05-Nov-2019/107628/201811020593/Form 2(Title Page) HIN 687602 th FORM2 THE PATENTS ACT 1970 (39 of 1970) & The Patents Rules, 2003 COMPLETE SPECIFICATION (See section 10 and rule 13) 1. TITLE OF THE INVENTION PROCESS FOR PREPARING DYDROGESTERONE 2. APPLICANTS NAME : Mankind Pharma Ltd. NATIONALITY : Indian ADDRESS : 208, OKHLA INDUSTRIAL ESTATE, PHASE-III, NEW DELHI-110020 3, PREAMBLE TO THE DESCRIPTION Complete The following specification particularly describes the invention and the manner in which it is to be performed.FIELD € THE INVENTION ‘The present invention relates to a method of preparing 9B,10s-5,7-diene steroids such as dydrogesterone by irradialing the corresponding 9u,10B-steroids with filtered ultraviolet light using single- mercury vapour lamp HtuminatingJamp, while limiting the formation of undesirable by products, wt ‘id mereury lamp isa low-pressure mereury_va ischarge lamp having a discharge glass tube filter having an absorption edge located below 260 nm with atleast 80% transmission be 00nm, and another discharge glass tube filter bein luminescent layer having an absorption edge located below 31) nm. inside with a BACKGROUND OF THE INVENTION 9f,100-5,7-diene steroids generally are intermediates in the synthesis of pharmacologically interesting compounds which ean perform a useful function in the human body. The hormone analogue 6-dehydro-9,100-piogesterone (98,100- pregna-4,6-diene-3,20-dione) or dydrogesterone is an orally active progestative hormone and is generally used to correct deficiencies of progesterone in the body. 9B, 1004.6 (dydrogesterone), dydrogesterone, m.p. 169-170°C, al room temperature a white fen-3,20-dione, also. known —as_—_dehydro-progesterone crystalline powder or light yellow , insoluble in water, soluble in ethanol, acetone and the like, Photochemical isomerization of steroids are important in the industrial synthesis of commercial products, For example, the photoisomerization of 7-dehydrocholesterol (7-DHC) yields previtamin Ds, which can be converted by conventional methods, such as by thermal rearrangement, to vitamin Dy, Vitamin Ds has many important uses. For example, vitamin Ds can be used as an additive to milk and in animal feeds to prevent rickets.‘A similar type of photoisomerization is carried out to produce 10,25- dehydroxyvitamin Ds. This is the actual active form of vitamin Ds that is responsible for regulating calcium metabolism. The syuthesis of dydrogesterone, developed by Philips-Duphar, also includes # photoisomerization of a steroidal intermediate, Recueil des Travaux Chimiques des Pays-Bas (1960), 79: 771-783 reported an optically sterol 2 as a starting material, which by Oppenauer oxidation, isomerization, catalytic hydrogenation, ozonation, addition, sodium dichromate oxidative dehydrogenation reaction provides dehydro-progestecone, The above said disclosure suffers from serious drawbacks such as very long synthetic route, use of large number of environmentally harmful substances, and each step is not high yielding, final yield is very low, hence the above said process can only be used as a study to explore, and there is no possible industrial production, ‘The preparation of dydrogesterone from pregnenolone is described by Rappoldt et al. in Recueil trav. chim. 1961, 80, 43, and 1971, 90, 27. Impoxtant intermediates in the synthesis of dydrogesterone are lumisterol2, 3-(ethylenedioxy)-98,10a-pregna- 5,7-diene-20-one and 3,20-bis(ethylenedioxy)-Obeta, 1Oalpha-pregna-S, ‘These intermediates can be prepared by inradiating the corresponding 94,108 isomers, namely ergosterol, 9a,10B-3-(ethylenedioxy)-pregna-5,7-diene-20-one and — 9a,10B-3,20-bis(ethylenedioxy)-pregna-5,7-diene, respectively, with ultraviolet light. This irradiation is preferably carried out with filtered ultraviolet light. A medium-pressure or high-pressure meroury lamp has so far been used for this purpose, In the above-mentioned publications, the desired 9,10a-5,7-diene steroids were formed during this photochemical isomerisation in yields of only: calculated on converted 9a,10B-isomer, US 4,601,855 discloses that the photochemical conversion of 94,10B-5,7-diene steroids or suitable seco-steroids (seco-steroids) into the corresponding 9,10a-5,7- diene steroids could be performed with a considerably higher yield if an antimony amp was used as the light source instead of a conventional medium-pressuremeroury lamp. It further discloses that the inadiation can be carried out by using two different lamps in suecession, first a conventional light source producing UV- radiation, e.g. a medium-pressure mereury lamp, and then an antimony lamp, to produce comparable results as with a one-lamp irradiation, In this manner 9f,10c- 3,20-bis(ethylenedioxy)-pregna-s, -diene could be prepared by conversion of the corresponding 94,10f-compound in a yield of approx. 30%, calculated on starting material, or of approx. 75%, calculated on converted material, in a reaction time of 6 to 7 hours as compared to the yield obtained by using high pressure mercury lamp. The above said process has several drawbacks. First, the production capacity, i.e. the conversion per time unit (per hour), does not fully come up to the producer's expectations. The intrinsic capacity of irradiation processes is always relatively small due to the required dilution of the solution to be inadisted. Further, an antimony lamp is expensive fo use making process un-economical. US 5,304,291 discloses irradiating the 9a,10B-3,7-diene-steroid or seco-steroid with filtered ultraviolet light from an indium lamp. The above indium Jamp can be used according to the method of the invention by passing the steroid-solution through a reservoir surrounding the lamp or by immersing the lamp in the solution to be irradiated. It further teaches that in the former method of irradiating a number of indium lamps can be used to improve the produetion capacity, around which lamps the solution to be irradiated can be passed in a continuous flow (annular flow reactor). In the latter method immersion lamps can be used, which are immersed in the solution accommodated in a reaction vessel (immersion photochemical reactor). To obtain an optimum results, the irradiation with the indium lamp is preceded by an irradiation procedure with a conventional light source producing UV-radiation, generally a normal medium-pressure or high-pressure mercury lamp. Although there are several processes known in the prior published references, however they suffer from serious drawback of using multiple lamps to obtain the desired compound in high yields,Therefore, an improved conversion per time unit is very important for effecting a commercially and technically attractive process. Further, there is a requirement for development of process that utilizes single iHumninating-Jampmereury vapour lamp equipped with two glass tube filters capable of transmitting light, at.a wavelength above 260nm, and above 310nm_ respectively, in order to avoid excess cost of production. ‘The present invention is focussed to the photoconversion of steroids on solid catalytic surfaces and more particularly to controlling the stereochemistry of the photoconversion reaction by irradiation with filtered ultraviolet light. OBJECT OF THE INVENTION It is an object of the invention to provide an improved methed of conducting the photoconversion of steroids_by irradiating with. single_mereury vapour lamp capable of transmitting fight at a wavelength 1601 and 310nm, respectively. + Another object of the invention is to provide a method of limiting the amount of undesirable byproducts formed when photoconversions are conducted, A further object of the invention is to provide a method of conducting the photoconversion of steroids in a simpler manner with less waste and fewer purification steps. It is the objective of the invention to considerably improve the capacity of producing 9B, 10a, $,7-diene steroids by irradiating the corresponding 9u,10B-5,7- diene steroids or seco-steroids, and, at the same time, to reduce the operating costs. SUMMARY OF THE INVENTIONThe pre ent inyention is focussed towards the developmeat of a method of conducting the photoconversion of steroids into desired products, while limiting the formation of undesirable by products is provided. Accordingly, the present invention provides process for preparation of 6-dehydro- 9B, 1Oa-progesterone (dydrogesterone) comprising of: a) irradiating 9a, 10, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 98, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein sé Cr is. 1 ig waving a, discharge glass tube. filter having an absorption edge loc wit D isi ri g filter being coated on inside with a luminescent layer having an absorption edge nm; and b) converting 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro- 9B, 10a-progesterone. ‘The present invention further relates to preparation of substantially pure 6-dehydro- 9P.100-progesterone (dydrogesterone) comprising of less than about 1.0% of total impurities, wherein said process comprising of: a) irradiating 90, 108, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein. said mercury. lamp. is a low-pressure mercury. vapour. discharge. lamp. having a discharge glass tube filter having an absorption edge located below 260 nm_with atleast 80% transmission below 300nm. and another discharge glass tube filter being coated on inside with a luminescent layer haying an absorption edge located below 310.nm; b) converting 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro- 9B, 10e-progesterone; and ©) purifying 6-dehydro-9B,10a-progesterone to get substantislly pure 6-dehydro- 9B, 10a-progesterone with purity of 99.0% and above,DB ‘ALL DES: RIPTION The present invention will now be explained in details. While the invention is susceptible to various modifications and alternative forms, sgecific embodiment thereof will be described in detail below, It should be understood, however that it is not intended to limit the invention to the particular forms disclosed, but on the contrary, the invention is to cover all modifications, equivalents, and alternative falling within the scope of the invention as defined by the appended claims. ‘The present invention provides a process wherein steroidal compounds ean be converted to desired products with increased stereochemical control compared to conventional processes, This is accomplished by restricting the reaction environment of the molecule being reacted to prevent the formation of undesirable side products, A low-pressure mercury vapour discharge lamp for radiation purposes having a discharge tube made of glass with selective transmission, the tube being coated on the inside with a luminescent layer. The discharge tube is made of glass having an absorption edge located below 260 and 280 nm and the tube has at 300 nm a transmission of at least 80%. ‘The present invention relates to a low-pressure mercury vapour discharge lamp for radiation purposes having a discharge tube made of glass with selective transmission, the tube being coated on the inside with a luminescent layer. Accordingly, in one embodiment, the present invention provides process for preparation of 6-dehydro-9B, 10a-progesterone (dydrogesterone) comprising of: a) irradiating 9a, 10, 3,20-bis (cthylenedioxy)pregna- .7-diene in presence of single mercury lamp to get 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein said mercury lamp is_a_low-pressure_mereury_vapour. discharge lamphaving, iseharge. glass tube. filter having. an absorption edge located below 260 ith atleast 80% transmission below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer havi i located below 310. nm; and b) converting 9B, 10, 3,20-bis (ethylenedioxy)pregna-5, 9B,10a-progesterone, am. In other embodiment, the present invention provides low-pressure mercury vapour discharge lamp for radiation purposes having a discharge tube made of glass with selective transmission, the tube being coated on the inside with a luminescent layer and is used for selective transmission of 9a, 108, 3,20-bis (ethylenedioxy)pregna- 5,7-diene in step (a). In another embodiment, the irradiation reaction is performed in a solvent selected from esters such as ethyl acetate, propyl acetate, isopropyl aceiate, butyl acetate, t- butyl acetate and the like. In farther embodiment, 98, 100, 3,20-bis (ethylenedioxy)pregns-5,7-diene obtained after imadiating 90, 10, 3,20-bis (ethylenedioxy)pregna-5,7-diene using single mercury lamp, can be crystallized using solvent selected from the group comprising of methyl ethyl ketone, methyl t-butyl ketone, methy! iso-butyl ketone, acetone ethyl acetate, isopropyl acetate, butyl acetate, n-propyl acetate, pentyl acetate, isopentyl acetate, t-butyl acetate and mixture thereof, In further embodiment, 98, 10a, 3, 20-bis (ethylenedioxy;pregna-5,7-diene is converted to 6-dehydro-98,10a-progesterone (dydrogesterone) in presence of Cr- Cs alcoholic hydrochloric acid, ethereal hydrochloric acid wherein said solvent is selected from the group comprising of diethyl HCI, ethanolic KCI, methanolic HCI, butanolic HCI, isobutanolic HCI, iso-butanolie HCI, n-pentanolic HCL, iso- propanolic HCI, n-propanolic HCl and mixture thereof.In second embodiment, the present invention provides a process for preparation of substantially pure 6-dehydro-9P, 10a-progesterone (dydrogesterone) comprising of Jess than about 1.0% of total impurities, wherein said process comprising of: a) irradiating 94, 10B, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 9B, 10a, 3,20-bis (ethylene dioxy)pregna-5,7-diene, sherein said_mercury lamp is a low-pressure mercury vapour discharge. lum ing an absorption edge located below 260 0% transmis mm, and snother discharge glass tube filter being coated on inside with a luminescent layer having an absorption edge located below 3 b) converting 9, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro~ 9,100-progesterone; and ©) purifying 6-dehydro-9,10a-progesterone to get substantially pure 6-dehydro- ‘9, 10a-progesterone with purity of 99.0% and above, In another embodiment, 6-dehydro-9B, 1 0a-progesterone is ptrified in step (c) by isolating from a solution comprising ester selected ftom eihyl acetate, propyl acetate, isopropyl acetate, butyl acetate, t-butyl acetate and the like. In third embodiment, the present invention provides a process for preparation of 6- dehydro-98, 10a-progesterone comprising the steps of: a) preparing 7a-bromo-3, 20-bis (ethylenedioxy)pregna ketal by treating pregna- 3,20-dione-dimethylene ketal with dibromodimethyl-hydrantein hydantoin, b) reacting 7a-bromo-3, 20-bis (ethylenedioxy) pregna ketal with teuabutyl ammonium halide in ethereal solvent to get 9a, 108, 3,20-bis, (ethylenedioxy)pregna-5,7-diene; ©) imradiating 9a, 10B, 3.20-bis (ethylenedioxy)pregna-S,7-diene in presence of single low pressure mercury vapour discharge lamp to get 98, 10a, 3,20-bis (ethylene dioxy)pregna-5,7-diene, wherein said single mereury vapour discharge all light below 260 nm with atleast 80% transmission below 300nm for 1-2 hourssucceeded by absorbs all the ht bel 4) converting 9B, 100, 3,20-bis (ethylenedioxy)pregna-5,7-ciene to 6-dehydro- 9B, 10a-progesterone in presence of acid; and ¢) isolating substantially pure 6-dehydro-9B, 10«-progesterone with purity of 99.0% and above by way of recrystallizing from solution comprising ester solvent, In another embodiment, the tetrabutyl ammonium halide is selected from tetrabuty! ammonium chloride, tetrabutyl ammonium bromide and tetrabutyl ammonium fluoride, In further embodiment, the ethereal solvent used in step (b) is selected from diethyl ether, tetrahydrofuran, methyl tetrahydrofuran, dioxane and the like. In further embodiment, the 6-dehydro-98, 10a-progesterone i.e, dydrogesterone prepared as per the process of the present invention is characterized by putity of 99.5% and above, In preferred embodiment, the 6-dehydro-9B, 10u-progesterone ie. dydrogesterone prepared as per the process of the present invention is characterized by purity of 99.9% and above, In another embodiment, the present invention provides a composition comprising dydrogesterone and at least one pharmaceutical acceptable excipients, wherein said dydrogesterone is prepared as per the process of the present invention, Now, the present invention will be explained in details through experimentations. However, the examples are provided as one of the possible way to practice the invention and should not be considered as limitation of the scope of the invention. 10Preparation of 74-bromo-3, 20-bis (ethylenediosy)pregna ketal Charged 200ml of pet ether and 50g of pregna-3,20-dione-dimethylene ketal followed by further addition of 100m of pet ether. To the above solution was added dibromodimethyl hydantoinbydrantoin and the reaction mixture was heated at reflux for 1.5 hrs. After cooling at 20°C, dimethyl hydantoinbydrantoin was filtered off, Distilled the pet ether and added ethyl acetate to the reaction mass so obiained, Re-crystallized the reaction mass with ethyl acetate to get 32g of 7a-bromo-3, 20- bis (ethylenedioxy)pregna ketal, ‘AMPLE 2, Preparation of 9a, 10f, 3,20-his (ethylenedioxy)pregna-5,7-diene To 300ml of methyl tetrahydrofuran was added 30g of 7eu-bromo-3, 20-bis (ethylenedioxy) pregna ketal followed by addition of 60g of tetrabutyl ammonium fluoride in 300 mi methyl tetrahydrofuran. Stimed the reaction mass at 30-35°C for 2 hrs. Cooled the reaction mass at 5-10°C and added ethyl acetate (100ml), Washed