Professional Documents
Culture Documents
19 11:30 Stránka 93
L. ZHANG1, X. LU2
1
Department of Orthopedics, University of Debrecen Medical and Health Science Center, Debrecen, Hungary
2
People’s Hospital of Baise, Guangxi, China
SUMMARY
Various surgical treatments for osteoarthritis (OA) secondary to hip dysplasia have been reported in the literature.
According to the position of the arthroplasty cup, generally they could be divided into two groups: the primary rotational
center (PRC) group and the high hip center (HHC) group. Some surgeons prefer the HHC technique. Without doubt it is less
demanding, but several concerns exist against the long-term stability. When restoring the PRC, since the dysplastic
acetabulum is usually shallower and underdeveloped, bone grafts or other biosynthetic materials are usually needed for the
ideal fixation. The source of grafts is quite wide. For example, they could be autologous (femoral head, iliac crest) or homo-
logous (allografts), bulky or morselized. Medial wall protrusion technique, as well as other materials like oblong cup, porous
titanium and tantalum augments, 3D printed implants could also be an option. Except these, reports are also divided into
cemented and cementless techniques. Therefore, no technique is perfect and clinical results so far are quite variable. We
think it’s necessary to compare the pros and cons between each other.
Key words: hip dysplasia, total hip replacement, cup position, secondary osteoarthritis.
INTRODUCTION
Epidemiology Biomechanics
Developmental dysplasia of the hip (DDH) is one of Depending on the severity of the disease (dysplasia,
the most common causes of secondary osteoarthritis subluxation, dislocation), DDH could differ in a wide
(OA) in early adulthood. In some European regions the spectrum. On one hand, the femoral head deformity and
prevalence is rather high, around 0.5% among newborns the shallow acetabulum forms a decreased articular
and it occurs six times more in females than in males. contact area and produces an increased pressure on the
According to national registration data, total hip re- joint cartilage, gradually causing early onset osteoarthritic
placement (THR) for secondary hip OA due to DDH is changes. On the other hand, according to Pauwels’ theory,
1.8% in Sweden, 9.0% in Norway and 8.9% in Hungary the lateral femoral head shift or shortened femoral neck
among all THR (26). length could change the lever arm of the abductor muscle
force, which finally leads to adverse effect on the hip
Pathoanatomy load and the force R will be more vertical (Fig. 1a) (34).
Generally, the acetabulum of DDH is shallow and has However, Pauwels didn’t take cranial shift into con-
an increased acetabular angle. The femoral head is sideration. By graphical and mathematical studies Erceg
partially or fully uncovered, the rotational center is dis- (13) declared that both lateral and cranial shift of the
placed laterally and cranially. The proximal part of the femoral head contributes to the increase of force R
femur is usually with increased antetorsion. The ideal (Fig. 1b). Therefore, in accordance with the pathophysio-
body weight pressure transferred from the acetabulum logical process of hip dysplasia, restoration is important
to the femoral head and neck is diminished, patients by placing the cup as close as possible to the primary
could present with coxa valga. The deformity also leads rotational center during THR.
to shortened length of gluteal muscles, consequent weak-
ness of the abduction, the iliopsoas and adductor muscles Classifications
are tense, altogether eventually causes Trendelenburg Several classifications of hip dysplasia have been pre-
type limping. sented during the last decades by different authors
093_100_zhang 11.4.19 11:30 Stránka 94
Fig. 2. Crowe’s classification I <50% subluxation, II 50%-75% subluxation, III 75%-100% subluxation, IV >100% subluxation.
