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  • Mutation

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    四叶草
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    4 views10 pages

    Mutation

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    四叶草
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    ‘SDS BIOLOGY 1 ($8015) TOPIC 7: MUTATION 32 GENE MUTATION 1, FIGURE 1 shows atype of gene mutation, Normal DNA AAG TGA_[ Go [| crr [cir “Normal polypeptide chain 5 Leucine Threonine Proline Glutamic Glutamic acid acid | ‘AAC TGA GGC_[ CAT CIT Abnormal polypeptide chain : Leucine “Threonine Proline Valine Glutamic aci Abnormal DNA FIGURE 1 (a) State the type of the gene mutation shown in FIGURE 1 [1 mark (FU Ko} (©) @_ Name the genetic disorder caused by the gene mutation as shown in FIGURE 1. [1 mark] Sickk -cell_Aremia (ii) Describe the symptoms of aed og 100. (2 marks] © [2 marks] (UPS 2005/2006) ° I Powered by (3 CamScanner 2 SDS BIOLOGY 1 (58015) TOPIC 7: MUTATION FIGURE 2 shows types of gene mutation, pron (HCHO He SICA IIE gy Protein Cie Hts Hobe He Hae Hite] gp ‘mRNA Gene mutation B Protein [met }{ ive Tas Hits HO FIGURE 2 (2) Name the type of gene mutation A apd B. 2 marks] fin A is ition while B dein () Between gene mutation A and B, which is more lethal? Give yeason. [2 marks] ai Hon ade (©) Give an example of disease caused by gene mutation. [1 mark] (UPS 2008/2009) FIGURE 3 shows mutation at a codon in a gene coding for -globin, Normal haemoglobin DNA ‘Mutant haemoglobin DNA. lel ell @ 63 Powered by CamScanner SDS BIOLOGY 1 (sB015) TOPIC7: MUTATION (©) Whatis the effect of gene mutation in FIGURE 3? Al cond ‘6 [2 marks} (ii) State one effect of mutant f-globin, [1 mark} | sickh - (@) Explain briefly how insertion ofa nucleotide base in a gene can shorten a specific Protein during frameshift mutation. marks] () (PSPM 2020/2021) Discuss the various types of gene mutation, [8 marks] me i (PSPM 2018/2019) Discuss the following types of gene mutations: (@) base substitution i [10 marks} ee (PSPM 2009/2010) Powered by (3 CamScanner 13 SDS BIOLOGY 1 (SB015) TOPIC 7: MUTATION Describe base insertion and base deletion mutations. [10 marks] (PSPM 2014/2015) Describe inherited disease sickle-cell anaemia. [10 marks] CHROMOSOMAL MUTATION (a) Define chromosomal aberration. [2 marks} dongs i cobs oles (b) _ FIGURE4 shows pair of homologous chromosomes that has undergone synapsis during meiosis. The alphabets below represent the arrangement of gene loci on the chromosomes. | | | _ A B.C G FED H I FIGURE 4 (What happen to the homologous chromosomes? {1 mark] Twelsion — (i) Explain briefly how does mutation in b(j) occur, 2 marks) of before wtfeded in te some dhamaome ii) Giye ONE example of physical mutagen, [1 mark] lal 6 Powered by (3 CamScanner SDS BIOLOGY 1 (5015) TOPIC 7: MUTATION 1 FIGURE 5 shows the type of chromosomal aberration, oc _ ae BLE, mak s Gacrs Ky 6.HGs.0 Eats es *eaged) A _ ; BERS OBE, B.

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