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Int. J. Oral Maxillofac. Surg.

2018; 47: 613–621


https://doi.org/10.1016/j.ijom.2017.10.014, available online at https://www.sciencedirect.com

Clinical Paper
Orthognathic Surgery

Correlation between B.-J. Choi1, B.-S. Lee1, Y.-D. Kwon1,


J.-W. Lee1, S.-U. Yun2, K.-S. Ryu1,
J.-Y. Ohe1

intraoperative proximal segment


1
Department of Oral and Maxillofacial
Surgery, School of Dentistry, Kyung Hee
University, Seoul, South Korea; 2Yuseong Sun
Hospital, Daejeon, South Korea

rotation and post-sagittal split


ramus osteotomy relapse: a
three-dimensional cone beam
computed tomography study
B.-J. Choi, B.-S. Lee, Y.-D. Kwon, J.-W. Lee, S.-U. Yun, K.-S. Ryu, J.-Y. Ohe:
Correlation between intraoperative proximal segment rotation and post-sagittal split
ramus osteotomy relapse: a three-dimensional cone beam computed tomography
study. Int. J. Oral Maxillofac. Surg. 2018; 47: 613–621. ã 2017 International
Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights
reserved.

Abstract. This study evaluated the effects of proximal segment rotation and the extent of
mandibular setback on post-sagittal split ramus osteotomy (SSRO) relapse using three-
dimensional (3D) analysis. Thirty-one patients diagnosed with a skeletal class III
malocclusion who underwent SSRO alone were enrolled in this study. The movements
of the mandibular condyles were assessed using cone beam computed tomography
(CBCT) and a 3D imaging program at 1 month before the operation (T0), 1 week
after the operation (T1), and 6 months (T2) and 1 year (T3) postoperative. Yaw and roll
were increased at T1 as compared to T0. However, the proximal segments reverted to
their original positions between T2 and T3. There was a positive correlation between
the extent of the posterior movement of the mandible and relapse at 6 months and
1 year postoperative. Although the proximal bone segments showed displacement in
three dimensions at T1, they reverted to their original positions over time. In addition,
Key words: SSRO; condyle position; CBCT;
although there was a positive correlation between the extent of the posterior movement relapse; pitch; yaw; roll movement.
of the mandible and the occurrence of post-surgical relapse at 6 months and 1 year
post-surgery, the rotation of the proximal bone segment during surgery had no Accepted for publication
relationship with postoperative relapse. Available online 13 November 2017

0901-5027/050613 + 09 ã 2017 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
614 Choi et al.

