factor for cardiovascular disease globally. Although Indian studies have addressed the
prevalence of hypertension and its associated factors, this study focuses upon women in the reproductive age group, 15–49
years, who have undiagnosed hypertension. We use NFHS-4 data for secondary analyses of prevalence and factors
associated with undiagnosed hypertension among women aged 15–49 years in India. Multiple logistic regression was
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undertaken to identify associated factors. Our analyses showed that overall prevalence of undiagnosed hypertension was
18.69% among women aged 15–49 years in India. In rural areas, it was 17.09% compared and 21.73% in urban areas. By
comparison, only 8.86% self-reported a diagnosis of hypertension. Factors associated with undiagnosed hypertension were
age, less than or more than normal BMI, higher wealth quintiles, no education, religion, caste, and geographical zones.
Almost one in five women aged 15–49 years in India has undiagnosed hypertension with implications for personal and
reproductive health.
Introduction [3]. The concept of cascade of care, that is, the proportion
with a relevant condition who have been screened, are
Hypertension is a major risk factor for cardiovascular aware of their diagnosis, are on medication, and have
disease (CVD) globally [1]. It is well-established that achieved control, is an important aspect of assessing the
treatment of elevated blood pressure (BP) results in huge performance of a health system. Wilber and Barrow first
gains in reducing CVD. According to World Health applied the “rule of halves” to the cascade of care on an
Organisation (WHO) estimates, raised BP causes 7.5 American population in 1972 [4]. The rule of halves states
million deaths annually and account for 57 million dis- that half of those hypertensive do not know, half of those
abilities adjusted life years (DALYs) [2]. The estimated who know are under treatment and half of those under
proportion of DALYs attributed to hypertension in India treatment have their BP under control. Prenissl et al. built
has risen from 21 million in 1990 to 39 million in 2016 the cascade of care in India measuring the loss of indi-
viduals at each stage of the process on National Family
Health Survey (NFHS-4) data [5]. They found that among
those with hypertension, 76.1% had been screened, 44.7%
* Vrijesh Tripathi were aware of their diagnoses, 13.3% were treated, and
Vrijesh.tripathi@sta.uwi.edu 7.9% had achieved control. This rule seems to work well
1 if we focus on those screened since nearly half of those
All Saints University School of Medicine, Roseau, Dominica
2
screened were aware of having elevated BP but the frac-
Faculty of Medical Sciences, The University of the West Indies, St
tions being treated were less than expected. According to
Augustine Campus, St Augustine, Trinidad and Tobago
3
a systematic review conducted by Anchala et al. [6],
Department of Mathematics and Statistics, Faculty of Science and
among Indians suffering from hypertension, only one-
Technology, The University of the West Indies, St Augustine
Campus, St Augustine, Trinidad and Tobago fourth in rural areas and one-third in urban areas, are
4 being treated while only one-tenth in rural and one-fifth in
Department of Clinical Medical Sciences, Faculty of Medical
Sciences, The University of the West Indies, St Augustine urban areas, have BP under control. In women, treating or
Campus, St Augustine, Trinidad and Tobago eliminating hypertension has the greatest impact of all
D. Talukdar et al.
Fig. 1 Flowchart showing NFHS-4 data on women aged 15–49 years, deriving the sample for women with undiagnosed hypertension.
Flowchart for undiagnosed hypertension.
Dadra & Nagar Haveli, Daman and Diu, Goa, Gujarat, and Results
Maharashtra, (5) southern zone comprising Andaman and
Nicobar, Andhra Pradesh, Karnataka, Kerala, Lak- Prevalence of undiagnosed hypertension
shadweep, Puducherry, Tamil Nadu, and Telangana, and (6)
north-eastern zone comprising Arunachal Pradesh, Assam, The prevalence of undiagnosed hypertension was 18.63%,
Manipur, Meghalaya, Mizoram, Nagaland, Sikkim, and 17.09% in rural areas, and 21.73% in urban areas. Table 2
Tripura. Diet had seven independent variables such as milk reports the socio-demographic characteristics and weighted
or curd, pulse or beans, vegetables, fruits, eggs, fish and prevalence of undiagnosed hypertension among women
chicken or meat. Each of these variables were subdivided who were found to be hypertensive upon screening of BP.
into two categories namely never or occasional and daily or
weekly. See Table 1 for categorizations used for the Age
variables.