the organic layer with 2x500m! of water. Evaportated the solvents to get crude ‘compound, Re-crystallized the crude compound with ethanol to get pure 9a, 10, 3,20-bis (ethylenedioxy)pregna-5,7-diene (20g). EXAMPLE 3 Preparation of 9B, 101, 3,20-bis (ethylenedioxy)pregna-,7-diene 20.0 g of 9a,10f-3,20-bis(ethylenedioxy)-5,7-pregnadiene were dissolved in 2 litres of ethyl acetate and the resulting solution was then irradiated with a low- pressure mereury vapour discharge lamp while cooling and in a nitrogen atmosphere, As glass tubes were used: a glass tube filter which absorbs all the light below 260 nm for 1-2 hours succeeded by a glass tube filter which absorbs all the light below 310 nm for 3-4 hours. Finally a solution was obtained, the dissolved substance of which according to HPLC-analysis is composed as follows: 50-54% a(10.0 g) of starting material, and 30-34% (6.0 g) of 9, 10a-3,20-bis(ethylenedioxy)- 5,7-pregnadiene. The reaction solution was worked up by evaporation, taking up the residue in 40 ml of ethyl acetate, and cooling to -10°C. A crystallisate was obtained which was filtered to get 9.0 g of starting material, Evaporated the mother liquor and added methyl isobutyl ketone and degassed the solution so obtained. The second crystallisate so obtained was then filtered to get Sg of desired compound, 98, 100, 3,20-bis (ethylenedioxy)pregna-5,7-diene. EXAMPLE 4 Preparation of 6-dehydro-9f,10a-progesterone (dydrogesterone) ‘To 5g of 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene was added ethanolic HCl in -40°C and stirred the reaction mass for 2-3 hrs. Charged dichloromethane to above reaction mass so obtained and stirred at room temperature, Washed the organic layer with 2100 ml of water and distilled the organie layer to get a residue, Purified the residue so obtained with ethyl acetate and recrystallized with ethyl acetate again to get pure compound. Yee Dated this, 1 day of June, 2018 Dr. Anil wae For Mankind Pharma Ltd, 2FLELD OF TRE INVENTION “The present invention relates to a method of preparing 98,100-5,7-diene steroids such as dydrogesterone by irradiating the corresponding 9u,10B-steroids with filtered ultraviolet light using single mercury vapour lamp, white limiting the formation of undesirable by products, wherein said mercury lamp is a low-pressure mercury vapour discharge lamp having a discharge glass tube filter having an absorption edge located below 260 nm with atleast 80% transmission below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer having an absorption edge located below 310 nm. BACKGROUND OF THE INVENTION 9B,100-5,7-diene steroids generally are intermediates in the synthesis of pharmacologically interesting compounds which can perform a useful function in the human body. ‘The hormone analogue 6-dehydro-9f, | Oa-progesterone (9B,L0a- pregna-4,6-diene-3,20-dione) or dydrogesterone is an orally active progestative hormone and is generally used to correct deficiencies of progesterone in the body. 9B, 100-4,6-dien-3,20-dione, also known —as_—_dehydro-progesterone (dydrogesterone), dydrogesterone, m.p. 169-170°C, at room temperature a white crystalline powder or light yellow , insoluble in water, soluble in ethanol, acetone and the like. Photochemical isomerization of steroids are important in the industrial synthesis of commercial products, For example, the photoisomerization of 7-dehydrocholesterol (7-DHC) yields previtamin Ds, which can be converted by conventional methods, such as by thermal rearrangement, to vitamin Dy, Vitamin D3 has many important uses, For example, vitamin D3 can be used as an additive to milk and in animal feeds to prevent rickets,A. similar type of photoisomerization is cartied out to produce 10,25- dehydroxyvitamin D3, This is the actual active form of vitamin Ds that is responsible for regulating calciun metabolism. ‘The synthesis of dydrogesterone, developed by Philips-Duphar, also includes a photoisomerization of a steroidal intermediate. Recueil des Travaux Chimiques des Pays-Bas (1960), 79: 771-783 reported an optically sterol 2 as a starting material, which by Oppenauer oxidation, isomerization, catalytic hydrogenation, ozonation, addition, sodium dichromate oxidative dehydrogenation reaction provides dehydro-progesterone, The above said disclosure suffers from serious drawbacks such as very long synthetic route, use of large number of environmentally harmful substances, and each step is not high yielding, final yield is very low, hence the above said process can only be used as a study to explore, and there is no possible industrial production, ‘The preparation of dydrogesterone fiom pregnenolone is described by Rappoldt et al. in Recveil tray. chim. 1961, 80, 43, and 1971, 90, 27. Important intermediates in the synthesis of dydrogesterone are lumisterola, 3-(ethylenedioxy)-98,10u-pregna- 5,J-diene-20-one and _3,20-bis(ethylenedioxy)-9beta, 1Oalpha-pregna-5,7-diene. ‘These intermediates can be prepared by irradiating the corresponding 94,108 isomers, namely ergosterol, 9u,10B-3-(ethylenedioxy)-pregna-5,7-diene-20-one and 94,10B-3,20-bis(ethylenedioxy)-pregna-5,7-diene, respectively, with ultraviolet light. This irradiation is preferably carried out with filtered ultraviolet light. A medium-pressure or high-pressure mercury lamp has so far been used for this purpose. In the above-mentioned publications, the desired 9,10a-5,7-diene steroids were formed during this photochemical isomerisation in yields of only 20% calculated on converted 9a,10f-isomer. US 4,601,855 discloses that the photochemical conversion of 90,10B-5,7-diene steroids or suitable seco-steroids (seco-steroids) into the corresponding 9f},1 04-5,7- diene steroids could be performed with a considerably higher yield if an antimony Jamp was used as the light source instead of a conventional medium-pressuremercury lamp. It further discloses that the irradiation can be carried out by using two different lamps in suecession, first a conventional light souree producing UV- radiation, e.g, a medium-pressure mercury lamp, and then an antimony Iamp, to produce comparable results as with a one-lamp irradiation, In this manner 98,10a- 3,20-bis(ethylenedioxy)-pregna-5,7-diene could be prepared by conversion of the corresponding 90,10f-compound in a yield of approx. 