Causes of angioedema

Histamine- Direct  Type 1 Associated pruritus & urticaria

mediated Mast cell hypersensitivity
angioede activatio reactions (IgE-
ma n mediated)
o Possible
triggers:
food,
insect
bites/sting
s, antibioti
cs,
latex, NSAI
Ds (less
commonly)
,
other aller
gens,
physically-
induced 
o Family
history of 
atopy


 Non-IgE-mediated
 Possible triggers:
NSAIDs (most
commonly aspirin) ,
opiates,
radiocontrast media

Bradykinin Excess  ACE inhibitors No pruritus or urticaria

-mediated bradykini
angioede n
m

 C1 inhibitor ↑↑ excess activation of C2,

deficiency
(hereditary/acquired C4
 )

  Occur in childhood, early

adolescent
 (no clinical picture)
 ↑↑ bradykinin (VD) (along
with C3a and C5a) 
o Facial swelling
without
urticarial
o Life threatening
laryngeal edema
o GIT
manifestations
 Treatment : C1INH
concentrate, kallikerin
inhibitor