(Crowe (7), Hartofilakidis (17), Eftekhar (12), Mendes should keep in mind that nowadays cup loosening is the
(27), Kerboul (25)) focusing on the severity of the ace- most frequent cause of revision, even for cases without
tabular deformity. hip dysplasia. A few decades ago an alternative technique
Among them Crowe’s (Fig. 2) and Hartofilakidis’ was in use: cement augmentation of the acetabular roof
classifications (Fig. 3) showed the best inter- and in- reinforced with previously inserted screws (41). Since
traobserver reliability and have been widely used. we know that this technique is foredoomed to failure, it
However, classification only by using a-p radiographs is no more an ideal choice. During THR in case of se-
may not provide enough information for surgeons to condary OA caused by DDH, a well-positioned acetabu-
plan the operation. As the severity of the deformity lar cup determines the long-term results after the
varies in a wide range, the classifications are not able to operation. We should be aware that when applying ace-
determine the size of the uncovered part of the femoral tabular grafting, surgeons are divided into two groups:
head accurately for every case. For precise surgical those using cemented cup and those using mainly unce-
planning, further X-ray and CT scans are necessary for mented one. Generally, according to the cup positioning
the most difficult cases. CT-based 3D printing could they can also be divided into two groups: placing the
also be a useful tool. cup into the PRC or out of it. The second group includes
HHC, protrusion socket technique and other different
Cup placement options techniques. In this paper, we aim to present all in detail.
Bone coverage of the acetabular cup is one of the
most important factors during the surgery of OA secondary MATERIAL AND METHODS
to DDH. Most authors suggest that host bone coverage
should be at least 70% to provide sufficient primary sta- We collected the main options proposed by the
bility, otherwise bone grafting is needed (24). Also, we literature. Interpretation of the data is difficult, and con-
093_100_zhang 11.4.19 11:30 Stránka 95
1.1.1 Cemented technique the donor site was the anterior iliac crest compared to
Most studies reported that the early-to-midterm (around the posterior iliac crest (2).
3 to 6 years) results are promising, the mechanical In 1988, Solonen (39) described the use of vascularized
loosening or failure rates were only 0%-5% (8), but long- pedicle iliac crest grafts in the reconstruction of large
term results are variable. Busch (5) reviewed 74 hips (pa- acetabular defects in three patients. Based on the deep
tients’ average age was 45 years) who underwent THA circumflex iliac artery, it seems to be ideal due to the
combined with autologous bulk bone graft (femoral head adequate length and diameter of the pedicle vessels
wedge was taken and fixed with two cancellous screws (Fig. 6). Although he reported satisfactory results, this
with its sclerotic concave side toward the defect as an technique has not gained popularity since then.
inlay graft before reaming) with an average 10.4 years’ Both Karakurum (21) and Delimar (9) separately
follow-up. The survivorship for all-cause was 98%, all reported through 6 and 10 cases of cadaver studies that
grafts incorporated and no additional radiographic loosening. pedicle iliac graft with deep circumflex artery and vein
Mulroy (30) applied an autogenous femoral-head graft to might be placed into any position in the acetabular roof
the acetabulum during THA for compensation of marked and might serve as a method of choice in patients with
osseous deficiency in 46 hips of OA secondary to DDH. combined hip dysplasia and deficient bone stock that
After an average of 11.8 years’ follow-up, the total need to undergo total hip replacement.
incidence of loosening was 46% and he suggested that Ikeuchi (18) introduced the iliac sliding graft technique
autologous bulk bone graft should be used only when the and applied to 19 cases of acetabular dysplasia in 2005
acetabular bone stock was extremely deficient. (Fig. 7). With a mean 3.4 years’ follow-up he declared
that this technique could be a useful alternative. The
1.1.2 Cementless technique relative advantages include intimate host-graft contact
More positive results have been reported in the literature and good stability of the graft compared with a femoral
using cementless acetabular cups. Tsukada (43) analyzed head autograft. The disadvantage of the iliac sliding
22 operated hip joints using uncemented cups. With an graft is its limited availability. Thickness of the graft
average 8.3 years’ follow-up, they found a 100% survival should be limited to 12 mm to 14 mm.
rate, without loosening. Therefore, even though this technique is not widely
Abdel (1) also reported on 35 operated hips with a used, however when no other method seems feasible for
mean follow-up of 21.3 years. The twenty-year sur- dysplastic hips, iliac bone grafts still could be a suitable
vivorship free from acetabular revision was 66%, all alternative choice.
bone grafts incorporated to the pelvis.
