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IFN r is thetriggerduring
He l
es
damosma
IL
so
Clostridiumdifficile
opportunistic bacteria
my
class l IFN's
No inhibition
on virus
infected
cells
PLasmacytoud dendritic cells
Starts at right side of the diagram were it says tissue damage.
Tissue damage leads to the formation of complement products that act as opsonins and afilitoxins and chemotactic agents.
Within a few hours of the onset of vascular changes neutrophils adhere to the endothelial cells and migrate out into tissue spaces.
Neutrophils phagocytose invading pathogens and release mediators that contribute to the inflamatory response.
Macrophages arrive about 5-6 hours after the inflamatory response begins
Activated macrophages secret cytokines incluiding IL 1, 6 and TNF allpha that reduce many of the localized systemic changes
Local inflamatory response can occur without the overt involvement of the immune system.
These function as bait to deactivate
l
and affinity are directly
Antibody
proportional