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[ir,vi.hi*c;v-fe
sedifi]entationRateAnalvzer {,

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 ri'ritirriir:iil!:
lri.li!:

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:iti:!:ilt:::iti: I

: , : ! , . .l 'I .l . : . ' I : . , ' :

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i.:,
:,..:,.: l;::,',',1' '.l
: - , : , , ' : , , , , , , ,t,., , , , . , - ,
ij$ül ,.,,r,,,
. : : r i : : . . : : : : :ii:j..:. : : i
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t ] : : . ! : t : : t : u : t : l u : . .t : :

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ISR ?t] * t{} PLU$ [iry,thr*cyte$edinr*nüatir¡n,
ka,teAn'*ly.aer

Cclnt*l:ts
 nSR ?0 " I ü FLUS ülythrocyte Sedirnsntati*n,RnteAnalyrer

ilhrlpter: 1. fiemffrel

ESR :ü '3i(lü I)|-U.SHryth:r:oeyl*Íledimentatiem

Rxe Analf'zer W$R)

instrutnsntctrntrottcdby nricro-coffiputer
*n,nlyxcris * filst onelnas}r*t$-$$e

$5¡$tgttl'

monitaringtlrc change
ü¿lamsa$ure1* tuhsssimultnneously,
Ithe iural.veer

rateduringthc wholetestingprocess.The
secfimentation
of tire crtr,rhrclcyte

The result is in mm/lh, it

of eachsampleis independent.
rnca$urenrcnt

rvill bc tiispiayedün LCn scrssn cfirectlyand prir*ed out by internal

print*r. "l*hes*clirnn:tatiousuÍvs of'3 minnts interval can be printed out

also.

$celpeaf ;*ppli*¡ltian;crythrucytes*dünentatitmrateanalysin

q Featr¡rcs:

t. LJtilizir:rg *f Micrc-prscs$sür tcch:rrcil,sgy"fulty controlled by

;r:rm¡:utcr prCIgfaffi$.

hleasurstimo: 3ü n:tin{c*rr*spondto WestergrenI hour result)

a\

á-"

: 'l'he H,SRresults under tnrnperatureof I5o C ^v 32oC cpn be

J .

to 18*Ü
coffIpsnsatsd
ar¡fcmlltically
 f.SR?{}* lü PLUS ürr¿th.r fir¡dirn$ntnfirrn
RateAnalyr,,$r

A
*T,
l-}r* {}rr:oughput
i$ up tü ?ü srirnples
pcr }rsnr

t R*sulÍs cilll he '$ispl*y*c{$n f-üil srrerfi and printed CIutby

iti Ir:'¡liil ¡-r,lirtf

*l'

S. Stiu:ciltrei
R"$-?32int*rfuc*, ciirllbc c*nn*{:[{}{ltc}{ixt$nra.}comput*l

Jbr r*lnr:l* *¿rmmunic¿rti*n

¡xl¿lcl*inprdlcss$
 II$R 2ü * l'ü llLU$ An$tyntst
. ry'thrucyte$ad,trnentstisn'Kq{.tt

tl} tqpt*r .? " S3rstsrffi ffitl¡t¡sf,l*rü

c*nsistsof the main unit {includingthe socketfar 1,{}

Ithe analS,zer rube,s),

iriternsl printe't:and,iffi$R
analysissystem,rtisplay,oper:atingüoffipcnent,'

tutres.
: : .:,:..,,.,,:
:,,r:t,,,,: " " '',"''.iJi,¡¡j.ii,¡¡liii=lrii¡iii+#ii
1¡,;tjffi;;
.lti',,,;':,;,,,¡;;'i,t,:r;jit;:'ri¡¡;¡,i¡"¡¡i¡rt.,.l.:
:;., ::,,,.:,'',,'',,:,,,:,i,:,.,,1fi't*,i,,;

Front pfln,sl

r ) ESI{tub* socket:to hold the samplefuhes

2,) LCn: to clisplaytenlperatttre,E$R tubest&fug,r,e$nlt,$üc¡
 - . Es,E.
¿tl+t$fI4}s. FryWrte qffEffiffi#i$nee¿nntvffir.
:
, i f
: i
ii
': I

Chapter
./'.\U ¿ 4 Y' - l'r -.

