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Olson CV 2019
Olson CV 2019
EDUCATION:
HONORS:
Marquette University College of Engineering Outstanding Teacher Year Award, 1996, 2003.
Proctor and Gamble American Physiological Society Graduate Student Award, 1991.
PROFESSIONAL EXPERIENCE:
2018 to Present Vice Chair for Academic Affairs, Department of Biomedical Engineering,
Marquette University and Medical College of Wisconsin, Milwaukee, WI.
FIELDS OF SPECIALIZATION:
Global respiratory health and appropriate technologies, high performance computing, cardiovascular
and pulmonary physiology, endothelial cell biology, mathematical modeling, mass transport, fluid
mechanics, optical instrumentation.
SCHOLARLY WORKS:
Olson, L.E., A. Pou, and T.R. Harris. Surface-area independent assessment of lung microvascular
permeability using an amphipathic tracer. J. Appl. Physiol. 70:1085-1096, 1991.
Olson, L.E., D.J. Staton, M. Young, R.L. Galloway, and T.R. Harris. Sulfhemoglobinated
erythrocytes as an optical intravascular tracer in the lung. Annals of Biomed. Eng. 22:319-327, 1994.
Olson, L.E., T.R. Harris, A. Pou, M.N. Sayed-Ahmed, and R.L. Galloway., An optical multiple
indicator dilution technique to measure lung permeability-surface area: calibration and baseline
measurement. IEEE Trans. Biomed. Eng. 42:451-463, 1995.
Feiring, A.J., and L.E. Olson. Coronary stent and over-the-wire catheter exchange using standard
length guide wires; jet exchange "JEX" practice and theory. Catheterization and Cardiovascular
Diagnosis, 42:457-466, 1997.
Olson, L.E., M.P. Merker, R.D. Bongard, B.M. Brantmeier, S.H. Audi, J.H. Linehan, and C.A.
Dawson. Kinetics of plasma membrane electron transport in a pulmonary endothelial cell-column.
Annals of Biomed. Eng. 26:117-127, 1998.
Merker, M.P., L.E. Olson, R.D. Bongard, M.K. Patel, J.H. Linehan, and C.A. Dawson.
Ascorbate - mediated transplasma membrane electron transport in pulmonary arterial endothelial
cells. Am. J. Physiol. (Lung Cell Mol. Physiol.) 274:L685-L693, 1998.
DeMarino, S., L.E. Olson, N.A. Pou, S.U. Adams, and T.R. Harris. Optical and radioisotope
indicator dilution measurements in pulmonary edema. Annals of Biomed. Eng. 26: 417-430, 1998.
Olson, L.E., Merker, M.P., Patel, M.K., Bongard, R.D., Daum, J.D., Johns, R.A., and C.A. Dawson.
Cyanide increases reduction but decreases sequestration of methylene blue by endothelial cells.
Annals of Biomed. Eng. 28(1):85-93, 2000.
Audi, S.H., Olson, L.E., Bongard, R.D., Roerig, D.L., Schulte, M.L., and C.A. Dawson.
Toluidine blue O and methylene blue as endothelial redox probes in the intact lung. Am. J. Physiol.
(Heart Circ. Physiol) 278(1):H137-H150, 2000.
Dawson, C.A., Audi, S.H., Bongard, R.D., Okamato, Y., Olson, L.E., and M.P. Merker. Transport
and reaction at endothelial plasmalemma: Distinguishing intra- from extracellular events. Annals of
Biomed. Eng. 28:1010-1018, 2000.
Effros RM. Hogan G. Wahlen Hoagland K. Olson L. and W. Lin. Protection of the lungs from acid
during aspiration. American Journal of Medicine. 111 Suppl 8A:56S-59S, 2001.
LaDisa, J.F., Hettrick, D.A., Olson, L.E., Guler, I., Gross, E.R., Kress, T.T., Kersten, J.R., Warltier,
D.C., and P.S. Pagel. Stent implantation alters coronary artery hemodynamics and wall shear stress
during maximal vasodilation. J. Appl. Physiol. 93(6):1939-46, 2002.
Gross, E.R., LaDisa, J.F., Weihrauch D, Olson, L.E., Kress, T.T. Hettrick, D.A., Pagel, P.S.
Warltier, D.C. and J.R. Kersten. Reactive oxygen species modulate coronary wall shear stress and
endothelial function during hyperglycemia. Am. J. Physiol. (Heart Circ. Physiol.) 284(5):H1552-9,
2003.