Age shows a linear relationship with undiagnosed hyperten-
Statistical analyses sion among women in rural areas. The relationship was not
linear in urban areas which saw a higher prevalence among
Analysis involved weighted data and we calculated overall women <25 years of age and above 40 years. The age group
prevalence of undiagnosed hypertension and its prevalence in 45–49 years showed the highest prevalence of undiagnosed
rural and urban areas. Logistic regression was chosen as the hypertension of 23.35%, with 22.80% in rural, and 24.49% in
appropriate statistical tool for analysis. Both unadjusted and urban areas, respectively. It is to be noted that undiagnosed
adjusted logistic regression models were analyzed for overall hypertension was fairly high even among younger age groups.
weighted odds ratio for women aged 15–49 years suffering
from undiagnosed hypertension [19]. The prevalence of Smoking status, alcohol, and tobacco consumption
undiagnosed hypertension among various geographical
regions was mapped using open GeoDa software for spatial Weighted prevalence of undiagnosed hypertension was
data analysis. Local Indicators of Spatial Association (LISA) 20.13% among smokers, 24.78% among alcoholics, and
is part of GeoDa statistical test, which supplement visualiza- 19.73% among tobacco users.
tion by creating hot & cold spots on the map [20]. All analysis
related to prevalence estimation of undiagnosed hypertension, Wealth index
body mass index (BMI) and other biomarkers and socio-
demographic profiles were conducted using Stata statistical In terms of wealth index, overall prevalence increased
software 14.2 (StataCorp LLC) [21]. from poorest to richest wealth index. It ranges between
D. Talukdar et al.
Table 2 Socio-demographic characteristics and Prevalence of undiagnosed hypertension in women (15–49 years).
Characteristics Undiagnosed hypertension Weighted prevalence of undiagnosed hypertension p value
Total (%) Overall (95% CI) Rural (95% CI) Urban (95% CI)
Age: years
15–19 20334 (18.05) 18.15 (17.93, 18.38) 15.34 (15.09, 15.59) 24.81 (24.35, 25.28) 0.000
20–24 19208 (17.05) 17.58 (17.36, 17.81) 15.55 (15.29, 15.81) 21.75 (21.32, 22.18) 0.000
25–29 17081 (15.16) 17.08 (16.85, 17.32) 15.69 (15.41, 15.97) 19.77 (19.35, 20.20) 0.000
30–34 14060 (12.48) 16.89 (16.63, 17.14) 15.80 (15.49, 16.11) 18.96 (18.51, 19.42) 0.000
35–39 14401 (12.79) 18.74 (18.47, 19.02) 18.02 (17.69, 18.36) 20.11 (19.63, 20.60) 0.000
40–44 13755 (12.21) 21.41 (21.09, 21.73) 20.47 (20.08, 20.85) 23.19 (22.64, 23.75) 0.000
45–49 13800 (12.25) 23.35 (23.01, 23.70) 22.80 (22.39, 23.22) 24.49 (23.89, 25.10) 0.000
Current smoking status
Nonsmoker 111095 (98.63) 18.61 (18.51, 18.71) 17. 06 (16.94, 17.17) 21.71 (21.53, 21.90) 0.000
Smoker 1545 (1.37) 20.13 (19.24, 21.04) 19.35 (18.40, 20.34) 23.89 (21.66, 26.28) 0.000
Current alcohol use
Nonalcoholic 110807 (98.37) 18.55 (18.45, 18.65) 16.98 (16.87, 17.10) 21.69 (21.51, 21.88) 0.000
Alcoholic 1832 (1.63) 24.78 (23.81, 25.78) 24.32 (23.25, 25.42) 26.85 (24.55, 29.28) 0.030
Current tobacco use
Nontobacco user 107350 (95.30) 18.58 (18.48, 18.68) 16.99 (16.88, 17.11) 21.71 (21.53, 21.90) 0.000
Tobacco user 5290 (4.70) 19.73 (19.26, 20.21) 18.96 (18.43, 19.50) 22.19 (21.19, 23.23) 0.000
Wealth
Poorest 17989 (15.97) 15.87 (15.66, 16.08) 15.72 (15.51, 15.94) 18.55 (17.57, 19.58) 0.000
Poorer 20575 (18.27) 16.89 (16.68, 17.10) 16.49 (16.27, 16.71) 20.06 (19.39, 20.74) 0.000
Middle 23459 (20.83) 18.80 (18.59, 19.02) 17.85 (17.61, 18.10) 21.60 (21.15, 22.05) 0.000
Richer 25634 (22.76) 20.58 (20.36, 20.81) 18.92 (18.62, 19.23) 22.30 (21.97, 22.63) 0.000
Richest 24982 (22.18) 20.79 (20.56, 21.02) 17.91 (17.50, 18.34) 21.84 (21.57, 22.12) 0.000
Education
No education 30820 (27.36) 18.32 (18.14, 18.51) 17.65 (17.45, 17.85) 21.32 (20.87, 21.78) 0.000