1.3 Intraosseous structural graft ISG technique
1.2 Autologous iliac crest bone and iliac sliding Szabó (40) reported the ISG technique. Through 3D
structural grafts model and cadaveric studies, he concluded that this
After the femoral head, iliac crest bone graft is a com- method provided good primary stability with a more fa-
monly used autograft during dysplastic THA. Both the vorable biological bone incorporation. A proximally fixed
anterior and posterior portions of the iliac crest are cortico-spongous plate is made for the cranial defective
often used for grafting (Fig. 5). quadrant of the acetabulum (Fig. 8). Patients’ x-rays
Systematic review reporting the overall complication showed stable fixation within short follow-up time.
rate by this technique was 19.37%, including infection,
fracture, chronic donor site pain, hernia, poor cosmetic 1.4 Autologous morselized bone graft
outcome, and hematoma formation (44). Postoperative Instead of the bulk bone graft, some studies also evaluated
complications were reported significantly higher when the use of autologous morselized bone graft. Studies sug-
093_100_zhang 11.4.19 11:30 Stránka 97
gested that faster bone integration could be attributed to (impacting the grafts into the acetabular defect before
better vascularization and the osteointegration achieved reaming), with average 7.6 years of follow-up. All cups
with bone particles compared with bulk bone grafts. Gross were stable and grafts were integrated and anatomy was
(29) packed the morselized autograft bone against the restored. He suggested results are satisfactory for a very
ilium and the shelf (femoral head) graft and found it demanding procedure.
useful in the dysplastic acetabulum (Fig. 9). He suggested Shinar (38) used cemented cups and studied 55 cases
that the abductor muscles both protect and help to with autologous grafts comparing with 15 allografts
consolidate the graft and even if the component fails, the cases for reconstruction of the acetabulum in THR (no
bone bed is provided for revision. He called this ’flying detailed method was mentioned in their paper). With
buttress graft’. However, since the morselized bone is 16-year-average follow-up, he declared that both the
usually difficult to fit, this method is not widely accepted. structural autologous grafts and the structural allografts
used in acetabular reconstruction in total hip replacement
1.5 Homologous structural bone graft functioned well for the initial 5 to 10 years. By the
Allografts could offer some advantages over autologous average 16.5 years, 60% hips treated with allografts and
bone because they are available even at large amount. 29% treated with autologous grafts had been revised.
They usually originate from living donors’ femoral head
(freeze dried graft processed by a bone bank) or fresh 2 PLACING THE CUP OUT OF PRC
frozen graft from multiorgan donors. 2.1 High Hip Center
The scaffold structure makes sure that it has good os- As the superolateral acetabular bone stock deficiency
teoconductivity. For freeze dried bone it is mainly is important in Crowe II-III types, the original anatomical
composed of Type I collagen. Protein and factors like hip rotation center might no longer be suitable for the
BMP-2, BMP-7, IGFs have also been reported to participate cup placement during arthroplasty. Therefore, according
in this process. Therefore, allograft might be an ideal to some surgeons proximal placement of the socket is
source for acetabular reconstruction. However, bone recommended when less than 50% coverage of the
allograft application should be cautious not only for a socket could be achieved at PRC. But how high should
lower integration rate, but also risks of HIV and hepatitis C it be? Normally the distance between the anatomical
virus infection and possibility of bacterial contamination. hip center and the inter-teardrop line ranges from 12 to
Usually fresher the graft, higher the risks. Most studies 15mm. In some studies, high hip center (HHC) was
about its application were mainly for hip revision cases. defined twice as long as this distance, the highest even
Blackley (4) studied 63 hips in which the prosthesis reaches to 60mm above the inter-teardrop line. Some
was cemented with a proximal femoral allograft. He re- defined the distance as “locating more than 35mm from
ported that the success rate for the patients was 77% the inter-teardrop line or 15mm higher than the appro-
after an average of 11 years of follow-up. ximate femoral head center”. There is no consensus on
Azuma (2) used cemented cups and corticospongious the clinical grounding of this technique (Fig. 10).
