9/12/2016 Mechanisms 

of action of N­nitroso compounds. ­ Abstract ­ Europe PMC

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 Mechanisms of action of N-nitroso compounds.
(PMID:2696579)
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Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Canada.

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Cancer Surveys [1989, 8(2):241-250]

Type: Journal Article, Review

Abstract

There is ample evidence from studies in experimental animals that N-nitroso compounds are carcinogenic
because in the body they form potent electrophilic alkylating agents. These reactive intermediates are formed
by spontaneous decomposition in the case of nitrosoureas and related compounds, or by metabolic activation
in the case of N-nitrosamines. The electrophiles subsequently react with DNA of target tissues to form altered
bases which leads to the initiation of carcinogenesis. There is now convincing evidence that the biological
activity of N-nitroso compounds in humans does not differ substantially from that in experimental animals.
We can therefore predict with a high degree of confidence that N-nitroso compounds including nitrosamines
are carcinogenic in man.

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