3 " Installa,ti€lrr
:
.:

I . Unpacking and inspectíng

:i
j

Carcfuliy opfin the carton when yfiH rsseive the goods, inspect the

instrumentt* nrakesurs it is in gaeidcondition,thefi checkthe aceessories

against the ¡:aclcinglist. N*tify the supplier irnmediately if you find

any'thingdanragsdor missing.Handlethe glnssH$R t$bessar$filtly.

2. Environm*nÍrequirements:

To en$urotlle instrument under cptimum working status, it must be

Ínstalledaccordingto the followingrequirernents:

l) Thc environnrentshouldbe clsnnand as fiee a$po$siblefrom the

clust

2t The instrumentshouldbe installedon a stfibleand solid platfornr

: that is free of mechanicalvibrationandaway flom vibration sCIurüe

3) Do nrit placethe instrurnentin directsunlight.
_*-_*
n +) Anrbisnttemperature:
l5oC-32oü,hümidity:lessthan85ya.

5) Tht: insfiument should be ew$y frorn ths strong electriral

int*rf*renü0

3. Installation

flay attcnti*ntc¡th$ following pointswhenyou irrstallthe Ínstr¡rment:

.4
 ESR?f) {' I 0 ptU"q Hrythrocyts SE¿liment¡¡tiun
Ratr An*lyaer

r) l"he püw*r adapter sf the instrun:rentis a thr*s*c*fs ssdkst, ths

gr*unrling tsrminal m,ustbs well tCInn$ütsdto gr,oundto ensure

*n*j r:*liahlecperatÍ,*n,"
sni'ut1,,

21 Tlre instrumentmust be placedhoriuontalto en$urethat ESR tube

v*rtic¿rl ¡*fter it been inserted into the hole. Mefinwhíle the
-
be placedstably,:retiably
instrunrentsheruld and anti-vibranf,After

tilcn, tum on the powsr, the instrurnent witl run self-test ffid

systernsetting autcmatically.
 Iiediirnentagion,
Rüts:,Arlsty,xrlr

Cha.pter 4- üperati,cn

t. Iteacling
principlc

Monitür I ü iitlr*s sirnultnne*uslyby thn mensuringboard that colu*¡sts

of
infitircclphctoccli. The vertical n:reasuring
interval is 0.l6nnm (i.e. the

rssohlti*rlE:f'theinstr:umcnt),
andtlrfimsssuringcy*lc is 3 minutsn"When

tlre tr¡h* i;rsertcct,

the analyzerar¡tomatienllysterJsthe meesurüffisnt,
The
tinle fnr tlle Jirstreacling
is setas'o{}lníil", anclths bloodlsvel in the tube
'l'hc
is heen d,*tectucl. acceptableumgü fbr the blood height settingis

5{}nlm''* 64rttnl {star-tingfrerm ths hoftom uf the HSR tube}, the

resüil]fir*nel*¿l
hr:ightis 55mm {th* cürresp*ndingv$lume is l.6ml, i.e.

t)"3?rrrlantico;rgulant
a¡rdl.?8n:l whüle bk:ocl),Tlh*t:perati4gmods is 30

min if nrcarlr¡r$$
fhe tubefor I0 tirncs,and6fl min if measures
the tube for ü

20 tírncs.iror the cletailsof measr.lring

referto "(lhapter5 - McasuringPrinciple"

snd salculatingprinciples,please
il
ü

?. Sar:rpl*f'rei:lr,ration

It requircsI.?Srnlwhotrr:'bl*od fr¡r enchsnrnple. Trhsbload c&nbe directly

injecteciinl* ths ESR tubewhich*ontainsü"3?mlantieCIagulant.