LaDisa, J.F., Guler, I, Olson, L.E., Hettrick, D.A., Kersten, J.R., Warltier, D.C., and P.S. Pagel.
Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear
stress produced by stent implantation. Ann. Biomed. Eng. 31(8):972-80, 2003.
R.M. Effros, Olson, L.E., Lin, W., Audi, S.H., Hogan, R., Shaker, R., Hoagland, K., and B. Foss.
Resistance of the pulmonary epithelium to movement of buffer ions. Am J. Physiol. (Lung Cell Mol.
Physiol.) 285:L476-83, 2003.
Savla, U*., Olson, L.E. and C.M. Waters. Mathematical modeling of airway epithelial wound
closure during cyclic mechanical strain. J. Appl. Physiol. 96(2):566-74, 2004.
LaDisa, J.F., Olson, L.E., Guler, I., Hettrick, D.A., Audi, S.H., Kersten, J.R., Warltier, D.C., and
P.S. Pagel. Stent design properties and deployment ratio influences indexes of wall shear stress: a
three-dimensional computational fluid dynamics investigation with a normal artery. J. Appl.
Physiol. 97(1): 424-30, 2004.
LaDisa, J.F., Olson, L.E., Guler, I., Hettrick, D.A., Kersten, J.R., Warltier, D.C., and P.S. Pagel.
Circumferential stress evaluated using time-dependent 3D computational fluid dynamics models. J.
Appl. Physiol. 97(1):424-430, 2004.
Ladisa, J.F., Olson, L.E., Guler, I., Hettrick, D.A., Kersten, J.R., Warltier, D.C., Pagel, P.S.
Circumferential vascular deformation after stent implantation alters wall shear stress evaluated with
time-dependent 3D computational fluid dynamics models. J. Appl. Physiol. 98(3): 947-57, 2005.
Ladisa, J.F. Olson, L.E., Molthen, R.C., Hettrick, D.A., Pratt, P.F. Hardel, M.D., Kersten, J.R.,
Warltier, D.C., Pagel, P.S. Alterations in wall shear stress predict sites of neointimal hyperplasia
after stent implantation in rabbit iliac arteries. Am. J. Physiol. Heart Circ. Physiol. 288(5):H2465-
75, 2005.
Ladisa, J.F., Olson, L.E., Ropella, K.M., Molthen, R.C., Haworth S.T., Kersten, J.R., Warltier,
D.C., Pagel, P.S. Microfocal X-Ray computed tomography post-processing operations for
optimizing reconstruction volumes of stented arteries during 3D computational fluid dynamics
modeling. Comput. Methods Programs Biomed. 79(2):121-134, 2005.
LaDisa JF Jr. Olson LE. Hettrick DA. Warltier DC. Kersten JR. Pagel PS. Axial stent strut angle
influences wall shear stress after stent implantation: analysis using 3D computational fluid dynamics
models of stent foreshortening. Biomedical Engineering Online. 4:59, 2005.
LaDisa JF Jr. Olson LE. Douglas HA. Warltier DC. Kersten JR. Pagel PS. Alterations in regional
vascular geometry produced by theoretical stent implantation influence distributions of wall shear
stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling.
Biomedical Engineering Online. 5:40, 2006.
Kranzer K., Olson, L., van Schaik, N., Raditlhalo, E., Hudson, E., Panigrahi, P., Bekker L.G.,
Quality of induced sputum using a human-powered nebulizer in a mobile human immunodeficiency
virus testing service in South Africa. Int J Tuberc Lung Dis. Aug: 15(8), 1077-81, August 2011.
Hallberg C.J., Lysaught M.T., Najarro R.A., Cea Gil F., Villatoro C., Diaz de Uriarte A.C., Olson
L.E., Treatment of asthma exacerbations with the human powered nebulizer: a randomized clinical
trial. Nature: Primary Care Respiratory Journal. 14:14016, 2014.
Hallberg C.J., Lysaught MT, Zmudka CE, Kopesky WK, Olson LE, Characterization of a human
powered nebulizer compressor for resource poor settings. Biomedical Engineering Online, 13:77,
2014.
Goulet, B., B. Mayer, and L.E. Olson. A comparative life cycle assessment between a metered dose
inhaler and electric nebulizer. Sustainabilty 9(10):1725 DOI: 10.3390/su9101725, 2017.
