Dynamical Systems in Neuroscience

Danish Hafeez Rana

IBA-KARACHI

August 15, 2022

Danish Hafeez Rana Dynamical Systems in Neuroscience

Structure of a Neuron

Danish Hafeez Rana Dynamical Systems in Neuroscience

Action Potential (or Spike)[1]

Danish Hafeez Rana Dynamical Systems in Neuroscience

Where Is the Threshold [2]

Danish Hafeez Rana Dynamical Systems in Neuroscience

Integrators versus resonators [5]

Danish Hafeez Rana Dynamical Systems in Neuroscience

Integrators versus resonators [5]

Danish Hafeez Rana Dynamical Systems in Neuroscience

Dynamical Systems and Building Models

A dynamical system
consists of a set of variables that describe its state and a law that
describes the evolution of the state variables with time (i.e., how
the state of the system in the next moment of time depends on the
input and its state in the previous moment of time).

Danish Hafeez Rana Dynamical Systems in Neuroscience

The Hodgkin-Huxley Model[3]

IK INa IL
z }| { z }| { z }| {
C V̇ = I − ḡK n4 (V − EK ) − ḡNa m3 h (V − ENa ) − gL (V − EL )
ṅ = αn (V )(1 − n) − βn (V )n
ṁ = αm (V )(1 − m) − βm (V )m
ḣ = αh (V )(1 − h) − βh (V )h

The variables n and m are called activation variables and h is

inactivation variable. The coefficients αn , βn , αm , βm , αh and βh
denote rate constants for the opening and closing of gates.

Danish Hafeez Rana Dynamical Systems in Neuroscience

Action potential in the Hodgkin-Huxley model

Danish Hafeez Rana Dynamical Systems in Neuroscience

Phase Portraits and Bifurcations

Danish Hafeez Rana Dynamical Systems in Neuroscience

Bifurcations

Danish Hafeez Rana Dynamical Systems in Neuroscience

Danish Hafeez Rana Dynamical Systems in Neuroscience
Classification of neurons

Danish Hafeez Rana Dynamical Systems in Neuroscience

References

Verma, Parul, et al. ”Using bifurcation theory for exploring

pain.” Industrial and Engineering Chemistry Research 59.6
(2019): 2524-2535.
Izhikevich, Eugene M. Dynamical systems in neuroscience.
MIT press, 2007.
Hodgkin, Alan L., and Andrew F. Huxley. ”A quantitative
description of membrane current and its application to
conduction and excitation in nerve.” The Journal of physiology
117.4 (1952): 500.
Fitzhugh, Richard. ”Thresholds and plateaus in the
Hodgkin-Huxley nerve equations.” The Journal of general
physiology 43.5 (1960): 867-896.
Izhikevich, Eugene M. ”Resonate-and-fire neurons.” Neural
networks 14.6-7 (2001): 883-894.

Danish Hafeez Rana Dynamical Systems in Neuroscience