DRUG DOSAGE THERAPEUTIC ADVERSE CONTRAINDICATION NURSING
ACTION EFFECTS CONSIDERATIONS
finasteride 0.4 mg orally Tamsulosin helps Tamsulosin is Sulfonamide Tamsulosin is used Proscar once a day; reduce the taken once a day, hypersensitivity to treat BPH. the dose may symptoms of an usually in the Tamsulosin is a non- Nursing be increased enlarged prostate morning after arylamine Considerations: to 0.8 mg gland by relaxing breakfast or the sulfonamide Avoid using with orally once a the muscles in the first meal of the derivative. In other alpha- day in patients bladder and day. The main patients with blockers. who fail to prostate so you side effects of sulfonamide Tamsulosin is respond to 0.4 can pee more tamsulosin are hypersensitivity, contraindicated mg once a day easily. When you feeling dizzy and allergic reaction to with strong CYP3A4 within 2 to 4 first take problems when tamsulosin has been inhibitors such as weeks tamsulosin, it may men ejaculate rarely reported. If a ketoconazole. make you feel (such as little or patient reports a Assess and monitor Renal Dose dizzy or no semen). serious or life- blood pressure, Adjustments lightheaded. If threatening especially after first Renal this happens it's Dizziness, sulfonamide allergy, dose because impairment best to sit or lie lightheadedness, the manufacturer tamsulosin may (CrCl greater down until your drowsiness, advises caution cause orthostatic than 10 feel better. runny/stuffy when administering hypotension. mL/min): No nose, or tamsulosin. adjustment Tamsulosin is in a ejaculation However, What teaching recommended class of problems may tamsulosin is not needs to be End-stage medications occur. If any of contraindicated for included to the renal disease called alpha these effects last use in patients with patient taking (CrCl less than blockers. It works or get worse, tell sulfonamide allergy. tamsulosin? Take 10 mL/min): by relaxing the your doctor or Based on clinical tamsulosin exactly Data not muscles in the pharmacist trials and post- as directed. Do not available prostate and promptly. marketing take more or less of bladder so that experience with it or take it more Liver Dose urine can flow To reduce the tamsulosin, the often than Adjustments easily. risk of dizziness potential for cross- prescribed by your Mild or and reactivity in patients doctor. Swallow moderate lightheadedness, with sulfonamide tamsulosin hepatic get up slowly allergy has not been capsules whole; do impairment: when rising from established. In post- not split, chew, No a sitting or lying marketing crush, or open adjustment position. experience, allergic- them. Your doctor recommended type reactions (such will probably start Severe hepatic Remember that as skin rash, you on a low dose impairment: this medication pruritus, urticaria, of tamsulosin and Data not has been and angioedema of may increase your available prescribed the tongue, lips, and dose after 2 to 4 because your face) have been weeks. Dose doctor has reported in some Adjustments judged that the cases, and, in very What are the For patients benefit to you is rare cases, in nursing who do not greater than the patients who had a considerations and respond to the risk of side history of sulfa patient teaching for 0.4 mg dose effects. Many allergy acetaminophen? after 2 to 4 people using this (manufacturer data Instruct patients to weeks, the medication do on file). According never take more dose may be not have serious to the than 4,000 mg of increased to side effects. manufacturer, acetaminophen per 0.8 mg orally clinical trials with 24 hours. This once a day Rarely, males tamsulosin did not includes all forms may have a screen for or of acetaminophen painful or exclude patients and prolonged with a history of acetaminophen- erection lasting 4 sulfonamide allergy; containing or more hours. If therefore, the products. Do not this occurs, stop actual potential for take using this drug sulfonamide cross- acetaminophen and get medical reactivity with with alcohol due to help right away, tamsulosin is the risk of liver or permanent unknown. Non- toxicity. Educate problems could arylamine that occur. sulfonamide acetaminophen can derivatives (e.g., increase tamsulosin) have anticoagulant been reported to be effects. proposed to have a lower risk of allergic reactions in patients with sulfonamide allergy, presumably due to the lack of one of the