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NDIN f w B @ searcH Draw 3 Tarot Cards for Free ot of Truth for Free: Victoria Tarot Reader CATEGORIES CERVICAL INTRAEPITHELIAL NEOPLASIA & CERVICAL CANCER Postec by Dr Vijay Sherker§ | Aug “8, 2022 | Farle Genital System & Breast Systemic Pethclogy | tee ILoVEPATHOLOGY CERVICAL CANCER llovepathology 2y Vay shankar Cervical Cancer wor cervical cecairoma is the fouth mi «in the developrrert of cexvicel “emmon carer in worren, Mast Highrisk “2Vs. important fat cance ma virus; DNA Virus, two mein 3 TO% of ceric HPV 16 & 18 belong to “i centers Low oncogenic risk viruses ar perianal wants (coneyloms acum isk arc togethereecou ause of sexuelly ensrittec vulvar, cerineal, anc un) From The Industry Le CroweSuikelsin Provento Stoo Malwer Draw 3 Tarot Cards for Free roves? Genital HPVinfecticrs- 90% cf infections ae clezed within 2 yees, Harris tke lenges to dee risk fhe ceveloprent cf c-vicl precursor lesions ane sutsecuent carcinomas Free: Draw 8 cards cemmon when there is Persistent infection the Tarot of Truth, discover what ye WHAT IS THE PREREQUISITE FOR PERSISTENT INFECTION? Recuires viral erty irto ture holds immetare basal entheial cells Surfeces coverec by mature squamous ecithelium a7 STANT te HPV infection WHAT ARE THE SITES SUCCEPTIBE TO HPV INFECTION? - penis, anc orepharyroc Sites in the ferale genital t tte epitrelial wavraerd toce'vik, Vagina, Vil that ere SUSCEPTIBLE to infection ez vBtrotogy or wor ray acess basal cells == deficiency 15 222 llon ef the erie vin ugh immature etre scuamous cls een Cire ste pathology ot ee a, scuzmocclurrer junction cf the erus- Ste of -2veassclteecercersinindidas Spherocyosis who orectice anal sex bb Souerrcus calls cf oroore-yngeeltosilar cysts Site cf HPweassocates cancers in incividuals who practice Oral sex eae Cenvcal How does HPV act as a carcinogen? Tift intrzepitretat Hpvisa srall rorervelogec DNA Virus, cont e-strance closed circular eoplesie & isasrall ramervelocec s. adouolestranes closed circle neoplese DNA gerem tec wit hstoresie proteins Protectec by a cans formes ky ‘wo late oroteins, Lt anc L2 basa regiors Long cortal region (LCR) = regultory function ofthe benscrition of the £6 anc E7 viel genes aly region > El, €2, 4, £5, £6, and =7, which enc Involves viral reaction endor coger Late region (.} ercoses the 1 anc L2 structural proteins, eso structural prteirs, 6 &£7 involved in carcinogenesis. Role of 6 1 Bind ane degrade tre tumor s é-associated protein 5-2) inti asco 3, Uoveguiates the excression oftelomerase Role of £7 Draw 3 Tarot ess0r protein 053 thrcugh te recruit 1. Bird anc seprade te tumorsuppresier rtein cB increase CDK activity Cards for Free Bins Cokirhitrs p21 827 “atest eexreson cf ese geesty dec meracting with 2 feo the corbined effect ofthe ceeve ois Lrrelated celle which further lee te cencer és illustreted below. Free: Draw 3 cards the Tart of Tut, 4 what yc Bind and degrade the tumor- Bind and degrade the tumor suppressor protein pRB suppressor protein p53 ‘sctedpatan (287) Inhibits CDK inhibitors p21 & p27} Inhibits apoptosis Affects the expression of S phase Upregulates the expression. genes by directly interacting with] of telomerase EF factors Increase CDK activity Unregulated cell cycle cancert Why low-risk HPVs are net implicated in cancer? 