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Review Continuum (Minneap Minn). 2016 Apr;22(2 Dementia):404-18.

doi: 10.1212/CON.0000000000000313.

Mild Cognitive Impairment

Ronald C Petersen

PMID: 27042901 PMCID: PMC5390929 DOI: 10.1212/CON.0000000000000313

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Abstract
Purpose of review: As individuals age, the quality of cognitive function becomes an increasingly
important topic. The concept of mild cognitive impairment (MCI) has evolved over the past 2 decades
to represent a state of cognitive function between that seen in normal aging and dementia. As such, it
is important for health care providers to be aware of the condition and place it in the appropriate
clinical context.

Recent findings: Numerous international population-based studies have been conducted to

document the frequency of MCI, estimating its prevalence to be between 15% and 20% in persons 60 Title & authors
years and older, making it a common condition encountered by clinicians. The annual rate in which
MCI progresses to dementia varies between 8% and 15% per year, implying that it is an important Abstract
condition to identify and treat. In those MCI cases destined to develop Alzheimer disease, biomarkers
are emerging to help identify etiology and predict progression. However, not all MCI is due to Figures
Alzheimer disease, and identifying subtypes is important for possible treatment and counseling. If
treatable causes are identified, the person with MCI might improve. Similar articles

Summary: MCI is an important clinical entity to identify, and while uncertainties persist, clinicians
Cited by
need to be aware of its diagnostic features to enable them to counsel patients. MCI remains an active
area of research as numerous randomized controlled trials are being conducted to develop effective
Publication types
treatments.

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Publication types
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms
Cognitive Dysfunction* / epidemiology
Cognitive Dysfunction* / physiopathology
Disease Progression
Humans

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Cited in Books
MedGen

Grant support
R01 AG041581/AG/NIA NIH HHS/United States
P50 AG016574/AG/NIA NIH HHS/United States
U01 AG024904/AG/NIA NIH HHS/United States
R01 AG011378/AG/NIA NIH HHS/United States
U01 AG006786/AG/NIA NIH HHS/United States

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