es bstract 203: Angiotensin I Induced ER Stress inthe Heart is Attenu... @ coeur menses ‘oup://yper-ahajournals.org/content/62/Suppl_1/A203 =24Q- POSTER SESSION! Hypertension Abstract 203: Angiotensin II Induced ER Stress in the Heart is Attenuated by Exercise Gustavo S Masson, Anand R. Nair, Mary E White, Deepmala Agarwal, Lisete C Michelini, Joseph Francis Hypertension, 2013;62:A203, Article Info & Metrics Abstract Recent evidence indicates that endoplasmic reticulum (ER) stress. Plays an important pathophysiological role in a number of chronic diseases including cardiovascular disease. In this study, we demonstrate that ANGII-induced ER stress in the heart is attenuated by exercise. Methods: Male rats were implanted with telemetry probes and tained to do exercise. After collecting baseline blood pressure, hypertension was induced by implanting osmotic minipumps containing ANGI 200ng/kg/min for 42 days or saline. Rats were randomized into sedentary (SED) or exercise trained (ExT). BP and ‘cardiac functions were measured by radiotelemetry and ‘echocardiography. At the end of the study, heart tissues were ‘analyzed for ER stress and hypertrophy markers by real time RT- PCR and Wester biotting Results: are tabulated. The protein expression pattern for Grp78 ‘and CHOP were similar to mRNA, Conclusions: 1. ANGII infusion induces ER stress in the heart and contributes to cardiac hypertrophy. 2. EXT attenuates hypertensive This Issue Hypertension ‘September 2013, ‘Volume 62, Issue Suppl 1 = Table of Contents Jump to 2 Article Info & Metrics Article Tools 20/07/2017 10:20TEEN NE Ee ee Se ee Abstract 203: Angiotensin Il Induced ER Stress in the Heart is Attema.. |nup://hyper-ahajournals.org/content/62/Suppl_1/A203, | response, cardiac hypertrophy and ER stress. 3. ER stress and ROS dependent mechanism contribute to ANGII induced cardiac © Citation Tools hypertrophy and contribute to the development of hypertension. SI SSS AIR Tag @ Articte Alerts amit) 3030 2 teense ie wots iscaet — tafeoas soz, mens @ Save to my Gye teats iueam iiieds (atten mae eae —uists— tates terest —tearroe— earn 252013 lossam == aara03 — [oatener Q, Request Permi: Cardiac hypertrophy ER Stress Exercise training Share this © 2013 by American Heart Association, Inc. Article ™% Email 4 Previous ‘4 Back to top > Share on Social Media Related Articles ‘No related articles found. Google Scholar Cited By... No citing articles found. Hypertension About Hypertension Email Alerts Information for: Instructions for Authors Open Access Information Advertisers sos 20/07/2017 10:20