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  • Virulence Factors of Salmonella Typhimurium

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    Tanveer Khan
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    Major virulence factors in Salmonella include adherence factors like fimbriae and curli that help it attach to surfaces, secretion systems that inject virulence proteins into host cells, and factors that provide resistance to stress, antimicrobial peptides, and serum allowing it to evade the host immune response. Salmonella regulates these virulence factors through systems like PhoPQ and RpoS and uses them to cause disease by mechanisms such as toxin production and immune system manipulation.

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    1. Virulence Factors of Salmonella Typhimurium

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    Major virulence factors in Salmonella include adherence factors like fimbriae and curli that help it attach to surfaces, secretion systems that inject virulence proteins into host cells, and factors that provide resistance to stress, antimicrobial peptides, and serum allowing it to evade the host immune response. Salmonella regulates these virulence factors through systems like PhoPQ and RpoS and uses them to cause disease by mechanisms such as toxin production and immune system manipulation.

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    5 views2 pages

    Virulence Factors of Salmonella Typhimurium

    Uploaded by

    Tanveer Khan
    Major virulence factors in Salmonella include adherence factors like fimbriae and curli that help it attach to surfaces, secretion systems that inject virulence proteins into host cells, and factors that provide resistance to stress, antimicrobial peptides, and serum allowing it to evade the host immune response. Salmonella regulates these virulence factors through systems like PhoPQ and RpoS and uses them to cause disease by mechanisms such as toxin production and immune system manipulation.

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    of 2

    Major virulence factors in Salmonella:

    1) Adherence
    Agf (Thin Aggregative Fimbriae or Curli)
    Related genes: csgA; csgB; csgC; csgE; csgF; csgG;
    -Lpf
    Related genes: lpfA; lpfB; lpfC; lpfD; lpfE;
    -MisL
    Related genes: misL;
    -Pef
    Related genes: pefA; pefB; pefC; pefD
    -RatB
    Related genes: ratB
    -ShdA
    Related genes: shdA
    -SinH
    Related genes: sinH
    -Type 1 fimbriae
    Related genes: fimA; fimC; fimD; fimF; fimH; fimI; fimW; fimY; fimZ;

    2) Antivirulence
    -GrvA

    3) Immune evasion
    -Vi antigen (S. enterica (serovar typhi))

    4) Magnesium uptake
    -MgtBC

    5) Regulation
    -Fur
    -PhoPQ
    -RpoS

    6) Resistance to antimicrobial peptides


    -Mig-14

    7) Secretion system
    -TTSS(SPI-1 encode)
    -TTSS(SPI-2 encode)

    8) Serum resistance
    -Rck

    9) Stress protein
    -SodCI

    10) Toxin
    -CdtB (S. enterica (serovar typhi))
    -Spv

    11) Unclassified
    -Mig-5

    12) Pathogenicity islands in Salmonella:


    -SPI-1
    -SPI-2
    -SPI-3
    -SPI-4
    -SPI-5

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