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S214 © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Secondary prevention periodontitis S215
vical lesions (NCCL) secondary to traumatic tooth brushing; (3) the management
of hypersensitivity, through professionally and self administered agents and (4)
the management of oral malodour, through mechanical and/or chemical agents.
Results and Conclusions: Patients undergoing supportive periodontal therapy
including PMPR showed mean tooth loss rates of 0.15 0.14 teeth/year for
5-year follow-up and 0.09 0.08 teeth/year (corresponding to a mean number of
teeth lost ranging between 1.1 and 1.3) for 12–14 year follow-up. There is no
direct evidence to confirm tooth brushing as the sole factor causing gingival reces-
sion or NCCLs. Similarly, there is no conclusive evidence from intervention stud-
ies regarding the impact of manual versus powered toothbrushes on development
of gingival recession or NCCLs, or on the treatment of gingival recessions. Local
and patient-related factors can be highly relevant in the development and progres-
sion of these lesions. Two modes of action are used in the treatment of dentine
hypersensitivity: dentine tubule occlusion and/or modification or blocking of pul-
pal nerve response. Dentifrices containing arginine, calcium sodium phosphosili-
cate, stannous fluoride and strontium have shown an effect on pain reduction.
Similarly, professionally applied prophylaxis pastes containing arginine and cal-
cium sodium phosphosilicate have shown efficacy. There is currently evidence
from short-term studies that tongue cleaning has an effect in reducing intra-oral
halitosis caused by tongue coating. Similarly, mouthrinses and dentifrices with
active ingredients based on Chlorhexidine, Cetylpyridinium chloride and Zinc
combinations have a significant beneficial effect.
Introduction
(PMPR) on secondary prevention of agement of hypersensitivity, through
periodontitis; (2) the occurrence of professionally and self administered
The objective of this consensus report gingival recessions and non-carious agents and (4) the management of
was to evaluate: (1) the effect of pro- cervical lesions (NCCL) secondary to oral malodour, through mechanical
fessional mechanical plaque removal traumatic tooth brushing; (3) the man- and/or chemical agents.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
S216 Sanz et al.
Effect of professional mechanical or more). The weighted mean tooth Influence of patient susceptibility in the
plaque removal (PMPR) on loss rate for studies with a 5-year efficacy of secondary prevention of
secondary prevention of follow-up was 0.15 0.14 teeth/year. periodontitis
periodontitis For studies with a longer follow-up, Based on one prospective observa-
Secondary prevention of periodontitis the weighted mean tooth loss rate was tional study (Rosling et al. 2001),
aims at preventing disease recurrence 0.09 0.08 teeth/year, correspond- where the frequency of recall visits
in patients previously treated for ing to a mean number of teeth lost was tailored to patient treatment
periodontitis. Disease recurrence relates ranging between 1.1 and 1.3 over a needs, a significantly increased inci-
to disease progression in a patient 12–14 year period. Moreover, data dence of tooth loss and amount of
previously successfully treated for derived from a systematic review attachment loss were observed for
periodontitis. Disease progression is (Chambrone et al. 2010) demon- patients highly susceptible to periodon-
defined as the continuation of signifi- strated that more than half of the titis.
cant attachment and/or bone loss, patients did not lose teeth and only a
minority were responsible for the Recommendations
clinically detectable by probing and/
or radiographic assessment, eventu- majority of teeth lost during SPT. The available evidence and expert
ally leading to tooth loss. opinion led the working group to
The optimal endpoints of active Optimal frequency of SPT in the long-term make the following recommendations:
periodontal therapy (APT) in the management of periodontitis • After effective active periodontal
management of periodontitis are the therapy (APT) patients should
reduction of signs of inflammation, The great majority of studies in this
systematic review (Farina et al. 2015) follow a specific supportive perio-
as defined by full mouth bleeding on dontal therapy (SPT) regimen,
probing scores (≤15%), the elimina- reported a frequency of SPT of 2–4
times per year, however, there were including PMPR+, based on 2–4
tion of deep pockets (PD ≥ 5 mm) sessions per year. However, the
and the absence of signs of active no prospective studies addressing the
selection of a specific treatment inter- frequency of SPT sessions should
infection as defined by the presence of be tailored to a patient’s risk
val or the customization of this inter-
suppuration. Whenever possible these
val based on the patient risk profile. • Since the level of compliance is
endpoints should be reached before unpredictable in the long-term,
the patient starts supportive perio- There are indications from retrospec-
tive observational studies that the specific measures should be
dontal therapy (SPT) in order to adopted/implemented to improve
optimize secondary prevention of frequency of recall visits based on the
patient risk profile may optimize the level of patient adherence to
periodontitis. It is, however, recog- the maintenance regimen in order
nized that not all patients will achieve long-term tooth retention.
