Clalees, Conelnsaler hos a bee abbad olemodleca, cootarsalon cl 400 cactess 40 te j P kalo wales Rachanisn { B kalo sled © a ¢o peor _ 2. oe ey) E(u) Pe Tal —COOR a) eenp a > Fee, i iar par’ “asian -of Rh a i DY ; Bad spect | cs Sg Bases aaah ate weld bphicles (uate Rota | Nani, KNB LoA Chubicwn abistceces! amide) EL,N | NaOH KOH | Pyridine ale ie ‘ oy od -cecet o—s \ = re 7 — com eu, owe eth atau. 7 : 2 ch—cy —c ea el 8 SS Sl, ot —cocel, —éy,—S —cet 58 —> Ca : . — B kelews: ay te i M + Hel : eee lascendng ~eaactioncooel : Q al _—— “ u ‘coOpEL, go eonel, Cet base 6(Q0 — aa coor p> ‘om cm nos ‘ J ee Sai. Rikkex Reaction | Acid eduaddt natecphlic ats da _olile bb a cnbaadion LetloasdP = kk eerie ponding hgdhely to Vow 40 = Ne oped 2S ee R ° Saw + R-eN = 7 0 Wechanisn D Fetwason dl carboaaton b) Bem_alkeene | Y= > ® os ) Rew 2 alatd ya £53 pe B Nacterphiie aod da nde toa &| eee tee just = TT 5 oe or ee. N= 7 + See Vo Ps —e—-Rk 7 a wo +R fe => Se ia wy, eH CR), Peficchnee anil Cpoaidaton dD alkese ath pecans | a atalalle m-cper is nie) = +necpah —> Nol The teeosilon slale io chich coyger edtel aed te 1 ss chlled aime Yeamblis @ belly and ao it ia Bellad, wmachaniso s machancio.:- = 6 u oe OQ — - Os +e Wo a) ioe wevek ov 5 Ay =o NE Ndchidas crt talone th, deg x -bychiegan lem Jake pal is aldol ansehen. Ne aah 480 molecales fe him a es *atuthonss ldohele [kone ht |. aaa |. ip aah ey aseaaInthe presence di the bone, the > enaywrocsicel kelones Pte € le ego Ther the cexbery ompoeind 4) lo (iy eS | by wel © sez sacly abchaclad bare “he Sera | Non ao anaymrnalicsl Kalose is heal ee. SE i Nees bi paketit scleig fecal, 4a cual, 40 a) =a 9 = a a a = 4D so Alaa aeldehydes bolh conlaiong am => Mrcad Ry Pach dco abdbydes aoolans aa | lon able aan gis each fb 4 Picea adshpe can Pave an erchle cad a aa aol as he onbonyl ampere | eis + ct-cu-cto OS 7 ° ew @ i cl,- E -4 oss. cid ° 2° t et -cy-cho + en-4-y —__s oe 1 i “| lly HCH ci, -C—4 ou 1 ety =H CH — cen (D oy eattads of © ey e-w 0, AP cho ee o® i i ch -4- 8 46, cio > ct- at — cio 2 © ae 4h 4 fon, 2y -cHe ~—» e + eye 21 ey es lap, \ as iy cl —— eile : cio ® B on? e i) Cig SY PAHO ae CHA ee Stor RR ‘© ely 2-4 +f, —=4 — cHo 7 ae a cu,— cH — cl —2HO | @ eu, 2D Too Alleserk adycles erly one cookeinng X-W ale © 7 > 1 yodiw on-enW uo, 2 erly 400° peodacks con te Somad —> 0 — cy, — cin ew ; 8, — c= cup \ He-8 4 cy eu » =i > ° us cH -c¥ ~cu-cho Ly ay dy 3 Sy te add en a wrlene dl * en altel a » Noces prodecd BOR Wy Adaledas , steullly ome xen lens Neches thor Haak to a Kesler 0h, 400 preclude ap helene wah A hich anlang ache y ay ic in Pincple yell extant ol Grae fae fe ke Tomed in sigolset cmecnle ee hes de cktehde and te Preocked dettsh hg tHE te cencllede . Nias deol tolls tee combed the able. =, a= Who x8 Seu & aut7 @ 9 eat bebe ew 3 ow. Oo, ft | r 9 ; = > 33 is eee ow wea-H + cu, 1 a an ai,-4h ~ <4, —cHo Ta i a q . © e 6 “Ei —e — city < caseh 9 ar,- 2- eu, Eo aes u,- & — cl, | es | ee > 3 7 ‘ Cy 2 ey | | au, eq, Stal cy | S lei, ee wog-u Wey } Cy, 2 ae, +ayse-w wt 2 < . j oH ° | ~Siy ” | SP ee hea } | 2a Hen ot "4 8 ° en— cd ty Uy | ck | Aro > o4,-ch-y oy] en -c—F —Cl; B byhoacg Perionctiy Nese —etthanitn Voted Brom tlone D Crna fil ° ri j u - Ald condenaatin a> Ss era ete ae oy 9 \pecase Adahyde iS Moe —eachle | < tcl cer tw eg oan 23 5 i 3 prealel_Ndol reaction | Abdgde hang ne X-W amd a oy Eel, + Sis oa * ae det! se a Relre ty x -canlon Othe alclehyle cas tee dig case ; ane quant cu oie| Joote Sere en worde fo ath Jo the cnkony) anton