Skeletal class III deformities can result from the superimposition of the anatomical of the surgical wound, bone fragment
either mandibular prognathism or maxillary structures, such as distortion in the hori- instability, malunion, or malocclusion,
deficiency, or the simultaneous occurrence zontal/vertical plane16. and none of them showed significant re-
of both conditions1,2. The sagittal split ra- Three rotational descriptors (pitch, roll, lapse requiring revision surgery.
mus osteotomy (SSRO) for the correction of and yaw) are used to supplement the planar
mandibular prognathism was first intro- terms (anteroposterior, transverse, and ver-
Surgical methods and materials
duced in the 1950s by Trauner and Obwe- tical) in describing the orientation of the line
geser and has been used widely since, as it of occlusion and the aesthetic line of the The BSSRO was performed according to
enables an intraoral approach and promotes dentition17,18. Recent three-dimensional the Obwegeser–Dal Pont method. With
bone healing by providing a large overlap of (3D) reconstructions have greatly contrib- regard to internal fixation, miniplates
bone segments3–5. Although the SSRO has uted to the understanding of the forward, and monocortical screws (Jeil Medical
been performed for decades, issues regard- backward, transverse, and rotational move- Corp., Seoul, South Korea) were used
ing postoperative stability and relapse con- ments of the distal segment of the mandible. for all subjects. Three screws were used
tinue to be raised, with many studies The complex movements required for the on each side of the mandible to fix the
reporting on these issues. surgical correction of dentofacial deformi- miniplate in place. Semi-rigid fixation was
Studies have reported long-term relapse ties clearly need to be assessed in 3D to accomplished with a titanium miniplate at
rates of between 2.0% and 50.3%, even improve postoperative stability and reduce the anterior mandibular ramus.
when rigid fixation was indicated for symptoms of temporomandibular joint dis- The proximal segment was placed in the
patients with mandibular prognathism orders after surgery19,20. primary section by measuring three points
post-orthognathic surgery. Factors affect- Cone beam computed tomography from the orthodontic brackets of the max-
ing post-SSRO stability have been inves- (CBCT) is a recently developed technolo- illa to a point on the ascending ramus
tigated in many studies. These factors gy that is used for 3D analyses of the using a condylar repositioning ruler
include the stability of the occlusion due craniofacial morphology and move- (Fig. 1). The distal segment was moved
to preoperative orthodontic treatment, soft ment21. The use of this technology is backwards, and semi-rigid fixation using
tissue tension around the mandible, the associated with a lower radiation exposure one monocortical miniplate and three min-
fixation method for the bone segments, and cost as compared to those of conven- iscrews per side was conducted after sur-
duration of intermaxillary fixation tional computed tomography (CT) or mag- gery. To prevent displacement of the
(IMF), condyle displacement, a change netic resonance imaging. Many recent proximal segment after mandible move-
in the position of the tongue due to man- studies have reported that 3D CT analysis ment, the monocortical miniplate was
dibular retraction, and the activity of mus- of patients receiving orthognathic surgery fixed by maintaining the overlap distance
cles such as the facial muscles, has good reliability and reproducibility22– between the segments. After locating a
24
masticatory muscles, and suprahyoid mus- . reference point on the ramus, three or
cles. Postoperative stability is reported to This study evaluated the effects of prox- more points on the maxillary orthodontic
depend on the combined result of these imal segment rotation and the extent of brackets were measured to this point be-
factors6–9. mandibular setback on post-SSRO relapse fore separation, so that the proximal seg-
The exact positioning of the proximal using 3D analysis. ment could be fixed in its original location.
segment after surgery has also been Additionally, to prevent condylar dis-
reported to be an important contributing placement caused by bony interferences
factor to postoperative stability. Komori Materials and methods between the proximal and distal segments,
et al. reported that skeletal relapse during an additional vertical osteotomy of the
Subjects
the initial IMF was greatly affected by the distal segment or grinding of the bone
surgical method, and that it could be re- This prospective study, performed be- interference on the lingual surface of the
solved by maintaining the position of the tween January 2011 and December proximal segment was performed. To sta-
proximal bone segment after surgery10,11. 2014, examined the mandibles of 31 bilize the postoperative occlusion, approx-
The position of the proximal bone segment patients who underwent bilateral SSRO imately 5–7 days of IMF with an inter-
and the extent of the posterior movement of (BSSRO) alone for the correction of skel- occlusal splint was applied. Physiotherapy
the mandible have also been described as etal class III malocclusion at the Depart- including mouth-opening exercises with
factors affecting post-surgical relapse12–14. ment of Oral and Maxillofacial Surgery of orthodontic elastics was started after re-
In other studies, condyle displacement due Kyung Hee University Dental Hospital. leasing the IMF, and was continued for 6
to the rotation of the proximal bone segment The BSSRO was performed by the same weeks. Postoperative orthodontic treat-
and the extent of the posterior movement of skilled surgeon, using semi-rigid fixation. ment was started 6–7 weeks after surgery.
the mandible have been reported as factors The subject group consisted of 14 male
contributing to postoperative relapse8,15. and 17 female patients, who ranged in age
Radiographic examination
Yang and Hwang reported that the clock- from 18 to 35 years at the time of surgery.
wise rotation of the proximal bone segment For all subjects, the difference in lateral The mandibular condyles were assessed
during surgery was associated with postop- movement between the left and right by CBCT in panoramic mode within 1
erative relapse2. mandibles was noted to be less than month before the operation (T0), within
For decades, studies examining the ex- 2 mm. Exclusion criteria included severe 1 week after the operation (T1), and at 6
tent of mandibular setback or the move- facial asymmetry, congenital malforma- months (T2) and 1 year (T3) postopera-
ment of the proximal segment, which tions such as cleft lip or cleft palate, tive. The Alphard-Vega 3030 Dental CT
affect postoperative relapse, have used systemic diseases, history of trauma, and system (Asahi Roentgen Ind. Co., Ltd,
two-dimensional (2D) radiography tools resorption of the mandibular condyle. Kyoto, Japan) was used in this study.
such as cephalograms. However, these During the follow-up period, the The patient’s Frankfort horizontal plane
studies are limited by the distortion of patients did not experience any infections was set parallel to the floor using a cepha-
Proximal segment rotation and post-SSRO relapse 615