Book Chapter
Dawson, C.A., R.D. Bongard, D.L. Roerig, M.P. Merker, Y. Okamoto, S.H. Audi, L.E. Olson, G.S.
Krenz, and J. H. Linehan. Pulmonary Endothelial Surface Reductase Kinetics. Whole Organ
Approaches to Cellular Metabolism, Permeation, Cellular Uptake, and Product Formation.
J.B. Bassingthwaighte, C.A. Goresky and J. H. Linehan, Eds. New York, Springer-Verlag, 1998.
Government Report
Olson, L.E., C. Villatoro, C. Santin. Estudio sobre: Eficacia del Nebulizador Manual en la práctica
de los Ecos Familiar en el Oriente de El Salvador: la atención de salud y el ahorro de costos. Report
to the Ministry of Health of El Salvador, April 2015.
Invited Paper
Olson, L.E., R.D. Bongard, M.P. Merker, J.H. Linehan, and C.A. Dawson. Endothelial transplasma
electron transport. Annals of Biomed. Eng. 25:S-19, 1997.
Olson, L.E., Galloway, R.L., Harris, T.R. Real-time assessment of lung microvascular permeability:
Use of a CO2 laser aids measurement of 1,2-propanediol concentration. Proc. IEEE/EMBS
13(1):281-2, 1991.
Olson, L.E., and Goldberg, J.R., International Service Learning Senior Design Projects: Human
Power and Medical Devices., Proceedings of FIE, F4B, 2007.
Olson, L.E., Glucksberg, M.R., Malkin, R.A., and Poluta, M. Special Session-Biomedical
Engineering Ethics and Standards in the Developing World. FIE Conference, 2007.
Herzfeld, D.J., Olson, L.E., and Struble, C.A. Pools of Virtual Boxes: Building Campus Grids with
Virtual Machines, Proceedings of the ACM VTDC, June 2010.
Olson L.E., Session on International Service Learning, BMES annual meeting, 2006. Presented
“Service learning solutions for appropriate respiratory technology in Central America.”
Olson, L.E., Glucksberg, M.R., Malkin, R.A., and Poluta, M. Special Session-Biomedical
Engineering Ethics and Standards in the Developing World. FIE Conference, 2007.
Olson, L.E., Founding Chair of Southeast Wisconsin High Performance Computing Consortium
(SeWHiP), Data Symposium, 2012.
Invited Lectures
Olson, L.E. Endothelial transplasma membrane electron transport: measurement and modeling.
National Simulation Resource on Mathematical Modeling Symposium, 1997.
Olson, L.E. "Bioreactor Studies and Vascular Anti-Oxidant Mechanisms" Pennsylvania State
University Biomedical Engineering Departmental Seminar, November 11, 1999.
Olson, L.E. “A better method for Cryopreserving Cells: Case Study of Erythrocytes” Medical
College of Wisconsin, September 26, 2002.
Olson, L.E., M.T. Lysaught, C.J. Hallberg, C. Villatoro. "The Human Powered Nebulizer."
IMECHE Appropriate Healthcare Technologies Seminar, London, September 18, 2013.
Conference Presentations
Harris, T.R., Olson, L.E., Pou, A. Lipid Solubility increases the sensitivity of indicators for
endothelial damage in the lung. Proceedings of the World Congress on Medical Physics and
Biomedical Engineering 33(1):351, San Antonio, TX, 1988.
Olson, L.E., Pou, A., Harris, T.R. Measurements of amphipathic and hydrophilic indicator-dilution
tracers in the lung provide a surface area independent assessment of permeability changes. FASEB J.
3:A1140, New Orleans, LA, 1989.
Olson, L.E., Pou, A., Harris, T.R. Evidence for the validity of 14C-1,4-butanediol (B) as a barrier-
limited, multiple indicator dilution (MID) tracer in the lung. FASEB J. 4:A1181, Washington, DC,
1990.
Olson, L.E., Galloway, R.L., Pou, A., Harris, T.R. Optical measurements in whole blood of tracers
for lung microvascular permeability. FASEB J. 5:A754, Atlanta, GA, 1991.
Olson, L.E., Pou, A., Syed - Ahmed, M.N., Galloway, R.L., Harris, T.R. On-line, optical
measurement of lung permeability surface area (PS) is sensitive to hypoxia and alloxan injury.
FASEB J. 7(3):A2924, New Orleans, LA, 1993.
Olson, L.E., R.D.Bongard, C.A. Dawson, and J.H. Linehan. On-Line detection of reduction and
sequestration of thiazine dyes by the lung. FASEB J. 8:A916, Anaheim, CA, 1994
Krenz, G.S., C.A. Dawson, J.H. Linehan, R.D. Bongard, M.P. Merker, and L.E. Olson. A simple
model of methylene blue reduction in the lung. Annals of Biomed. Eng. 22:44, Tempe, AZ, 1994.
Olson, L.E., M.P. Merker, R.D. Bongard, J.H. Linehan, and C.A. Dawson. Effect of hypoxia and
potassium ferricyanide on thiazine dye reduction and uptake in a cell-column model of the
pulmonary microvasculature. Annals of Biomed. Eng. 23:S-12, Boston, MA, 1995.
Olson, L.E., M.P. Merker, J.H. Linehan, and C.A. Dawson. Effect of flow on thiazine dye reduction
and uptake in a cell-column model of the pulmonary microvasculature. FASEB J. 10:A719, Atlanta,
GA, 1995.
Olson, L.E., R.D. Bongard, S.H. Audi, D.L. Roerig, J.H. Linehan, and C.A. Dawson. Plasma protein
binding and Toluidine Blue O (TBO) reduction in the pulmonary circulation. FASEB J. 11:A100,
University Park, PA, 1996.
Olson, L.E., R.D. Bongard, M.P. Merker, S.H. Audi, M.L. Schulte, J.H. Linehan and C.A. Dawson.
Comparison of transplasma membrane electron transport by pulmonary endothelial cells in situ and
in cell culture. Annals of Biomed. Eng. 24:S-27, University Park, PA, 1996.
Olson, L.E. and A.J. Feiring. Analysis of dynamics of a novel technique for over-the-wire balloon
catheter exchange during stent deployment. Annals of Biomed. Eng. 24:S-27, University Park, PA,
1996.
Dembowski, E.T.(UG), L.E. Olson, G.S. Krenz, S.H. Audi, C.A. Dawson, and J.H. Linehan. Effect
of on-line sampling and dye properties on optical measurements in a flow-through endothelial cell
system. Annals of Biomed. Eng. 24:S-54, University Park, PA, 1996.
Olson, L.E., R.D. Bongard, M.P. Merker, M.K. Patel*, J.H. Linehan, and C.A. Dawson. Endothelial
redox status and transplasma membrane electron transport. FASEB J. 11:A136, New Orleans, LA,
1997.
Bongard, R.D., L.E. Olson, M.K. Patel*, J.H. Linehan, C.A. Dawson, and M.P. Merker.
Dehydroascorbate stimulates pulmonary arterial endothelial cell transplasma membrane electron
transport. FASEB J. 12:A182, San Francisco, CA, 1998.
Olson, L.E., R.D. Bongard, M.P. Merker, M.K. Patel*, J.H. Linehan, and C.A. Dawson. Effect of
cyanide on kinetics of extracellular reduction and intracellular reoxidation of Methylene Blue (MB)
by endothelium. FASEB J. 12:A182, San Francisco, CA, 1998.
Olson, L.E., Merker, M.P., Bongard, R.D., Linehan, J.H., and C.A. Dawson. Cell column studies of
endothelial transplasma membrane electron transport (ETMET) mechanisms. Annals of Biomed.
Eng. 26(S):S-51, 1998.
Vosniak, K.J., Olson, L.E., Clough, A.V., Linehan, J.H., and C.A. Dawson. Computational fluid
dynamics model study of transit time through arterial trees. Annals of Biomed. Eng. 26(S):S-65,
1998.
Olson, L.E., Audi, S.H., Lin, N., Lin, W., and C.A. Dawson. Adaptation to hyperoxia results in
pulmonary sequestration of toluidine blue O (TBO+). FASEB J. 13:A184, 1999.
Clough, A.V., Haworth, S.T., Vosniak, K.J.*, Dawson, C.A., and L.E. Olson. Transit time through
the pulmonary arterial tree: Experimental and modeling observations. FASEB J. 13:A428, 1999.
Olson, L.E. Yakubovich, O., Clough, A.V., and C.A. Dawson. A fast algorithm for predicting
transit times through arterial trees. FASEB J. 14:A168, 2000.
Olson, L.E., Effros, R.M., Hogan, G., and W. Lin. Alveolar pH changes and trans-alveolar
transport.
Annals of Biomed. Eng. 28(S):S-48, 2000.