allografts (repeatedly packed the femoral-head allograft
chips into the acetabular defect and temped until a solid 2.1.1 Arguments in favor of HHC
cancellous wall was produced) for 24 cases of severe Due to numerous factors affecting the clinical results
acetabular bone deficiency. With mean 5.8 years follow and the lack of standard evaluation system, it is still de-
up, he reported two components migrated but none of the batable whether HHC technique could achieve satisfactory
patients had revision because of loosening or infection. clinical results. Generally, it has advantages such as no
Traina (42) used structural allograft and primary press- need of bone grafting, better cup coverage without bone
fit cup for 23 patients with severe acetabular deficiency grafting and shorter operation time.
093_100_zhang 11.4.19 11:30 Stránka 98
Kaneuji (20) reported that hip center elevation (17) firstly devised this
(26.8±4.8mm from the bottom of the teardrop) with ce- method by perforating the
mentless cups without lateralization and structural bone medial acetabular wall with
graft was well tolerated for hip dysplasia and is a a reamer in 1978 and defined
durable alternative solution. 30 hips were included in it as "cotyloplasty”.
his study, and the average follow up was 15.2 years. No In 1999, Dorr (10) included
loosening or Trendelenburg limping sign were identified 24 hips, with an average
in the end. 7 years’ follow-up reporting
Hampton (15) reported on 20 hips with HHC more that the medial protrusion
than 35mm proximal to the interteardrop level, after ce- technique is a predictable,
mentless THA combined with cancellous bone grafting. reproducible method for ob-
The average 16.3 years’ survival could reach 92%. taining fixation of a porous-
Christodoulou (6) used the biconical threaded coated, hemispherical ace-
Zweymüller cup and included 34 hips, the mean follow- tabular component in a dys-
up was 8.3±3.5 years. No grafts were used. The mean plastic acetabulum. He sug-
distance of the cups from the interteardrop line was gested that the anterior and
39.7mm. Results showed the mean polyethylene wear posterior column should not
rates and the cup survivorship rates in the near-normal be reamed too thin and the
and HHC groups were not different. defect must remain only me-
dially ( 25%), otherwise the Fig. 11. Medial wall
2.1.2 Arguments against HHC press-fit metal shell can cause protrusion technique
Contrary to the above-mentioned authors, some studies fracture through the anterior (cotyloplasty).
state that HHC diminishes the biomechanical character- or posterior column.
istics of the dysplastic hip and should be avoided. Kim (23) in his 16 cases filled the medial wall defect
Pagnano (33) performed HHC for 145 hips, without with cancellous bone chips acquired from the resected
grafting and the mean follow-up period was 14 years. femoral head and inserted a cementless cup. After more
He reported that cemented cups which were more than than 2 years he observed despite of a large amount of
15mm superior to the center of the femoral head without bone chips was impacted, most of them were gradually
lateral displacement had an increased rate of loosening resorbed. The thin medial wall might be troublesome
and needed revision for both femoral and acetabular when performing revision surgery. So the safe margin
components. of protrusion in cotyloplasty seems to be 50-60% of the
Georgiades (14) included 53 cases of cementless cup, acetabulum (the amount of cup surface beyond the
with minimum 10 years’ follow-up. He reported that Kohler’s line). Using a larger cup is recommendable as
cranial positioning of the acetabular component of more it has more bone contact.
