АНТИЕПИЛЕПТИЧНИ ЛЕКАРСТВА (АНТИКОНВУЛСАНТИ)

I. Производни на барбитуровата киселина

Phenobarbital (5-Еthyl-5-phenylbarbituric acid)

Luminal, Adonal, Seconal

O
C2H5 NH
O
NH
O

Мephobarbital (5-Еthyl-1-methyl-5-phenylbarbituric acid)

Mebaral, Mephyltaletten, Phemiton, Prominal

O CH3
C2H5 N
O
NH
O

Primidone (5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione)
Hexamidine, Mylepsin

O
C2H5 NH

NH
O

II. Хидантоинови производни

Phenytoin (5,5-Diphenylimidazolidine-2,4-dione)
Difhydan, Alepsin, Dilantin, Solantin

NH
O N O
H
Fosphenytoin (2,5-Dioxo-4,4-diphenyl-imidazolidin-1-yl)methoxyphosphonic acid)
Cerebyx, Prodilantin

H
N O
N OH
O O OH
P
O

Ethotoin (3-Ethyl-5-phenylimidazolidine-2,4-dione)
Peganone

NH
O N O
C2H5

III. Сукцинимидни производни

Ethosuximide (3-Ethyl-3-methypyrrolidine-2,5-dione)
Aximide, Suxilene, Rontone, Pyknolepsinum

CH3
C2H5

O N O
H

Phensuximide (1-Methyl-3-phenylpyrrolidine-2,5-dione)
Milontin

O N O
CH3
IV. Оксазолидиндионови производни

Trimethadione (3,5,5-Тrimethyloxazolidine-2,4-dione)
Тrimethinum, Тroxidone

CH3
H3C O
O N O
CH3

V. Бензодиазепинови производни

Diazepam (7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one)
Relanium, Valium

H3C
O
N

Cl N

Lorazepam (7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one)
Ativan

H O
N
OH
Cl N

Cl

Clonazepam (5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepine-2-one)
Clonopin, Rivotril

H O
N

O2N N

Cl
Midazolam (8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine)
Versed

N
N

O2 N N

VI. Производни на ГАМК

Vigabatrin (RS)-4-Amino-5-hexenoic acid)

Sabril

H2N COOH

Gabapentin (2-[1-(Aminomethyl)cyclohexyl]acetic acid)

Gabarone, Neurontin, Nupentin

CH2NH2
CH2COOH

Pregabalin (S)-3-(Aminomethyl)-5-methylhexanoic acid)

Nervalin

H2 N COOH
CH3

CH3

Tiagabine (R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl] piperidine-3-carboxylic acid)

Gabitril

N
COOH

CH3
S
S
CH3
VII. Други

Carbamazepine (5H-Dibenz[b,f]azepine-5-carboxamide)
Tegretol

N
CONH2

Oxcarbazepine (10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide)
Trileptal

N
CONH2

Sodium valproate (Sodium 2-propylpentanoate)

Convulex, Depakin, Leptilan

COONa

Lamotrigine (6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine)
Lamictal

H2N N NH2

N
N

Cl
Cl

Levetiracetam (S)-2-(2-Oxopyrrolidin-1-yl)butanamide)
Keppra

N O
CHCONH2
C2H5