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Biohackers Invisible Immunity
Biohackers Invisible Immunity
INVINSIBLE IMMUNIT Y
B IOHACKE R’S H AND BO O K: SP E CIAL ISSU E
Publisher:
Biohacker Center BHC Inc.
PO Box 955
FI-00101 Helsinki, Finland
ISBN: 978-952-68458-4-5
This book is based on the personal experiences of its authors, and the advice it contains is based on a combination of experience and scientific reseach.
This book and the viewpoints that it expresses should not be treated as medical advice. Consult with your doctor before ordering or using any of the herbs
or supplements mentioned in this book.
FUNGUS PARASITES
VIRUSES CARCINOGENS
PH AG OSY TOSI S
ST RUCTUR E MECHANISM
• Cellular structures of the outer surfaces • Mechanically stop microbes from penetrating
on the body (skin and mucous membranes) tissues
• Skin oiliness, acid mantle and sebum • Stop microbes from attaching themselves
• Movements of mucous membrane cilia onto cells
• Fluid layer of mucous membranes (extra- • Kill microbes physically and chemically
cellular fluid volume and microbe-killing
substances)
• Natural bacterial flora on the surface of • Stops invasive microbes from attaching
the skin and mucous membranes themselves onto cells
• Produce substances to destroy intruders
• Proteins and signal molecules in the blood • Promote the elimination of microbes in the
plasma (C-reactive protein, interleukins, blood and tissues (for example by accelerating
beta-2 microglobulin, etc.) the inflammatory reaction at the infection site)
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T cell
1. A B cell binds to the antigen 1. A T cell binds to the surface
for which it is specific. B cell of the infected cell, and
proliferates and becomes activates.
plasma cells or memory cells.
Cytokines (intercellular
Activates
B cell transmitter)
helper T cell
2. Activation of macrophage
4. Cytokines transform
(enhanced phagocytic, ie.
B cells into antibody-
ingesting activity).
providing plasma cells.
2. The B cell, often with
stimulation from a
helper T cell, differenti-
ates into a plasma cell.
Cytotoxic 3. T cell (CD8) becomes cytotoxic
T lymphocyte T lymphocyte, and is able to
Memory cell induce cell death (apoptosis)
Plasma cell of target cell.
Some T and B cells differ-
entiate into memory cells
that respond rapidly to any
secondary encounter with
3. Plasma cells proliferate
an antigen.
and produce antibodies
against the antigen. Target cell with disrupted
cell membrane.
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Cell-mediated immunity is a part of adaptive immunity that These include viruses, mycobacteria and protozoa. Unlike
is based on lymphocytic function. It focuses primarily on humoral immunity, cell-mediated immunity does not involve
fighting the pathogens multiplying within the body’s own antibodies.
cells.
STRUC T UR E MECHANISM
Natural killer cells • Kill viruses and protozoa after activating the inflammatory reaction
• Produce virus-destroying interferons
Phagocytic cells • Occur in the circulation, lymph nodes, spleen and liver
(monocytes and macrophages) • Remove identified intruder microbes by internalizing them
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Like cell-mediated immunity, humoral immunity is a part of The defense mechanisms of humoral immunity are the re-
adaptive immunity. It is responsible for fending off patho- sponsibility of the antibodies circulating in the blood and on
gens that occur outside cells. These include various bacteria the surface of mucous membranes, as well as cytokine and
and toxins secreted by this bacteria. complement systems.
STRUCTUR E MECHANISM
Antibodies occurring in the • Attach to the surface of the microbe, helping to identify and kill the intruder
surface fluids of mucous
membranes (IgA)
Cytokine and complement • Having identified the target, accelerate the inflammatory reaction to
systems eliminate microbes
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Medicine-related immunity-impairing factors include in the Nutrition chapter of the Biohacker’s Handbook. Simi-
antibiotics, cancer and arthritis medication and cortisone larly, the extended use of long-acting cortisone treatments
treatments. Unnecessary antibiotics interfere with natural for various inflammatory conditions and diseases such as
bacterial flora and may therefore increase the risk of infec- asthma and arthritis may impair the immunity response14
tion. Related issues and treatment methods are discussed
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and increase the risk of bacterial and fungal infections.15
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E F FE C TS OF T RAI N I N G ON I M M UN I T Y 1 8
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MA R K ER DE S C R I PT I O N TARGE T
White blood cells (leukocytes) See image “Immune system cells” for more details Target within reference values
Erythrocyte sedimentation The rate at which blood cells sediment in a tube in a Target <15 mm/h
rate (ESR) one-hour period
C-reactive protein (CRP) The primary marker of an acute infection or inflamma- Target value <1 mg/L.
tion. In the event of a bacterial infection, the CRP value In severe cases CRP may reach
increases significantly (roughly speaking, a value above 300–500.
50 is considered to be caused by a bacterial infection).
