Drosophila vs.

yeast Atg1
3/4/05

fly: 9 YSSKDMLGHGAFAVVYKGRHRK-KHMPVAIKCITKKGQLKTQNLLGK---EIKILKELTE 64
Y+++ +G G+FA VY+G K VAIK +++ +LK + LL EI ILK++
yeast: 24 YTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSR-AKLKNKKLLENLEIEIAILKKIK- 81

Query: 65 LHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRL------------ 112

H ++V L+DC+ + L+MEYC GDL L + L E+ L
Sbjct: 82 --HPHIVGLIDCERTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSE 139

Query: 113 ------------FLVQLAGAMKALYTKGIVHRDLKPQNILLS------------HNYG-- 146

+L QLA A+K L +K +VHRD+KPQN+LLS H G
Sbjct: 140 NHNGLHRAFVLSYLQQLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFV 199

T176 (=T229 S6K, T342 Akt)

Query: 147 --KTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLG 204
LP LKIADFGFARFL ++A TLCGSP+YMAPE++ +Y++KADLWS+G
Sbjct: 200 GIYNLPI-----LKIADFGFARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVG 254

Query: 205 TIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPS--GVSPDLRDLLLCLLRRNSKDR 262

T+V++ G PF A EL ++ AN PS + P+L++L+ LL + R
Sbjct: 255 TVVFEMCCGTPPFRASNHLELFKKIKR-ANDVITFPSYCNIEPELKELICSLLTFDPAQR 313

Query: 263 ISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPL- 321

I +E FF ++ + ++ L D+P L +S +
Sbjct: 314 IGFEEFFANKVVNEDLSSYE-------------------LEDDLPELESKSKGIVESNMF 354

Query: 322 -QQQLEQELKL--VKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSEN- 377

+ L ++ K LA Q E + +++ PA+ T SN
Sbjct: 355 VSEYLSKQPKSPNSNLAGHQSMADNPAELSDALKNSNILTAPAVKTDHTQAVDKKASNNK 414

Query: 378 -NSGSCSSHEDSDDFVLVPKNLPEDQRQGLAQVQAQPASGGQRPQQQQNQSSPPRPSSLP 436

++ S ++V+V K E + + + A G P ++ +S + L
Sbjct: 415 YHNSLVSDRSFEREYVVVEKKSVE-----VNSLADEVAQAGFNPNPIKHPTSTQNQNVLL 469

Query: 437 ISEPKPVPAP-ARRQVARPGPL--TVATLGGQQIPRSQPISVKQPRPDQRKSSVSSDINS 493

+ P + Q P L T ++ GG ++P R+ S+S S
Sbjct: 470 NEQFSPNNQQYFQNQGENPRLLRATSSSSGGSD-------GSRRPSLVDRRLSIS----S 518

Query: 494 ISPP-AVQFAIGTPPTRMRSASGGSLSETPPPHAPSTWQVSPGHSQSPLRRSGNSSPVLP 552

++P A+ A+G TR+ GG+ + S SP +SQ+ L + L
Sbjct: 519 LNPSNALSRALGIASTRL---FGGANQQQQQQQITS----SPPYSQTLL--NSQLFHELT 569

Query: 553 SAALTKLPTLGSP-TMLVAPGSLGSIGSAGSGSENNNQHHMLGPRAFTLPELGAT--GGL 609

+ ++ L P T+ + ++ SI + L +AF + +
Sbjct: 570 ENIILRIDHLQHPETLKLDNTNIVSILES------------LAAKAFVVYSYAEVKFSQI 617

Query: 610 HSLLDT--GAGGGGEPHAFQAPELSEETLMD--REHNETLSKLNFVLALTDCIQEVADSR 665

L T G + + ++EE D E +ETL K
Sbjct: 618 VPLSTTLKGMANFENRRSMDSNAIAEEQDSDDAEEEDETLKKYK--------------ED 663

Query: 666 CAPLSTFMVAGSQSAAQAASADAQQIPPHAPEHCKRAERLVLLVRGLQLLSSGMNLASQQ 725

C TF + SA SA ++ P + E +VL ++ L +LS M + S
Sbjct: 664 CLSTKTFGKGRTLSATSQLSATFNKL-PRSEMILLCNEAIVLYMKALSILSKSMQVTSNW 722
Query: 726 LSNGQLKPSSNVKNALL----------------------TMNAKYRSMLFESKRLNGSGL 763
Q K S N L+ + K+ S + E++ L G
Sbjct: 723 WYESQEKSCSLRVNVLVQWLREKFNECLEKADFLRLKINDLRFKHASEVAENQTLEEKGS 782

Query: 764 LQKANAFNITADKILYDYALDMCQAAALDELL-KNTKNCFERYNTAHILLHSLVQ----- 817

++ + +K+LYD AL++ + AA EL +N NC Y T+ +L + +
Sbjct: 783 SEEP----VYLEKLLYDRALEISKMAAHMELKGENLYNCELAYATSLWMLETSLDDDDFT 838

Query: 818 --------------KCNHPQDK------------MMLNKYRDAVEKRLSILQQ 844

K N +DK +++ KY D++ RL IL+Q
Sbjct: 839 NAYGDYPFKTNIHLKSNDVEDKEKYHSVLDENDRIIIRKYIDSIANRLKILRQ 891