proposed structural sites of action for sulfonamide allergy (arylamine group in the N4 position). One large retrospective cohort study has reported that in patients with the presence of an allergic reaction after exposure to a sulfonamide antibiotic, 9.9% had an allergic reaction after receiving a non-antibiotic sulfonamide derivative, and 1.6% of patients who lacked an allergic reaction after sulfonamide antibiotic exposure had an allergic reaction after administration of a non-antibiotic sulfonamide derivative (adjusted odds ratio 2.8; 95% CI, 2.1—3.7). A causal relationship between sulfonamide hypersensitivity and allergic reactions with non-arylamine sulfonamide derivatives has not been definitively established and remains controversial. In general, patients with a documented sulfonamide allergy are considered to be predisposed for development of allergic drug reactions. Until further data are available, caution is prudent when administering sulfonamide derivatives to patients with a documented sulfonamide hypersensitivity. Tamsulosin Dosage Forms Finasteride is in a Finasteride can Finasteride is Many people take Hcl(Tamsulosin & Strengths class of give you side contraindicated in it for many months ) 1mg medications effects such as those with or even years (Propecia) called 5-alpha not being able to hypersensitivity to without any 5mg (Proscar) reductase get an erection any component of problems. inhibitors. (impotence) and the formulation. However, there Benign Finasteride treats having less Finasteride is have been reports Prostatic BPH by blocking interest in sex. contraindicated in of breast cancer in Hyperplasia the body's These side children. some men taking Proscar: 5 mg production of a effects usually Furthermore, finasteride, but this PO qDay; male hormone pass after a finasteride is is rare. Speak to assess that causes the while. If these contraindicated in your doctor if you response after prostate to side effects do pregnant women or get any changes in 12 weeks to 6 enlarge. not go away, are women of your chest area months Finasteride treats worrying you or childbearing age. such as lumps, pain male pattern hair affecting your sex or swelling, or Androgenic loss by blocking life, speak to Women and discharge from Alopecia the body's your doctor. children should not your nipples. (Men Only) production of a use this medicine. Propecia: 1 male hormone in Women who are mg PO qDay the scalp that pregnant or may for at least 3 stops hair growth. become pregnant months should not handle crushed or broken Female tablets. Finasteride Hirsutism can be absorbed (Off-label) through the skin 5 mg PO qDay and cause birth defects in male Dosage babies. Modifications Renal impairment: Dose adjustment not necessary Hepatic impairment: Caution in liver dysfunction; monitor
trospium Overactive Trospium Dry mouth, General Take tablet 1 hour
chloride Bladder antagonizes the constipation, Information before meals or on Immediate effect of stomach upset, Trospium is an empty release: 20 mg acetylcholine on headache, dry contraindicated in stomach at least 1 PO twice daily muscarinic eyes, dizziness, patients who have hour before meal Extended receptors in blurred vision, or demonstrated Release: 60 cholinergic ally drowsiness may Alcohol should not hypersensitivity to mg PO qDay innervated occur. If any of be consumed organs. Its these effects last the drug or its within 2 hours of Renal parasympatholytic or get worse, tell ingredients. administration. Impairment action reduces the your doctor or Anticholinergic CrCl <30 tonus of smooth pharmacist medications Obtain a complete mL/min: 20 muscle in the promptly. Trospium exhibits health history mg immediate bladder. anticholinergic including release PO Trospium activity that may be cardiovascular qHS; extended chloride, additive to other disease, diabetes, release not tolterodine anticholinergic and pregnancy. recommended tartrate, medications. CrCl≥30 fesoterodine Evaluate laboratory Avoid ethanol mL/min: Dose fumarate and findings such as ingestion adjustment propiverine electrolytes, not provided hydrochloride Avoid ethanol glucose, complete by seem to have the ingestion within 2 blood count, renal manufacturer; most unfavorable hours of taking function studies monitor for properties with trospium extended- increased regard to release capsules. Obtain baseline adverse increased heart