pon in the same Individual is temered eneotype 1c) phenotype J Mosaics [b) sencotyp transcriptional processing of RNA i ouaryo s1 Which of the flowing occu ding post-tramript , : asad at i ecitsgunte Foen!guaniggf Adlon of «polyA nb 63. Presenso of 2 different gencoty) 65, Diffiront forms of the gono are terined alleles AB TRUE Ib) FALSE 66. In reciprocal translocation segments from homologous chromosomes are changed Js) TRUE Alby FALSE 67. Mutation by recduetion in mferoRNA which targets oncogenes results In Ja) Silencing of oncogenes Dey overexpression of oncogenes Ic) has no releation with oncogenes 68 Amino acids in the cytoplasm are activated by ATP and get linked to tRNA. PP During the process of Fries PF daring the procces of translation Jc) Amino acids are never activated by ATP 09. Chiasmata occurs at prophase I of meiosis between Ja) sister chromatids Perivon sister chromatids Ic) no chiasmata at prophase I 7, Removal of introns from heterogenus,nuclear RNA is done by Ja) Removal of exons SS isan Je) microRNA 71. Down syndrome may be due to reciprocal translocation Feereat etonrer Ci) ‘FALSE 7. Adult stem cells can remain in quiescent stage for long periods of time By Ae) TRUE, 1b) FALSE Ja) TRUE, Ib) FALSE of mutation, one base pair is replaced with another one it 1b) Morosomny #8 syndrome patients will have Gera digit) 1b) FALSE Hogues sich as acyclovir can be used as anti viral. drug |b) FALSE osome is characteristic to Jenkemin 5 hronie myeloid leukemia Te) acu be used to: oo paternity or maternity. 2 Detect iromosomal struct structure changes, avidin are used in EJSH technique Ib) FALSE myeloid leukemia soto tniegel plaripatedt-stem (IPS) cell byiactivation at Sox? and ¢-Mye genes: Te) ERGF and Oct-4 genes in-situ perel® Western Ic) Nonsense mnuatation: bs : oe pe ea wi ‘anicronatellite DNA Jc) minisatellit Ja) microRNA $i. HD. and Hj are linker histones [a) TRUE ASF FALSE ions that occur in the somatic cells are not heritable 5. Muta . po tno |b) FALSE 86. In a cross between a black-skinned individual and a white-skinned individual the children will intermediate in color (tan is is an example of es 1b) incomplete penetrance Ja) partia) recessi incomplete dominance 87, Philadelphia chromosome is characteristic to Edward syndrome. [a) TRUE “ALSE. ‘88. Favism is more common in AS nates than females [b) females tan mates Ic) no difference between them 89. Klinefelter syndrome patients have high levels of La) Testosterone ASV FSH and LT hormones Ic) progesterone 9. Polyploidy refers to: [2 Bere copies oF « gene adjacent ‘pL ini leach other on a chromosome nal with complete extrac) a chromosome which has replicated sets of chromosomes but not divided 1. ‘Testis determining factor is carried on the X chromosome la) TRUE FALSE 92. Isochromosome can be seen in a) patau syndrome PH re Syndrome Je) Edward syndron iptional processi Addition of a Z-metiiy! guanosin Jeap at the 5’ end tiption, RNA polymerase binds at Ib) ai ing of RNA in eukaryotes? “|? Addition of a poly-A at the 5* end Ie) An enhancer nd transfer RNAs, are called 1b) Coding DNA e i caused by what type of mutation ? mutation — |b) frameshift mutation itia marriediormal female, the percentage o} ese 7 DNA determines how many divisions the cell will unce 1b) FALSE Ic) Ribosomal RNA (eg) chitdron witt be xk Dee) "gO pyould represent a If lysomile condition SS tinomie conctition treating BCR-ABL fusion induced CML Ib) FALSE wes during melosis is called le) Genotype Te) Oncogene f103. In nonsense mutations we will have Ae meated protein [b) Normal protein Ic) Over expr 101, Karyotyping of a person with Testicular feminization syndrome will show prese bodies oe Ja) TRUE, ber "ALSE, 105. ‘To ensure replication fidelity ,DNA polymer Iins a prooftending activi exonuclease activity). © enzyine (3 5']b) lias a proofreading activity (5+ 3° Jexonniclense activity). }€) has