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  • Ana - Lab (For PRCTCL Journal)

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    2K20PHA92 Qamar
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    pharmaceutical analysis

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    ana_lab (for prctcl journal)

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    pharmaceutical analysis

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
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    49 views10 pages

    Ana - Lab (For PRCTCL Journal)

    Uploaded by

    2K20PHA92 Qamar
    pharmaceutical analysis

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 10
    af ; le Axt Se faci t oh webe Se Object: Estimate As tisha , a Reyuirements: ° phen by Acid basvstitration. / a - Chemicals: Aspirin 50% *? bye roxide 0.1N SOml or absolute alcoho! 20ml, Phenolphthalein (in ss ware: Measurin ee : Measu i j Ba nel bance suring cylinder 25/50 and 100ml, conic flask 250 and 500m beaker 250/500ml, glass rod, 4) paratus / | ie or er had gee et Analytical blancs, ron ail aluminium foil, filter hice: . face mask and marker pen ‘Y tration / Titrimetri 2} eaton Titimerie analysis / Titrimetry: Refers t0 ae syoline of a solution or amount of reagent / stan ‘act quantitatively witl i meninete Weer ly with a measured volume of solution of on fone / Reference / Titrant The solution of accurately known stré cate BS Soe Eien 1 ana substance being determined or estim; Eealvalence /tieoreGes! point: wine the reaction of titer and tier is cor fea ed The point where the equivalence point is observed physicall toichiometric polat: The mio ot which titer and titrant requirgd to physically observation of equivalence point. Titration error: difference of volume or amount Indicator: a chemical which shows observable physical Piimary standard: A chemical with high chemical purit Secondary standard: the purity of a chemical we chemical reaction to make it as primary standard. Standard solutions: the concentration is a general term’ ed to refer the quantity of a substance in a defined ared in which the / known volume of solution. In quantitative es analysis, base unit is mole. Mole: As per IUPAC “The mole i = 3 substance which contains as many as elementary units as there are atoms in 0.012 kilogram of carBy . The elementary unit must be specified and may be an atom, ae cule fon, radical, electron other partifes or specified group of such particles? Molarity-— number of moles{vplagegf solution in lies. it Equivalent wae of solution in litres. hy metry / Acid base titratio ds by hydrolysis with a standard acid ak bases by hydrolysis with a standard iven samph \dicator), Sodium sb, tissue : Me the reaction. end point: :gen eqhiyalence and end point of titrant be the end or completion of reaction. ings, standard solution is preps fimetry and alkali hose formed from salts of weak aci free acid or those formed from salts of we Neutralisation rea{jon / Titration of free bi (acidimetry tkitragan base (alkalimet i Wve the combination of hydrogen and hydroxide ions to form water. standard solution: 1% available in pure state, prepared simply by weighing ov sntial to weigh out exactly an required and the a solution of definite molar strength is definite fraction or dissolving it an appropriate solvent Tt is not esse ent to prepare the solution a little more concentrated thi ed molarity by using MiVi=M2V2. ‘a be obtained in a state of high purity and are suitable prepare standard solutions: sodium carbonate, sodium hydrogen phthalate, benzoic acid, sodium tetra bora eilphamic acid, potassium hydrogen fodate,soditum oxalate silver, silver nitrate, sodium chloride, potassi chloride, iodine, potassium bromate, potassium iodate, potassium dichromate, lead nitrate etc. a mol mole in practice it is more convenie to dilute it with solvent to obtain requir Following is a list of some substances which cat Eye } t é When the reagent is not available in pure foem as in the ¢qse of andy alka potassium hydroxide, barium hydroxide, potassium permanganate, ammonium sodium thiosulphate). Some inorganic acids and various deliquescent chemicals tl prepared and then standardised by titrations against a solution of a pure substance of known conce! The titration error and other errors are considerably reduced. Deseripti : Aspirin is known as acetyl salicylic acid and used non-steroidal anti- drug. It is white color powder has molecular weight 180.57 and mostly soluble in absolute alco neutral acetone, chloroform ether and dimethyl sulphoxide. It is less soluble in water because hy’ nonpolar nature due to presence of carboxylic acid and ester group. When aspirin reacts bicarbonate (NaHCOs) it forms H2COs (H20 + CO:) which acts like explosive. Aspirin is treated with strong base sodium hydroxide (NaOH) it released H” to combine with OH’ of/Na roduce water while sodium salt of acetyl salicylic acid (weak acidic salt). Procedure: Dissolve equivalent weight of 500mg aspirin from given sample in absolute et acetone 20ml. Filter the sample solution and titrate with 0.1N sodium hy solution as indicator. Each ml of 0.1 N sodium hydroxide is equivalent to Preparation of phenolphthalein indicator: Dissolve 0.5g of phenolphthalein in 50 ml ethanol and add 5Oml precipitate forms. droxide

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