7 protelrs cf ewrsk PVs bind RB with lower affity ES protelrs cf lwrsk Vs fll tc bing p53 zltogether o all women exposed to HPV develop Cancer? INO. Ctres factors cc olay a rlel Exposure to Co carcinegers & Host imvrune statis ltuence whether an ~2V infection represses or persists Cervical intraepithelial Neoplasia (Squamous intraepithelial Lesions) Oldest classification Wild eysplesia Noserate oyspesia Severe oysplasia ecireme in situ ‘CIN classification Nt Nt avi Present classification ( Two tiered system) levmgrade squarrous in-apitrell lesion (LSIL)& igh grade squarro.s intraepithelial lesicn (SIL) the dlssifiatcn isaslusvetec below Severe | | Carcinoma Dyspisia Ins vasive ‘What are the differences between LSIL and HSIL, itisasillustrated oelow Morphology of SL: Dizgrcsis fis 22sed on nuclear atyciaincucing Nucleer cenlewerert rysercnrcmesie (cer staining coarse chroraticgrancles &variticn in oucler size end shane “These are Cften eecempariec oy Hela” cyteplasm callec as KOILOCYTIC atypla RECENT COMMENTS Val Plant anry18 2020 enDysgerminoma: Overy Barre Klossner nAscitic Fluid Analysis Common Questions sy ‘Advertise For Free aruny 8, Fo nants hhemoglcbirometer ‘Alia Faljrwary192320 cn enign Prostatic Hyperplasia @PH) Jermaine Malone BD ‘cnENDOVETRIOSIS ‘CERVICAL CARCINOMA ‘Al ercinorras are caused oy highs HPS. They include ‘squeTcus cel carcinome - 80% Aeecccarcinema = 154 Aceresquamous are revrcendoatire caciremes = 5% Grossly: They can be Excrhytic/ Furgating , cert & letrative Nscrescepicaly as mentioned aacve. microscopy Squamous cell ‘adeno carcinoma squamous ‘Staging of cervical cancer is illustrated below TY¥¥ sage] | Sone? Stee Dssse bond cei, || Dsese 0 oa Tati ‘Confined 10 || gut NOT to pelvic wall? lower /3" of bladder/rectum/ eves | "wer /Stahanna_ "ane | dates Sy saviniroe [SE [x 3% ™ | Clinical features Iveloviy of tre patients presents with abnoral pee smer during screening Programs.Averege ege- 45 ~ 50yrs owever, Symptors incuse a. Postcotal cr intermenstrualoledig. Stage Th er higher bs, Costructve uropathy 2nd renal allure = With growth ito pararetria end involvement of ureters, Fain = pelvic wall cr lumboszcral reve reot invasion. cc. paraturia, rectal kleecing, or corstisaticn- aladce” or rectal invcivementi> advanced stages ‘Treatment ‘SuneTiially invasive squarrous cell carcinoras- Cervical core excision Invasive carcers = Hysterectomy with lymph ree cissection ‘Aeverced lesions ~ Reclation ard chemotherapy {lick or the lnk below to view the vioe tutorial cn cerca intraepithelial neoplasia ano cervical cercer ‘Squamous intraepithelial lesion & CA.. ome: f wo t PinS a eB RATE: «< PREVIOUS Next> ‘Accholic liver disease: Merchology, Clinical Pathclogy cf Heresitary Sphercoytosis features & Come ABOUT THE AUTHOR Dr Vijay Shankar S itn more than 17 years of experience es an acacerricien, He has develoces the ert of cantent geveraticn to make the lezrrirg more fun Loves to premote socal eeciafor ecuestio" ir Pathclogy RELATED POSTS: Fibroadenoma Pathology of Pathologyof CHRONIC + Breast Endometrial © Schwanioma VENOUS ses, 206 Hyperplasia yrezy.200 CONGESTION ~ Novena LUNG ay3s7m0 fy¥Go

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