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Gold Nanoparticles in Cancer Treatment

 Krzysztof Sztandera
, 
 Michał Gorzkiewicz
, and 
 Barbara Klajnert-Maculewicz*
Cite this: Mol. Pharmaceutics 2019, 16, 1, 1–23
Publication Date:November 19, 2018
https://doi.org/10.1021/acs.molpharmaceut.8b00810
Copyright © 2018 American Chemical Society
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SUBJECTS:
 Cancer,
 Cells,
 Metal nanoparticles,
 Nanoparticles,
 Toxicity

Molecular Pharmaceutics
Abstract

Colloidal gold has been studied for its potential application in medicine for centuries.
However, synthesis and evaluation of various gold nanoparticles have only recently been
met with a wide interest of scientists. Current studies confirm numerous advantages of
nanogold over different nanomaterials, primarily due to highly optimized protocols for
 the production of gold nanoparticles of countless sizes and shapes, featured with unique
properties. The possibility to modify the surface of nanogold particles with different
targeting and functional compounds significantly broadens the range of their potential
biomedical applications, with particular emphasis on cancer treatment. Functionalized
gold nanoparticles exhibit good biocompatibility and controllable biodistribution
patterns, which make them particularly fine candidates for the basis of innovative
therapies. Considering the high amount of scientific data on nanogold, this review
summarizes recent advances in the field of medical application of gold nanoparticles for
the therapy of cancer.

KEYWORDS:

 gold nanoparticles
  nanogold
  nanotechnology
  nanomedicine
  cancer therapy
  cancer treatment

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 Gold Nanoparticles: Past, Present, and Future

Rajesh Sardar, Alison M. Funston, Paul Mulvaney*, and Royce W. Murray

Publication Date (Web): July 2009
 Gold Nanoparticles in Chemical and Biological Sensing

Krishnendu Saha, Sarit S. Agasti, Chaekyu Kim, Xiaoning Li, and Vincent M. Rotello*

Publication Date (Web): February 2012
 Turkevich Method for Gold Nanoparticle Synthesis Revisited

J. Kimling, M. Maier, B. Okenve, V. Kotaidis, H. Ballot, and A. Plech

Publication Date (Web): July 2006
 Gold Nanoparticles:  Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and
Nanotechnology

Marie-Christine Daniel and Didier Astruc

Publication Date (Web): December 2003
 Determination of Size and Concentration of Gold Nanoparticles from UV−Vis Spectra

Wolfgang Haiss, Nguyen T. K. Thanh, Jenny Aveyard, and David G. Fernig

Publication Date (Web): April 2007

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