Bài tập chương 4: PHẢN ỨNG CỦA CARBONYL

1. Predict the major product for each of the following reaction sequences:

c)

d) e)
2. Choose a Grignard reagent and a ketone that can be used to produce each of the following
compounds:

3. Identify the structures of compounds A to E below:

4. Draw the major product for each of the following reactions

5. Give structures for compounds A–E.

6. Give the structures of the carbonyl compounds and alcohols needed to form each of the
following unstable hemiacetals in solution:

7. What is the main product of each of the following reactions?

8. What is the main product when each of the following carbonyl compounds is reduced with
NaBH4 in an alcoholic solution?
9. Outlined here is a synthesis of glyceraldehyde. What are the intermediates A–C and what
stereoisomeric form of glyceraldehyde would you expect to obtain?

10. Propose three methods to synthesize diphenylmethanol from carbonyl compounds and
Grignard reagent.
11. How can we prepare the ketoalcohol from the keto ester shown below?

12. Show how benzaldehyde could be synthesized from each of the following:
(a) Benzyl alcohol (b) Benzoic acid (c) Phenylethyne
(d) Phenylethene (styrene) (e) C6H5CO2CH3 (f) C6H5CN
13. Starting with benzyl bromide, show how you would synthesize each of the following: