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Volume 162 #2  August 2022

EDITORIALS
271 Defibrotide Has a Role in COVID-19 Therapy
Antonio Macciò; Giorgio La Nasa; Sara Oppi; Clelia Madeddu
>>See article, 346

274 Balancing the Benefits and Harms of Lung Cancer Screening: Much Work to Be Done
A. Cole Burks; Jason Long; M. Patricia Rivera
>>See article, 475

277 Swimming-Induced Pulmonary Edema: A Swedish Experience

Peter Wilmshurst
>>See article, 410

279 Loss of Heterozygosity for Tuberous Sclerosis Complex and Mammalian Target of Rapamycin
Signaling: The Keys to Understanding the Pathogenesis of Diffuse Cystic Lung Diseases?
Marissa O’Callaghan; Cormac McCarthy
>>See article, 385

281 We Must Keep Our Cool Regarding the Effect of Therapeutic Hypothermia After In-Hospital Cardiac
Arrest
Markus B. Skrifvars; Janus C. Jakobsen
>>See article, 356

283 Spirometry as a Predictor of Cardiometabolic Disease

Tianshi David Wu
>>See article, 421

285 Implications of the COVID-19 Pandemic for the Well-Being of the ICU Workforce Considerations for
the ICU Interprofessional Team
Michelle E. Kho; Julie C. Reid
>>See article, 331

POINT AND COUNTERPOINT

288 POINT: Does Normothermic Regional Perfusion Violate the Ethical Principles Underlying Organ
Procurement? Yes
Matthew DeCamp; Lois Snyder Sulmasy; Joseph J. Fins

290 COUNTERPOINT: Does Normothermic Regional Perfusion Violate the Ethical Principles Underlying
Organ Procurement? No
Les James; Brendan Parent; Nader Moazami; Deane E. Smith

292 Rebuttal From Dr DeCamp et al

Matthew DeCamp; Joseph J. Fins; Lois Snyder Sulmasy

293 Rebuttal From Dr James et al

Les James; Brendan Parent; Nader Moazami; Deane E. Smith

CHEST COMMENTARY
295 Smokefree New Zealand 2025: A Beacon for Global Tobacco and Nicotine Policy Reform
Adam Edward Lang; Alain Braillon

CHEST (USPS 157-860 ISSN 0012-3692) is published monthly for the American College of Chest Physicians by Elsevier, Inc., 360 Park Avenue South, New York,
NY 10010-1710. Periodicals postage paid at New York, NY and additional mailing offices.
POSTMASTER: Send address changes to CHEST, Elsevier Periodicals Department: 3251 Riverport Lane, Maryland Heights, MO 63043.

Continued
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ASTHMA
Original Research
297 Results of a Phase 2b Trial With GB001, a Prostaglandin D2 Receptor 2 Antagonist, in Moderate to
Severe Eosinophilic Asthma
Mark H. Moss; Njira L. Lugogo; Mario Castro; Nicola A. Hanania; Andrea Ludwig-Sengpiel;
Dinesh Saralaya; Rafal Dobek; Iñigo Ojanguren; Ivan Vyshnyvetskyy; Jean-Marie Bruey; Robin Osterhout;
Cindy-ann Tompkins; Karen Dittrich; Kartik Raghupathi; Hector Ortega; on behalf of the LEDA
Investigators

CHEST INFECTIONS
Original Research
309 The Radiographic and Mycobacteriologic Correlates of Subclinical Pulmonary TB in Canada: A
Retrospective Cohort Study
Angela Lau; Christopher Lin; James Barrie; Christopher Winter; Gavin Armstrong; Mary Lou Egedahl;
Alexander Doroshenko; Courtney Heffernan; Leyla Asadi; Dina Fisher; Catherine Paulsen; Jalal Moolji;
Richard Long

COPD
Original Research
321 Optimizing COPD Acute Care Patient Outcomes Using a Standardized Transition Bundle and Care
Coordinator: A Randomized Clinical Trial
Chantal E. Atwood; Mohit Bhutani; Maria B. Ospina; Brian H. Rowe; Richard Leigh; Lesly Deuchar;
Peter Faris; Marta Michas; Kelly J. Mrklas; Jim Graham; Raymond Aceron; Ron Damant; Lee Green;
Naushad Hirani; Kelly Longard; Virginia Meyer; Patrick Mitchell; Willis Tsai; Brandie Walker;
Michael K. Stickland

CRITICAL CARE
Original Research
331 The Influence of the COVID-19 Pandemic on Intensivists’ Well-Being: A Qualitative Study
Kelly C. Vranas; Sara E. Golden; Shannon Nugent; Thomas S. Valley; Amanda Schutz; Abhijit Duggal;
Kevin P. Seitz; Steven Y. Chang; Christopher G. Slatore; Donald R. Sullivan; Catherine L. Hough;
Kusum S. Mathews
>>See editorial, page 285

346 Defibrotide Therapy for SARS-CoV-2 ARDS

David Frame; Gianni B. Scappaticci; Thomas M. Braun; Mary Maliarik; Thomas H. Sisson; Steven W. Pipe;
Daniel A. Lawrence; Paul G. Richardson; Michael Holinstat; Robert C. Hyzy; Daniel R. Kaul;
Kevin S. Gregg; Vibha N. Lama; Gregory A. Yanik
>>See editorial, page 271

356 Targeted Temperature Management After In-Hospital Cardiac Arrest: An Ancillary Analysis of
Targeted Temperature Management for Cardiac Arrest With Nonshockable Rhythm Trial Data
Alexiane Blanc; Gwenhael Colin; Alain Cariou; Hamid Merdji; Guillaume Grillet; Patrick Girardie;
Elisabeth Coupez; Pierre-François Dequin; Thierry Boulain; Jean-Pierre Frat; Pierre Asfar; Nicolas Pichon;
Mickael Landais; Gaëtan Plantefeve; Jean-Pierre Quenot; Jean-Charles Chakarian; Michel Sirodot;
Stéphane Legriel; Nicolas Massart; Didier Thevenin; Arnaud Desachy; Arnaud Delahaye; Vlad Botoc;
Sylvie Vimeux; Frederic Martino; Jean Reignier; F. S. Taccone; J. B. Lascarrou
>>See editorial, page 281

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How I Do It
367 Positive Stimulation for Medically Sedated Patients: A Music Therapy Intervention to Treat
Sedation-Related Delirium in Critical Care
John Head; Virginia Gray; Faisal Masud; Jennifer Townsend

DIFFUSE LUNG DISEASE

Original Research
375 Provider Perspectives on and Access to Palliative Care for Patients With Interstitial Lung Disease
Rebecca A. Gersten; Bhavna Seth; Luis Arellano; Jessica Shore; Lanier O’Hare; Nina Patel; Zeenat Safdar;
Rachana Krishna; Yolanda Mageto; Darlene Cochran; Kathleen Lindell; Sonye K. Danoff; on behalf of the
Pulmonary Fibrosis Foundation

385 Pulmonary Langerhans Cell Histiocytosis and Lymphangioleiomyomatosis Have Circulating Cells With
Loss of Heterozygosity of the TSC2 Gene
Davide Elia; Olga Torre; Chiara Vasco; Jens Geginat; Sergio Abrignani; Elisabetta Bulgheroni; Elena Carelli;
Roberto Cassandro; Gustavo Pacheco-Rodriguez; Wendy K. Steagall; Joel Moss; Sergio Harari
>>See editorial, page 279

Guidelines and Consensus Statements

394 The Role of Genetic Testing in Pulmonary Fibrosis: A Perspective From the Pulmonary Fibrosis
Foundation Genetic Testing Work Group
Chad A. Newton; Justin M. Oldham; Carolyn Applegate; Nikkola Carmichael; Karen Powell; Dan Dilling;
Shelley L. Schmidt; Mary Beth Scholand; Mary Armanios; Christine Kim Garcia; Jonathan A. Kropski;
Janet Talbert; and the Pulmonary Fibrosis Foundation Genetic Testing Work Group
Research Letters
406 Outbreak of Silicosis in Workers Producing Artificial Stone Skirting Boards: A Novel Application of
Silica-Based Composites
Steven Ronsmans; Pieter Goeminne; Naïm Jerjir; Vicky Nowé; Eline Vandebroek; Stephan Keirsbilck;
Birgit Weynand; Peter H. M. Hoet; Jeroen A. J. Vanoirbeek; Wim A. Wuyts; Jonas Yserbyt; Benoit Nemery