Primary 13661 (12.13) 18.07 (17.80, 18.35) 16.75 (16.44, 17.07) 21.67 (21.11, 22.25) 0.000
Secondary 53422 (47.43) 18.68 (18.53, 18.82) 16.70 (16.53, 16.87) 22.13 (21.88, 22.38) 0.000
Higher 14736 (13.08) 19.69 (19.40, 19.97) 17.57 (17.15, 18.01) 21.10 (20.73, 21.49) 0.000
Social caste
Caste 100176 (89.17) 18.69 (18.59, 18.80) 17.09 (16.96, 17.21) 21.77 (21.58, 21.96) 0.000
Tribe 7507 (6.68) 18.42 (18.04, 18.80) 17.76 (17.36, 18.16) 22.29 (21.25, 23.36) 0.000
No caste/tribe 3886 (3.46) 17.43 (16.94, 17.93) 15.97 (15.37, 16.58) 19.90 (19.06, 20.78) 0.000
Do not know 770 (0.69) 18.79 (17.63, 20.02) 16.01 (14.59, 17.55) 22.56 (20.65, 24.58) 0.000
Religion
Hindu 90190 (80.07) 18.48 (18.37, 18.59) 17.02 (16.90, 17.15) 21.77 (21.56, 21.98) 0.000
Muslim 15428 (13.70) 18.56 (18.30, 18.83) 16.46 (16.12, 16.80) 21.11 (20.70, 21.52) 0.000
Christian 3153 (2.80) 23.08 (22.38, 23.79) 21.96 (21.09, 22.86) 24.90 (23.74, 26.10) 0.000
Others/not stated 3869 (3.43) 19.43 (18.88, 19.98) 18.00 (17.34, 18.68) 21.93 (20.99, 22.90) 0.000
BMI
Underweight (<18.5) 30295 (27.07) 21.28 (21.07, 21.49) 19.11 (18.88, 19.35) 28.49 (28.00, 28.98) 0.000
Normal (18.5–24.9) 57349 (51.24) 16.57 (16.45, 16.69) 15.23 (15.09, 15.38) 19.51 (19.27, 19.75) 0.000
Pre-obesity 17545 (15.68) 20.39 (20.12, 20.66) 20.08 (19.71, 20.45) 20.72 (20.33, 21.11) 0.010
(25–29.9)
Obesity Class I 5099 (4.56) 25.02 (24.43, 25.62) 25.46 (24.54, 26.41) 24.72 (23.95, 25.49) 0.171
(30–34.9)
Obesity Class II (35–39.9) 1158 (1.03) 27.20 (25.88, 28.56) 26.48 (24.27, 28.81) 27.58 (25.95, 29.26) 0.377
D. Talukdar et al.
Table 2 (continued)
Characteristics Undiagnosed hypertension Weighted prevalence of undiagnosed hypertension p value
Total (%) Overall (95% CI) Rural (95% CI) Urban (95% CI)
Obesity Class III (≥40) 477 (0.43) 26.24 (24.27, 28.32) 21.58 (19.04, 24.35) 31.09 (28.13, 34.21) 0.000
Zones
Northern 12846 (11.40) 17.07 (16.80, 17.34) 14.23 (13.92, 14.55) 21.95 (21.47, 22.44) 0.000
Central 24161 (21.45) 15.38 (15.20, 15.56) 14.53 (14.33, 14.74) 17.68 (17.32, 18.05) 0.022
Eastern 22070 (19.59) 16.30 (16.10, 16.49) 15.82 (15.60, 16.04) 18.01 (17.57, 18.45) 0.000
Western 21055 (18.69) 23.56 (23.28, 22.78) 21.16 (20.80, 21.54) 26.24 (25.82, 26.66) 0.003
Southern 28653 (25.44) 22.55 (22.33, 22.78) 21.97 (21.67, 22.28) 23.32 (22.97, 23.68) 0.000
North-Eastern 3856 (3.42) 18.79 (18.26, 19.33) 18.28 (17.69, 18.87) 20.94 (19.71, 22.24) 0.000
Diet
Milk/curd (N/O) 35717 (31.71) 18.01 (17.85, 18.18) 16.99 (16.80, 17.18) 21.09 (20.74, 21.45) 0.000
Milk/curd (D/W) 76923 (68.29) 18.93 (18.81, 19.05) 17.16 (17.01, 17.30) 21.94 (21.73, 22.15) 0.000
Pulse/beans (N/O) 11331 (10.06) 18.43 (18.12, 18.73) 17.15 (16.81, 17.50) 21.90 (21.28, 22.54) 0.000
Pulse/beans(D/W) 101308 (89.94) 18.65 (18.55, 18.75) 17.09 (16.96, 17.21) 21.71 (21.53, 21.90) 0.000
Vegetables (N/O) 16575 (14.72) 18.36 (18.10, 18.61) 17.09 (16.80, 17.38) 21.46 (20.97, 21.96) 0.000
Vegetables (D/W) 96064 (85.28) 18.68 (18.57, 18.78) 17.09 (16.97, 17.22) 21.77 (21.58, 21.96) 0.000
Fruits (N/O) 59244 (52.60) 17.67 (17.54, 17.80) 16.60 (16.45, 16.74) 21.32 (21.03, 21.61) 0.000
Fruits (D/W) 276117 (56.12) 19.83 (19.68, 19.98) 17.98 (17.79, 18.18) 21.98 (21.75, 22.21) 0.000
Eggs (N/O) 63998 (56.82) 17.70 (17.57, 17.82) 16.30 (16.16, 16.44) 21.03 (20.79, 21.28) 0.000
Eggs (D/W) 48642 (43.18) 20.01 (19.86, 20.17) 18.45 (18.25, 18.65) 22.52 (22.26, 22.79) 0.000
Fish (N/O) 74088 (65.77) 18.32 (18.20, 18.44) 16.69 (16.55, 16.83) 21.92 (21.69, 22.15) 0.000
Fish (D/W) 38551 (34.23) 19.25 (19.08, 19.42) 17.98 (17.77, 18.19) 21.41 (21.11, 21.70) 0.000
Chicken/meat(N/O) 73749 (65.47) 17.80 (17.68, 17.91) 16.40 (16.26, 16.53) 21.16 (20.94, 21.39) 0.000
Chicken/meat(D/W) 38891 (34.53) 20.44 (20.26, 20.62) 18.92 (18.69, 19.15) 22.60 (22.31, 22.89) 0.000
N/O never/occasional, D/W daily/weekly.