d Velome alkacks “eS 4 1, me a \E al the artery! antes of he Valor agrees mt adele auch 4 vy G adied coed | > cas, i BN SS a “ae Adel ~accton alee called clean eose asi ae eon aining thos ging = prcdect deed Ran the : a 2 xt all Seledieed aloo = Nelnd ai) condnedon, | — rotad AID eackon this pri ey + Kale Mewe the Galanen ae etal sre ay 9 | cM duadel ald sex? | } ts Sa : dhe Kelone , bexaause aldehyde 3 nite d 8 | Oheroice | | seactive aud — 4 veu,d oy ai > “ft | lo the praaenae el bulky qoap Ike f Fae Hea St os 5 Litkcan ch - iaopropgl amide qmup “4 I Ss o __ ee et F = iP 2B} a ri Le Gaibacion 6 Uimal Bem the aldolrd feo te loo «, Bey > sci +t, AL cH, = ? s i 5 + al m Oo 8 vo euycro E > en -c— , al ey bs a — g . ey bc 5 — u cs, ie \ > cucu + a pe Se. et, —cle Lad) eu, cho CF ; 4g —e + Su. ~cllg —> ch,—c- eh —O8 RL ae \ 6 m en 46 mat) 6 ; Cent zzet, baecin ——— frcorke Adeides acd clphete one oth no xe Chen deeded oh Net oy Bkeng, lwxees eedetges coon zen tee? Worn tenc, ene wcheccles beta ex dees arthes to the acd ond teap cA 40 te * clechd. Dd aticto spel SEH + ReocNa 7 ack. Deu ae eg Nath 3 a Tr eu 2" eucH a a ead “is ee coon Mechantan The wechanisn De canine oe? itl. ves = badtio (0°) oh Rect el tls to te C0 40 gue the Tellecing crepoend: the cheng & donalng chaeeky ef of » ord © grea Leklale the clit, a) sath: Lycioge? to Laatee oth 4. | whos the W? dees Dawe A clas weleadle AP clclcheple - Folly the ron Le cca xeculling in the Resection of Stay ad anborylale ail ¢ & of R-e_y 40% —> acrey ba a ; ed + RQ sah —s R-d-of + obey \ a i ¥ ; § eu j Prien i = R-e-€ = eo (>) | I (R-cy-c0) | ;> Evidence Tot this mechanism beer the tees” £a5 un in _ te secoeta ech coolan mo «-decketion indicating thal the hydingen comes Sens i) Ugdeide too tances. a es i na Sicukees eo ah i se D) Probes hacdles: °e rte = it + R-<4,-08 \ a Aswaand caonimund geeckon chen dee Accel aldchydes , one “a sie, east then uch & Weg? none cartizang Kear”) > called ciosaadl Gar ate senc” \ aUdete haing 00 x-ll and Reno sm the yeckichon dhe load end the orci | Ode Gales, Grae Helo le woe Warche 4, hes aldehyde Jeaarde nuctecphiles Wo) ay “apd gues a hgh Concenteaion OD he today a0 weal aamizen sea? be NH Heto + qizcho SEH, peo? 4 ALi, on. oe 1 > Wty Gansta Gls E08 2 fue es \ 4 Be Giscu9d) LES, > \lendlecles Gamnize teas?pe, acid and leche we pracnl 54) aane welecle. > lbleinadl GarciznO Yenc” a= Kalo alddydes gue inlerw a! eg, | is ! Kea eee eee Rac— ¢—08 | % z oy 8 ee ed R-ce——3 5 R—c—on —— \ —7 woo ie i D ¢ ° e—oé aos | \ — \ > | i RQ Hw—c—R Rewer \ OH. Benzein Condecsaton | —— ay. AC ally the aditdon of ome mdbade d cllchde to the CaO gicup QV another. he 460 wmoleciles TF cldchyle ebvnecly psddin alilerenl Qunctione- “ha one shel no Songer bas a e+ bend io the Product is called becase dbase donated de byteger PH | oxygen tthe other madlax, the acaepler. Sega) can padlotn only one of hace Tunclon ag: p-dioety) amino benzaldehyde is col an complet Ed only a cboaw Benzvin« 9 ties type D tee” cr? cs aed ahyt | >To + of QED I an os = fey en io +eqrobn ce Sls (exy—n{a-d—e-) — 4 ou Z. @iQ-8 a ee iH o BS) v ba oe Dd amy an : nu | — > caf : | the ven? to xevesctle he vay tap te boas of { ety ce a oma ~ eat +3 —eQ “ale = | t \ L fib an ahydiide Tan alipade aod 2 en eo “ Heyes + Goyen —§ | ot ys we cy Sty N= whe gs TOL 5 a cont Kroevenagel Kea” the condenacton oP aldahydle kelen2 ih exchve W- comport ot the Pop 2-cM,~2' ox z-cHR-2' Ghewe = oa 2 beng 203 a ah e Af = " ty & Ck OH lene GP CEL Ndcrade 4 kelooe