to enhance the effectiveness of
these endpoints, but indeed they will the intervention
still benefit from SPT. Importance of compliance with preventive • Patient motivation and instruc-
Professional mechanical plaque professional intervention tion in oral hygiene practises
removal in the context of secondary should be combined with PMPR
prevention of periodontitis (PMPR+) Patients irregularly complying with
is the routine professional mechani- the planned SPT regimen, including
cal removal of supragingival plaque PMPR+, have shown greater rates of
Recommendations of future research
and calculus with sub-gingival tooth loss and disease progression
debridement to the depth of the sul- when compared to regularly complying Further research is necessary to eval-
cus/pocket. This is part of SPT, patients over a 5-year follow-up period uate the impact of PMPR on the
which should also include the evalu- (Costa et al. 2014). Data derived from long-term secondary prevention of
ation of oral hygiene performance, retrospective observational studies periodontitis. Areas of further
motivation and re-instruction in oral support these observations. research should include:
hygiene practices and, when appropri- • Studies aimed to further assess
ate, smoking cessation, control of co- Importance of self-performed plaque the efficacy of PMPR, including
morbidities and promotion of healthy control in the efficacy of secondary evaluation of methods and instru-
lifestyles. As part of this intervention, prevention of periodontitis ments/devices for supragingival/
a periodontal examination must be The importance of self-performed subgingival periodontal debride-
conducted with the aim of early plaque control cannot be properly ment, as well as the frequency of
detection of deepening pockets inferred from the systematic review sessions
(PD ≥ 5 mm), which should undergo (Farina et al. 2015) since, in the • Development of reliable outcome
active periodontal therapy. majority of the studies, patient measurements to assess the pro-
motivation and instruction in oral gression of periodontitis once
hygiene practices were combined with APT has been completed
Rate of tooth loss in the long-term
SPT. However, a substantial perio-
management of periodontitis The design of RCTs to assess sec-
dontal deterioration was observed in
Studies included in the systematic patients enrolled in a mainte- ondary prevention of periodontitis
review (Trombelli et al. 2015) nance regimen based solely upon should include:
reported no to low incidence of self-performed plaque control with- • Allowance for a potentially large
tooth loss during follow-up (3 years out SPT. incidence of dropouts up to a 30%)
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Secondary prevention periodontitis S217
• Assessment of patient compliance manual versus powered toothbrushes bone dehiscence, tooth-related fac-
• Studies of the potential impact of in relation to the development or
progression of gingival recession or
tors such as crowding or displacement
from the arch (e.g. as a result of natu-
residual site-specific periodontal
conditions (i.e., CAL, PD, BoP NCCLs. There is evidence from ral development or orthodontic treat-
at completion of APT) on the studies of patients with pre-existing ment), presence of restorations
long-term efficacy of routine gingival recession that users of pow- extending close to or below the gingi-
PMPR protocols ered toothbrushes experience greater val margin, and dental appliances.
• Adequate reporting of the inter- reductions in gingival recession than
users of manual toothbrushes, but
Local factors may also promote
plaque accumulation, which may
vention
• Documentation of the need for the magnitude of the difference after
1 year (approximately 0.2 mm) is of
increase the risk for an inflamma-
tory aetiology of gingival recession.
additional APT due to periodon-
titis progression during SPT minimal/no clinical relevance. There Patient-related factors can include
• Documentation of patient reported is currently no evidence from inter-
vention studies regarding the impact
compliance with oral hygiene instruc-
tions, ability to use oral hygiene
outcomes, including adverse events
and complications, pain and dis- of manual versus powered tooth- products, and deleterious habits.
comfort, gingival recession, dentin brushes on the development or pro-
hypersensitivity, aesthetic impair- gression of NCCLs. Importance of local and patient-related
ment factors on NCCLs
• Provision of data on the cost- Evidence on the importance of tooth Local and patient-related factors can
effectiveness of the intervention brushing techniques, frequency and
be highly relevant in the development
properties of the toothbrush on gingival
recession
and progression of NCCLs associated
with tooth brushing, though this was
Evidence for the occurrence of Observational studies have associ- not addressed specifically in the sys-
gingival recession and non-carious ated non-complex brushing techniques tematic review (Heasman et al. 2015).
cervical lesions as a consequence of (such as horizontal scrub) and increased Local factors can include tooth-
traumatic tooth brushing brushing force with the development related factors such as crowding or
Traumatic tooth brushing is any form and progression of gingival recession. displacement from the arch, abrasion
of toothbrush use that results in Increased frequencies of tooth brush- (e.g. highly abrasive dentifrice) and
damage to the periodontal or dental ing and increased bristle hardness gingival recession. Patient-related fac-
tissues. Gingival recession is the api- have also been associated with gingi- tors include erosion (e.g. associated
cal migration of the gingival margin val recession. It is acknowledged that with diet, frequent intake of acidic
below the cemento-enamel junction tooth brushing routinely involves soft drinks, gastric reflux, and envi-
exposing the root surface. A non- the use of dentifrices; however, the ronmental factors). It has also been
carious cervical lesion (NCCL) is a specific effects of dentifrice were not postulated that bruxism may contrib-
loss of hard tissue from the cervical addressed as part of this review. ute to the development of NCCLs
region of a tooth that is not related through abfraction, though research
to caries. Evidence regarding the importance of evidence is very limited in this regard.
