accumulation of mutations acquisition of resistance to apoptotic signals acquisition of invasive properties Figure 16.1 Tumour transformation involves the progressive accumulation of multiple nutations that allow the tumour cells to survive, proliferate, and resist apoptotic signals. extracellular matrix, proteolytically degrade the matrix, and then find its way out of he basement membrane that allows it to migrate to other tissues or organs. A single Mutation cannot endow all these characters on the malignant cell. Thus, tumour formation is a multi-steo process requiring the accumulation of numerous(eto oF Ant Anwe as least the Hnital stayen, div Wat wend Gut distress ‘danger Yah fine deta Kuvtattite tHe mnie eyateun and ave likely thee AT aurvedilance during the Withal phases af develuprient Onve solid wale boy it e row tayaalvely aunt cequite ena © OF the praduction of camnen dissuption tn Wee af eventy thal wo ds outlined below (hye 162) shy inducing apoptosis and secreting pro-inflammatory eytokines sKines released av a result of the inflammatory response recruit ayes to the site The NK cells and macrophages activate one of IEN-yand I-12 detivated macrophages help in further issue debris from the dead and dying cells causes maturation gens 10 the regional lymph nade where they induce "Tht cells and CDS* CTLs, These effector T cells hor ells, The CDS’ Pelle alsa heln the R celle in