AMIR Reporting Protocol 2022 Implementation of AMR case definitions for TESSy Given the typology of data for AMR surveillance, which refers to laboratory isolates rather than to cases of cease, te flowing case deriton hasbeen implemented Inthe Recor ype NQUNTECTE fay reporting to TESSy: ‘The bacterial species under surveillance are: ‘+ Streptococcus pneumoniae (STRPNE) + Staphylococcus aureus (STARUR) + Enterococcus faecalis (ENCFAE) «Enterococcus faecium (ENCFAI) «Escherichia col (ESCCOL) «Klebsiella pneumoniae (KLEPNE) + Pseudomonas aeruginosa (PSEAER) + Acinetobacter species (ACISPP). ‘Allisolates from blood and/or cerebrospinal fluid for which a susceptibility test has been performed, have to be included. “The generic case definition of antibiotic resistance defined in the Commission implementing decision laying down cace defritions for reporting communicable ciseases to the Community network: EARS- Net requires the use of EUCAST dinical breakpoints inline with the EU case definitions; starting from 2020 (2019 data), countries and laboratories using other guidelines are not eligible to participate in EARS-Net surveillance, Reporting of quantitative susceptibility data is strongly encouraged. Duplicates from the same patients should be eliminated taking only the first by date of sample collection and isolate source. Table 8 lists all microorganism and antibiotic agent combinations under surveillance by EARS-Net. When, according to the EUCAST guidelines, a specific type of test is to be used, the method is indicated next to the antimicrobial. If records referring to additional combinations are uploaded, they will be filtered out by the system - oq TERK site Table 8: Microorganism and antimicrobial agent combinations under surveillance by EARS-Net (isolates from blood and/or cerebrospinal fluid) ‘Streptococcus pneumoniae (STRPNE) | Oxacilin (OXA) ~ Disk difusion Penicilin (PEN) ~ MIC test Clarithromycin (CLR) ~ MIC test Erythromycin (E2Y) -thromycn (AZM) ~ MIC test Lewaflownein (LUM) Moxifoxacn (MFX) Norfloxacin (NOR) — Disk diffusion CCofotaxime (CTX) - MIC test Ceftriaxone (CRO) = MIC test ‘Staphylococcus aureus (STARUR) Cefexitin (FOX) — Disk dusion Oxacilin (OXA)® ~ MIC test Levofloxacin (LVX) Ofioxacin (OFX) Ciprofiexacin (CIP) 1. Commission Implementing Decision on the communicable diseases and related special health issues to be covered by epidemiological surveillance - Annex 1 (replacing Commission Decision No 2000/96/EC). Available at:AMIR Reporting Protocol 2022 ‘Narfloxacin (NOR) ~ Disk diffusion Vancomycin (VAN) ~ MIC test Rifampin (RIF) Linezolid (LNZ) DDaptomycin (DAP) ~ MIC test Enterococcus faecalis (ENCFAE) ‘ampicilin (AMP) “Amoxicilin (AMX) ~ MIC test Gentamicin-High (GEH) Vancomycin (VAN) ‘Teicoplanin (TEC) Lunezolid (LNZ) Faterococcus faecium (ENCFAT) “aripicllin (AMP) ‘Amoxil (AMX) ~ MIC test GGentamicin-High (GEH) ‘Vancomycin (VAN) ‘Telcoplanin (TEC) LUnezolid (LNZ) ‘acharichia coli (ESCCOL) ‘amipicllin (AMP) /Amaxicilin (AMX) ~ MIC test ‘Amoxiclin-clavulanc acid (AMC) Piperacilin-tazobactam (TZP) CCefotaxime (CTX) Ceftazidime (CAZ) Ceftriaxone (CRO) Cefepime (FEP) GGeritamicin (GEN) “Tobramycin (TOB) ‘Amikacin (AMK) Ciprofloxacin (CIP) Levofloxacin (L020) Ofloxecin (OFX) Norfloxacin (NOR) Moxifloxacin (MFX) Imipenem (1PM) Meropenem (MEM) Ertapenem (ETP) Tigecyaline (TGC) Colistin (COL) - Broth microditution ‘iebsiella pneumoniae (KLEPNE) “Rmvoxiclin-clavolanc acid (AMC) Piperaclin-tazebactam (TZP) Cefotaxime (CTX) Ceftazidime (CAZ) Ceftriaxone (CRO) ~ Page 23 0137[AMR Reporting Protocol 2022 ‘Cefepime (FEP) Gentamicin (GEN) Tobramycin (TO8) Aikacin (AMK) Oproftoxacin (CIP) Levofloxacin (LVX) Ofloxacin (OFX) Norfloxacin (NOR) Moxifloxacin (MEX) Imipenem (1PM) Meropenem (MEM) Ertapenem (ETP) CColstin (COL) ~ Broth microdilution ‘Pseudomonas aeruginosa (PSEAER) | Piperacilin/Tazobactam (12) Piperacilin (PIP) Ceftazidime (cAZ) Cefepime (FEP) ‘Tobramycin (108) ‘Amikacin (AMK) Ciprofloxacin (CIP) Levofloxacin (LVX) Imipenem (1Pm) Meropenem (MEM) CColistin (COL) + Broth microdilution ‘Acinetobacter species (ACISPP) ‘Gentamicin (GEN) ‘Tobramycin (TO) ‘Amikacin (AIK) Ciprofloxacin (CIP) Levofloxacin (LVX) Imipenem (1P™) Meropenem (MEM) Clistin (COL) - Broth microdilution * Meticilin (MET), fucloxacilin (FLC), cloxecilin (CLO) or dicloxacilin (DIC) are accepted as markers for ‘oxacilin (OXA) resistance if oxacilin is not reported.