Gross, E.R., Olson, L.E., Weihrauch, D., Kersten, J.R., Hettrick, D.A., Pagel, P.S., and D.C.
Warltier. Acute hyperglycemia alters shear and oxidant stress in coronary arteries in vivo. Annals of
Biomed. Eng. 28(S):S-63, 2000.
LaDisa, J.F., Olson, L.E., DiCaprio, F., Guler, I., and D.C. Warltier. In vivo measurement and fluid
dynamics modeling of hemodynamic changes produced by coronary stenting. FASEB J. 2001.
LaDisa, J.F., Olson, L.E., Hettrick, D.A., Guler, I., DiCaprio, F., Pagel, P.S., Kersten, J.R., and D.C.
Warltier. Computational fluid dynamics modeling of hemodynamic changes caused by coronary
stenting in vivo. Ann. Biomed. Eng., 2001.
LaDisa, J.F., Olson, L.E., Guler, I., Gross, E.R., Hettrick, D.A., Kersten, J.R., Warltier, D.C., and
P.S. Pagel. Coronary stent implantation alters wall shear stress during maximal vasodilation. IEEE
Engineering in Medicine and Biology Proceedings v2 2002:1228-9, 2002.
Schedgick, D.J.*, Olson, L.E., Bigelow, L.K. and W.E. Brower. Cryopreservation of erythrocytes
without a cryoprotectant by rapid quenching and rewarming. Cryobiology, 2002.
LaDisa, J.F., Warltier, D.C., Olson, L.E., Kersten, J.R., and P.S. Pagel. Shear-modulated neointimal
hyperplasia after stent implantation. FASEB J. 2003.
Ladisa, J.F., Olson, L.E., Kersten, J.R., Warltier, D.C., and P.S. Pagel, Wall shear stress varies with
stent properties and correlates with sites of neointimal hyperplasia. Ann. Biomed. Eng., 2003.
Zitomer, D., Olson, L.E., Borg, J. International Service Learning at Marquette University. Role of
Engineering at Catholic Universities (RECU) Conference in Dayton, OH 2005.
Olson, L.E., LaDisa, J.F. A model of Shear-Dependent neointimal growth of stented vessels, Ann.
Biomed. Eng. 2007.
L.E. Olson. Human Powered Nebulizer is Equivalent to Commercial Nebulizer in rate of Liquid
delivery. BMES 2009
Olson LE, “The Human Powered Nebulizer in Developing World Applications,” Presentation at
Unite For Sight Conference, Yale University, April 2010
Olson LE, Zmudka CE, Hallberg CJ, Kopesky WK, Lysaught MT, Particle size measurements of the
human powered nebulizer, BMES 2012.
Co–Investigator (J.H. Linehan P.I.) – National Institutes of Health, Heart Lung and Blood Institute:
“Lung Metabolism of Vasoactive Hormones”, for $132,062 per year from 1995 – 1999.
Role: Develop mathematical models and numerical solution methods for identification of parameters
of endothelial function. Develop new optical methods for investigation of lung metabolism.
Principal Investigator - Anthony J. and Rose E. Bagozzi Medical Research Fellowship: “Equipment
and Supplies for Endothelial Cell Investigation”, for $9,300 from 1996 – 1999.
Co–Investigator (. J.H. Linehan, P.I.) - Ralph and Marion Falk Medical Research Trust:
“Primary Pulmonary Hypertension”, for $360,000 from 1997 – 1998.
Role: Develop probes of endothelial function, which influence the pulmonary hypertension. Use
computation fluid mechanics to study mechanical aspects of pulmonary.
Investigator, NSF Grant, “Acquision of a Linux Cluster to Support College-wide Research and
Teaching Activities” 2006.
Principal Investigator, NCIIA Grant, "The Human Powered Nebulizer" for $45,000, from 2010-
2011.
Co-PI, NSF Grant, " MRI: Acquisition of a Parallel Computing Cluster and Storage for the
Marquette University Grid (MUGrid)", for $560,000 from 2009-2011.
Principal Investigator, CTSI Grant, “Toward a bioinformatics and bioengineering core for
Southeastern Wisconsin: Internship Program.” $50,000, 2015-2016.
Principal Investigator, Seed Enterprise Fund Grant, Marquette University and WEDC, “Human
Powered Nebulizer” for $50,000, 2017.
Courses Taught
Thesis Advisor:
Thesis Committees:
SERVICE ACTIVITIES:
Professional Service
Professional Societies