Infertility and herbals

1. Cinnamomun Cassia (Kayu Manis Cina)

Efek : Increased granulosa production of progesterone

2. Paeonia lactiflora (Peony Tiongkok)

Efek : Increaed SHBG , Reduced LH , Reduced LH:FSH ratio , Improved ovulation in
women with PCOS
3. Glycyrrhiza spp (Akar Manis)
Efek : Improved ovulation in women with PCOS

4. Trigonela Foenum-graecum (kelabat)

Efek : Improved the ovarian function and menstrual cycle regularity, could increase the
fertility rate

5. Asparagus pubescens
Efek: females showed aggressive behavior toward to the males, preovulatry luteinizing
hormone (LH), prolactin and progesterone release.
 Herbal and Breast Cancer
1. Aloe vera
Efek: mechanism of aloe gel extract in regulating cancer cell apoptosis via modulating
the mitochondrial metabolism and imply a possible application of AVBEC for the
treatment of malignant cancer

2. Typhonium flagelliforme extract (Daun Keladi)

Efek: TFTe can induce apoptosis in bCSCs (breast cancer stem cell) by decreasing
survivin expression levels and increasing the levels of caspase-9 and caspase-3

3. Curcuma longa or turmeric (kunyit)

Efek: Curcuma longa extract (CL), a natural compound induces apoptosis in several
cancer cells by targeting various molecules and possess fewer side effects. p53 and
survivin as molecular targets of CL contribute to caspase-3-dependent apoptosis in
TNBC cells and this compound represents an attractive p53- and survivin modulating
agent in TNBC
4. Camellia sinensis or green tea (teh hijau)
Efek: It has also been shown to inhibit proliferation of breast cancer cells and to block
carcinogenesis. It was found that increased Camellia sinensis consumption may lower
the risk of breast cancer. Camellia sinensis intake was shown to reduce the risk of
breast cancer incidence.

5. Panax ginseng or ginseng (gingseng)

Efek: The treatment resulted in inhibition of cell proliferation in a dose-and time-
dependent manner. p53, p21WAF1and p16INK4A expression levels were up-
regulated in ginseng treated MDA-MB-231 and MCF-7 cancer cells compared to
untreated controls and in MCF-10A cells. The expression levels of Bcl2 in the MDA-
MB-231 and MCF-7 cells were down-regulated. In contrast, that of Bax was
significantly up-regulated.
6. Clinacanthus nutans (daun belalai gajah)
Efek : the presence of sulphur-containing compounds in the leaves of C. nutans that
displayed anticancer effects which explains its ethnomedicinal application against
breast cancer.

7. Eriocaulon Cinerum R.B

Efek : one of the compounds has a good cytotoxic activity, The active compound has a
flavonoid, which plays a role in several anticancer mechanisms.

8. Allium sativum (Bawang Putih)

Efek : Exposure to ASB extract caused a significant cytotoxicity effect on MCF-7 and
MDA-MB-231 cell lines. A significant activation of caspase-9 was observed in both
tested cell lines, indicating that the cytotoxic activity is mediated in an apoptotic
manner.
Herbal and Cancer Serviks
1. Nerium oleander L. extract
Efek: The extract of Nerium oleander L. contains potential bioactive compounds that
inhibit HeLa cell proliferation, cell migration and arrest cell cycle at the G2/M phase.

2. Astragalus
 Efek:  Astragalus-containing CHM might be a potential option for cervical cancer to
enhance the curative efficacy and reduce CT toxicity.

3. Berry Extract
Polyphenol-rich berry extracts were screened for their antiproliferative effectiveness
using human cervical cancer (HeLa) cells grown in microtiter plates. Rowan berry,
raspberry, lingonberry, cloudberry, arctic bramble, and strawberry extracts were effective
but blueberry, sea buckthorn, and pomegranate extracts were considerably less effective. 

4. Azadirachta indica
Nama daerah: Imba, Mimba (Jawa); Membha, Mempheuh (Madura); Intaran, Mimba
(Bali)
Efek : sebagai penghambatan tergantung dosis MNBE (Ekstrak kulit neem metano) pada
pertumbuhan dan migrasi sel kanker serviks. Sebagai anti kanker dengan beberapa produk
turunan tanaman telah diteliti secara ekstensif dan terbukti efektif melawan sel kanker dengan
efek samping yang minimal.

5. Chromolaena odorata
Nama lain antara lain Siam-Kraut, agonoi, bitter bush, chromolaena, hagonoy, herbe du
Laos, huluhagonoi, jack in the bush, kesengesil, mahsrihsrihk, masigsig, ngesngesil,
otuot, rumput belalang, rumput golkar, rumput putih, sandanezw, triffid
weed, dan wisolmatenrehwei
Efek : mendasari kematian sel dengan menghambat pertumbuhan karena aktivitas
antiproliferative dan digunakan sebagai kemoterapi