Professional Documents
Culture Documents
INFORMATION/INDICATIONS
In patients with systemic hypotension, signs of cerebral hypoperfusion, progressive heart failure,
angina, or life-threatening ventricular arrhythmia, medical therapy should be started immediately
until temporary pacing is initiated.
External pacing does not provide reliable ventricular stimulation and should only be considered
when administration of a chronotropic drug, temporary or permanent pacing is not available.
All prescriptions should be prescribed in terms of isoprenaline hydrochloride. There are various
strengths and salts of isoprenaline.
ADMINISTRATION
Preferably administered via a central venous access to avoid potential venous irritation as the
preparation has a low pH.
Please ensure that you double check the strength and salt form of preparation being administered
and volume to be added to infusion bag.
The dose used for severe bradycardia is 1 – 4micrograms/min given by intravenous infusion.
Agitate to mix
Dose in microgram/min 1 2 3 4 5 6 7 8 9 10
Agitate to mix
Dose in microgram/min 1 2 3 4 5 6 7 8 9 10
Infusion rate (ml/hr) 1.5 3 4.5 6 7.5 9 10.5 12 13.5 15
CAUTIONS
Isoprenaline should be used with caution in patients with ischaemic heart disease, diabetes,
hypertension and hyperthyroidism.
SIDE EFFECTS
Arrhythmias, sweating, tremor, headache and flushing.