Dietary habits years old and adjusted OR 1.59 (95% CI, 1.54–1.65) for the
age group 45–49 years old. Comparatively in urban areas,
In terms of diet, 20.44% women who consumed chicken/ younger women at ages 20–39 were more at risk than
meat daily or weekly, 20.01% women who consumed eggs women at ages 40–49 years.
daily or weekly, and 19.25% women who consumed fish
daily or weekly had undiagnosed hypertension. Smoking status, alcohol, and tobacco use
Multiple logistic regression analyses Women smokers possess higher risk, overall adjusted OR
1.13 (95% CI, 1.07–1.20), rural adjusted OR 1.12 (95% CI,
Table 3 reports the unadjusted and adjusted odds ratio along 1.05–1.19) and urban adjusted OR 1.14 (95% CI,
with 95% confidence interval for undiagnosed hypertension 1.00–1.31) compared to nonsmokers. Alcohol consumption
in women aged 15–49 years. increased risk, overall adjusted OR 1.37 (95% CI,
1.29–1.45), rural adjusted OR 1.36 (95% CI, 1.28–1.45),
Age and urban adjusted OR 1.22 (95% CI, 1.08–1.39). Tobacco
users had a marginal risk compared to nontobacco users,
Age is a risk factor in multiple logistic regression model overall adjusted OR 1.06 (95% CI, 1.03–1.10).
with 40–44 years old, adjusted OR 1.20 (95% CI,
1.17–1.23) and 45–49 years old, adjusted OR 1.33 (95% CI, Wealth index
1.30–1.37).
The multiple model denotes high risk for rural population Compared to those in the poorest wealth bracket, all other
adjusted OR 1.40 (95% CI, 1.35–1.45) for age group 40–44 quintiles including middle wealth quintile had adjusted OR
Prevalence and associated factors of undiagnosed hypertension among women aged 15–49 years in. . .
Fig. 2 Map of India showing statewise depiction of prevalence of undiagnosed hypertension among women aged 15–49 years in rural
India. The prevalence of undiagnosed hypertension in Rural India.
1.12 (95% CI, 1.10–1.15), richer wealth quintile regression model showed a slightly increased risk for col-
had adjusted OR 1.24 (95% CI, 1.21–1.27), and richest lege graduates in rural areas, adjusted OR 1.08 (95% CI,
wealth quintile had an adjusted OR 1.27 (95% CI, 1.04–1.12), but this factor was not significant in the urban
1.23–1.30). Compared to those in the poorest and overall analyses.
wealth quintile, the poorer were not significantly different in
the rural areas with adjusted OR 1.01 (95% CI, 0.98–1.03) Caste and religion
and urban areas adjusted OR 1.06 (95% CI, 0.98–1.15).
Women who did not belong to caste/tribe were more sus-
Educational attainment ceptible to undiagnosed hypertension in rural areas, adjus-
ted OR 0.91 (95% CI 0.86–0.95), and among women who
Educational status also impacted risk as educational did not know their caste in urban areas, adjusted OR 1.25
attainment was a protective factor. Multiple logistic (95% CI, 1.11–1.40) compared to caste women. Christians
D. Talukdar et al.
Fig. 3 Map of India showing statewise depiction of prevalence of undiagnosed hypertension among women aged 15–49 years in urban
India. The prevalence of undiagnosed hypertension in Urban India.
were more likely to have undiagnosed hypertension adjus- areas at risk, adjusted OR 1.37 (95% CI, 1.34–1.40). They
ted OR 1.13 (95% CI, 1.08–1.18) than Hindus in both rural, were also at risk if in pre-obesity, obesity class I, obesity
adjusted OR 1.13 (95% CI, 1.07–1.20) and urban, adjusted class II, and obesity class III categories.
OR 1.22 (95% CI, 1.05–1.20) areas.
Geographical zones
BMI
Compared to those in northern zone, those in Western,
Compared to normal BMI, all other categories were risk adjusted OR 1.45 (95% CI, 1.41–1.49) and Southern,
factors for undiagnosed hypertension. Those who were adjusted OR 1.33 (95% CI, 1.30–1.37) zones were at risk.
underweight (BMI < 18.5) were at risk, adjusted OR 1.43 In urban areas, those in the Western zone were at greater
(95% CI, 1.41–1.45), with those in urban areas being at risk, adjusted OR 1.23 (95% CI, 1.18–1.28). In rural areas,
higher risk, adjusted OR 1.61 (95% CI, 1.56–1.66) and rural those in the Western zone, adjusted OR 1.57 (95% CI,
Table 3 Odds ratio and 95% confidence interval for undiagnosed hypertension in women (15–49 years).