ondenaes 4 _ fa oo whale edes io the Peacence a bees re atm a ue ane aed te ee a S oe gue x, -epcy aales called qhaicte b ct cA R 1s ) aes the « ctled Dassen wen?. the ghadic cates endewes lace Clerk ytole to Thin glyectc god ahch endesp a de- cuboagldve neassongecek (6 the Ppreaenas D ocd 4 Yom a Wires eartoony) compound “he | evel pecesses 4theeles consid d te chon BP me can a6 aldelyk, Mechanisio A hindered rae Bich as Plassun 4, | bedenide (Keemes) 3 used Zo that on* | Dapacemed a te chlesle tc dickwwad Conpacal oth rerowl da pinion, by Grete hindwance the Careanion thus loined Jo a carkoryl xp R a eek Aled the i Town 9 | bephaks E a ; catkong cartcon to to80 | pees eae RSL exes oo 8 Cxyantn the Caryanion displaces he | R i 1 oO & 09 io am ichva reeclecileas racleophylic Wy 0 Pos bocu a ee R battalion to Tom _lgidie ales ,¢ 6 i fn Row a ! BR Pe > PP rs HIN a * £ \ chy — NR, ee ® (B-evive cavbon, . « ey ' ng . | S Cachenwedet's caalt (eo ~ci,['r° | a . > “ bedehe coor, aa iy : Manvich ea” \ compoancls conlaning aleact — NLL tag et pa ae - a : a ay Ou x4 atom Condlenaes ath HEI in the pres. aoe & Nil, OF Texoine (R- Ni) oS 2 amine aes CRD givieg P - arm canbenyl compound alle} Wannich base ach a uma is colli Wis od as a Stuce SD ith ¢ | Amottgl arine Vor mrannich xe? Tee ween acdc Compemds Aches alatelyy Yelnes olltles alkyne? | Nhocompeicds, | na “Oe toacnich wen? Catt phanyl ge) Se ws haley Kea? procaata ends acidic caodifonsd te onclisctlle aorkerg! comport coo, vetlel Ton , chich afacke the ‘aio en gas P -a5ne caxtkorg) Compocind = pt UR ce ec® + Ba Ge. kOe ered oo Nechanisio — | HO ety. ct, — Bi - Ne. i. i a N@ hi, — tno : — ; | a uynyct aye a PR D wtally on inion ton Reemalon ccsee by He A's cue TB awaine caackeryl Be eee eA Chl fos ‘ ' Blaby | Ketone +t (5 naling X- 1 aclono » a FRR ¢ 1! mero fer, ae Ps a= + Wonk Ws Rg te 2 Nat, te | Taya 1 ol = a t (<4, : iH So ctpey opt Ss eq cnc cy — | ety = —¢ wee? ots 4 3) ee ret — = —R-e= cur! | -10 Peete & ge en otek nie @& Coney, acum wer - ee -ey et -N CE >@ = Jie Acot elias Wemen olled <-eze-0 —_s Ce ene che . oe al rps Fig ee co + HO __s oan aH nite, (ea) ] Ken Sernes (e-eal et —— an are “eh = ee ib Necdumion PT encmine ‘ee? reese e * Commonly asd ame cee 2 nines ee oe Renelidine RN 4fee ive Change is Aeloaaliced fet tre tng So Me cblain ayn Ral atric => Mddlon do Baler addel to alkene ip the preene ff om ad to ge alos accoding 1 tnatkerikey's rule e -c# cu, + aia ol, ot 2 pxpand. [he cctttion BP ccles to a rclecale asked bydreahon| | he Rk as he tacainfe mackse 4 = a = acy mS eynaice: % ~, a wou so 40 Aleres chaviatsy = fidten do bydhoges bales ca ol + Was —> SU, Cll, — Bs Comin’ aftiers) an 2 Ban crcymmatncd allen Ae th chlanad is basal o eskoun' tous viche - Remally Oty Wx ceo = a © me ee ma Oe ee ae © euy- cull, \y ¥ 7 ee ae | ee pt crowide + Uclesscyctia compoucds Rae 1 | oN - are ae aepeptcle aelechales i ae 4 ee #2, Seg a eas ar Ig 8 ¥ Q ae . ‘ eo | D adtied quer Sap ' ok =e OR Az 2 ey " — “NTS — & ; ow us | SR ae SQ an a ‘ A Sede || — 9 ‘ —s wae odo Leclont zation. ® StatMized Midas ~teack ath eb coats. cies ita vided canboryl compound 40 give cyclo popme = ahen V6 unaalralel anbougiia ad deswvales. , p fe 7 1 tyeled oth iodine io tee pescen d é ie || neb-cf Godiews bicatbonde ja lactone ic Yunoacl this! | wee + hae —> Ph = ; - | Ph “SK i a E- eo | vs i sez? ia Kooen aa lodeleonization hs ment ee > ie ee | Hulls idea oo acl al wldel 9 6 flan Kroon ae ladabaclizaton "B double bende hale dactonization.