EDUCATION AND CLINICAL PRACTICE

Original Research
410 Swimming-Induced Pulmonary Edema: Evaluation of Prehospital Treatment With CPAP or Positive
Expiratory Pressure Device
Claudia Seiler; Linda Kristiansson; Cecilia Klingberg; Josefin Sundh; Annika Braman Eriksson;
Daniel Lundeqvist; Kristofer F. Nilsson; Maria Hårdstedt
>>See editorial, page 277

421 Role of Pulmonary Function in Predicting New-Onset Cardiometabolic Diseases and Cardiometabolic
Multimorbidity
Guochen Li; Yanqiang Lu; Yanan Qiao; Die Hu; Chaofu Ke
>>See editorial, page 283

HUMANITIES
Exhalations
433 The Vexing Voyage of Vasopressin: The Consequences of Granting Market Exclusivity to Unapproved
Drugs
Liam Bendicksen; Aaron S. Kesselheim; Benjamin N. Rome

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PULMONARY VASCULAR
Original Research
436 BMI and Treatment Response in Patients With Pulmonary Arterial Hypertension: A Meta-analysis
Breanne E. McCarthy; Robyn L. McClelland; Dina H. Appleby; Jude S. Moutchia; Jasleen K. Minhas;
Jeff Min; Jeremy A. Mazurek; K. Akaya Smith; Jason S. Fritz; Steven C. Pugliese; Ryan J. Urbanowicz;
John H. Holmes; Harold I. Palevsky; Steven M. Kawut; Nadine Al-Naamani
Research Letters
448 Comparison of Full-Dose vs Moderate-Dose Systemic Thrombolysis for the Treatment of Patients
With Acute Pulmonary Embolism
Ana Jaureguízar; Cassius Iyad Ochoa Chaar; Alfonso Muriel; Jerónimo Ramón Vela Moreno; Ido Weinberg;
Antonella Tufano; José F. Varona; Behnood Bikdeli; David Jiménez; Manuel Monreal; on behalf of the
Registro Informatizado de la Enfermedad Tromboembólica (RIETE) Investigators

SLEEP
CHEST Reviews
452 Cannabinoids, Insomnia, and Other Sleep Disorders
Isobel Lavender; Iain S. McGregor; Anastasia Suraev; Ronald R. Grunstein; Camilla M. Hoyos

THORACIC ONCOLOGY
Original Research
466 Rapid FEV1 Decline and Lung Cancer Incidence in South Korea
Hyun Woo Lee; Hyo-Jin Lee; Jung-Kyu Lee; Tae Yeon Park; Eun Young Heo; Deog Kyeom Kim

475 Invasive Procedures and Associated Complications After Initial Lung Cancer Screening in a National
Cohort of Veterans
Eduardo R. Núñez; Tanner J. Caverly; Sanqian Zhang; Mark E. Glickman; Shirley X. Qian;
Jacqueline H. Boudreau; Donald R. Miller; Renda Soylemez Wiener
>>See editorial, page 274

485 Frailty in Patients With Lung Cancer: A Systematic Review and Meta-Analysis
Klara Komici; Leonardo Bencivenga; Neal Navani; Vito D’Agnano; Germano Guerra; Andrea Bianco;
Giuseppe Rengo; Fabio Perrotta

ONLINE EXCLUSIVES

NOVEL REPORTS
e73 Bilateral Bronchoscopic Lung Volume Reduction After Surgical Fissure Completion
Majid Shafiq; Emily Polhemus; Ryan Perkins; Victoria Forth; M. Blair Marshall

