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    Vitamin D is a steroid hormone that regulates calcium homeostasis directly and through its effects on cells involved in calcium regulation. Vitamin D3 must be hydroxylated in the liver and kidney to be active. In the kidney, it increases phosphate reabsorption and in the gut it increases calcium absorption. In bone, it stimulates bone-resorbing cells through a ligand, though its effects are not fully understood. Vitamin D-deficient rickets can be type 1, with a lack of enzymes to hydroxylate vitamin D3, or type 2, with receptor resistance and high calcitriol levels. Osteoporosis patients often have decreased vitamin D and calcium absorption and lower calcitriol levels,

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    Vitamin D is a steroid hormone that regulates calcium homeostasis directly and through its effects on cells involved in calcium regulation. Vitamin D3 must be hydroxylated in the liver and kidney to be active. In the kidney, it increases phosphate reabsorption and in the gut it increases calcium absorption. In bone, it stimulates bone-resorbing cells through a ligand, though its effects are not fully understood. Vitamin D-deficient rickets can be type 1, with a lack of enzymes to hydroxylate vitamin D3, or type 2, with receptor resistance and high calcitriol levels. Osteoporosis patients often have decreased vitamin D and calcium absorption and lower calcitriol levels,

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    8 views1 page

    #26 Missing Filename File

    Uploaded by

    rheza
    Vitamin D is a steroid hormone that regulates calcium homeostasis directly and through its effects on cells involved in calcium regulation. Vitamin D3 must be hydroxylated in the liver and kidney to be active. In the kidney, it increases phosphate reabsorption and in the gut it increases calcium absorption. In bone, it stimulates bone-resorbing cells through a ligand, though its effects are not fully understood. Vitamin D-deficient rickets can be type 1, with a lack of enzymes to hydroxylate vitamin D3, or type 2, with receptor resistance and high calcitriol levels. Osteoporosis patients often have decreased vitamin D and calcium absorption and lower calcitriol levels,

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    Vitamin D

    Basic Science AAOS

    Definition - unique steroid hormone that can modulate


    calcium haemostasis directly or thru its effects on the
    differentation & development of the various calcium
    regulating cell systems

    Vit D3 - must be hydroxylated in liver then in kidney

    Kidney - inc PCT reabsorption of phosphate


    GIT - inc active transport of Ca
    Bone - not fully understood
    - stimulates osteoblasts to secrete osteoclast-activating
    substance Osteoprogetegerin ligand (OPGL)
    -> activates osteoclasts & induces bone resorption

    Vit D dependent Rickets


    Type 1 - lack of renal enz to hydroxylate D3
    - tf only have 25-hydroxyD3
    - treat c large doses of calcitriol daily -> get nephrocalcinosis

    Type 2 - receptor resistance


    - have high levels of calcitriol

    Osteoporosis
    - pts c osteoporosis have dec absorption & dec calcitriol levels
    - thought that ~ 10% of osteoporosis pts have low vit D3 levels
    - conflicting evidence on role of calcitriol in osteoporosis

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