This is to

sntiur* pr{}i}'ir volume cf the b}md, in th,e H$,R tulle, There are tu¡a

ilrclicntirlg}in*$ $;! the ü$trtt¿rhe.tnjectth* blood into the tube unfil ths
 |SSRzfi " lS PLLI$ EryfhrCIcytsS,ediffisnüetionRateAnalyzer

le,,'slis l:'*tlu:$n thr) t&'ü liües, then $eftlthe tuh* tightl)¡ $rith a rubber

üo\r*r' slclrvlyl"*v*r$*the tuh* f*r at l$sst 5 tirnesto nrix the n*ticuagulant

¿li:lrfri']r*l r: b I *e:rl c*:tt¡tl*t*ly.

Noücl Air huhbles sfrould l¡e excluder! frarn the anti*ccngnlafed

bluod.

3. Labol

Every HSR rubc)has a }abel.The label shouldbe qttqchedon:the tube ftatly,

c¡therwiscth* tubs mey be not abls to insert into the hole ór cünnot reach

thc b*ttom nnd ca.usswrüng measuringrssult. Thc coffect label position

on thü ESR tubc is shownas figure4-1. Therearetwo indicatinglines on

'I'he distancebeh¡veen
the tw'a lines is 9mnt, the position is
the labell.

position of the blood height

shou,nas H in figure 4- l. The recCIrnrnended

th4} is 55mm {ccrrespnndingt$ I "6rntr,i"e" ü.32m} *nticoagu}antffitd

1.28rnlrvholebtood).The bloodlcvel shouldreachbetweentwo indicator

lines,thusthe analyzercandetectthe bloodlevel correctly.

;
 .- EsR ?$ * l{} pl.lJs Erythrccytefiedimcnt¿rionRateAnalvzer
f

Slnr:d
lel,*l

Figur* 4- I

Ncfel the injccted htroad nnd cüsgulent sftould n$t exceÉd the

r¿r¡ge *f L[. [n figure 4-Io fhe maximurn value of M is 64mrn and the

minimrrru is S{}mm.This is the effectiveblaod height.

4. Sam¡:lernixi:rg

'The
lñ.t l
snm¡:lenrust be fully rnixed bsfbrs measuring,The methsd is

irr "secficn ?: Sarnplepreparation",or you can u$s the rotated

inclicatccl

mixcr*r s¡recial
mixcr.

--
;
Ins*rt
5. Sanrple

The *us¡p[s shc,uld be ir¡xerfed inf* the xnnlyrer ñmrnedlintely aft*r

'l'iler,;Jtlr*o
rnixing. it is suggestcdto mix the salnplenear the anatryzer.
The

sarnpletu[-,ccalr be insq:rtedint* the anslSrzeret eny time. Syrnbol rt*--'o

indi**tes ttrr* p*siti*n is free to u$s. AJt'er the tube inser,ted, th$

üorrospr:ntlin¡¡p*síti*n wíll show d1+*'{as positinn #ü3 in figure 4-3)"

r $ '
 EfüR?.t)# t ü PI"{J$ Hrythrocyre$ediraent*rionR*reAnatyzer
!

Wlcn thu .msrrLlrfinl$ntfinish, fhe rss$It will be displayedon the $srs,en

'uxxx' in¿lícates
{aspositi*n/l{}4irr llgurv 4*2j, $ymbal the me&srJrsm$nt

r¡f th*l ¡:irni{:ion

h*s [r.:*rrcnnc*llcdby the *p*r;rt*r:{as p*sitinn #0s in

figure4-?)"

¡
ttu,3"f
f]l 02 ü3 ü4 ü5
;** + L7 XHH.

o: 'j$
:: :1 :s * * F S

Figure4*2

R.cnicve
6. lia.lrrpJe

.tloNO'Fpull out BSI¿tubecfuríngtesting.