Variables Unadjusted odds ratio (95% CI) Adjusted odds ratio (95% CI)
Overall Rural Urban Overall Rural Urban
Age, years
15–19 1 1 1 1 1 1
20–24 0.96 (0.94, 0.98)*** 1.02 (0.99, 1.04) 0.84 (0.81, 0.87)*** 0.96 (0.94, 0.98)*** 1.01 (0.99, 1.04) 0.88 (0.85, 0.92)***
25–29 0.93 (0.91, 0.95)*** 1.03 (1.00, 1.06) 0.75 (0.72, 0.77)*** 0.92 (0.90, 0.95)*** 1.02 (0.99, 1.05) 0.80 (0.77, 0.83)***
30–34 0.92 (0.89, 0.94)*** 1.04 (1.00, 1.07)* 0.71 (0.68, 0.74)*** 0.91 (0.89, 0.93)*** 1.03 (0.99, 1.06) 0.76 (0.73, 0.79)***
35–39 1.04 (1.02, 1.06)** 1.21 (1.18, 1.25)*** 0.76 (0.73, 0.79)*** 1.02 (0.99, 1.05) 1.19 (1.16, 1.23)*** 0.81 (0.77, 0.84)***
40–44 1.23 (1.20, 1.26)*** 1.42 (1.38, 1.46)*** 0.91 (0.88, 0.95)*** 1.20 (1.17, 1.23)*** 1.40 (1.35, 1.45)*** 0.97 (0.93, 1.01)
45–49 1.37 (1.34, 1.41)*** 1.63 (1.58, 1.68)*** 0.98 (0.94, 1.02) 1.33 (1.30, 1.37)*** 1.59 (1.54, 1.65)*** 1.04 (0.99, 1.09)
Current smoking status
Nonsmoker 1 1 1 1 1 1
Smoker 1.10 (1.04, 1.17)** 1.17 (1.10, 1.24)*** 1.13 (1.00, 1.29)*** 1.13 (1.07, 1.20)*** 1.12 (1.05, 1.19)** 1.14 (1.00, 1.31)*
Current alcohol use
Nonalcoholic 1 1 1 1 1 1
Alcoholic 1.45 (1.37, 1.53)*** 1.57 (1.48, 1.67)*** 1.32 (1.17, 1.49)*** 1.37 (1.29, 1.45)*** 1.36 (1.28, 1.45)*** 1.22 (1.08, 1.39)**
Current tobacco use
Nontobacco user 1 1 1 1 1 1
Tobacco user 1.08 (1.04, 1.11)*** 1.14 (1.10, 1.18)*** 1.03 (0.97, 1.09)*** 1.06 (1.03, 1.10)*** 1.04 (1.00, 1.08)* 1.07 (1.01, 1.14)*
Wealth
Poorest 1 1 1 1 1 1
Poorer 1.08 (1.05, 1.10)*** 1.06 (1.03, 1.08)*** 1.10 (1.02, 1.19) 1.03 (1.01, 1.05)** 1.01 (0.98, 1.03) 1.06 (0.98, 1.15)
Middle 1.23 (1.20, 1.25)*** 1.16 (1.14, 1.19)*** 1.21 (1.13, 1.30)*** 1.12 (1.10, 1.15)*** 1.05 (1.02, 1.08)** 1.12 (1.04, 1.21)**
Richer 1.37 (1.35, 1.40)*** 1.25 (1.22, 1.28)*** 1.26 (1.18, 1.35)*** 1.24 (1.21, 1.27)*** 1.10 (1.07, 1.14)*** 1.18 (1.10, 1.27)***
Prevalence and associated factors of undiagnosed hypertension among women aged 15–49 years in. . .