30%, calculated on starting material, or of approx. 75%, calculated on converted material, in a reaction time of 6 to T hours as compared to the yield obtained by using high pressure mercury lamp. The above said process has several drawbacks. First, the production capacity, i.e. the conversion per time unit (per hour), does not fully come up to the producer's expectations. The intrinsic capacity of irradiation processes is always relatively small due to the required dilution of the solution to be inadiated. Further, an antimony lamp is expensive to use making process un-economical. US 5,304,291 discloses irradiating the 90,10-5, liene-steroid or seco-steroid with filtered ultraviolet ight from an indium lamp. The above indium lamp can be used according to the method of the invention by passing the steroid-solution through a reservoir surrounding the lamp or by immersing the lamp in the solution to be irradiated, It further teaches that in the former method of irradiating a number of indium lamps can be used to improve the production capacity, around which lamps the solution to be irradiated can be passed in a continuous flow (annular flow reactor), In the latter method immersion lamps can be used, which are immersed in the solution accommodated in a reaction vessel (immersion photochemical reactor). To obtain an optimum results, the irradiation with the indium lamp is preceded by an irradiation procedure with a conventional light source producing UV-tadiation, generally a normal medium-pressure or high-pressure mercury lamp. Although there are several processes known in the prior published references, however they suffer from serious drawback of using multiple lamps to obtain the desired compound in high yields.‘Therefore, an improved conversion per time anit is very important for effecting a commercially and technically attractive process. Further, there is a requirement for development of process that utilizes single mercury vapour lamp equipped with two glass tube filters capable of transmitting light at a wavelength above 260nm, and above 310mm respectively, in order to avoid excess cost of production. ‘The present invention is focussed to the photoconversion of steroids on solid catalytic surfaces and more particularly to controlling the stereochemistry of the photoconversion reaction by irradiation with filtered ultraviolet light. OBJECT OF THE INVENTION It is an object of the invention to provide an improved methed of conducting the photoconversion of steroids by irradiating with single mercury vapour lamp equipped with two glass tube filters capable of transmitting light at a wavelength above 260nm and 310nm, respectively. Another object of the invention is to provide a method of limiting the amount of undesirable byproducts formed when photoconversions are conducted. A further object of the invention is to provide a method of conducting the photoconversion of steroids in a simpler manner with less waste and fewer purification steps. It is the objective of the invention to considerably improve the capacity of producing 98, 10a, 5,7-diene steroids by inradiating the corresponding 9u,10B-5,7- diene steroids or seco-steroids, and, at the same time, to reduce the operating costs. UMMARY OF THE INVENTE‘The present invention is focussed towards the development of a method of conducting the photoconversion of steroids into desired products, while limiting the formation of undesirable by products is provided. Accordingly, the present invention provides process for preparation of 6-dehydro- 9B, 1Oa-progesterone (dydrogesterone) comprising of: a) irradiating 9a, 10, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein said mercury lamp is a low-pressure mercury vapour discharge lamp having a discharge glass tube filter having an absorption edge located below 260 nm with atleast 80% transmission below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer having an absorption edge located below 310 nm; and b) converting 9B, 100, 3,20-bis (ethylenedioxy)pregna-5,7 9B, 10a-progesterone. jene to 6-dehydro- ‘The present invention farther relates to preparation of substantially pure 6-dehydro- 98,1 0a-progesterone (dydrogesterone) comprising of less than about 1.0% of total impurities, wherein said process comprising of: a) irradiating 9a, 10B, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 98, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein said mercury lamp is a low-pressure mercury vapour discharge lamp haying a discharge glass tube filter having an absorption edge located below 260 nm with atleast 80% transmission below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer having an absorption edge located below 310 nm; b) converting 9, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-Jiene to 6-dchydro- 9B, 10a-progesterone; and ©) purifying 6-dehydro-9P,10a-progesterone to get substantially pure G-dehydro- 9f,10«-progesterone with purity of 99.0% and above.DETAILED DESCRU The present invention will now be explained in details, While the invention is susceptible to various modifications and alternative forms, specific embodiment thereof will be deseribed in detail below. It should be understood, however that it is not intended to limit the invention to the particular forms disclosed, but on the contrary, the invention is to cover all modifications, equivalents, and alternative falling within the scope of the invention as defined by the appended claims. The present invention provides a process wherein steroidal compounds can be converted to desired products with increased stereochemical control compared to conventional processes. This is accomplished by restricting the reaction environment of the molecule being reacted to prevent the formation of undesirable side products. A low-pressure mercury vapour discharge lamp for radiation purposes having a discharge tube made of glass with selective transmi jon, the tube being coated on the inside with a luminescent layer. The discharge tube is made of glass having an absorption edge located below 260 and 280 nm and the tube has at 300 nm a transmission of at least 80%, ‘The present invention relates to a low-pressure mercury vapour discharge lamp for radiation purposes having a discharge tube made of glass with selective transmission, the tube being coated on the inside with a luminescent layer. Accordingly, in one embodiment, the present invention provides process for preparation of 6-dehydro-98, 10a-progesterone (dydrogesterone) comprising of: a) irradiating 9c, 108, 3,20-bis (ethylenedioxy)pregna-5, single mereury lamp to get 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein said mercury lamp is a low-pressure mercury vapour discharge lamp -diene in presence of having a discharge glass tube filter having an absorption edge located below 260nm with atleast 80% transmission below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer having an absorption edge Jocated below 310 nm; and b) converting 9B, 10a, 3,20-bis (ethylenedioxy)pregna-S,7-diene to 6-dehydro- 98,100-progesterone. In other embodiment, the present invention provides low-pressure meroury vapour discharge lamp for radiation purposes having a discharge tube made of glass with selective transmission, the tabe being coated on the inside with a luminescent layer and is used for selective transmission of 90, 10B, 3,20-bis (ethylenedioxy)pregna- 5,7-diene in step (a) In another embodiment, the irradiation reaction is performed in a solvent selected from esters such as ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, t= butyl acetate and the like, In further embodiment, 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene obtained after irradiating 90, 108, 3,20-bis (ethylenedioxy)pregna-5,7-diene using single ‘mercury lamp, can be crystallized using solvent selected from the group comprising ‘of methyl ethyl ketone, methyl t-butyl ketone, methyl iso-buty! ketone, acetone ethyl acetate, isopropyl acetate, butyl acetate, n-propyl acetate, pentyl acetate, isopentyl acetate, t-butyl acetate and mixture thereof. In further embodiment, 98, 10a, 3, 20-bis (ethylenedioxy)pregna-S,7-diene is converted to 6-dehycro-98,10a-progesterone (dydrogesterone) in presence of Ci- Cs alcoholic hydrochloric acid, ethereal hydrochloric acid wherein said solvent is selected from the group comprising of diethyl HCI, ethanolic HCI, methanolic HCI, butanolic HCI, isobutanolic HCl, iso-butanolic HCI, n-pentanolie HCl, iso- propanolic HCI, n-propanolic HCI and mixture thereof.In second embodiment, the present invention provides a process for preparation of substantially pure G-dchydro-98, 10c-progesterone (dydrogesterone) comprising of less than about 1,0% of total impurities, wherein said process comprising of: a) isradiating 94, 10f, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 9B, 100, 3,20-bis (ethylene dioxy)pregna-5,7-diene, wherein said mereury lamp is a low-pressure mercury vapour discharge lamp having a discharge glass tube filter having an absorption edge located below 260 nm with atleast 80% transmis on below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer having an absorption edge located below 310 nm; b) converting 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro- ‘9B, 10a-progesterone; and ©) purifying 6-dehydro-98,10a-progesterone to get substantially pure 6-dehycro- 9B, 10a-progesterone with purity of 99.0% and above. In another embodiment, 6-dehydro-98, 10u-progesterone is purified in step (¢) by isolating from a solution comprising ester selected from ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, t-butyl acetate and the like, In third embodiment, the present invention provides a process for preparation of 6- dehydro-98, 100-progesterone comprising the steps of: a) preparing Ja-bromo-3, 20-bis (ethylenedioxy)pregna ketal by treating pregna- 3,20-dione-dimethylene ketal with dibromodimethy! hydantoin, b) reacting 7a-bromo-3, 20-bis (ethylenedioxy) pregna ketal with tetrabutyl ammonium halide in ethereal solvent to get 94, 108, 3,20-bis (cthylenedioxy)pregna-5,7-diene; ©) inadiating 9a, 108, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single low pressure mercury vapour discharge lamp to get 9, 10a, 3,20-bis (ethylene dioxy)pregna-5,7-diene, wherein said single meroury vapour discharge lamp is equipped with two discharge glass tube filters wherein first filter absorbs all light below 260 nm with atleast 80% transmission below 300nm for 1-2 hourssucceeded by second filter being coated on inside with a luminescent layer which absorbs all the light below 310 nm for 3-4 hours; 4) converting 9f, 10a, 3,20-bis (ethylenedioxy)pregna ‘T-diene 10 6-debydro- 9B, 10a-progesterone in presence of acids and ©) isolating substantially pure 6-dehydro-9B, 0«-progesterone with purity of 99.0% and above by way of reerystallizing from solution comprising ester solvent. In another embodiment, the tetrabuty! ammonium halide is selected from tetrabuty} ammonium chloride, tetrabutyl ammonium bromide and terrabuty! ammonium fluoride, In further embodiment, the ethereal solvent used in step (b) is selected from diethyl ether, (etrahydrofuran, methyl tetrahydrofuran, dioxane and the like. In further embodiment, the 6-dehydro-9P, 10a-progesterone i.e. dydrogesterone prepared as per the process of the present invention is characterized by purity of 99.3% and above. In preferred embodiment, the 6-dehydro-98, 10a-progesterone i.e. dydrogesterone prepared as per the process of the present invention is characterized by purity of 99.9% and above. In another embodiment, the present invention provides a composition comprising dydrogesterone and at least one pharmaceutical acceptable excipients, wherein said dydrogesterone is prepared as per the process of the present invention, ‘Now, the present invention will be explained in details through experimentations. However, the examples are provided as one of the possible way to practice the invention and should not be considered as limitation of the scope of the invention. EXAMPLES 10EXAMPLE 1 Preparation of 7a-bromo-3, 20-bis (ethylenedioxy)pregua ketal Charged 200ml of pet ether and S0g of pregna-3,20-dione-dimethylene ketal followed by further addition of 100ml of pet ether. To the above solution was added dibromodimethyl hydantoin and the reaction mixture was heated at reflux for 1.5 hrs. After cooling at 20°C, dimethyl hydantoin was filtered off. Distilled the pet ether and added ethyl acetate to the reaction mass so obiained. Re-crystallized the reaction mass with ethyl acetate to get 32g of Ta-bromo-3, 20-bis (ethylenedioxy)pregna ketal. EXAMPLE2 Preparation of 94, 10, 3,20-bis (cthylenedioxy)pregna-5,7-iene To 300ml of methyl tetrahydrofuran was added 30g of 7a-bromo-3, 20-bis (cthylenedioxy) pregna ketal followed by addition of 60g of tetrabuty! ammonium fluoride in 300 mil methy! tetrahydrofuran, Stirred the reaction mass ai 30-35°C for hrs. Cooled the reaction mass at 5-10°C and added ethyl acetate (100ml). Washed the organic layer with 200ml of water. Evaporated the solvents to get crude compound. Re-crystallized the crude compound with ethanol to get pure 9a, 108, 3,20-bis (cthylenedioxy)pregna-5,7-diene (20g). EXAMPLE 3 Preparation of 9, 101, 3,20-bis (ethylenedioxy)pregna-5,7-diene 20.0 g of 9a,10B-3,20-bis(ethylenedioxy)-5,7-pregnadiene were dissolved in 2 litres of ethyl acetate and the resulting solution was then irradiated with a low- pressure mereury vapour discharge lamp while cooliig end in a nitrogen atmosphere. As glass tubes were used: a glass tube filter which absorbs all the light below 260 nm for 1-2 hours succeeded by a glass tube filter which absorbs all the light below 310 nm for 3-4 hours. Finally a solution was obtained, the dissolved substance of which according to HPLC-analysis is composed as follows: 50-54% uw(10.6 g) of starting material, and 30-34% (6.0 g) of 9B, 10a-3,20-bis(ethylenedioxy)- 3,T-pregnadiene. ‘The reaction solution was worked up by evaporation, taking up the residue in 40 ml of ethyl acetate, and cooling to -10°C. A crystallisate was obtained which was filtered to get 9.0 g of starting material, Evaporated the mother liquor and added methyl isobutyl ketone and degassed the solution so obiained. The second ccrystallisate so obtained was then filtered to get 5g of desired compound, 9, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, EXAMPLE 4 Preparation of 6-dehydro-9f,10a-progesterone (dydrogesterone) ‘To 5g of 9, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene was added ethanolic HCI in -40°C and stirred the reaction mass for 2-3 lars. Charged dichloromethane to above reaction mass so obtained and stirred at room temperature, Washed the organic layer with 2100 ml of water and distilled the organic layer to get a residue, Purified the residue so obtained with ethyl acetate and recrystallized with ethyl acetate again to get pure compound, Dated this, 1* day of June, 2018 Dr. Anil Kunfar For Mankind Pharma Ltd, 22WECLAIM 1. A process for preparation of 6-dehydro-9, 10a-progesterone, wherein said process comprising of: ) irradiating 9c, 10, 3,20-bis (cthylenedioxy)pregna-5,7-diene in presence of single mereury lamp to get 9B, 10a, 3,20-bis (ethytenedioxy)pregna-5,7-diene, wherein said mereury lamp is a Jow-pressure mercury. vapour discharge lamp having a discharge glass tube filter having an absorption edge. located below 260 nm with atleast, 80% transmission below 30 id another discharge glass tube filler being coated on inside with a absorption edge located below 310. nm; and inescent laver having an. b) converting 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro-98,10a- progesterone. ‘he-proeess-as-claimed-in-claim-t.-wherein-seid-meroury-lamp-is-<-low-pressure-mereury vapour discharge-damp having «-discharge-tube-made-of-glass-with-seleotive-transmission.-th ‘tube-being-eoated-on-the-inside-with-a-lumineseentlayer-and-wherein-the-discharge-tube-is, inde-of glass-having-an-absorption-edge-toeated-below-260-and-280-nm-and-the-tabe-has-t 300-nn-a-trensmiasion- oFatleast 8086. 32. The process as claimed in claim 1, wherein said irradiation reaction of step (a) is performed ina solvent selected from ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, and t- butyl acetate, 43, A process for preparation of substantially—pure—6-dehydro-9B, 10a-progesterone (dydrogesterone) comprising of less than about-1.0% of total impurities, wherein said process comprising of: a) irradiating 9a, 10, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 98, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein said mercury lamp is a low-pressure mercury vapour discharge lamp having a discharge glass tube filter having an absorption edge located below 260_nm_ with atleast 80% transmission below 300nm, and another discharge t ide. absorption edge located below 310 nm; coated on ii scent layer having an 13b) converting 9f, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro-9,100~ progesterone; and ©) purifying 6-dehydro-9B,10a-progesterone to get substantialty~pure~6-dehydro-9P,10a- progesterone