If you pull rlrit ths tube during testing,th* analynerwill give CIut'ob$sp"

sound¿ffidthe tcst will be cancelied.Then after sns measuringcycle, the

stafua*f r,}rccorr$$pondingpositionwill changefrom cc4rr

to 'o---", Vfhen
q

the test finish, the r"csultwill be displayedon the fflffs$pondingposition

{aspositir'¡n#04in figure 4-2}. Rsmnvetke sampletnbcnthenthe statusof

positianchang*sto *n*--",trtindicatesthe positio¡lis flee

the ca,rr"esg:einding

ffircinervs*m¡:l* c*rilb* insertedfbr testing"

 BsR },(]'t I t) FLt]$ sryrhrocvtc$edímentation
RateAnnlvzer
' 1

7. hterla*e

Turn on l]rs p$tvtr' ths instrumentwill ruxrself-ts*,t,aft&r a fuw seconds,

thescn:enwill cfi*play:

Fñ"3*f
n 1 r\ ¡ drr ? n { ü4
L¡.I" f/L¡ ü5
PT

üs r)? sfi $s 1ü

Iiigur* 4-3

If'tir* sülf""te$t
failed, th"ü$orfirnrvill disptray"ERRI", flnd the insfrument

rvill hait.

'f'uirl
B"I or"rtltc pow*r, tht; in$trunrr¡:rt
n¡nssr¡lf*testautonratically.

8.2'After l,t'ar"ming
up finr 15 rninutss,insert the sarnpletub,esinto the

sockel ;Hrci$türt tlr* tüstiug. The rssult will be prínted CIutautomaticatly

e,

oncütlrctestfinish.

8"3Folvuroff the instrunrentwhenall testnfinishsd

 HSR.?{}* l{} PLUS f:rythr**yts $$dim.snt¿¡tion:RtrteAnalyz,er

q-:hffiTlttr- 5 . IM easltrin"g Principle

h"lctlr*d
I . fu{,;asur-ing

"['hs¡:rinriptr* üf'dat* reniling is shclrn¡n

in Figr.u:e5*1. The moving nrenof

tr¡rtir:alr:*upl*:r(T"X-RX)is C.' L is thrl hottom pasition,FI is

thc i:nJiürr,(i
;

pnsitinn"
th* t*1"r

ür,iring thr: m*r'ümsnt of the lnkarcd *pti*al *onrplor{TX-RX) fx*nt

b*rtonr{1,}t* top {tt), if th* infrarcdlight crrnnot rs*ch ths reteiver*then

ir rr:*r¡psrh* intraredlight is obstruetedby high densityr*d blond cells.

ünc-. r.hsinfiar,*d light üll:nSr)thr*ugh ESR tub* and reach th'ereceiver,

t* cnlculatethe distsncet{)
v,¿illssnd signalt* the compr.rt*r
the r*ct-.i',,*r

ths bottütrl1"

'nfthe bloodin the ISSRtu}¡eat ü min.

!".1: {!rrtrreight

L,2:tirrrhcight$f ths bloodin the ASRtubc at 30 min.

I-3: rhehr:ightof theblootlin th* EStl tubeat 60 min.

K: rlrs height of the blo,odin the HSR turbewhen the optical coupler

q to thn li6ttom. It is decidedby the sy$t$mitself end setting

r1r{}1/ús

jr: tll* co:nPuter.

whnle blnnd into .HSRtub*, the

Ha*htimu acldingt.6nrl anti*coagulatcd

h*ight rf'th* bl*ocl in,illhe slightlyrhang*ddue to the diffuronssof the

'[."ü this rJii&rürr*e,tlte inshtrm*nt witrl tske intcr
fiSlt tu[:r". {:ürn¡}ütlri&re

ac*oupt r.rf ¡h* initiai height in & certaiu rffngfl asd the s*dir,n$ntation
 EsR 2ü e l0 FI"[Jfi tirytfrr*cyreÍiedimentationRate
T

p*r'cenftlg*,

FigureS-I

I): liSIt trihesr:cket.

f;l: "fh* highostpositionof tlre*ptical c*utrller{rx-RX).

