Drol Susej Z.

Picazo
BSN 2-A-4
Pharmacology

“W16”
Renovo Mirador

1.)

Enhancing the anticancer effect of paclitaxel by using

polymeric nanoparticles decorated with colorectal cancer
targeting CPKSNNGVC-peptide

The lack of specificity in cancer treatment is a key drawback. Selective administration of

chemotherapeutic drugs to tumor areas has advanced rapidly in recent years as a diagnostic and
therapeutic tool in the fight against cancer. Using a tumor homing peptide (CPKSNNGVC, CPK
in short) as a nanoparticle surface-bound targeting ligand, we design a unique polymeric
nanoparticle delivery method that targets both MCT1 receptor-positive cancer cells and
angiogenic endothelial cells. Multipotent drug paclitaxel (PTX)-encapsulated poly (dl-lactide-co-
glycolide) (PLGA) nanoparticles (diameter of 215 4 nm; zeta potential of 12 3 mV; 16–17.5
percent w/w PTX) were manufactured utilizing an emulsion-solvent evaporation process. The
CPK peptide was then attached to the nanoparticle surface using maleimide-thiol chemistry
(CPK-PTX-NPS). In MCT1 receptor-overexpressing colorectal cancer (CRC) cells, the
extremely stable CPK-PTX-NPs demonstrated MCT1 receptor-mediated cellular uptake and
apoptosis-mediated cell death, whereas the other non-targeting nanoparticles failed to show
MCT1 receptor-mediated cellular uptake. In a chick embryo angiogenesis experiment, the
targeted CPK-PTX-NPs preferentially suppressed the development of new blood vessels from
pre-existing blood vessels (angiogenesis). Finally, our findings reveal that MCT1 receptor-
selective, PTX-encapsulated, and CPK peptide-decorated polymeric nanoparticles operate as
effective carriers for CRC-specific drug delivery, resulting in dramatically improved therapeutic
efficacy.

2.)
 Senior citizens in the Philippines cope with disease with the aid of family and friends, as
well as their faith in God. Even the tiniest improvement in a disease or condition is regarded as
noteworthy. Patients' health-care decisions are heavily influenced by Filipino families. To keep
the peace in the family, patients often give up their desires and comply with the demands of a
more powerful family member. Filipino senior citizens often self-manage their influences by
noting symptoms, researching possible causes, estimating the severity and threat to functional
capacity, and considering the financial and emotional burden on the family before seeking
professional help.