Cambridge University Press
978-1-107-57925-5 — Personalized Anaesthesia
Edited by Pedro L. Gambús , Jan F. A. Hendrickx
Table of Contents
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Contents
List of Contributors vi
Foreword ix
Introduction xii
Section 1: Basic Principles
1. Principles of Quantitative Clinical
Pharmacology 1
Pedro L. Gambús and Sebastián Jaramillo
2. Pharmacokinetic and Pharmacodynamic
Modelling in Anaesthesia 14
María J. Garrido and Iñaki F. Trocóniz
3. Drug Interactions: Additivity and Synergy
among Anaesthetic Drugs 29
Jacqueline A. Hannam and Timothy G. Short
4. Covariate Analysis in Clinical Anaesthesia 40
Luis I. Cortinez and Brian J. Anderson
5. Signal Analysis and Response
Measurement 63
Umberto Melia, Erik W. Jensen and José F.
Valencia
6. Application of Pharmacokinetics and
Pharmacodynamics and Signal Analysis to
Drug Administration in Anaesthesia 82
R. Ross Kennedy
Section 2: Targeting Efects
7. Hypnotic Efect: Inducing Unconsciousness
and Emergence from Anaesthesia 103
Sergio Vide, Catarina Nunes and Pedro Amorim
8. Analgesia: Efects on Response to Nociceptive
Stimulation 117
Emmanuel Boselli and Mathieu Jeanne
9. Personalized Sedation and Analgesia 128
Michael M. Beck, Jefrey B. Horn and Ken B.
Johnson
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10. Respiratory Depression 146
Malin Jonsson Fagerlund
11. Immobility 157
Klaus T. Olkkola and Douglas J. Eleveld
12. Efects on Brain Function 175
Neus Fabregas and Adrian W. Gelb
13. Targeted and Individualized Perioperative
Medicine for Cognitive Dysfunction 197
Pauline Glasman, Alice Jacquens and Vincent
Degos
14. Cardiac and Haemodynamic Function 206
Kai Kuck, Natalie Silverton and Michael K.
Cahalan
15. Efects of Anaesthesia on
Thermoregulation 222
Oliver Kimberger
16. Efects of Perioperative Management on
Kidney Function 238
Xavier Borrat and Jordi Mercadal
17. Efects on Liver Function 245
Andre M. De Wolf and Jan F. A. Hendrickx
18. Efects on Fluid Balance 257
Robert G. Hahn
19. Ventilation during General Anaesthesia 271
Lluís Gallart
20. Epilogue: Artiicial Intelligence Methods 285
Sebastián Jaramillo, José F. Valencia and Pedro
L. Gambús
Index 291
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