'l']r*
[*.: l*west positionc¡füheo¡:ticalcou¡:ler{TX-RX}

I{" r{.ecl
hlooclcells

S: lll**d Sr:rum

t: Irdeasuríng
rflng$
e,

'"lllrt-r
K: riistanüefrsm thebottomof ESRtubeto position"L,',

l,l : lniriaihsight(at0 min)

. L2- "fhchcightof rcclbloodcell at 30 min.

 a

ESR2tl s t 0 PLU$ Eryrtrceytc$edimenüutioq

Rsft Amry¿er
-l

2. Calculnticn

J'hec¿tJculation
of 3ü min Sedimentation
percerrtage
is asfannula(l)

?i'S3ü'* I 00{Lt¿?y{t I +K) {t}

After sum$rilriuíngabundqüI,t
üesfingresnlts from plsfiry of,t*oap,italsand
'
labs, k:runulai2) is fa convsrf sedimentatiCIn
percent*gnai SiUmin to

I lr result.
Wustergrr-:rt

Y*aX+b {2)
1': Wrrsts¡
g!:or]result

persentage
X: ScclimentatiCIn

a, b: cqrnstant

W*stcrgrcnJh rosul,tis calculatcdfrom,(&1,bl) nndYoS3,0*.

3. Conrpensate
t$ Westerg¡ü{r
resultnt tr8" t

T'he calculateciHSR result at different temperafnrcsar$ autonraticnlty

to the standard Vt'estcrgrenESR result at t I " C by

cc,tnp$nsatecf

intcrptilationffiüthod.The ialrgeof temperaturecampensaticnis I5oC*

3?"C. trflhe tfirnlt$rllfürsis Iswsr than l5o ü, the rssult wil,l,be,con$idered

accordingtry.If the tempemtureis higher

as at I 5" C:¿inclbc cornpensated

than 3?o{ 1,the result will b* consideredas at 32oC and be cornpensated

accarulingty.

I rrperatian
Th* rosonlmr:ndeil temperature
is l5oC*32o C "
I
t
I

I
It * , 1S
I
 s$R?(}* ts pLUs :
I
:
ManuelC*mpens¿*ion*
tabls
I ft.,{] l 5 "c l s ot 20"c 25"C 3Sot
C*nrp*rrsi,rticn Test 'fest
Test Test Test
v*luc ltesult Res*Xt Rssult Result Result
5 4 5 5 6 I
1{} I IÜ IO 12 16
?t} I8 2ü 2l= 2,5 3r :
3{} 27 3ü 3t 37 4,5
4ü 3(r 4ü 42 49 58
5ü 46 50 5? 6ü 7l
6ü 55 62 7l s2
7{) 63 7A ?? B2 93
*gg_ 72 80 ü2 p3 1,04
_?g_ &l 9ü s3 x$3 t14
t(}0 9ü rss r03 il4 125

', i,

::
,{. nSR clri-l,'t:
"

ESI{ cr¡rv* is retri$ved from the sedirnentatianpcrcentagercsults th,at :

ofrtaincrJ
ev*ly 3 minutes.30minHtiRsunt'eis shcrvmras
figure S-Z-

Figure5-2 3{}minESRcnrve
 illiR xl * ltl l'l-tJs li.rythrocytc
$cdim*nt¿rüicnr
Rat$A,naly?sr

{h:cr-:thc'{*¡t llnishcd, thi: print,*rll,ill i¿uti:t:¡:liLlically

print nut th* nSR

i'*s,lil{:ili.rt'i/ J Il'Ji,:.:
rr1*il}"\¡L¡"

-['hc
f *¡rr"liltis as h*lorv:
¡rrir:tir"lg,

f $R *urue i*s *h*u¡nin figur"*S-3)

Serinl[tr:"(}ü-t .S*ria/¡Vc.üCII

P ü S :ü 1 f;Sñ fu$epasifinn;Sf

Tñh¡lF';f{il F"Tü1St üonrp*nsa{edres¿rlfru{erfo f Soü

Res{-¡ll:-33mffi1/1h Tfte rcsulf sf sed¡¡nenfa#*¡'r

rpfe ís 33rnm1
ñnur ft4/esf*rEren)

t {
a ;