High-sensitivity C-reactive Marker of silent inflammation Target level <0.55 for men,
protein (hs-CRP) <1.00 for women
Interleukin 6 (IL6) An elevated value may predict a subsequent increase Target <5.9 ng/L
in CRP
Homocysteine Related to oxidative stress Target <10 µmol/L, ideally 5–6
Interleukin 8 (IL8) Increases as a result of a high level of homocysteine, Target <62 ng/L
may predict a subsequent increase in CRP
Tumor necrosis factor alpha A key marker in systemic inflammation Target <8.1 ng/L
(TNF-α)
Calcitriol Often elevated in the event of chronic infection When suspecting chronic infection,
(1,25(OH)2D) or inflammatory conditions in which macrophages the target level is <150 pmol/L
produce high levels of calcitriol and the level of
vitamin D receptors (VDR) is decreased
FRAS test (Free Radical Assesses the body’s level of oxidative stress (d-ROMs) Target values: d-ROMs 250–300;
Analytical System) and the antioxidant potential of blood plasma (BAP) BAP 2200–4000
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Provitamin D enters
circulation via skin Bones
Active form of
vitamin D
Liver Intestine
Absorption from the Kidney
intestine into circulation
Food sources of
vitamin D (10–20 %)
V ITAM IN D
Vitamin D has a crucial role in balancing the immune sys- Vitamin D also regulates the genes that determine whether
tem. Vitamin D acts as a kind of a power supply for T cells. a T lymphocyte becomes a killer, helper or memory cell in
When an immune reaction takes place, a phagocytic cell the immune system.
traps the pathogen and presents it to a T cell which pro-
duces a VDR receptor. The receptor binds vitamin D from Vitamin D deficiency is a predisposing factor for autoim-
the blood, waking up the T cell. As a result, helper T cells mune diseases such as MS, diabetes, psoriasis, intestinal
give away the intruder and killer T cells attempt to eliminate inflammation and arthritis. Additionally, those suffering from
the uninvited guest. Without vitamin D the T cells will never vitamin D deficiency more often contract influenza and the
wake up to finish the job.60 common cold.61
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Turkey tail and the extracts thereof (PSK, PSP),70 The effects of medicinal fungi on the immune system
hen-of-the-woods and the extracts thereof (Maitake may be more widely explained in the future by their
D-fraction)71 72 and shiitake and the extracts thereof effect on the intestinal microbiome.74
(AHCC, LEM, KS-2, lentinan)73 appear to be beneficial
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IM MUNI T Y J UI CE F LU K I L L E R S O U P
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IRR ES I STI B LE B ER RY CR EA M
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Best wishes,
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O LLI S OV I J Ä RV I , M.D.
Dr Olli Sovijärvi is a pioneer of holistic medicine in Finland. At the beginning of his career Dr Sovijärvi
worked as a medical duty officer at the Finnish Red Cross Blood Service. In 2006 he graduated from
the University of Helsinki with a Licentiate degree in Medicine and became self-employed in 2008. In
2010–2011 Dr Sovijärvi completed an Integral Theory degree at the John F. Kennedy University, focusing
on psychology and philosophy.
For the first five years of his career as a physician Dr Sovijärvi was employed by Finland’s first medical
recruitment agency. The job description involved scheduled patient care as well as emergency care and
being on call. He has worked at nearly 50 different clinics around Finland.
His numerous media appearances, social media articles and Finland’s first health podcast have expanded
the general public’s awareness of what health care can be. Dr Sovijärvi has also acted as consultant to
various companies and service providers operating in the fields of wellness and health technology.
Since 2013 Dr Sovijärvi has been practicing medicine at a private clinic that specializes in nutrition and
holistic health care. The clinic employs physicians and nurses practicing functional medicine. The clinic
features the only trace element laboratory in Finland. He also runs training sessions and presentations on
the topics of biohacking, performance optimization, nutritional issues and maintaining the intestinal bal-
ance. In his free time he enjoys athletics, playing with his child, music and good humor.
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Teemu Arina is a world-renowned expert on digital work, learning and leadership, a serial technology
entrepreneur and a speaker specializing in futuristic themes. He is also a front man of the Quantified Self
movement in Finland as well as the founder and curator of the Biohacker Summit event.
Mr Arina is considered one of the key thinkers of digitalization worldwide. His special areas of interest
include key issues in online learning, social media, digital work, digital health and holistic well-being.
He is a 2015 Leonardo Award Laureate with the theme “Humanity in Digitization”. The science award is
sponsored by the European Parliament, the German Ministry of Education and Research and UNESCO. It
is awarded annually to individuals who have produced pioneering work in the field of learning.
As a professional speaker, Mr Arina gives an average of 100 lectures per year in countries such as the
United States, the United Kingdom, Japan, the Netherlands, Italy, Spain, Russia and Germany. In Finland
he was a finalist for the Speaker of the Year award. Mr Arina has consulted senior management on initia-
tives involving digitalization, coached startup businesses and acted as the chairperson for steering com-
mittees of online learning development projects funded by the European Union.
He started his first technology company at the age of 16 and worked as a high school teacher at 17.
Through teaching he developed an interest in online learning, intelligent human behavior and
overcoming various boundaries. In his free time Mr Arina enjoys tinkering with technology, cycling,
photography, spending time outdoors and cooking.
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Jaakko Halmetoja is a nutrition expert, non-fiction writer and active lecturer. He is passionate about
maintaining a state of exceptional health through nutrition and lifestyle in a way that is fun and enjoyable.
Known as a pioneer of the superfood phenomenon, popularizer of the chaga mushroom and other
medicinal fungi and “chocolate alchemist”, Mr Halmetoja has introduced the general public of Finland
to the health benefits and unique uses of various foods and medicinal plants through TV and radio
appearances and more than 600 public lectures.
Mr Halmetoja has been running a business since he was 20 years old. He trained as a paratroop jaeger in
the Finnish Defence Forces and has previously won the Finnish championship in submission wrestling. As
an entrepreneur he manages cafés that specialize in producing super-healthy delicacies. More recently Mr
Halmetoja has acted as an advisor to several growth companies operating in the health sector, in Finland
as well as internationally. Jaakko spends his free time in the garden or outdoors getting exercise – with a
smile on his face.
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