rotation about the three perpendicular axes


(horizontal, longitudinal, and vertical)17.
A 3D coordinate system (x, y, z) was
employed to quantify spatial changes in
the condyle position. Spatial changes were
presented in degrees with coordinates to
evaluate the amount (distance, in milli-
metres) and direction (x, y, z) (Fig. 3).
Anatomical points and lines were placed
on the 3D images to define the degree of
surgical change (Figs 4 and 5).
Rotation around the side-to-side axis is
called pitch. Rotation around the front-to-
back axis is called roll. Rotation around
the vertical axis is called yaw. Thus, the
following measurements of the proximal
segment were made in this study: (1)
pitch rotation, i.e. the angle formed by
the Frankfort horizontal plane and the
line connecting the highest point of the
condylar head and the coronoid process;
(2) roll rotation, i.e. the angle formed by
the Frankfort horizontal plane and the
line connecting the outer and inner poles
of the condylar head; (3) yaw rotation, i.e.
the angle formed by the sagittal plane and
the line connecting the highest point of
the condylar head and the coronoid
process.

Statistical analysis
The mean and standard deviation were
calculated for each of the measured values
for each time period. The statistical sig-
nificance of the correlation was deter-
mined by analyzing the extent of the
posterior movement of both the proximal
Fig. 1. (a) Condylar repositioning ruler. (b) Measurement method for placement of the proximal bone segment and the mandible, and the
segment in the primary position: three points were measured from the orthodontic brackets on
post-surgical relapse between 6 months
the maxilla to a point on the ascending ramus using the condylar repositioning ruler.
and 1 year after surgery, using Pearson’s
correlation test at a 95% confidence level.
lostat. Tube parameters were specified after surgery (T1), 6 months after surgery IBM SPSS Statistics version 20.0 software
(tube voltage of 80 kVp, tube current of (T2), and 1 year (T3) after surgery. (IBM Corp., Armonk, NY, USA) was used
5 mA, and exposure time of 17 s) and the for the statistical analysis.
image was taken in panoramic mode. This
Measurement of posterior movement of the
study was approved by the Clinical Re-
mandible and post-surgical relapse Results
search Ethics Committee of Kyung Hee
University Dental Hospital. 3D coordinates (x, y, and z axis values) of Three-dimensional movements of the
the left and right mental foramina and the proximal segment
pogonion were measured at the different
time points: 1 month before surgery Yaw and roll were increased immediately
Imaging procedure after surgery (T1), as compared to  1
(T0), immediately after surgery (T1), 6
The CBCT scan data were stored in 0.3- months after surgery (T2), and 1 year after month before surgery (T0). However,
mm-thick raw DICOM files, and OnDe- surgery (T3) (Fig. 2). the proximal segments reverted to their
mand3D imaging software (CyberMed original positions over time (T2–T3)
Inc., Seoul, Korea) was used for the 3D (Tables 1 and 2).
Three-dimensional aspects of the proximal
image analysis and multiplanar image re-
construction. All measurements were per- segment rotation
Relationship between posterior
formed by the same examiner to reduce The rotations of the left and right proximal
movement of the mandible and relapse
human error, and the data collected were bone segments were measured in 3D:
converted into images using OnDe- movement in 3D space, i.e. translation The average extent of the posterior move-
mand3D at the different time points: 1 (forward/backward, right/left, up/down) ment of the mandible was
month before surgery (T0), immediately was recorded in combination with the 6.77  4.23 mm, and the average extent
616 Choi et al.