than 25mm (25–35mm) superior to the teardrop line led In 2008, Hartofilakidis (16) included 93 hips with a
to statistically significantly higher aseptic loosening of minimum 10 years’ follow-up reporting that when 80%
the femoral components. of the implant could be covered, a cementless acetabular
Nie (32) analyzed 18 patients’ pelvic radiologic results component appeared to be acceptable and provided
one day after the cementless THA surgery and he also durable fixation. Cotyloplasty was used in more deficient
studied the biomechanical consequences of superior hips.
placement of the hip center. He found that for Crowe
type I/II hip dysplasia, HHC (even 5mm above the 3 SPECIAL IMPLANTS
anatomic hip center) disturbs the biomechanical load 3.1 Traditional manufacturing
above the acetabular dome, which is critical to the A combined superior and posterior segmental cavitary
stability and survivorship of the acetabular component. deficiency will cause an oblong defect. In such situations,
For HHC technique, there is no study directly comparing hemispherical implants are not suitable as the antero-
the difference between cemented and cementless cups. posterior acetabular diameter doesn’t allow large reaming
Results with cemented fixation showed acetabular loo- without sacrificing the ventral and dorsal acetabular
sening rates ranging from 16% to 42% within 5 years. rim. Large amount of superior bone grafts will be used
However, studies of cementless cups showed greater and the long-term stability remains questionable. The
than 80% survivorship even beyond 15 years and no non-spherical cups are usually indicated when the ace-
acetabular failures at a minimum of 10 years in THA tabulum presents with a longer longitudinal diameter
for Crowe I to III hip dysplasia (31). and shorter transverse diameter. Unlike extra-large un-
cemented component (the so-called Jumbo cups) which
2.2 Medial wall protrusion technique (cotyloplasty) requires extensive reaming, this cup could obtain enough
In 1976, Dunn and Hess (11) formulated a method by stability in both the anterior and posterior column. There
intentionally crossing the medial wall and placing the are mainly two types of oblong cups: the bilobed oblong
cup beyond the ilioischial line to avoid bone grafting acetabular component (BOFOR cup Smith and Nephew,
(Fig. 11). 22 hips were operated and all had pain relief Plus Orthopaedics AG, Rotkreuz Switzerland, S-ROM
and gait improvement. Instead of osteotomy, Stamos Oblong Cup Depuy, Johnson and Johnson, Warsaw, IN)
093_100_zhang 11.4.19 11:30 Stránka 99
CONCLUSIONS
8. Delimar D, Aljinovic A, Bicanic G. Failure of bulk bone grafts 28. Merle D'Aubigne R, Postel M. Arthroplasty of the hip with acrylic
after total hip arthroplasty for hip dysplasia. Arch Orthop Trauma prosthesis for recent and old fractures of the femoral neck. Mem
Surg. 2014;134:1167-1173. Acad Chir (Paris). 1952;78:695–704.
9. Delimar D, Cicak N, Klobucar H, Pecina M, Korzinek K. Acetabular 29. Morsi E, Garbuz D, Gross AE. Total hip arthroplasty with shelf
roof reconstruction with pedicled iliac graft. Int Orthop. 2002;26:344– grafts using uncemented cups. A long-term follow-up study.
348. J Arthroplasty. 1996;11:81–85.
10. Dorr LD, Tawakkol S, Moorthy M, Long W, Wan Z. Medial 30. Mulroy RD, Jr., Harris WH. Failure of acetabular autogenous
protrusio technique for placement of a porous-coated, hemispherical grafts in total hip arthroplasty. Increasing incidence: a follow-up
acetabular component without cement in a total hip arthroplasty note. J Bone Joint Surg Am. 1990;72:1536–1540.
in patients who have acetabular dysplasia. J Bone Joint Surg Am. 31. Nawabi DH, Meftah M, Nam D, Ranawat AS, Ranawat CS.
