JAMA | Relew Acute Pancreatitis AReview Maia Meds YO. be. MO... ered 5 Reda oe rte sro and tna management adaware wae mown states lich eth tet of iste ‘eSEVTONS MEDUNE vaste va Pb syste Cone abso ‘egnge ss pblsedbetwen Lins 2009 3nd hig 20204 ae "econo pede xcs hagmagenert armor rf ancien rates ae net Sorscatngosama chaste Baie Infect Seartyn at Panes SAP) ante ae ys and Cnc eth ‘Baten PACE ok vp precvecptter dass 28 seven sere pre vse Mant daly reer Ws feratfoist actrees, xy agesie Rrenchaoard eater toh reacted wth ve testa onde cpr yet id 2 ‘atc esc have be deteined Te nde ace pnceats shakdbesouhtinalpttsntieonsraegesh dtc dee ‘essitoncooding she ned rngand frp 2ae pees ‘O¥CLUBO RELEVANCE Ase anestacenle destin sey and cose Monet dagmossand sate fever eeuece epermonuesret. Sng tan Scoring ates ae sell adits et sheldotsapesededallgrest. Fs ‘Srgsa bea econe hn Imanagenert anion eve foretrantepreet, Mine nw cn en (eieoememescssah su ors 4000209209 ontario ‘Stereo re Stiopwptonecratiy cone Latepmcnstinonedimortenmen svn ‘crete tes hapten inthe Utd States Teieece cf atepancetsbesiatedat Speer Approaatl 80kef patents deeomidtomod oteaeree dene bence fra ahreBhous How. ‘Seon ithe devep severe deze with arta ‘ate of epoca 20%." Theperosetisrevewstosan- eeendencrepragterecagon cf ese sve. id ednuonmarageent and edocton madre Nerten recone se. Methods ‘bled and the Cacrane abses were searched fr Engh ‘basing cies rom rary 2008 rough As ta tery 2200 Wve ert formed the rlerences of reacted ates, eles. meta ajses dace pines Slt tes ir t02008 wee ‘httrhorclcte Engage Tanda res A pubis nd cos indued were muti gentenby he avon od secede icalimpatance nd ‘vance whee tothe gel meal eadesp of [Hw Sty scatides were inde, wich ertaned 8 RTS, ‘eimeasranes an Seine ides, Pathogens and logy ‘aseptic ogee acest foreimuesebeecthepmcess egtabrg pete reas nf chat ypiogentoypn thes (tegration te dst enzymes tenn se, srothecargermtcxace site marodpesonct ear sécprendyma®*Pmoesticatcbstonteg galsonersoe ntslsenealtemrecamencanefaar Garage are Inceassinatal presi testa ema, mc aca cl ame revidibetepacesictisie Merah pay _scrrinuymoybecasedyarety ofertas has en, whic pues pin achat peep sto (02021 American Madson. lh vere, ‘Deane rm piomaneertcam Uae of Meee by VRQ JAMANET on 124002,ncitevor tebe Fer a ‘eel Ms anions A Mele nsenind RePreit sneha ce tara ares onesmoss sche lhe mma ong proc it Sota hide oe tebe ‘re on obeyoea vere nese) Steere Nenagh ety easel pepe mons retomitiies Psa Maire ead cn e w sch tt enen ororec heey a mtn emo tng so odbc mer eae Ma worn doce hte And endef ess ad ene paneer eal canton sg, eco drone parlor ‘Sinner ‘cat Presenter sndDagrs ‘dopant tna ens ‘stmt atom dasa a ‘Sienna eee tet sale sanechtcenindcteoessen one 2M e208 Wine nee ‘rlrste pcre epee tises Hewes minalqt netfee ‘teen eens oa ew Marc crapstaedcte emai rlir nec wth ef a etoopmeas wth ety whe seeststonters bape 2 Renioan code theta 2 Bestescmerfoe tous rst | ce ming atepeceter eg ie {computed seg ao magnetic reso Sem etoe Steet Voopntite 2. phn re * pnt fawn tre eee om en 2 ecko wt eet apse Veto apntre bi) Stgeogmisue tere Set Neem ec meena ‘eretcomorcd fe enh etasom eet pe Aerating wth oes ‘aniteutntaptereendcenvopensenet Asien! ston ontphichescmnanne, supe Cmetedtronty Dorper ce cine Oi me etl eae ce esterday ‘geet doesn Pueoara Petron iserysce pcenenot pee srvteaanconiaeity we seme rrgresetneetly pect Coach, inteyomra Todorov ed Ate a tenures erg cence se eos pce ener ‘rtm seta int frat aos ‘Scapa grea nc ete icp mmr onan eae hon rena Scenarist Secuschaoprtcectasarae 2 ere Madcap Aa, ‘emt pe matt abet au suas aah beeet ne Reve Ecstion Toneine Marstons, and Management of Ande Prete aa (et | oe (oom FL i: 3 ‘Neatly | een Anns bincuee | Steen » [Sean po a a eee [ost snc lotr ore | | > ansgement Scapa onto ‘ikl Modteanashal srg senta Ope Dpncion treo hos tocar ‘moved ee un rt sor peavey xgmspten st = > a "Sere ransom ere Reis OOF a Bowerdargmare Somrirmovinehndh ak Deets as ema aes$0,08 Keogormontandimis 1k AME 1336943 ag ‘eect erect eect ae om aan attad a3 angnaa ST ma Seabees oo owe ten ox, 810 SON. Disease Seriya Rak Saft TheRiCpaceacstepncettssevety bythe reeeeandc: rationef gana i espa idrey andra as ‘eterna he mode Marl cone ster Te a ‘hepresece of lcalconplcton Pts who oral compl Cations or orzn fare hve mou pees. atets wth ‘varsent onan ureecoverywihn48hows) andrea Dleatonshave moderate severe ait panes, and pate ithpersten rpntolirebeyend 48 houswthorwieutaca Conpleatonshve severe cvtepancedits(Box20, Mldpance us the mot common frm of ete pancreatitis andi sel ling attri charged whinawed Paes th made seve ardsere ease ctenhaveaprouadedecine ‘ore weeks tomar due tole conor and organ dj fencton ie ‘Ger the varble cri eouse nate pest andthe scatman tense cues eel kscrshorbeen evlopedta pret otcone (able 2) Tes cst ys tensmayassitindeternngte apoio Oe sie car ini IU] Ws or) and ude anteater manage (©2021 Anerican Mosel Acsoeiton.Alvghtsrexared, smetaonepeced sna dss hau el edn deiscnngin ste areh Sotrg Scshudretren cage Teens ‘ec bed yao ea M4 oe the tee seat owe te scgopers enters aqre te She rei neenontenre a ho, eA aire scone de seettonedc dame ey ndatany pooch ‘stu Arce error oeaoaireet ‘cae stiredntntnta erates eas tetas sey soneheranty cre ‘ested 2008 a ed ast srrsy Seles ate tad esnog Blau pene ns Bal. npared net sau Semen ssrsesnone AS eater one aaaoE dente anata ahooreeceee cowescrewe selbst andthe tha eat an 20% erry eeboes ‘onetalycutstietonondstsnoseeene ee 298A say 26. 200 ene 5 ae ana ea Mba by VRMJAMANET 0 1242023 os{RC 7 Compan a AMNOTE RAT nd ae Sar er he Revd es Gain bin Sere eee OW) ican ity sores "Sheamyeee SS 080 SSoeramtsse entseaeh ‘Seine hewn Esior7.100) teatena) Raper I Maa hi eiee reese ee oct tse ao THIR> mai Cagney Adi Sige coun 60 igen seaeeyne 33008 ‘teen Teton Sr mt PetenctmerdhynkP anata kD someon ian sos2¢a5) Skins S88 oz0099 ioneseaa) rok eua3y Tete Somat ease wo Tei “eatin in aa Beast ty os cin ied an 0 ane reo Pn, ae {feelangr S85 ptemcatimney ene one ac wtb ca sneer ect Ua was associated wth developing organ fale (od to ORL. 74 (25% CL 28195). persistent organ fae (OR 127195%CL.47- 339), andparcreac neous (OR.AB(GS%CL 18-85). BAP Is widely used because of ts smphoty and ease of alton able.” haddontoscong stems, neu biomarers may ko havepredictvevaleinaete pancetta ten CRP) 's commonly obtained in hosptaze patents, CRP levels of 980 gl or gate win the st 48 hous of misono an abao. baeinceaseof greater than SO mg/L haveptive predictive al- es of317%and7743 for predingsevre iene. especie” Racoog seringaytems.suchasthe CT Sevety Inde may also be useful to accurately dagnose the exe and seve of pancetis? However magrgecresarenetelabe when sans sre obained at the time of émsionbecasecontastenhanced (Cray underestimate or incre cat bese eveyiRs obtained ess than 72hows after symptom ens" Tere: fore, CTisecommende erin the eae curse tofu recog. ze the extent of cease procesin patients with modetetely se