no relation with pri activity 106, DNA glycosylase enzyme removes abnormal bases due to damay ‘TRUE |b) FALSE 107. we uso fluorcent dyes in karyotyping technique la) TRUB Jef aise Ke from oxidation and alkylation 108, During transcription, which strand is read by the RNA polymera Ja) Terminal 1b) Coding ys Template strand 109. In paracentric inversion the centromere is involved Ja) TRUE 110. Nucleosides can be phosphorylated by kinases to form S56 Nucleotides 1b) Ribose sugar Ic) codons ILL. Changing the codon AGC to AGA represents a framshift mutation Ja) TRUE, oe FALSE 112. Total sequence of nitrogenous bases in DNA that specifies the amino acid sequence of a protein molecule is known as JP The gene [b) SuRNA Ic) microRNA 113. Fluorescence in-situ hybridization technique can be used to amplify selected regions of DNA Ja) TRUE Aby FALSE If you inject embryonic stem cell directly to humans a) it will develop into liver and blnd.J4¥f it will cause teratoma c) it will be differentiated into bone q cells one marrow stromal stem cells can differentiate to different types of blood cells [b) FALSE single chromsomes [b) FALSE olesterolaemia is due to mutation [b) missense mutation Je) nonsense mutation oid levkemia (CML) can be identified by as a reciprocal trans! cation ee 9 and 22 [b) chromosomes 9 and 21 Je) diromosomes 8 an urner syndrome would represent 1b) polysomie condition are identified as Jb) Hematopoietic stem cells Je) trigomic condition Je) Totipotent stem cellso ; ar ofS Bie HOMIES +sact as a ‘mitotic clock? that counts the number of divisions Ta) centromers 1b) centrosome Jomere length 23. Synapsis of homologous chromosomes occurs at metaphase I la) TRUE DOF FALSE 24. Mutation by amplification in the miRNA which regulates .,. ++ can lead to cancer development nor SUPprEssor genes 1b) oncogenes Ie) pseudogenes 25. Factors ‘influencing tooth crown size is found on Ta) x chromsome. 1b) chromsome 7 Ase Chromsome 26. Down syndrome may be due to |p ‘Trisoiny in chromosome 13 Pp reciprocal translocation between| chromosomes 8 and M4 potent stem cells Dental pulp of 3rd molar Robertsonian translocation hee foween chromsomes 14 and 21 + Is considered as a source of multi Ja) Celis obtained fro 28. Symmetric division ‘TRUB 29. All are characteristics of a) UAG, UAA and UGA are Ie) none of the above ells gives rise to two identic: Ib) FALSE the genetic code except : the stop| :hter cells overlapping lp Ho spaces between them ig Sequences of the gene Dr Gaing sequences of the gene Je) Oncogene dition to a DNA. Sequence would not cause a frameshift n mutation? AbyGce Ie) cc ous nuclear RNA is which form of mRNA? 1b) Unspecified Pr Gina \ ASE timers Ve) 3 pri Ive spludle fibers can be dispreued using drugs as : 1b) ‘Tyrosine kinase inhibitors le) Ribavirin with a high proportion of positive 1b) Arginine and dopamine analysis of : microsatellite DNA ly charged amino acids such as $e) Lysine and aspartic acid Ie) minisaetite DNA tained by genes Hy Ie) EDGr: In meiosis ts termed disjunction Pa PALse [b) FALSE Sahes ~> fr Enbrye =a Ie) Ligate the 2 strands PA Nneseotide excision rerun. =43. Induced pluripotent stem cells are made in Jabs and behave like adult stem colls in diffepgugjation capacity i: PO TRUE Ib) FALSE -#4\, Duplication of genes in the chromsome occurs due to PRoromat crossing over during mei Ro |? non disjunction 45. DNA polymerase enzyme ts involved in the Process of protein synthesis fa) TRUE py FALSE 46. Identity the correct order of organization of genetic material genome, chromosome, gene. nu-[b) gene from largest to smallest , genome, imcleotide, ao (9) ‘genome, gene , chromosome, 1 jeleotide Imosome: jeleotide 4? Monsomy can occurs due to 19) eyajunction pp mn lag 1c) polyploidy Embryonic stem cells can be differentiated to all types of cells dg TRUE 49. Banding techniques are used to detect Chromesomal aberrations 1b) FALSE: 1) protein snstations 50. Redundancy of the genetic code can load to fa) Frameshift station Je) molecular mutations Tb) Missense snutation Silent mutation 1b) Coding DNA deficiency (favism) is applying lominance pose att) Complete dominance pattern oy Ie) Ribosomal RNA tiked pattern of inheritance inheritance Bee of inherit technique can be used for detection of: 5 1b) single micleotide polymorphisin in genetics describes ation low In|) The ole of tations in disease | Ic) frameshift mutation Jc) The role of disease. 