tooth brushing technique, frequency
Evidence that tooth brushing causes and properties of the toothbrush on Recommendations
gingival recession or NCCLs NCCLs
The available evidence and expert
It is difficult to assess the natural While there is evidence that specific opinion led the working group to
history of gingival recession or tooth brushing techniques, increased make the following conclusions and
NCCLs, for which best evidence sug- tooth brushing frequency and increased recommendations:
bristle hardness have been associated
gests a multi-factorial aetiology.
There is currently no direct evidence with development of NCCLs, the data • Gingival recession can result in
compromised aesthetics, dentine
to confirm tooth brushing as the sole from individual studies are conflict-
hypersensitivity, plaque accumu-
factor causing gingival recession or ing, which prevents reaching clear
lation and development of caries
NCCLs, though it is recognised that conclusions.
and/or NCCLs, endodontic com-
this may occur, since the observation plications, gingival inflammation
that tooth brushing has contributed Importance of local and patient-related and periodontal attachment loss
to the development of gingival reces-
sion or NCCLs is usually made after
factors on gingival recession
• NCCLs can result in compro-
Local and patient-related factors mised aesthetics, dentine hyper-
the diagnosis. can be highly relevant in the sensitivity, plaque accumulation
development and progression of gin- and subsequent gingival inflam-
Evidence regarding the importance of gival recession associated with tooth mation, development of caries,
powered versus manual brushes brushing, though this was not endodontic complications and
in relation to gingival recession or addressed specifically in the system- increased risk of tooth fracture
NCCLs
atic review (Heasman et al. 2015). • It is recommended to instruct
There are no epidemiological studies Local factors can include gingival and motivate patients in the
that have evaluated whether there biotype, dimensions of gingiva, pres- performance of appropriate tooth
are differences between users of ence of anatomical factors such as brushing techniques, tooth brush-
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
S218 Sanz et al.
• Use of negative and positive control • Tongue cleaning has an effect in • A better understanding of its
reducing intra-oral halitosis caused aetiology and pathogenesis
hepatic cirrhosis). • Provide periodontal therapy Holland, G. R., Narhi, M. N., Addy, M., Ganga-
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
S220 Sanz et al.
Quirynen, M., Roldan, S., Schulze, H., Sterer, Trombelli, L., Franceschetti, G. & Farina, R. Address:
N., Tangerman, A., Winkel, E. G., Yaegaki, (2015) Effect of professional mechanical plaque Mariano Sanz
K. & Rosenberg, M. (2014) Halitosis manage- removal performed on a long-term, routine Professor and Chairman of Periodontology
ment by the general dental practitioner—results basis in the secondary prevention of periodonti-
Faculty of Odontology
of an international consensus workshop. Journal tis. A systematic review. Journal of Clinical
of Breath Research 8, 017101. doi:10.1088/1752- Periodontology DOI: 10.1111/jcpe.12339
University Complutense of Madrid
7155/8/1/017101. West, N. (2015) Management of hypersensitivity: Plaza Ramon y Cajal, E-28040 Madrid
Slot, D. E., Geest, S., Van der Wijden, F. & efficacy of professionally and self administered Spain
Quirynen, M. (2015) Management of oral mal- agents. Journal of Clinical Periodontology DOI: E-mail: marianosanz@odon.ucm.es
odour. Efficacy of mechanical and/or chemical 10.1111/jcpe.12336
agents: a systematic review. Journal of Clinical
Periodontology DOI: 10.1111/jcpe.12378
Clinical Relevance the sole factor causing gingival reces- Conclusions: The consensus devel-
Secondary prevention of periodontitis sion or NCCLs, effective measures oped a series of recommendations
aims at preventing disease recurrence should be implemented to prevent based on scientific evidence and
in patients previously treated for traumatic tooth brushing. expert opinion of group partici-
periodontitis. This is accomplished There is evidence for efficacy for both pants. The oral health care team
by routine professional mechanical self and professionally applied agents in and public health officials should
plaque removal as part of supportive the treatment of dentin hypersensitivity. implement these at the population
periodontal therapy, resulting in a There is evidence for efficacy for and individual level.
minimal incidence of tooth loss. mouthrinses and dentifrices with
Although there is no direct evi- active ingredients in the management
dence to confirm tooth brushing as of oral malodour.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd