To evaluate the efficacy and safety of cycloplasty with focused ultrasound in the treatment of glaucoma.

37 eyes of 37 patients with primary or secondary glaucoma were included, without achieving intraocular pressure

control. Focused ultrasound cycloplasty was performed. Visual acuity, intraocular pressure and number of hypotensive

medications, was recorded, before the procedure and during the postoperative check-ups on day 1, week 1, month 1,

month 3 and month 6. As well as the presence of adverse effects. The comparative analysis, was carried with Graphpad

9.0.0 Software. A statistically significance result, was established at p<0.05%.

The most common diagnosis, was neovascular glaucoma (n=15), followed by primary open-angle glaucoma (n=10). The

rest, were glaucoma secondary to: retinal surgery (n=5), pseudoexfoliation (n=2), penetrating keratoplasty (n=2), steroids

(n=1), thyroid orbitopathy (n=1), and uveitis (n=1). Mean intraocular pressure, before the procedure, was 27±13 mmHg. In

the postoperative check-ups, the mean intraocular pressure was 20±7.5 mm Hg (day 1), 15±11 mm Hg (week 1), 17±12

mm Hg (Month 1), 17±13 mm Hg (Month 3), and 18±10 mm Hg (Month 6), obtaining a statistically significance (p=0.001).

The average of hypotensive medications used, prior to the intervention, was 4. Decreasing to 3, in all postoperative

check-ups (p>0.001). The average visual acuity, prior to the procedure, was 1.4 LogMar. Six months after the procedure,

it was 1.43 LogMar, without statistically significance difference (p=0.97). The most common adverse effects, were

conjunctival hyperemia (n=29) and cellularity 1+, in the anterior chamber (n=14). There were no adverse effects, that

required surgical intervention for their resolution, and nor loss of light perception. Failure of the procedure, was observed

in 7 eyes (18%). Which underwent Ahmed valved implant (3), trabeculectomy (2), transscleral micropulsed laser (1), and

endocyclophotocoagulation (1).

Focused ultrasound cycloplasty, is useful to achieve target intraocular pressure in patients with uncontrolled glaucoma.

The most common adverse effects, are mild and reversible. In case of procedure failure, it does not limit the performance

of subsequent surgical interventions.

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