weight, vital signs effects rate side effect Prostatic especially blood when compared hypertrophy, renal pressure and pulse. Hepatic to the other disease, renal Impairment antimuscarinic failure, renal Assess for adverse Use with drugs impairment, urinary effects such as caution; dose (darifenacin retention, urinary hypotension, adjustment hydrobromide, tract obstruction palpitations, not provided solifenacin Due to the dizziness, by succinate and anticholinergic abdominal cramps, manufacturer oxybutynin effects, trospium is diarrhea, hydrochloride). headache, nausea, contraindicated in and vomiting. patients with urinary retention. Teach the patient Anticholinergics to rise from lying or may precipitate sitting, to standing urinary retention in slowly to avoid patients with dizziness or falls. preexisting urinary Teach the patient, tract obstruction or family, or caregiver how to monitor prostatic pulse and BP, hypertrophy, so ensure the proper caution is use and functioning warranted. In of any home addition, altered equipment pharmacokinetics of obtained. trospium occur in renal impairment Instruct the patient to stop taking the (CrCl < 30 ml/min) medication if BP is and renal failure; 90/60 mmHg or dosages should be below the adjusted. Use with parameters set by caution in other the health care patients with provider. And significant renal promptly notify the disease. Extended- provider. release dosage Instruct patient forms (e.g., who is taking Sanctura XR) are not potassium-wasting recommended for diuretics (Thiazide), use in patients with loop-diuretics severe renal (Furosemide) to impairment or renal consume foods failure (CrCl < 30 high in potassium: ml/min). fresh fruits such as Closed-angle strawberries and glaucoma, contact bananas, dried lenses fruits apricots and Trospium is prunes, vegetables such as tomatoes, contraindicated in dried beans, orange patients with juice and other uncontrolled closed- fruit juices. angle glaucoma. Trospium may increase intraocular pressure and aqueous outflow resistance in patients with closed-angle glaucoma (also called narrow-angle glaucoma) so caution is advised in patients with treated disease. Trospium is not contraindicated in patients with chronic open-angle glaucoma. The anticholinergic effects of Trospium may make the eyes dry and this can cause irritation for wearers of contact lenses. Gastroesophageal reflux disease (GERD), gastroparesis, GI obstruction, ileus, pyloric stenosis, toxic megacolon, ulcerative colitis Trospium has a direct antispasmodic effect on smooth muscle that can delay gastric emptying and is therefore contraindicated in patients with gastric retention (e.g., gastroparesis, GI obstruction, pyloric stenosis). Trospium is not recommended for use in the setting of ileus, toxic megacolon, or severe ulcerative colitis. In general, gastroesophageal reflux disease (GERD) may be aggravated using anticholinergic medications. Hepatic disease Hepatic disease (e.g., cirrhosis) can significantly alter the disposition of trospium. Caution is advised by the manufacturer when administering trospium to patients with moderate or severe hepatic disease. Driving or operating machinery Patients should be advised to use caution when driving or operating machinery while receiving trospium until the effects of the drug are known. Anticholinergic drugs in general can cause blurred vision, dizziness, or somnolence in some patients. However, CNS related side effects are expected to be minimal in trospium-treated patients as it does not cross the blood- brain barrier; EEG data before and after trospium therapy show no significant changes. Continued precautions with driving or other tasks are not expected. Autonomic neuropathy, myasthenia gravis Anticholinergics in general may exacerbate the clinical symptoms of patients with myasthenia gravis or autonomic neuropathy. Pregnancy Trospium is classified in FDA pregnancy risk category C. There are no studies of trospium in pregnant women. Trospium was not teratogenic at statistically significant levels in rats or rabbits administered doses up to 200 mg/kg/day; this dose corresponds to systemic exposures up to approximately 16 and 32 times, respectively (based on AUC), the clinical exposure at the maximum recommended human dose (MRHD) of 60 mg. Trospium should only be used in pregnancy if the potential benefit justifies the potential risk to the fetus.