Richest 1.39 (1.36, 1.42)*** 1.17 (1.13, 1.21)*** 1.23 (1.15, 1.31)*** 1.27 (1.23, 1.30)*** 1.08 (1.03, 1.12)*** 1.16 (1.07, 1.25)***
Education
No education 1 1 1 1 1 1
Primary 0.98 (0.96, 1.01) 0.94 (0.91, 0.96)*** 1.02 (0.98, 1.07) 0.97 (0.95, 0.99)** 0.98 (0.95, 1.00) 0.99 (0.95, 1.04)
Secondary 1.02 (1.01, 1.04)** 0.94 (0.92, 0.95)*** 1.05 (1.02, 1.08)*** 0.97 (0.95, 0.98)*** 1.01 (0.98, 1.03) 0.97 (0.94, 1.01)
Higher 1.09 (1.07, 1.12)*** 0.99 (0.96, 1.03) 0.99 (0.95, 1.02) 1.00 (0.97, 1.03) 1.08 (1.04, 1.12)*** 0.97 (0.93, 1.02)
Social caste
Caste 1 1 1 1 1 1
Tribe 0.98 (0.96, 1.01) 1.05 (1.02, 1.08)** 1.03 (0.97, 1.10) 0.99 (0.96, 1.02) 1.01 (0.98, 1.05) 1.00 (0.93, 1.06)
No caste/tribe 0.92 (0.89, 0.95)*** 0.92 (0.88, 0.97)** 0.89 (0.84, 0.94)*** 0.91 (0.87, 0.94)*** 0.91 (0.86, 0.95)*** 0.93 (0.88, 0.98)*
Do not know 1.01 (0.93, 1.09) 0.93 (0.83, 1.03) 1.05 (0.93, 1.17) 1.11 (1.03, 1.21)* 0.98 (0.87, 1.09) 1.25 (1.11, 1.40)***
Table 3 (continued)
Variables Unadjusted odds ratio (95% CI) Adjusted odds ratio (95% CI)
Overall Rural Urban Overall Rural Urban
Religion
Hindu 1 1 1 1 1 1
Muslim 1.01 (0.99, 1.02) 0.96 (0.94, 0.99)** 0.96 (0.94, 0.99)** 1.02 (1.00, 1.04) 1.02 (0.99, 1.05) 0.96 (0.93, 0.99)**
Christian 1.32 (1.27, 1.38)*** 1.37 (1.30, 1.45)*** 1.19 (1.12, 1.27)*** 1.13 (1.08, 1.18)*** 1.13 (1.07, 1.20)*** 1.22 (1.05, 1.20)***
Others/not stated 1.06 (1.03, 1.10)** 1.07 (1.02, 1.12)** 1.01 (0.95, 1.07) 1.02 (0.98, 1.06) 1.13 (1.08, 1.19)*** 0.93 (0.87, 0.98)*
BMI
Normal (18.5–24.9) 1 1 1 1 1 1
Underweight (<18.5) 1.36 (1.34, 1.38)*** 1.31 (1.29, 1.34)*** 1.64 (1.60, 1.69)*** 1.43 (1.41, 1.45)*** 1.37 (1.34, 1.40)*** 1.61 (1.56, 1.66)***
Pre-obesity (25–29.9) 1.29 (1.27, 1.31)*** 1.40 (1.36, 1.43)*** 1.08 (1.05, 1.11)*** 1.14 (1.11, 1.16)*** 1.23 (1.20, 1.27)*** 1.05 (1.02, 1.09)***
Obesity Class I 1.68 (1.63, 1.74)*** 1.90 (1.81, 2.00)*** 1.35 (1.30, 1.42)*** 1.40 (1.35, 1.45)*** 1.62 (1.53, 1.70)*** 1.29 (1.23, 1.35)***
(30–34.9)
Obesity Class II 1.88 (1.76, 2.01)*** 2.00 (1.78, 2.25)*** 1.57 (1.44, 1.71)*** 1.52 (1.42, 1.63)*** 1.68 (1.49, 1.89)*** 1.47 (1.35, 1.60)***
(35–39.9)
Obesity Class III 1.79 (1.61, 1.99)*** 1.53 (1.31, 1.79)*** 1.86 (1.61, 2.15)*** 1.60 (1.44, 1.78)*** 1.44 (1.23, 1.69)*** 1.75 (1.52, 2.02)***
(≥40)
Zones
Northern 1 1 1 1 1 1
Central 0.88 (0.86, 0.90)*** 1.02 (1.00, 1.06) 0.76 (0.74, 0.79)*** 0.91 (0.88, 0.93)*** 1.04 (1.01, 1.08)* 0.74 (0.71, 0.77)***
Eastern 0.95 (0.92, 0.97)*** 1.13 (1.10, 1.17)*** 0.78 (0.75, 0.81)*** 1.00 (0.97, 1.03) 1.16 (1.12, 1.20)*** 0.77 (0.73, 0.81)***
Western 1.50 (1.46, 1.53)*** 1.62 (1.56, 1.67)*** 1.26 (1.22, 1.31)*** 1.45 (1.41, 1.49)*** 1.57 (1.52, 1.63)*** 1.23 (1.18, 1.28)***
Southern 1.41 (1.38, 1.45)*** 1.70 (1.65, 1.75)*** 1.08 (1.04, 1.12)*** 1.33 (1.30, 1.37)*** 1.59 (1.54, 1.65)*** 1.04 (1.00, 1.08)*
North-Eastern 1.12 (1.08, 1.17)*** 1.35 (1.29, 1.41)*** 0.94 (0.87, 1.02) 1.14 (1.09, 1.19)*** 1.32 (1.25, 1.39)*** 0.90 (0.82, 0.98)*
Diet
Milk/curd (N/O) 1 1 1 1 1 1
Milk/curd (D/W) 1.06 (1.05, 1.08)*** 1.01 (1.00, 1.03) 1.05 (1.03, 1.08)*** 0.94 (0.93, 0.96)*** 0.95 (0.93, 0.97)*** 0.96 (0.94, 0.99)*
Pulse/beans (N/O) 1 1 1 1 1 1
Pulse/beans (D/W) 1.01 (0.99, 1.04) 1.00 (0.97, 1.02) 0.99 (0.95, 1.03) 1.00 (0.98, 1.03) 0.99 (0.97, 1.02) 1.02 (0.98, 1.07)
Vegetables (N/O) 1 1 1 1 1 1
Vegetables (D/W) 1.02 (1.00, 1.04)* 1.00 (0.98, 1.02) 1.02 (0.99, 1.05) 0.98 (0.96, 1.00) 0.97 (0.94, 0.99)** 1.00 (0.96, 1.03)
Fruits (N/O) 1 1 1 1 1 1
Fruits (D/W) 1.15 (1.14, 1.17)*** 1.10 (1.08, 1.12)*** 1.04 (1.02, 1.06)*** 1.03 (1.01, 1.04)** 1.02 (0.99, 1.04) 1.00 (0.98, 1.03)
Eggs (N/O) 1 1 1 1 1 1
Eggs (D/W) 1.16 (1.15, 1.18)*** 1.16 (1.14, 1.18)*** 1.09 (1.07, 1.11)*** 1.09 (1.07, 1.11)*** 1.05 (1.03, 1.07)*** 1.11 (1.08, 1.14)***
