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# M.Sc. Statistics / M.A.

Statistics
PGSTAT-01 / MASTAT-01

Mathematical Analysis
Integral as a function of a parameter. Differentiation with in sign of integration, Fourier series, Functions of bounded variation. Absolutely continuous functions. Riemann Stieltjes integrals. Basic theorems. Metric spaces. Open and closed sets, Convergence of sequences, Completeness of R. Baires theorem. Cantors ernary set as example of a perfect set which is now here dense. Continuity and uniform continuity of a function from a Metric space to a Metric space. Compact spaces and compact sets. Continuity and compactness.

Books recommended:
1. 2. 3. 4. Rudin. N.: principals of mathematical analysis. Royden II.I Real analysis. The Macmillan. Wider: D.V: Advanced calculus. Goldberg. R. R.: Methods of real analysis.

PGSTAT-02 / MASTAT-02

## Probability and Distribution

Probability space of a random experiment .probability measures random variables as a measurable function. Field induced by a sequence of random variables, decomposition of distribution functions in purely discrete, absolutely continuous and singular components. CR-inequality. Cauchy-Schwartz inequality. Holder inequality. Minkowski inequality, Jensen inequality. Lyapunov inequality. Kolmogorov inequality. HajckRenyki inequality. Sequences of distribution functions. Helly Bray theorem. Different types of convergence of sequence of random variables distribution function of random vectors, Weak and strong law of large numbers. Khinchin. Borel and Kolmogorav theorems. Borel-Cantelli lemmas and zero-one law. Characteristic function. Inversion theorem. Continuity theorem. One dimensional central limit problem : lindeberg-levy, Lyapunov, Lindeberg-Feller theorems.

Books recommended:12345678910Bhat. B.R. : Modern probability theory. Eisen. M. : Introduction to mathematical probability theory. Loeve M. : Probability theory. Rohatgi /V.K. : In introduction to probability theory and its applications. Gnedenko B.V. ; The theory of probability. Feller W. : In introduction to probability theory and its applications, vol I and II. Hogg. Tanis & Rao : Probability & statistical inference. Chung K.L. : A course in probability theory. Tucker. H.G. : A graduate course in probability theory. Chow Y.S. and Teicher. II : Probability theory.

PGSTAT-03 / MASTAT-03

Statistical Inference
Estimation : Sufficiency. Completeness. Rao-Black well theorem, Lehman Schaffer theorem, Cramer-Rao inequality minimal sufficiency. Completeness, Bounded completeness, Ancillary statistics. Basus theorem on independence of Statistics, Exponential family, Bhattacharya bound. Chapman Robbins and Kiefer (CRK) bound, maximum likelihood estimation. Zehna theorem for invariance. Cramer theorem for weak consistence, asymptotic normality. BAN and CAN estimators, asymjptotic efficiency, relation between confidence estimation and hypotheses testing. Generalized Neyman Pearson lemma. UMP tests for distributions with MLR. LR tests and their properties. UMPU tests, similar regions, Neyman structure. Invariant tests.

Books recommended :
1234Lehman E.L. : Testing statistical hypothesis. Lehman E.L. : Theory of point estimation. Rohatagi V.K. : An introduction to probability theory and mathematical statistics. Primal Mukhopadhyay : Mathematical Statistical

PGSTAT-04 / MASTAT-04

## Linear Models and Design of Experiments

Linear Estimation- estimable functions, estimations and error space, Best linear unbiased estimate (BLUE). Markov theorem distribution of quadratic form, Estimable linear hypotheses generalized F and T tests. Analysis of Variance : Two-way classification with equal number of observation per cell and Tukeys test general two-way classification. Analyses of covariance, 2n , 32 and 33 factorial experiments complete and partial confounding. Balanced Incomplete Block Design (BIBD), construction of BIBD, intra block and inter block analysis, split plot design.

