RANITIDINE

_________________________

A Drug Study Presented to the

Faculty of Nursing Department to
Trina Domanais, RN, MN, MAN

_________________________

In Partial fulfillment of the

Requirements in NCM 221 - RLE
ELECTIVE DR NURSING ROTATION

Submitted by:
Karen B. Belarmino, St. N.
BSN 4H

April 21, 2022

 RANITIDINE
Generic Name ranitidine

Brand Name Zantac, Zantac-75, Zantac-

150, Ranixidine (IVTT)
Drug Pharmacologic Class:
Classification Histamine H2 Receptor
Antagonist
Therapeutic Class: Antiulcer
Pregnancy Category: B

Mode of Action Inhibits histamine action at histamine 2 receptors of gastric parietal cells.
Therapeutic Effect: Inhibits gastric acid secretion. Reduces gastric volume,
hydrogen ion concentration of gastric juice.
Indications with  Erosive esophagitis  Adult: PO 150 mg qid for up to 12 wk
a Suggested Child >1 mo: PO 5-10 mg/kg/day in 2-3
Dose divided doses
 Duodenal ulcer  Adult: PO 150 mg bid or 300 mg/day after
pm meal or at bedtime, maintenance 150
mg at bedtime
Infant and child: PO 2-4 mg/kg bid, max
300 mg/day
 Gastric ulcer  Adult: PO 150 mg bid 3 6 wk, then 150 mg
at bedtime
Infant/child: PO 2-4 mg/kg bid, max 300
mg/day
 GERD  Adult: PO 150 mg bid
OFFLABEL uses  Prevention of  Administered before elective surgery to
aspiration improve the gastric environment at the time
pneumonitis, upper of induction of anesthesia, thus reducing
GI bleeding the potential risk of pneumonitis, if the
aspiration of gastric contents occurs
following the induction of anesthesia.
Drug  Drug-drug  Magnesium or aluminum antacids may
Interactions decrease absorption. May decrease
absorption of atazanavir, itraconazole,
ketoconazole.
 Lab Values  Interferes with skin tests using allergen
extracts. May increase serum ALT, AST,
GGT, creatinine.

Contraindication Hypersensitivity to drug or its components; Alcohol intolerance (with some

oral products); History of acute porphyria
Side Effects Occasional (2%): Diarrhea. Rare (1%): Constipation, headache (may be
 severe).
Adverse Effects CNS: headache, agitation, anxiety
GI: nausea, vomiting, diarrhea, constipation, abdominal discomfort, or pain
Hematologic: reversible granulocytopenia and thrombocytopenia
Hepatic: hepatitis
Skin: rash
Other: pain at I.M. injection site, burning or itching at I.V. site,
hypersensitivity reaction
Nursing 1. Assess vital signs.
Responsibility 2. Obtain history of epigastric/abdominal pain.
3. Obtain baseline renal function, LFT.
4. Monitor serum ALT, AST levels, BUN, creatinine.
5. Assess mental status of the patient.
6. Ask or question about present abdominal pain, or GI distress.
 7. Smoking decreases effectiveness of medication.
8. Do not take medicine within 1 hr. of magnesium- or aluminum-
containing antacids.
9. Transient burning/pruritus may occur with IV administration.
10. Report headache. • Avoid alcohol, aspirin.

REFERENCES:
Jones, D., & Bartlett, A. (2020). Nurse's drug handbook (20th ed.). Sudbury, MA: Jones
&Bartlett Learning.
Skidmore, L. (2019). Mosby’s Nursing Drug Reference (32nd Edition). St. Louis, Missouri:
Elsevier.