1.

Pharmacokinetics is:

a) The study of biological and therapeutic effects of drugs

b) The study of absorption, distribution, metabolism and excretion of drugs

c) The study of mechanisms of drug action

d) The study of methods of new drug development

2. Which route of drug administration is most likely to lead to the first-pass effect?

a) Sublingual

b) Oral

c) Intravenous

d) Intramuscular

3. Most of drugs are distributed homogeneously.

a) True

b) False

4. Half life (t ½) is the time required to:

a) Change the amount of a drug in plasma by half during elimination

b) Metabolize a half of an introduced drug into the active metabolite

c) Absorb a half of an introduced drug

d) Bind a half of an introduced drug to plasma proteins

5. Pharmacodynamics involves the study of following?

a) Mechanisms of drug action

b) Biotransformation of drugs in the organism

c) Distribution of drugs in the organism

d) Excretion of drug from the organism

6. It occurs when the action of one drug reduces or blocks the effect of a second.
A. Synergy

B. Antagonist

C. Antagonist effect

D. adverse effect

7. This occurs when the body recognizes the drug as foreign and responds by histamine release.

A. Allergic reaction

B. hypersensitive reaction

C. selective toxicity

D. nephrotoxicity

8. Absorption occurs at a slower rate when drugs

are administered by the oral, I.M., or subQ and IV routes

A. True

B. False

9. A therapy that is used used for end-stage or terminal diseases to make the patient as comfortable as
possible.

A. Acute therapy

B. Maintenance therapy

C. Supportive therapy

D. Palliative therapy

10. If the kidneys are not eliminating properly, the parent drug and metabolites accumulate and can
cause prolonged action or toxicity.

A. True

B. False

C. Forda No

D. Ayaw