Books recommended :
1234567Joshi. D.D. : Linear estimation and design of experiments. Joshi. D.D. : Linear estimation and design of experiments. Giri N. : Analysis of variance. Das M.N. and N.C. Giri. : Design and analysis of experiments. Kempthorne. O. : Design and analysis of experiments. Mann. H.B. : Design and analysis of experiments. Manteimery Douglas S. : Design and analysis of experiments

PGSTAT-05 / MASTAT-05

Survey Sampling
Sampling Theory : stratified sampling. Post-stratification and deep stratification. Methods of allocation. ratio and regression estimators, double sampling in ratio and regression estimation. Cluster sampling with equal clusters two stage and multi-stage sampling. nonsampling errors. Varying probability sampling with and without replacement, cumulative total and Lahiris methods of selection. Estimation of population mean. Desraj ordered estimates, Horvitz-Thompson estimator. Midzuno and Narain system of sampling.

Books recommended :
1234567Sukhatme P.V. B.V . Sukhatme. S. Sukhatme and C. Ashok : Sampling theory of surveys with applications. Murthy. M.N. : Sampling theory and methods. Des Raj. : Sampling theory. Singh D and F.S. Chaudhary : Theory and analysis of sample survey designs. Mukhopadhyay P. : Theory and methods of survey designs. Daroga Singh and F.S. Chaudhary : Sampling survey designs. Sampling techiuq III Edition : W.G. Cochran : Puls wiley student Edition.

PGSTAT-06(P) / MASTAT-06(P)

## Practical based on PGSTAT-04 / MASTAT-04

PGSTAT-07(P) / MASTAT-07(P)

## Practical based on PGSTAT-04 / MASTAT-04

PGSTAT-08 / MASTAT-08

Stochastic Process
Two state Markov sequences, markov chains, determination of n-step transition probabilities, ChapmanKolmogorov equations, first return and first passage probabilities, classification of states, communication states, periodicity, stationary probability distributions and limit theorems for ergodic chains, continuous time Markov processes. Poisson (point) process, birth and death processes, random walk and gamblers ruin problem.

Books recommended:
123Medhi. J. : Stochastic Processes. Srinivasan. S.K. and K.M. Mehta : Stochastic Processes. Parzen E. : Stochastic Processes.

PGSTAT-09 / MASTAT-09

Decision Theory
Decision theoretic problem as a game, basic elements, optimal decision rules, unbiasedness, invariance, ordering. Bayes and minimax principles, generalized. Bayes rules, extended Bayes reles, admissibility, completeness, minimal complete class, separating and supporting hyperplane theorems, minimax theorem, complete class theorem, equalizer rules, examples, multiple decision problems.

Books recommended :
123Ferguson. T.S : Mathematical statistics A decision theoretic approach. Berger J.O. : Statistical decision theory Fundamental concepts and methods, Springer Verlag. Degroot M. : Optimal statistical decisions. : Springer Verlag.

PGSTAT-10 / MASTAT-10

Multivariate Analysis
Multivariate normal distribution, Characteristic function, Maximum likelihood estimators of the mean vector and covariance matrix, Multiple and partial correlation coefficients and partial correlation coefficients and their null sampling distributions, Wishart distribution. Hottelings T.- Mahalanobis D2 and their applications, Discriminant analysis.

Books recommended :
1234Anderson. T.W. : Multivariate analysis. Srivastava M.S. and C.G. Khatri : Introduction to multivariate statistics. Seber G.A.F. : Multivariate observations. Giri N. : Multivatiate statistical inference.

PGSTAT-14(P) / MASTAT-14(P)

## Optional papers (Select any two)

PGSTAT-11 / MASTAT-11

Nonparametrics
Order statistics, Distribution of maximum, minimum and r-th order statistic, Joint distribution of r-th and s-th order statistic, distribution of range, confidence intervals for quintiles, Fooleries limits. Sign test. Welcoxon test, Median test, Run test, one sample and two sample location tests. Application of U-statistic to rank tests. One sample and two sample Kolmagorov-Smirnov tests. Run tests. Pitman ARE.

Books recommended :
1234Gibbons J.D. : Nonparametric statistical inference. Randles N.C. and D.A. Wolfe : Introduction to the theory of nonparametric statistics. Rehman E.l. : Nonparametric statistical methods based on ranks. Garesh. J: Nonparametric statistics.

PGSTAT-12 / MASTAS-12

Econometrics
Linear regression model. Assumptions, estimation of parameters by least squares and maximum likelihood methods tests of hypotheses and confidence estimation for regression coiffeuse R2 and adjusted R2 point and interval predictors, use of dummy variables, estimation of parametric by generalized equation (SURE) model and its estimation, simultaneous equations model, concept of structural and reduced forms, problem of Winterization rank and order conditions of indentifiability, indirect least squares, two stage least ranks.

Books recommended :
123J.Johnstem : Econometrics Method. Hadge. G.G. W.E. Griffiths L.C. Hill Lutkepohl and T.C. Lec. : The theory and practice econometrics. Gujrati D.N. : Basic econometrics Megraw Hill.

PGSTAT-13 / MASTAT-13

Demography
Block -1. Unit-I : Migration

Introduction, Estimation of life time and inter-censal migration from place of birth statistics, estimation of internal migration from statistics on duration of residence, at a fixed proor date. Indirect measure of net internal migration based on growth rate method, methods to estimate intercensal migration-using vital statistics, life time survival ratio method and census survival methods, estimation of international migration. Block-2. Stable Population Theory Introduction, basic concepts of stable, quasi-stable, stationary and nonstable populations, vital rates and characteristics of stationary stable population and quasi-stable population. Definition of intrinsic rates of natural increase, intrinsic birth rate and intrinsic death rate, their relationship, derivation of Lotkas formulae of fundamental relationship instable population. Computation of intrinsic rate of natural increase and construction of stable age distribution from the given fertility and mortality schedules, relationship between net reproduction rate(NRR), intrinsic rate of natural increase and mean length of generation, concept of mean interval between two generations. Block-3.Fertility & Fertility Models.

Unit -2

Unit-1

Unit-2

Unit-3

Unit-1 Unit-2

: :

Introduction, crude birth rate (CBR), gross fertility rate (GFR,) age specific fertility rate) ASFR), total fertility rate (TFR), gross reproduction rate (GRR) Period and cohort measures, use of birth order statistics, child women ratio, ownchildren method, children ever born(CEB) data and with data on current fertility, Brass P/F ration for adjusting fertility rates. Simple model on time of first birth/conception and number of births/conception n specified time, birth interval models, study of fertility through birth interval analysis. Block-4. Mortality

Unit-3

Unit-1 (STDR).

: Introduction, crude death rate (CDR), specific death rates (SDR), standardized death rate

Unit-2 : Life table, abridge life table, model life table of UNO (old and new), coale and demny model, brass model through logit transformation.

Books recommended:
1. F. Ram & K.B. Pathak : Teaching of Demography Analysis.

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M.Sc. Biochemistry
PGBCH-01 Cell biology and bimolecules.
1Cell Biology : Biochemical organization, general structure of prokaryotic and eukaryotic cell, structure of cell wall and cell membrane, nucleus, endoplasmic reticulum. Mitochondria, chloroplast, golgi apparatus, ribosome, lysosomes, cytoskeleton. Biomopecules : Carbohydrates Classification, structure and properties of monosaccharide, disaccharides and polysaccharides. Proteins- Primary, Secondary tertiary and Quaternary structures, structure of hemoglobin in lipoids-Types, structure and function of lipids. EnzymesGeneral properties, classification, enzyme catalyzed reactions and kinetics. Nucleic acids structure and function of nucleotides, structures of RNA and DNA denaturation of DNA.

2-

## PGBCH-02 Analysis Biochemistry

12345Spectorscopy- Visible and Uv specrascop and its applications. Chromatography- Principle: this layer, ion exchange and get filtration chromatography. HPLC, FPLC. Centrifugation- Principle of centrifugation, types of centrifuge, differential centrifugation, density gradient, ultracentrifugation. Electrophoresis techniques-general principles, electrophoresis of proteins, PAGE and SDS[AGE, A grease gel electrophoreses for DNA, Iselectric - focusing. Microscopy Basic principles, light and electron microscopy.

PGBCH-03 (P)
12345Estimation of carbohydrates using colorimetric methods. Determination of protein using blurt reagent. Estimation of RNA using orcinol reagent. Assay of urease activity in seeds of Cajuns Cajuns.

