BETA BLOCKERS

DR NADEEM YAQOOB
 Adrenoceptors

α1…
Blood vessels Vasoconstriction
Pupillary dilator m. Mydriasis
Prostate Contraction
α2…
Presynaptic terminals Inhibition
Blood vessels vasoconstriction
Ciliary epithelium ↓ Aq. production
 Adrenoceptors
• β1
• Heart stimulate
• Ciliary epithelium ↑Aq production
• Juxtaglomerular cells ↑renin release
• β2
• Respiratory smooth m relax
• Uterine smooth m relax
• Vascular smooth m of skeletal m relax
• Skeletal m K uptake
 Adrenoceptors
• D1
– Renal blood vessels vasodilation
• Beta 1 selective
– Acebutolol
– Atenolol
– Esmolol
– Metoprolol
• Beta non selective
– Propranolol
– Timolol
• Partial agonists
– Pindolol
– Acebutolol
• Local anesthetic activity
– Or membrane stabilizing effect
– Propranolol
 Clinical uses
• Hypertension
• Angina
• Arrhythmias
• Chronic heart failure
 Clinical uses
• Glaucoma
• Pheochromocytoma
• Thyrotoxicosis
• Tremors
• Stage fright
• Migraine
• Infantile hemangioma
 Adverse effects
• Bradycardia
• AV block
• Acute heart failure
• Asthma
• Sedation, fatigue
• Sexual dysfunction
• Insulin dependant diabetes mellitus