vereor severe acutepancretits. Management ‘Overview of Management ‘Therese 2canestnesnantepancestiismanagement regard: Jessofthe etiology) fidresesctatanomaitahnarresrets, 386 MMA 726.207 Vee Ker ue pesfsion and @) mutton suport to counter the atabolic ‘Sateanddecensethestectinfecousconplestons. id Rescaten Intravascular volume depletion fom fd sequestration assci- sted with pancreatic perpanceik. and stem edema cha acessicofpatentsthacutepancentts. Vorstng redicedra Intake. nd perpanceate inflammation contibute to fd def ts Thediishedcaatngvoume odstoderensedtesieper- ‘ionand may rein ukiorgnfakure ntsc vluesta tuscan be esimatedby observing tal sigs and mein urine vtput, BUN, and hematocrit. A low intravascular volume in cexsesconpliationsand martalty ate. Foreample.inastidy of Ssropatentsithacaepanceatts eer Seng/tneeaee BUN JevelWthinthe fest 24 hous of admision wa atocated whan Inaessed ORormortaltyby2.2(95%CL19:23).* anther say hoaspatients tact pancrestsfeundanassocationhes pialmartltyinpatene whan aémision DUNIevel greater than 20 mg/dL (OR.45{95%C1 25-83). andany ten BUN evel 24 hoursafteradisonwasasocted with anORol43 (85% CL23- 79) for deat Ths, mostsconng systems wedi acute panere- atisincorportea make ofvolmesttus (ate). Technical gielinesfortidressctaton froma ruber of ‘expert rope agree that ravens volume restsciton shold belniated at oon a the agnosis acte pancreatitis srmade, (© 2021 American Madea! Association, Al ght racened. naded From: bts:iJamanctmor con Universty of Meinarne by VM JAMANET on 10747022edn Ci Redew Edveton om commence wii Penn gene et See __wtncene fe Re OUI ‘nttveran eae ey ‘erlow ualty a eirce Moderate evidence Quay of edece: noe redler feananeraeee id 23a hl en Seovcoiumen! — fofdeadeerte tdremancensted alla erat auntie ret Nercmmnenae, erie tentrey Pewecsenig ca Mcammdtinente, Satta, te siotS0ntha enter taco ean BM, ta = Tern en et a may Tyme of Rid tor tat 3 Ege acento penta Andee tee tage tn Xereomen edn ten Triste atte sotytenince — aletieewtince tenes Oui ene ete eliettedmpone —tyactenantn we eg eae Perteentes y ieraeyadrciey Sennen fotestesoted Mires eee ‘ teins erected? Quy eine BN OIE icra purer Ai ton Boris cece na ‘Type ttre Maerate-quality of vience Morecarmendatin mecomia aa Mani oine remeron Sorwlenaetcenes Caml Reve eee Ulett ces tranny evine gutted tt Egret enantio aan Secreomtitn'e thea? Uaweetyevince cmon, “Groleysectemy inary AP _ SS Tee eto Someone ———————— essen 0 oie ‘Rn tag FR Conoco ston step Rn incense 80 Hontresnoge Wc seni "Uae ang ean hon sg ada endl Oy tein er cnr ntpee SEES, ten ane partenariat bouts sea ine the patents th amergency department and tats tori ata formdstons are prefered able), Specialy, lactated Ringe solution recommeded by mest gudeines be- ‘auseof an stociatonbetweenan apparent sntefimmatryet fect and decesed eds of eveerng SIS 24a corpareé ‘wth nontalssne. The eden favoring one crystal femal toner another ick tomaderate quay. The American College tearvoenterlog/sAC hte ances askFerceon Qt ty pide eda met anasreorting deceased odes oe eb RS nh laated ine soston compared wth noma Sehensedfortheintdrenseratennacrepoceatts(0R, ‘035 95% co 98) 294 Mises nats wasted on 3 [Tsolehicheny demonsratedasficteflect frac ‘otedRngrsohten.* Nosavhetesracanmend tring tren han eatin to specte measurable gets of perfusion. Forex Spl thebeats of Pane lyReneican Pa enc hzoaton (APAPA ecomendsacsalldlsonct StolomLnghentocroreresscatn gaat eg ea fuel esta per nate ean aelpesire 65 65mm, inecatpors0s tal mUchematc. 