E$R2t)* iü FLUS

L,hapter 6_ Specificatfcrns
Ar*il tl f' A pp!ícstion: Hrythrercytes$dinrent¿rtion
rate analysin
:
Mc:asurilr,l
ti¡nc;i0 minutes
'l'hroughp*t:
*p t* ZSsamplesperhour
Readingc,h¿urnel:
I0 _
Londir:gcapabilitSr:Max Iü *amplesat a rime
t-orrdi
ng ¡rirtt*m:ranclom
Analysisresult:in w$stergrenHSRvalus(rum/th)
I'cn:perature$ompensation:
referto l goc automatically.
Measu¡"irr¡l
principle:Infiarcdbarrier
I
Re*dingr*solution:0"?mm
Re¡rr6¿
ucihility: ":3Va CIr * ?nrm./
Ih
Resulri'*sclution:I nrm/lh
Bioodlsrrr:lrlnge: 50min*64rnrn
Ilisplay: Lüfi sürcsnwifh backlight
Intedü,ce:
l{$-232serialpc,rr
Print: ir'¡te*raltherrnaireconler(nptional)
Fr:wcrsup¡rly:AC tüüV-Ziüq S0/6SHz*I Hz
Fower:50W
pifm0nsirin {LxWx}.I):32CIx 26üx l j,g mrn
]rf*t \Scight:Slcg
{}pcrati ri¡rcnncl
ilions:
T*rnper:afur*:I jo C*32* C

f Iumiciity: {BS%
 ' . . . : .
EfiR 20 " tü pLU$ frytlroq{c $s,ff'*}€ffittrtisn
ftstg,Annb{rff

Cheptef 7, hdsilrtelrsr*:n

l" No spr:r:ificmaintenanos
requircd.Keepthe operationenvirbnmentdry

and rl*an. Kc*¡: fhe H$R tubs h*le $wey from rhe dust, CIthenryrse
,it wjll
afl'cct thc pc|furmance of ths opti:cal couplen (TX-R.H) *nd rnnl*e it
. : .
unslable,hlandlethe glassHSRfuhevery carefullyro avaid broken.Avoid
''"
directsunligl'
rf ro the instrument.

:. Ilo n*t *lean the instrumentsurfbcewithwet cloth,*f rs ,liquid.

Preventthe liquid Ílom flowing intu the HSRtube holes,othsrwiseit will

the dam*gethc instfum$nf"

11
 II|iR 20 * 1üPÍ"U,s ryte$edím$ntationRateAnalyzer

il l:apter I . Tr*urbl,esh(]{}timg

1,, ¡$su:l-tth* n$tq tr¡hs. nftcr *n*sn'lsaxulingcyc'le,the sc.reen$how$ü.

""1
r i

in flgurc4-2
#CIS
syrnhollike ¡:ri:sition
'f,hc
Cnus*: bloocllevel in HSII tube exceedsthe measuringtange,CIr
i
n**trrutspilretrtrnutcrin.lisínsidetheh'*l*.

Z. Tht3ruotrr dr:ssn'tstopduringtestingandgtveseiutnbnonnutnoise.

honrdis rnalfuncfiCIn' ,
t¡¿usc:Th{l opticalcoupleron the meanuring

3,Th*pcrsitiorrshcws¿s+''butnctubgimserted'

Causr::Thc opticnl coupleron the measuringboardis mslfunction,or

by clustor oi[.
seriouslyüontarninatecl

4. Sclf'-tcstlaifu:d,the screcnshorvs"ERRI", the instrumsnthslts.

*ouptrer*n the measuringbcard is r,nalfrrnction

fiaun*: T'he6pf;ici*1
pswsr ox}"
5. No dis¡:lay*rr ths scrsen,ilft{:r

n) Chnckthe power suPPlY;

4 - * ¡
"

b) Chc:ckthc fusc. If broken,replacewith a ns\¡¡CIne.

I8'