1016/22, 11:24 AM hipshwrw.erd york.ac-uk/prosperaldisplay_racord php ?RacordlO=124734 NIHR | Aeielite PROSPERO frat Reeth International prospective register of systematic reviews Association between fat free mass/lean body mass and metabolic syndrome in children: systematic review Diana Cordoba, tris Iglesia Altaba, Alejandro Gémoz Brutén, Jose Antonio Casajis Mallén, Luis Moreno Aznar ion Diana Cordoba, Iris Iglesia Altaba, Alejandro Gémez Brutén, Jose Antonio Casajis Mallén, Luis Moreno Aznar. Association between fat free massilean body mass and metabolic syndrome in children: systematic review. PROSPERO 2019 CRD42019124734 Available from: https:/www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019124734 Review question Is there an association between fat free mass/lean body mass and metabolic syndrome in children? Searches The keywords that we will use to search for articles will be searched MeSH (Medical Subject Headings, PubMed), The respective keywords and index terms are: Body composition, lean body mass, fat free mass, lean mass, lean tissue mass, skeletal muscle mass, muscle mass, fat-free mass index (FFMI), metabolic, syndrome, insulin resistance and insulin sensitivity. The indexed terms of the same keyword will be combined using the Boolean operator "OR" and the group of indexed terms of each of the keywords will be combined with the Boolean operator "AND", The asterisk (") and quotes () truncation elements will also be used. (((’Metabolic Syndrome"[MeSH] OR "Insulin Resistance"[MeSH] OR “Insulin sensitive") AND ("Body Composition"[MeSH] OR “lean body mass” OR “fat free mass’OR “lean mass” OR ‘lean tissue mass” OR “skeletal muscle mass” OR “muscle mass” OR “fat free mass index” ) AND (infant{MeSH] OR child[MeSH] OR adolescent[MeSH)))) The following databases will be searched: PubMed (NCBI, U.S. National Library of Medicine), ScienceDirect (Sciverse, Elsevier), Embase (OvidSP, Wolters Kluwer), Scopus (Elsevier), Web of Science, and SciELO- Scientific Electronic Library Online, The search will be limited to human studies and articles published in English or Spanish Types of study to be included Inclusion criteria: we will include studies in children that evaluate at least once fat-free mass, lean muscle mass, skeletal muscle mass, muscle mass, free fal mass index (FMI). Finally, written studies in English or Spanish will be included. Boys and/or girls from birth - 18 years. Exclusion criteria: studies in animals and studies in adults. Works without summary and full text in English and Spanish. Condition or domain being studied Fat-‘ree mass (FFM) represents approximately 80% of the body weight and includes: bones, muscles, extracellular water, nervous tissue and other cells that are not adipocytes or fat cells. To determine its content is of great importance for health, since itis involved in several metabolic processes, for example: energy expenditure, glucose metabolism and secretion of myokines, which improve insulin sensitivity and stimulate lipolysis (Brown, 2014). The muscle mass is the quantitatively most important component of fat- free mass, it is currently known that alterations in the amount and function can affect health and have hitpsiwwncrd.york.2c.ukprosperoldsplay_record.php?Recorl 124734 aore, 11:26 AM hips:hwwn.er york ae.uk/prosperlsispay_recard php?RecordD=124734 important implications in the risk of developing insulin resistance in children and adolescents, ultimately impacting the quality of life until adulthood (Steene-Johannessen, 2009, Benson, 2006). This review evaluates the potential association between fat-free mass / lean body mass and metabolic syndrome. Participants/popul: n Participants included boys andlor girls from birth - 18 years. Intervention(s), exposure(s) Not applicable: association between fat free mass/ lean body mass and metabolic syndrome in children. Comparator(s)/control Body composition measurements will be obtained by all methods described in the literature (hydrodensitometry, plethysmography by air displacement, isotopic dilution, electrical bioimpedance, double X-ray absorptiometry, anthropometry and computed tomography). Main outcome(s) Lean body mass, Fat free mass. Lean mass. Lean tissue mass Skeletal muscle mass. Muscle mass. Fat- free mass index (FFMI) HDL-C imc Blood pressure Glucose Waist circumference Triglycerides Insulin Additional outcome(s) Not applicable. Data extraction (selection and coding) 1 cas ‘Two reviewers will Independently examine each database to obtain potential publications. The relevant articles will be obtained in their entirety and will be evaluated by the reviewers according to the inclusion and exclusion criteria. The discrepancies between the reviewers will be resolved by consensus. The arbitration of a third reviewer will be used for the unresolved discrepancies. For the extraction of data from each study, tables will be created in the Microsoft Excel program with the following information: author, date of study, study design, location, inclusion and exclusion criteria, data of the participants, methodology used to evaluate the Fat Free mass (FFM) /lean body mass (LBM) and results. Risk of bias (quality) assessment Risk of bias will be evaluated according to the Cochrane collaboration. (Higgins JPT, Green S, Sterne JAC, Egger M, Moher D, Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions Version 510, Chichester, UK: John Wiley & Sons, 2011.) Strategy for data synthesis (1 art Researchers will create tables to summarize the included studies. For continuous data, differences in means (DM) with a 95% confidence interval (95% Cl) will be used. The categorical data will be reported as hitpsiwwncrd.york-2c ukprosperoldsplay_record.php?RecordlO=124734 241016/22, 11:24 AM hipshwrw.erd york.ac-uk/prosperaldisplay_racord php ?RacordlO=124734 relative risks (RR) with a 95% Cl. The effect models will be applied for continuous and categorical data, calculating the effect size for each result. The sources of heterogeneity will be carried out through the analysis of subgroups and the evaluation of quality when the information is available. The heterogeneity of the studies is proven by the I statistic, this statistic describes the variance between the studies as a proportion of the total variance (<25% low heterogeneity, 25% at 50% moderate heterogeneity, > 50% at 75% high heterogeneity and > 75% very high heterogeneity). The associated P value of the heterogeneity of, the studies will be calculated, with a non-significant result indicating the absence of heterogeneity. All analyses will be performed using the Open Meta [Analyst] software. Analysis of subgroups or subsets IFit is possible, we will use variables that may influence the association between Fat free mass/ lean body mass and metabolic syndrome in children, such as age groups, body composition measurement technique and sex Contact det for further information Diana Cordoba d.cordoba@javeriana.edu.co Organisational affiliation of the review University of Zaragoza Review team members and their organisational affiliations Ms Diana Cordoba, GENUD (Growth, exercise, nutrition and development) Research Group. University of Zaragoza. Zaragoza, Spain. Department of Nutrition and Biochemistry, Faculty of Sciences, Pontifical Xavierian University, Bogota, Colombia Dr Iris Iglesia Altaba, GENUD (Growth, exercise, nutrition and development) Research Group. University of Zaragoza. Zaragoza, Spain Dr Alejandro Gémez Brutén. GENUD (Growth, exercise, nutrition and development) Research Group. University of Zaragoza. Zaragoza, Spain Professor Jose Antonio Casajtis Mallén, GENUD (Growth, exercise, nutrition and development) Research Group. University of Zaragoza. Zaragoza, Spain Professor Luis Moreno Aznar. GENUD (Growth, exercise, nutrition and development) Research Group. University of Zaragoza. Zaragoza, Spain Type and method of review Meta-analysis, Systematic review Anticipated or actual start date 01 December 2018 01 September 2019 Funding sources/sponsors University of Zaragoza. Zaragoza, Spain. The Carolina foundation scholarships Conflicts of interest Language English Country hitpsiwwncrd.york.2c.ukprosperoldsplay_record.php?Recorl 124734 341016/22, 11:24 AM hipshwrw.erdyork.ac-uk/prosperaldisplay_racord php ?RacordlD=124734 Spain Stage of review Review Ongoing Subject index terms status ‘Subject indexing assigned by CRD Subject index terms Body Composition; Child; Humans; Metabolic Syndrome Date of registration in PROSPERO 05 April 2019 Date of first submission 08 February 2019 Stage of review at time of this submission Stage Started Completed Preliminary searches Yes No Piloting of the study selection process No No Formal screening of search results against eligibility criteria No No Data extraction No No Risk of bias (quality) assessment No No Data analysis, No No The record owner confirms that the information they have supplied for this submission is accurate and complete and they understand that deliberate provision of inaccurate information or omission of data may be construed as scientific misconduct. The record owner confirms that they will update the status of the review when it is completed and will add publication details in due course. Versions. 05 April 2019 PROSPERO ‘This information has been provided by the named contact for this review. CRD has accepted this information in good ‘and registered the review in PROSPERO, The registrant confirms thatthe information supplied for this| submission is accurate and complete. CRD bears no responsibil or lability for the content ofthis registration record, any associated files or external websites. hitpsiwwncrd.york.2c.ukprosperoldsplay_record.php?Recorl 124734 a