Fig. 2. Superimposition of the pre- and postoperative CT images in the 3D coordinate system. The 3D coordinate system (degrees) shows the
direction and measurement. (a) Frontal view; (b) lateral view.

of relapse at 6 months postoperative was Rotation of the proximal segment in an increase in the posterior movement of
1.04  1.03 mm (Table 3). There was a relation to posterior movement of the the mandible. However, This tendency
positive correlation between the extent of mandible was reversed at 6 months and 1 year
the posterior movement of the mandible postoperatively and increased with an in-
Immediately after surgery, the pitch
and relapse at 6 months and 1 year post- crease in the posterior movement of man-
movement was observed to decrease with
operative. dible. The yaw movement showed a
Proximal segment rotation and post-SSRO relapse 617

Many studies have reported factors that


influence post-SSRO relapse6–8,26. Joss
and Vassalli reported short-term relapse
rates ranging from 1.5% to 32.7% with
bicortical screws, 1.5% to 18.0% with
miniplates, and 10.4% to 17.4% with
absorbable screws, and long-term relapse
rates of 2.0% to 50.3% with bicortical
screws and 1.5% to 8.9% using mini-
plates12.
Fig. 3. Orientation of the proximal segment in three dimensions. Pitch (rotation about the x
Van Sickels et al. defined ‘early relapse’
axis): proximal direction (+), lateral direction ( ). Roll (rotation about the y axis): clockwise
rotation (+), counter-clockwise rotation ( ). Yaw (rotation about the z axis): medial direction as the tendency to relapse within 6–8
(+), lateral direction ( ). weeks post-surgery, and proposed that this
could be prevented by positioning the
proximal segment in the primary position
negative correlation with the posterior Discussion
during surgery27. However, Mobarak et al.
movement of the mandible only immedi-
Various complications have been reported reported that the rearrangement of the
ately after surgery (Table 4).
following orthognathic surgery for the muscles caused by the clockwise rotation
improvement of aesthetic and functional of the proximal segment, although influ-
aspects of patients with a skeletal class III encing early postoperative changes, does
Extent of the relapse at 6 months and malocclusion, such as relapse, temporo- not seem to be associated with marked
1 year post-surgery and the rotation mandibular joint dysfunction, and pares- relapse15.
pattern of the proximal segment thesia25. Relapse is an important factor, In this study, 3D CBCT, which results
Correlation between the extent of relapse not only in terms of aesthetic and func- in less anatomical superimposition and
at 6 months after surgery and rotation of tional improvements, but also because low distortion, was used to analyze post-
the proximal segment was similar to that of its association with the success of the surgical relapse in relation to the rotational
observed 1 year post-surgery. Pitch and surgery. In particular, BSSRO for setback aspect of the proximal segment after
roll movements at 6 months and 1 year of the mandible is known to be associated orthognathic surgery. The change in posi-
after surgery showed positive correlations with a high tendency to relapse in tion of the proximal segment from its
with the amount of relapse at 6 months and patients with a skeletal class III primary position could be seen in all
1 year post-surgery (Tables 5 and 6). malocclusion9. dimensions – yaw, pitch, and roll – imme-
diately after surgery. However, a return of
the proximal segment to its primary posi-
tion was observed at 6 months postopera-
tive, and the position of the proximal
segment then stabilized up to 1 year post-
operative. The direction of rotation of the
proximal segment postoperative was ob-
served to vary with the type of movement:
yaw and roll movements tended towards
the proximal side, while pitch tended to-
wards rotation in a clockwise direction.
In this study, 3D CT images were super-
imposed using OnDemand3D based on the
maximum mutual information algo-
rithm28. The accuracy and robustness of
the image fusion method with the use of
this software was investigated in a recent
study using a dry skull model29. After the
attachment of titanium markers to the dry
skulls, image fusion was performed using
OnDemand3D. Image fusion was found
not to be affected by positional change.
The mean error (0.396  0.142 mm) can
be regarded as clinically acceptable in
terms of accuracy for the evaluation of
surgical changes in the proximal segment
rotation by 3D CBCT.
Choi et al. reported an increase in hori-
zontal displacement (intergonion distance
and inter-ramus width) of the proximal
Fig. 4. Reference points: (1) Cl: outer pole of the condylar head; (2) Cm: inner pole of the segments after mandibular setback sur-
condylar head; (3) Cs: highest point of the condylar head; (4) Cc: highest point of the coronoid gery30. The findings of the present study
process; (5) Lc: line from Cl to Cm; (6) Ls: line from Cs to Cc. show a similar post-surgical increase in
618 Choi et al.