Fish (N/O) 1 1 1 1 1 1
D. Talukdar et al.
Prevalence and associated factors of undiagnosed hypertension among women aged 15–49 years in. . .
Dietary habits
1
Among dietary eating patterns, those consuming milk/curd
on a daily/weekly basis were less likely, adjusted OR 0.94
0.95 (0.93, 0.97)***
Discussion
Overall
This in no way overlaps with the women who did not report is a point of concern even among younger age groups, those
being hypertensive yet could be categorized as hypertensive under 30 years of age, which is consistent with other studies
based solely upon the data of their measured BP. This was [22, 23]. These cases could also be related to oral contra-
defined as “undiagnosed hypertension” in our analyses and ceptive pills induced hypertension since it is suggested that
its prevalence was 18.63%. A second methodological dif- BP rises after menopause in most women due to withdrawal
ference from other studies is that we applied thresholds of of endogenous estrogen, a potent vasodilator [10, 31, 32].
70–270 mmHg for systolic readings and 40–140 mmHg for Undiagnosed hypertension could have unforeseen con-
diastolic readings in defining hypertension. This enabled us sequences for maternal and child care programs since
to reject improbable values. hypertension during pregnancy leads to complications in
Several smaller cross-sectional studies have reported both mother and child.
varying prevalence rates for reported and unreported pre- Corsi and Subramanian found that increase in wealth led
valence of hypertension. Chakraborty and Mandal [9] found to an increase in hypertension from 11 to 17.1% [22]. Our
the prevalence of hypertension to be 24.1% in a rural area in study also found that an increase in wealth led to an increase
West Bengal in India while Undavalli et al. found pre- in the prevalence of undiagnosed hypertension across both
valence of undiagnosed hypertension at 10.1% in villages in rural and urban areas. Hypertension tends to be inversely
a rural area in India [25]. Shukla et al. [26] found the pre- related to socioeconomic position in high income countries
valence of undiagnosed hypertension to be 26% in an [33] with the opposite being the case in low- and middle-
apparently healthy population in Western India. Singh et al. income countries [34]. However, being in poorest or richest
found an overall prevalence of 32.96% in urban Varanasi in wealth quintile alone cannot be responsible for high rates of
Uttar Pradesh in India [27] while a study by Banerjee et al. undiagnosed hypertension in India because low levels of
found hypertension prevalence at 42% with newly detected awareness and poor access to health facilities [26] are
cases at 19% in a study conducted in a slum population in restricted to those belonging to the poorest wealth quintiles
urban Kolkata in West Bengal in India [28]. The wide in both rural and urban areas.
variations in prevalence rates point to methodological dif- Those women who did not know their caste or did not
ferences as well as large regional, geographical, cultural, reveal their caste were more likely to have undiagnosed
and social factors that determine prevalence rates. hypertension than those who knew/disclosed their caste.
Our study found that the prevalence of undiagnosed Women who followed the Christian faith were more likely
hypertension was higher among women in urban India than to have undiagnosed hypertension than those women who
in rural India. This could be related to higher awareness and followed the Hindu faith. Though any discussion of dif-
better health facilities in urban areas than rural areas, or it ferences only due to caste and religion is insensitive to their
could be attributable to diet and stress-related issues as position in local social hierarchies, it could be conjectured
suggested by Swain et al. [8]. However, this tends to that caste and religion do play a role in their choice of diets
hypothesize that the rural population are poor, less educated and lifestyles.