35%-44%) The ik dfudonsbasdvetogzesteressciatenpabenswt re ‘Casing ine senses oie mustavaysbe caer, (©202 Anerican Madea Aasoition. Agha ‘Theses can manifests pumonary eden. "ion ating to rypowa, and intra-abdominal yperension.™ ston Theprovson of maton isan epee vpartant feature the care of pa: acepancentis OModerteleevereandscwerescite siismay ange in tocol aroge i Teo eon tay eee tandoctnotic- ‘teric mmphatics, This could re tsaganivisheee: U0 nan 2.200 ee Mer tered, ewnane r psumaneks ery f Mere by VRALUAMANE a tnngnence ao he ‘pas eter nove pert. A Coane Items 8 studies ching 8 patents compared ‘ealntiten sto srerteanatinleteteaten ce eats. cng tt etal atin massed wth de ans amatayateieh .05125C,028 051. hlecgnfate R085 (95%c, 057.08). aespench {econ R09 [95% 0, 073.068). On top aa or Severo ances te daca rds pts ‘ecangerennionv ener BCIBS8X ‘coos-asen Ne umrecesay vated free suming tin pts abo sete paces The at "een pees fo the Ante arms sca ‘en(AGA)*Aate Pret Foreen Qala qu ‘neater oper ne cre tg eer eng tin 272s ile) Oe netanase7 RCTS wth sips derensrated tinged engin hours fasion compared wth dele rt feeding (©24hous) operator wa rssh ceeine ‘mpl cfr (OR 04 S5CLO2079 P= 008) ‘nator pe tee vingoanatiostul besa ona lotto sede" pstes rerabhtotese ethinyl artes nape ten Ge mscptic eras aetna rte trl eg ue opalescent aansicbe sed option 2h. any ates maha thee fee ‘noes The eras galesfonth Evepen Soe) {or hriatirten nbn reamed Peaing ruven srs ral peers th eto moet eee te pnts wnt ich tion song Teo ton Rl Somer ret O02 pe Spenerratsemngal Alster ae prasad ret netorl ee Fates ith evidence of mabaepson ante) ere latin fs ene neces ray eee snsponnesicomresrpenerosnsedtbcotentr theatre tampaegecnetonpoatte ‘aie niente re reed ‘eect AskedactonanFlowp Care Oateytacom (ibis ae ste cna ste pancets Wen dle ‘sty setperamed he neon oe ete panei fare ae ek recone ee nent na edn 40 das ft arg, TherSkiwnenetozz% 25 et ccyictny et promed Eny ula ath 2 ot sal expel re) afew strep ron tet th ape icons ef wae pet Smeednisin cept may notte esters ‘ine tert reenter rd pan oe ‘eran tether pia he pe ‘Dad nde epson wiht te sensed, ‘pe eeemmtmedely Rtn ene coer peters ete {ee paren eed anes Pats wih ese ‘Sever oF severe acute pancreatitis should be evaluated fox Pat aver caletons pit haem by performing carat entanced CT or Mt exasratin. For patients nave Beinn cece ae pee er ce ac pte ca te Infection of he prsaeeati hid calections and tation of ‘aaltaten fom abugngrevapetoneun. Te apron shuld aloe ut the i colectns reso after wating 6 sete te tel sent eee Lory be canine theta ag ret {9 ortciom trey fc wh ghee sel credung t enmant ntt emcee fon ec gg Sue tert torts dee! cory or _Paterts wha arebigh sual rk but ts iteveron may ct ‘wh tera ctatepery ace dete Asesinas Atheletes dander eprereureteatparrett Pa 2 16CL I 3881 5 erhedintineto rae andovane noe 8 carn 216 85%50.273090} ethene {2drnicpewest Te AGtrrmendspertorargsae ‘sd akahdontepeces bn argent ‘ahs anatonsen scoot se Ofer entire heen ttheeehcrtera toutes sedregmeng wig cin Seay roca se Felonies hamaclp trp ce tess, isd ett 2 Foro eee {este nlmrtighrenrmdespoecee Teletem ees lace ese ee Into tei titine ete Pte the elo recent esate ste pancetta pen ‘drxpaeess wn Seep ens eee Fal ‘eye pets trent sepa ‘matt atcokc sae est ane let isc ster nang et {esl pepesrgio cre anawuts eerie ‘ce abc alg une et a hak Jetepce Preece en ky mis St pate The est npr se eae ete {epee eg ata a Sopa tea cece ea Oe eO (220 Antanas asco. A ee mad snd Fro: panne. ay Mabey VM SAMANET 4Pate wth persone esti lover nin es tt Symes erga ‘considered unsafe during the admin, within 204 weds after chore to reduce risk of reaurence of acte pancreatitis inp tient and outpatient acho modteonlcessaton strates are ey helpful used bothin the hospital and outpatient stings ame wR ‘Accepted ter Peon Sperber 78.200. ‘cect: Tis areca 18.207,ofs nce poste reste tee ‘pred thellba ate eden, 2022 ofuiheuntefmeneelrueeate etlebadeectn, aot oneness ‘sacra ate he dain yt Hiaissanacsaren te vines 2001204 sett 2. cassis Cpe rene, sdnisonnncs pees 00 Aioisonepocy ate nemo. Tacestemtel 10959020025 2. nde rl ASMA, ‘enpordweknincene nf ovtcmest {etepsoeatsnhaspaledpatensin te Ae Crittenton Unitations “Thereewhassomelntations Fest formalsstematicreven was ‘ot perormed, Second 3 compres eikiation fact pa atismanapement(e or neooticngacte pancetta am Dleations, r other sequelae of acute pancreatitis) was not e- ‘eed Tied although the importance of id resuscitation nd rutrtionin then management of acute panes wdc cepted the evidence for spect ntervetionsiinied, of mer _Ratolow quay. and eperted inconsistent finns. Furth meth odolgaldversty and stata heterogenty were frequently tecourtered For example themetz-anaysesonthe fidandnut- tional management of ce pancreatitis inccrprated a combina: ‘ono tudes that ued eter the RAC seve casa. anal tematveoraudated severity scoring ste. Thishasimpatons ‘when comparngmethodsof marageent andthe effcton disease vey ith there re several aie panes management sddenesof varying qty Features of idles withthe highest ‘uatylnce hose endorsed by profesional organizations (eg IAP, GA.ACG) nce asa frecarmendstirs, nd provide dence dng the various recommendations Conclusions eteparesti compl dseasttatarsnsevertyandcouse, rapt ganz andeatiictonofseveryiivences proper man agunentSerngstenseustuladuncsbssboudretapesade icaljgert. Fuidmrapemert. ution andrdkeductonstat- cesar eryimportant pecs ofcarefrantepancreatis. 1, Haney edgoatlR nA Reb Praveen comme rots soy Bose, ‘Hig Abe, eh Tevet exclu akun aginst Petecescaiondtbertl pee, Tirana 000 SA. 12 UA ouR Zing LUZ Glmapainget Peweniachtcchinbepaiagesect Sa ee eee, Umelsmteton 2081208 Re 209; pee Noes ceteret SO eee ‘cess euros ‘catondea: Ala. 4. opp sMAAG. ates RW en D as, od Ai VS Ah Eta ‘easton wai oretttone( 8a Mt Redman edsendoconseh Inder soe amet opo CRCP eee fosplerarstdaedtonre nce Deng benensrge Matos Celi of hema prot letter Alters 5 Fosmah Nees. koe ee parti corns 20S 1, Yong en NZ, seers ery retain Settee Mewes Rabe, pe Enid eSNG, Agate es nine 720), ‘Aisi ce ere eFC acuatouton gs 2 er ee Cen Tcangogedenogfete Ze MEF Anse Deshe AF Basch carat ret sdesmesNeerepte, ‘atin We enrages tobi ‘pester consdentonarsRefen Pie ‘crac rd orgs Wa Isonnuercrtnger Man cae Medes Ma anos onan 1 sete 24 cnc WH a ime trees ae enc pce ome [Bunter ctensnnaleyosia PS banca nestor 20760 7 rich te Bais Ate banc Lowe 701355088595, 1. awa Begin A Semeby Lena tepraen ed becomponet axateby Sichettgesme oneaaream 9 Us He Fuss Mego A, Santo Rlea belakedraiayemin haanpneats pts 209470 YR Onalt ah Aspemacreten nd Ital sey kpc, estore) 208; 29 362 16. PapacitouGNaoe6o10Stes AataPaceatsPaertRegey oan Now Teen eperence (UbmRENTED on Geer SEDONNO che. eins Seber Lec, Ushi Mate update Cr coal ie 198)40) WA, Jann 201 Vere 5 Naber {© 2021 American Medial Associslon. Allighs reserved, faded Fro: ipljamaneswokcomy Univer o Melbvorn by VRM JAMANET on 10247022