Fig. 5. Measurement of the proximal segment rotation (degrees): (a) pitch movement (Pm): angle between the Frankfort horizontal plane and Ls; (
b) roll movement (Rm): angle between the Frankfort horizontal plane and Lc; (c) yaw movement (Ym): angle between the sagittal plane and Ls.
Proximal segment rotation and post-SSRO relapse 619

Table 1. Average angle of the proximal segment at T0, T1, T2, and T3a; mean  standard horizontal displacement on both sides of
deviation ( ). the proximal segment, due to its tendency
T0 T1 T2 T3 towards proximal rotation during yaw and
Yaw 4.39  3.20 5.47  3.85 5.42  3.86 4.55  2.87 roll movements. Yoo et al. reported no
Pitch 16.03  6.74 15.78  6.55 15.29  6.53 14.78  5.45 significant correlation between the hori-
Roll 7.05  5.47 7.61  5.25 7.10  4.8 6.81  3.91 zontal displacement of the proximal seg-
a
T0: within 1 month before the operation; T1: within 1 week after the operation; T2: 6 months ments and the amount of mandibular
postoperative; T3: 1 year postoperative. setback movement31. In contrast, although
the present study showed no significant
correlation in the amount of mandibular
setback movement and the roll movement
Table 2. Changes in the proximal segmenta; mean  standard deviation ( ). of the proximal segment, the results indi-
T1 T0 T2 T1 T3 T1 cated a positive correlation with yaw
movement, indicating that the horizontal
Yaw 1.76  2.88 0.73  1.87 0.52  0.24
Pitch 1.30  2.18 2.05  1.85 1.24  0.85 displacement of the proximal segment
Roll 0.45  2.45 0.40  2.53 0.20  0.33 could be caused by the yaw movement
a rather than the roll movement of the prox-
T1 T0, T2 T1, and T3 T1 indicate the change between T0 and T1, T2 and T1, and T3
and T1, respectively. Positive values indicate an increase and negative values a decrease. T0: imal segment.
within 1 month before the operation; T1: within 1 week after the operation; T2: 6 months Studies have reported antero-inferior
postoperative; T3: 1 year postoperative. changes in the condylar positions in most
mandibular prognathism patients post-
SSRO32,33. Spitzer and Sitzmann sug-
gested that the anteromedial rotation of
the condyle causes an increase in the
mandibular condyle distance, and that this
Table 3. Relationship between posterior movement of the mandible and relapsea; mean distance increases in correspondence with
 standard deviation (mm). an increase in the retraction of the mandi-
Posterior movement Relapse Pearson correlation coefficientb ble34. The results from the present study
T1 T0 6.77  4.23 confirm this correlation, as a significant
T2 T1 1.04  1.03 0.502** positive correlation was found between
T3 T1 0.98  0.53 0.373** the extent of setback movement of the
a
T0: within 1 month before the operation; T1: within 1 week after the operation; T2: 6 months mandible and the tendency of both the
postoperative; T3: 1 year postoperative. pitch movement to rotate in the clockwise
b
Pearson correlation test: **P < 0.01. direction, and the yaw movement in the
proximal direction. While clockwise rota-
tion of the proximal segment was found to
cause an antero-inferior positional change
of the mandibular condyles attached to the
Table 4. Correlation of rotation of the proximal segment in relation to posterior movement of proximal segments, the rotation of the yaw
the mandiblea; Pearson correlation coefficientb. movement of the proximal segment
T1 T0 T2 T1 T3 T1 caused a positional change of the condyle
Yaw 0.235* 0.037 0.104 in the lateral position. Manipulation of the
Pitch 0.557** 0.212* 0.127* proximal segment during SSRO may
Roll 0.037 0.085 0.102 cause intra-articular oedema and result
a
T0: within 1 month before the operation; T1: within 1 week after the operation; T2: 6 months in inferior displacement of the condyle
postoperative; T3: 1 year postoperative. at an early stage. In the present study,
b
Pearson correlation test: *P < 0.05, **P < 0.01. the condyle tended to move back antero-
superiorly from T1 to T2, representing
recovery towards the preoperative posi-
tion. The reason for this is probably mul-
tifactorial. Postero-inferior displacement
Table 5. Correlation of the extent of the of the condyles may stretch the mastica-
relapse at 6 months post-surgery and the Table 6. Correlation of the extent of the tory muscle and the temporomandibular
rotation pattern of the proximal segmenta; relapse at 1 year post-surgery and the rotation ligament. Hence, this recovery movement
Pearson correlation coefficientb. pattern of the proximal segmenta; Pearson may well be the combined result of mas-
T2 T1 T3 T1 correlation coefficientb. ticatory muscle and ligament stretching,
Yaw 0.142 0.024 T2 T1 T3 T1 resolution of oedema, and removal of the
Pitch 0.557* 0.537* Yaw 0.224 0.104 splint.
Roll 0.217** 0.274** Pitch 0.632* 0.478* Mobarak et al. suggested a relationship
a
T1: within 1 week after the operation; T2: Roll 0.215* 0.117* between the amount of mandibular set-
6 months postoperative; T3: 1 year postoper- a
T1: within 1 week after the operation; T2: back and mandibular relapse, and also
ative. 6 months postoperative; T3: 1 year postoper- between the clockwise rotation of the
b
Pearson correlation test: *P < 0.05, ative. proximal segment and the amount of pos-
**P < 0.01. b
Pearson correlation test: *P < 0.05. terior mandibular movement15. In con-
620 Choi et al.