and in lower wealth quintiles. Some regional epidemiolo- Compared to those with normal BMI, women who were
gical studies have found an urban–rural convergence in in underweight and pre-obesity, obesity classes I–III, were
hypertension prevalence [29, 30]. Gupta [29] suggests that more prone to suffer from undiagnosed hypertension. An
this urban–rural convergence of hypertension in India is due important finding is that lower BMI is a risk factor that has
to rapid urbanization of rural populations with consequent not received much attention in previous studies. A study on
changes in lifestyles (sedentariness, high dietary salt, sugar, African and Asian populations had also found extremely
and fat intake) and increase in overweight and obesity. low or high BMI levels to be associated with increased risk
Nevertheless, our study found the prevalence of undiag- of hypertension [35]. Another study had found BMI under
nosed hypertension was 17.09% in rural areas and it was 18.5 kg/m2 to be a risk factor for CVD [36]. The effect of
21.73% in urban areas. BMI increase was more pronounced among those living in
Our multiple logistic regression suggests that an increase rural areas than in urban areas for those women who were
in age leads to an increase in the probability of undiagnosed classed under pre-obesity, obesity class I, and obesity class
hypertension. This was even more visible in the rural areas II categories. This suggests that in general more women
than in the urban areas since age became a risk factor in with increased BMI in the rural areas have undiagnosed
rural areas from ages 35 and above while ages 40 and less hypertension than those in urban areas. Most studies com-
were a protective factor in urban areas. It shows poor pare BMIs higher than normal with normal BMI. Shihab
general awareness and screening opportunities among et al. [37] found that the rate of change in BMI over the life
women in the rural areas regarding their health concerns in course increased the risk of incident hypertension. Basu and
higher age groups and conversely for lower age groups in Millett reported that obesity increased the probability of
urban areas. It is to be noted that undiagnosed hypertension hypertension by 3.7 times [38]. They found ≥10%
Prevalence and associated factors of undiagnosed hypertension among women aged 15–49 years in. . .
prevalence of obesity even among the lowest income not being treated. Since these women are in the reproductive
quintiles. Obesity is a known risk factor for hypertension age, elevated BP levels could have detrimental effects on
[39, 40] though Swain et al. did not find hypertension women and their unborn children. Undiagnosed, hence
related to obesity among women [8]. untreated and uncontrolled, BP could have health con-
Women living in the Western zone in the urban areas sequences in the short term and long term. We recommend
were more likely to suffer from undiagnosed hypertension regular screenings for early detection and treatment of
than those living in the northern zone. Women living in hypertension in a bid to reduce NCDs incidence in India.
rural areas in the Western, Southern and North-Eastern
zones were more likely to have undiagnosed hypertension Limitations
than those in the northern zone. This is a significant finding
as it may be related to lack of information, education, or This study has various limitations. It is based upon sec-
communication among women living in these zones. ondary data available from a cross-sectional NFHS survey
Anchala et al. [6] found the pooled prevalence of hyper- that assesses relationships at one point in time. In addition,
tension for the rural and urban population in North India to there is a recall bias and low truth quotient associated with
be 14.5% and 28.8%. The corresponding figures for East all survey instruments. Our particular study may also suffer
India were 31.7% and 34.5%, for West India 18.1% and from a misclassification bias since we clubbed together
35.8%, and for South India 21.1% and 31.8%. The defini- missing observations with NO self-reported hypertension.
tion for the four zones was different from the NFHS defined We relied on BP measurements to detect undiagnosed
six zones in India. Gelsetzer et al. [23] found prevalence of hypertension. However, measurements made on a single
hypertension to be highest in the northern states of Punjab occasion do not have a strong predictive power for CVD in
and Himachal Pradesh, the southern state of Kerala, and the epidemiological studies [30]. Further, if we applied the
north-eastern states of Sikkim, and Nagaland. They had no AHA new thresholds of 130/80 for stage 1 hypertension, the
data available for Jammu and Kashmir and Gujarat. A number of people with undiagnosed hypertension would be
WHO-STEPS cross-sectional survey in Punjab found an substantially more. Lastly, the survey population was
overall prevalence of 40.1% with 28.7% of cases being restricted to women aged 15–49 years. It is known that
newly diagnosed in rural areas and 27.2% being newly hypertension affects greatly those aged above 50 years.
diagnosed in urban areas [39]. Our study found that
undiagnosed hypertension was highest in the state of Tel-
angana in both rural and urban areas. Summary
Women eating eggs, and/or chicken/meat on a daily/
weekly basis were more likely to suffer from undiagnosed What is known about topic
hypertension than those women who never/occasionally eat
these items. Eating vegetables was a protective factor. This ● Raised blood pressure causes 7.5 million deaths
is in line with other studies that found a vegetable diet to be annually.
a protective factor in hypertension [26] and recommend a ● Factors associated with hypertension include age, higher
diet rich in fruits, vegetables and low-fat dairy products in BMI, poor access to health facilities, rural area of
all stages of high BP management [41, 42]. residence and irregular lifestyles.
Smoking status, tobacco, and alcohol consumption had
minimal effects on the prevalence of undiagnosed hyper-
tension among women aged 15–49 years. What this study adds
Ethical approval We obtained permission from the United States 14. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA,
Agency for International Development-supported Demographic and et al. Seventh report of the Joint National Committee on Pre-
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Potential US population impact of the 2017 ACC/AHA high
Publisher’s note Springer Nature remains neutral with regard to blood pressure guideline. J Am Coll Cardiol. 2018;71:109–18.
jurisdictional claims in published maps and institutional affiliations. 17. Choi W-J, Lee H-S, Hong JH, Chang H-J, Lee J-W. Comparison
of the JNC7 and 2017 American College of Cardiology/American
Heart Association Guidelines for the Management of Hyperten-
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