CHEST PEARLS
e77 A Young Child With Recurrent Pneumonia and Hemoptysis During the COVID-19 Pandemic
Zirun Zhao; Rachel Choe Kim; Felix Tavernier; Rachana Choksi; Trevor Van Brunt; James Earl Davis;
Katharine Kevill; Helen Hsieh

e81 A 60-Year-Old Woman With Posterior Mediastinal Tumor

Nobuyasu Wakazono; Arei Mizushima; Yukiko Maeda; Natsuko Taniguchi; Katsura Nagai; Atsuo Hattori;
Toshiyuki Harada

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e85 A 54-Year-Old Man With Migratory Pulmonary Consolidation and Progressive Dyspnea
Juei-Yang Ma; Cheng-Hao Chuang

e89 An Adolescent With a Retropharyngeal Swelling: To Drain or Not to Drain? Keeping a Broad Vision
During the COVID-19 Pandemic
Sybren Robijn; Stan van Keulen; Godelieve Verhage-Damen; Stijn Bekkers

CHEST IMAGING AND PATHOLOGY FOR CLINICIANS

e93 An Unusual Source of Tension
Patrick J. Sylvester; Akshay B. Vijayaraman; Carleen R. Spitzer

ULTRASOUND CORNER
e99 Sudden Hemodynamic Instability After Unproning a Patient With COVID-19 Pneumonia
André C. G. Hirano; Livia M. G. Melro; Bruno A. M. P. Besen

CORRESPONDENCE
e103 In Real-World Studies, Comparisons of Predictive Values Are Confounded by Prevalence
Gene Pennello
Response—Valeria S. M. Valbuena; Ryan P. Barbaro; Dru Claar; Thomas S. Valley; Robert P. Dickson;
Steven E. Gay; Michael W. Sjoding; Theodore J. Iwashyna

e104 A Nonrigorous and Incorrect Evaluation of the Fast Fit Test

Lisa M. Brosseau; Rachael M. Jones
Response—Adrian Regli; Aine Sommerfield; Britta S. von Ungern-Sternberg

e106 Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease

Paul D. Blanc; John R. Balmes; Carrie Redlich
Response—Kartik Kumar; Michael R. Loebinger

e108 Prehospital Management of Swimming-Induced Pulmonary Edema: Is CPAP the Best Lifeguard?
Paolo Ruggeri; Alastair Glossop; Antonio M. Esquinas
Response—Claudia Seiler; Maria Hårdstedt

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Article-specific audio discussions can be found online at

https://journal.chestnet.org/podcast-archive-2022

Accompanying videos for articles can be found in the supplemental

materials section of the individual article view on the CHEST website.

Article-specific visual abstracts can be found online at

https://journal.chestnet.org/infographics

Recordings of journal club webinars can be found online at

https://journal.chestnet.org/journalclub

Article-specific animated videos can be found online at

https://journal.chestnet.org/animations

Continued chestjournal.org
 Contents

COMING SOON

ASTHMA Asthma Control, Airway Mucus, and 129

Xe MRI Ventilation After a Single Benralizumab
Dose

CHEST INFECTIONS Influenza Testing and Treatment Among Patients Hospitalized With
Community-Acquired Pneumonia

COPD Impact of Airline Secondhand Tobacco Smoke Exposure on Respiratory Health and Lung
Function Decades After Exposure Cessation

CRITICAL CARE Psychiatric Outcomes in ICU Patients With Family Visitation: A Population-Based
Retrospective Cohort Study

DIFFUSE LUNG DISEASE Cough-Specific Quality of Life Predicts Disease Progression Among
Patients With Interstitial Lung Disease: Data From the Pulmonary Fibrosis Foundation Patient Registry

EDUCATION AND CLINICAL PRACTICE The Contribution of Anthropometry and

Socioeconomic Status to Racial Differences in Measures of Lung Function: A Systematic Review

HUMANITIES Withdrawing Life-Sustaining Therapies and the Conundrum of “Brain Death”:

A Clinical Case at the Intersection of Spiritual and Clinical Care for Muslims

PULMONARY VASCULAR Impact of Esophageal Pressure Measurement on Pulmonary

Hypertension Diagnosis in Obese Patients

THORACIC ONCOLOGY The Association of Health-Care System Resources With Lung Cancer
Screening Implementation: A Cohort Study

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