## PGBCH-04 : Nutrition and Physiology.

1. 2. 3. 4. 5. 6. Basic Concepts Function of nutrients. Measurement of caloric value of food. Basal metabolic rate (BMR) : factors affecting BMR. Recommended dietary allowances. Elements of Nutrition Dietary requirements of carbohydrates, lipids and proteins. Concepts of protein quality. Essential amino acids, essential fatty acids and their physiological functions. Vitamins and Minerals Dietary sources, biochemical functions, requirements and deficiency diseases associated with vitamin B Complex. Introduction to Physiology. Blood Composition and functions of plasma, erythrocytes, Leucocytes and thrombocytes. Blood coagulation. Digestive system Compositions, functions and regulation of saliva, gastric, rancreatic, intestinal and bile secretions. Respiration- Air passages and lung structure, work of breathing and its regulations.

## PGBCH-05 : Bioenergetics and Metabolism.

123Bioenergetics General concepts. Biological oxidation-reduction reactions, redox potentials. High energy phosphate compounds- ATP, Phosphate group transfer. Coenzymes and Cofactors Types and functions of NAD+, FAD, Pyridoxal phosphate and B12 coenzymes. Carbohydrate Metabolism Glycolysis, Fermenation, TCA cycle, electron transport chain, oxidative phosphorylation, gluconeogeneses. Energetic and regulation of metabolic cycles. Amino Acids Types and classification. General reactions of amino acids metabolism, transmutation, decarboxylation, desalination. Special metabolism of methionine, tryptophan and leucine. Urea Cycle Metabolism and regulation.

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5-

## PGBCH-06 (P) Practical based on PCBCH-04 and PCBCH-05.

12345Tests for amono acids. Separation and identification for amono acids by paper chromatography. Ascorbic acid (Vitamin C) measurement by titrimetric method using dye DCPIP. Microscopic study of blood cells. Urea estimation of biological samples by colorimetric method.

Books recommended :
123Principals of Biochemistry : Lehninger, Nelson and Cox. Student Edition, CBS Publishers and Distributors, Delhi. Textbook of Biochemistry and Human Biology : Talwar and Srivastava. Eastern Economy Edition, Prentice Hall, India. An Introduction to Practical Biochemistry : DT Plummer, Tat Mc Graw-Hill Publishing Co. Ltd. New Delhi.

## PGBCH-07 : Microbiology and Immunology.

Prokaryotic and eukaryotic cells, Modern approaches to bacterial taxonomy, Methods in microbiology, Microbial growth, Metabolic diversity among microorganisms, Host-Parasite relationship, Microbial diseases with reference to tuberculosis, cholera, AIDS, Rabies, food born discases, Bacterial transduction, conjugation and recombination. Antibiotics-mode of action, mechanism of drug resistance.

## PGBCH-08 : Enzymology and Enzyme Technology.

Nomenclature and classifaction of enzymes, General properties of enzymes-active sites, cofactors and specificity, enzyme kinetics, Mechanism of enzyme action and regulation-Isozymes, Multi- enzyme compels, Allosteric enzymes, Isolation, Purification and large scale production of enzymes with principles and

application of enzymes in medicine, food, detergent, dair, leather industry. Enzyme immobilization methods, applications, advantages and disadvantages.

## PGBCH-10 : Basic Biotechnology.

Role of biotechnology in medicine, industry, agriculture and environment, production of bread, beer, cheese and antibiotics, enzyme biotechnology, call culture-methods and application, Biotransformation, Immunochemical applications. Microbial polysaccharides and single cell oils, Upstream and downstream processing, Microbial biotechnology, Principles and applications of biotechniques, Food biotechnology.

## PGBCH-11: Introductory Biochemistry

Classification, structure and properties of amono acids, Structure and function of proteins, DNA-protein and protein-protein interaction, protenin folding and related diseases, protein sequencing, proteomics. Nucleis acids. Watson-Crick model of DNA, structural polymorphism of DNA and RNA, Biosyntheses of purines and pyrimidines, DNA-drug interaction. Carbohydrates- classification and structure, their syntheses and breackdown. Classification structure and functions of lipids, oxidation of lipids, biosyntheses of farty acids. Metabolomiss.

## PGBCH-12(P) Practicals based on PCBCH-10 and PCBCH-11

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