DRUGS FOR TX OF CHF

DIURETICS
A. LOOP OF DIURETICS Inhibits Na-K-Cl cotransporter - Initial tx in acute heart
(FUROSEMIDE) – IV failure
- Site: Ascending loop of
henle (25% Na reabsorbed)

B. THIAZIDES Inhibit Na-Cl cotransporter - DOC for Hypertension

(Hydrochlorothiazide) assoc. w/ heart failure
- Site: DCT (5%)
C. Potassium Sparing Aldosterone receptor - Maintenance tx in HF
(Spironolactone) antagonist - Site: Collecting Duct
- Weak diuretic
- Additive beneficial effects w/
ACE inhibitors and beta
blockers