1b) FALSE Te) An enhancer Fe) Has no relation with cancer a1. Equalization in the gene products between males and females is termed Dosage compensation 1b) penterence Je) Bar Body 2. Isochromosome is a chromosome with 2 identical arms Jef TRUE 1b) FALSE @ % Myotonie dystrophy is caused by which type of mutations 7 Ja) substitution imtation Bef Dynamic mutation Jc) frameshift mutation 4 Down syndrome may be due to ‘Trisomy in chromosome 21 |b) ‘Trisomy in cliromsome 13 Je) Trisomy int Chroinsome 18 §. According to Chargait’s Rule of base pairing, the amount of adenine is equal to that of guanine Ja) TRUE Mev faise Thymine dimers can be removed by ye ‘Nucleotide excision repair [b) Misinactch repair Ic) Base exeision repair 7 During DNA replication, the role of DNA helicase is to P Add the RNA primer |b) To stabilize the single stranded fey To uniwinid the original DNA structure molecule _S@ 8. Testicular feminization syndrome genotype will be [b) xxx ATXY .) nino acids are joined by peptide bond at tay P Ribao [b) B site of Ribsome ASA site of Ribsome int mutation ....., ‘base pair is replaced by ai [b)Tsertion of bases J?) Destion oases + Are the shortest DNA repeated sequence tellite DNA. [b) Minisatetite DNA Ie) satellite DNA is due to chromosomal abnormality In chromosome number Ib) 18 te) 21 debate on using ipheral blood stem cells Je) Liver stew cells Ib) Pe downregulated in cancer cell JO PMB Ie) Pleuripotent expanding triplet repent 16) point umtation acterized by ‘ Truncated protein Te) Ring ehromesomes g no acid are called 10) Propnsation Jo) dynamic mutation BS ester vitae in human cells2) eho 6) Lang ening RSA 61 aia aes Nimes 7 sna ct ain cos eet ca 3 Tarner xemtrome aw ie 18) on Baa ly 1B) 2 Mar bonds ©) No Bar beatin sche inher of divisions: 1b) comtronone £6) Tene lenge ‘8) Trvatment of gvavtie Mhennen a) Establish tery or mhaeraity €)/ Deteet dhtoniacnl srnetine oN ne f& Which of the following, is tne about DNA replication? a) the Iesing strond t sephentest b) the leading: Continuo whi: he ging strand contin is replicated lincontinyonisly————— os eh rial the same Civica Oromo rt fied Frerlucts between ines nnd etales terme b) nemerince 4) Dosge cosmpensation ©) Bar Bexiy i epee. sina S) AUG a tp ee ine in Wuthang only ro sie iS Fond on ) chrome 7 : ne eirmwcine 7, 2 DY Crease 25. The toed that DNA is amiparilll means thot gt bee ‘strand ts perpendicular on the b) Phe ‘ond OF one strand ix pp e) The a hence et a site to he Sen of the otliet, ay ench ther, 261 m9 with emo lin sntried hiorind fenaale) what is the Percentage of lea ir a) 50re Oa ji 27. Different forms of the get mee termed 8), Genome 1b) Alles é Micropatellite instability (NST) may Oe Ble emeee 32. DNA polyinerse enzyme £5 Bills the neve straws 38, GOPID deficiency: (Savisnn) iol ae Alominaaye pattern of ibe B ‘wsnce Dieser ner Niven 38, Monsom can cum die 10 0 (BY napa tng a asaeanicn ae high, ee ore Ea emery atr reroll any ot > Otic nen Mirochondrt 4 honda ert eee vn ‘vending to Chan 3 lenin! eens. Rat Me rmct tiie wpe AT 22 Hunoa, Dood grep * «) eae ae Noes ©) Purim Gr € 3 leaner S d in 6) Nilinked bY Mendetian Patter of ‘nheritance €) X tnt pat ter of ineritane =) Phenotype. 56, DNA is fotind io ‘the neles GB) mitocbondrin p) ribosoit “57. AF this is the Bae some a of DNA ‘complimentary DNA strand? h