CYTO311 01

CYTOGENETICS TERM
WEEK 10: PEDIGREE ANALYSIS

PEDIGREE ANALYSIS

Pedigree Reveals Patterns of Inheritance of Human Traits

• The traditional way to study inheritance has been to

construct a family tree, indicating the presence or
absence of the trait in question for each member of each
generation. Such a family tree is called a pedigree. By
analyzing a pedigree, we may be able to predict how the
trait under study is inherited
AUTOSOMAL RECESSIVE TRAIT
Pedigree Conventions

• A pedigree chart displays a family tree and shows the

members of the family who are affected by a genetic trait.
• Consanguineous
➢ The parents are related (first cousins)
➢ They are connected by a double line
• Sibs
➢ short for siblings
➢ connected by a horizontal sibship line
• Monozygotic
➢ for identical twins
➢ diagonal lines are linked by a horizontal line
AUTOSOMAL DOMINANT TRAIT
• Dizygotic
➢ for fraternal twins
➢ same as monozygotic but lacks a connecting
line
• Proband
➢ individual whose phenotype first brought
attention to the family
➢ indicated by an arrow connected to the
designation p
➢ can be applied to either male or female

Please refer to the supplemental video uploaded on our

canvas module for better understanding. Thank you!

BS MEDICAL LABORATORY SCIENCE | CYTO311 | MIDTERM | LAYAN, JAYVHIE 1