with purity of 99.0%- to, 99,.99%wiwand-above. ‘54. The process as claimed in claim 43, wherein said 6-dehydro-9P, 10c-progesterone putified in step (c) is performed by isolating from a solution comprising ester selected from ethyl acetate, propyl acetate, isopropyl acetate, buty! acetate, and t-butyl acetate-and-the tike, ‘56. The process as claimed in claim 34, wherein said proeess-comprising-the-steps-0& 8} preparing-Fa-brome-3;-20-bis-(ethylenediony)pregna-ketal-by-treating-pregne-3,20-dione- dimethylene-ketalvith-dibromedimethythydrantoin; ‘bp reacting 7e-bromo-3,-20-bis-(ethylenedioxypregna-ketal-with-tetrabutyLammoniune-helide inethereal-solvent-to-get-9a;-10B;3,20-bis (ethylene dioxy}pregna-s.7-dienes e}radiating 9a;-10f,3,20-bis (ethylenedioxy)pregna-S,7-diene in- presence of single meroury. Jamp-to-get9f;-104,3,20-bis (ethylene dioxy)pregna-S,7-dienes }-converting-9B;—-W0a;—-3,20-bis-(ethylenedioxy}pregna-5,7-diene—to~G-dehydto-98;10a- progesterone in-presenee-of acids and e}isolating substantially pure-6-dehydro-98,10-progesterone-with patity-0£ 99.0% and-above by-way-of reerystallizing from solution comprising ester solvent irradiation reaction in step (a) is carried out by using single low-pressure mereury vapour discharge lamp equipped with two discharge glass tube filters wherein first filter absorbs all light below 260 nm with atleast 80% (ransmission below 300nm_for 1-2 hours succeeded by second filter being. coated on inside with a luminescent layer which absorbs all the light below 310 nm for 3-4 hours. 67, The process as claimed in claim 36, wherein said tetsabuty!-ammonium-halide-is-seleeted Srom-etrabutylammonium-ebloride; tetrabuty ammonium-bromide-and-tetrabutyl ammonium fluoride-- 98, 100, 3,20-bis (ethylenedioxy)pregna-5,7-diene of step (a) is purified by: (taking the 98, 100, 3,20-bis (ethylenedioxy)pregna-5,7-diene as of Lin ethyl acetate at -10°C to get precipitates: Gi) filtering the precipitates and evaporating mo! 4 ed in step (a) her liquor to get crude compound:(iii) taking the crnde compound in methyl isobutyl ketone fo get pure pre (iy) filtering the preei tates; and tates 10 get pure 9B, 10a, 3.20-bis (ethylenedioxy)pregna-5,7-di &--Phe-proeess-as-clainied~in-claint-6,-wherein-said-substantially-puse-6-dehydro-9B 10a progesterone-is-charaeterized-by-purity-of99.5% and-above: 9--Fhe-process-as-laimed-in-elaim-6,-wherein-seid-ethereal-solvent ic selected-from-diethyt ether: tetrahydrofuran, methyl-tetrahydroferan,-and dioxane: ‘10--Phe processas claimed in -claim-twhereit-said 6-dehydro-9B;100-progesterone is used-for preparing —composition—-comprising—6-dehydro-9810a-progesterone—and—at-—least—one pharmaceutical aceeptable exeipients, You Dated this, 1" day of June, 2018 Dr. Anil Kumér For Mankind Pharma Ltd. 151. A process for preparation of 6-debydro-98, 10a-progesterone, wherein said process comprising of a) irradiating 90, 108, 3,20-bis (ethylenedioxy)pregna-5,7-diene in presence of single mercury lamp to get 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene, wherein said mereury lamp is a low-pressure meroury vapour discharge lamp having a discharge glass tube filter having an absorption edge located below 260 nm with atleast 80% transmission below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer having an absorption edge located below 310 nm; and. b) converting 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro-98,10a- progesterone, 2. The process as claimed in claim 1, wherein said irradiation reaction of step (a) is performed in a solvent selected from ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, and butyl acetate. 3. A process for preparation of 6-dehydro-98, 100-progesterone (dydrogesterone) comprising of less than 1.0% of total impurities, wherein said process comprising of: 4) irradiating 9a, 10, 3,20-bis (ethylenedioxy)pregna-S,7-diene in presence of single mereury lamp to get 9B, 100, 3,21 s (ethylenedioxy)pregna-5,7-diene, wherein said mereury lamp is 4a low-pressure mercury vapour discharge lamp having a discharge glass tube filter having an absorption edge located below 260 nm with atleast 80% transmission below 300nm, and another discharge glass tube filter being coated on inside with a luminescent layer haying an absorption edge located below 310 nm; b) converting 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene to 6-dehydro-98,10u- progesterone; and ©) purifying 6-dehydro-9f, 10a-progesterone to get 6-dehydro-9, 1 0a-progesterone with purity 0f 99.0% to 9. 99%wiw, 4, The process as claimed in claim 3, wherein said 6-dehydro-9, 10u-progesterone purified in step (c) is performed by isolating from a solution comprising ester selected from ethyl acetate, propyl acetate, isopropyl! acetate, butyl acetate, and t-butyl acetate. B5. The process as claimed in claim 3, wherein said imadiation reaction in step (a) is carried out by using single low-pressure mercury vapour discharge lamp equipped with two discharge glass tube filters wherein first filter absorbs all light below 260. um with atleast 80% transmission below 300nm for 1-2 hours succeeded by second filter being coated on inside with a luminescent layer which absorbs all the light below 310 nm for 3-4 hours, 6. The process as claimed in claim 3, wherein said - 9, 10a, 3,20-bis (ethylenedioxy)pregna- 5,7-tiene of step (a) is purified by: (D taking the 9B, 10a, 3,20-bis (ethylenedioxy)pregna-5,7-diene as obtained in step (a) of claim 3 inethyl acetate at -10°C to get precipitates; Gi) filtering the precipitates and evaporating mother liquor to get crude compound; ii) taking the crude compound in methyl isobutyl ketone to get pure precipitates; and (iv) filtering the precipitates to get pure 9B, 10, 3,20-bis (ethylenedioxy)pregna-S,7-diene. Dated this, 1" day of June, 2018 Dr. Anil Kéimar For Mankind Pharma Ltd, 14