trast, Lai et al. reported no significant thought to be caused by factors such as 3. Trauner R, Obwegeser H. The surgical cor-
correlation between the amount of man- the change in position of the tongue, rear- rection of mandibular prognathism and retro-
dibular setback and long-term relapse35. In rangement of the muscles, tension in the gnathia with consideration of genioplasty. II.
the present study, the amount of mandib- soft tissue surrounding the mandible, and Operating methods for microgenia and dis-
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during surgery was not significantly cor- observed in the temporomandibular joint ittal split osteotomies to advance the
related with relapse. However, the pitch area, and the bone segments reverted to mandible. Oral Surg Oral Med Oral Pathol
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significant positive correlation with re- lation between the extent of the posterior tors contributing to relapse in rigidly fixed
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mal segment showed a clockwise rotation rence of post-surgical relapse at 6 months 1989;47:451–6.
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gap in the mandible, in order to minimize 10. Komori E, Aigase K, Sugisaki M, Tanabe H.
the displacement of the mandible. This is Cause of early skeletal relapse after mandib-
thought to have played a role in reducing Funding
ular setback. Am J Orthod Dentofacial
the displacement of the proximal segment This work was supported by a grant from Orthop 1989;95:29–36.
postoperatively36. Kyung Hee University (20146074). 11. Komori E, Sagara N, Aigase K. A method for
Lee et al. suggested placing the proxi- evaluating skeletal relapsing force during
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preoperatively marked point for reference, Competing interests nathic surgery: a preliminary report. Am J
to provide postoperative stability37. In this Orthod Dentofacial Orthop 1991;100:38–
study, more than three reference points None declared. 46.
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tic brackets, and measurements to the sagittal split osteotomy setback surgery with
Ethical approval
ascending ramus were made before the rigid internal fixation: a systematic review. J
osteotomy, in order to be able to place This study was approved by the Clinical Oral Maxillofac Surg 2008;66:1634–43.
the proximal segment back in its original Research Ethics Committee of Kyung Hee 13. Wen-Ching Ko E, Alazizi AI, Lin CH.
position. This might have been responsi- University Dental Hospital (Institutional Three-dimensional surgical changes of man-
ble for the lack of correlation between Review Board, IRB – KHD IRB 1411-1). dibular proximal segments affect outcome of
postoperative relapse and the rotation pat- jaw motion analysis. J Oral Maxillofac Surg
2015;73:971–84.
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mensional cone-beam computed 1992;50:1164–72.
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