1999;81:83–92. Durable fixation achieved with medialized, high hip center
11. Dunn HK, Hess WE. Total hip reconstruction in chronically cementless THAs for Crowe II and III dysplasia. Clin Orthop
dislocated hips. J Bone Joint Surg Am. 1976;58:838–845. Relat Res. 2014;472:630–636.
12. Eftekhar NS (ed). Total hip arthroplasty. Mosby, St. Louis CV, 32. Nie Y, Pei F, Li Z. Effect of high hip center on stress for dysplastic
1993. hip. Orthopedics. 2014;37:637–643.
13. Erceg M. The influence of femoral head shift on hip biomechanics: 33. Pagnano W, Hanssen AD, Lewallen DG, Shaughnessy WJ. The
additional parameters accounted. Int Orthop. 2009;33:95–100. effect of superior placement of the acetabular component on the
14. Georgiades G, Babis GC, Kourlaba G, Hartofilakidis G. Effect rate of loosening after total hip arthroplasty. J Bone Joint Surg
of cementless acetabular component orientation, position, and Am. 1996;78:1004–1014.
containment in total hip arthroplasty for congenital hip disease. 34. Pauwels F. Biomechanics of bone grafts. Acta Orthop Belg.
J Arthroplasty. 2010;25:1143–1150. 1971;37:701–725.
15. Hampton BJ, Harris WH. Primary cementless acetabular components 35. Raposo-Amaral CA, Denadai R, Chammas DZ, Marques FF,
in hips with severe developmental dysplasia or total dislocation. Pinho AS, Roberto WM, Buzzo CL, Raposo-Amaral CE. Cleft
A concise follow-up, at an average of sixteen years, of a previous Patient-Reported Postoperative Donor Site Pain Following Alveolar
report. J Bone Joint Surg Am. 2006;88:1549–1552. Autologous Iliac Crest Bone Grafting: Comparing Two Minimally
16. Hartofilakidis G, Georgiades G, Babis GC, Yiannakopoulos CK. Invasive Harvesting Techniques. J Craniofac Surg. 2015;26:2099–
Evaluation of two surgical techniques for acetabular reconstruction 2103.
in total hip replacement for congenital hip disease: results after 36. Russotti GM, Harris WH. Proximal placement of the acetabular
a minimum ten-year follow-up. J Bone Joint Surg Br. 2008;90:724– component in total hip arthroplasty. A long-term follow-up study.
730. J Bone Joint Surg Am. 1991;73:587–592.
17. Hartofilakidis G, Stamos K, Karachalios T, Ioannidis TT, Zacharakis 37. Schuller HM, Dalstra M, Huiskes R, Marti RK. Total hip recon-
N. Congenital hip disease in adults. Classification of acetabular struction in acetabular dysplasia. A finite element study. J Bone
deficiencies and operative treatment with acetabuloplasty combined Joint Surg Br. 1993;75:468–474.
with total hip arthroplasty. J Bone Joint Surg Am. 1996;78:683– 38. Shinar AA, Harris WH. Bulk structural autogenous grafts and
692. allografts for reconstruction of the acetabulum in total hip ar-
18. Ikeuchi M, Kawakami T, Kitaoka K, Okanoue Y, Tani T. Total hip throplasty. Sixteen-year-average follow-up. J Bone Joint Surg
arthroplasty with a sliding iliac graft for acetabular dysplasia. Am. 1997;79:159–168.
J Bone Joint Surg Br. 2005;87:635–639. 39. Solonen KA, Rindell K, Paavilainen T. Construction of acetabular
19. Jafari SM, Bender B, Coyle C, Parvizi J, Sharkey PF, Hozack WJ. bone stock. A staged cementless arthroplasty of the hip. Arch
Do tantalum and titanium cups show similar results in revision hip Orthop Trauma Surg. 1988;107:263–267.
arthroplasty? Clin Orthop Relat Res. 2010;468:459–465. 40. Szabo J, Mano S, Kiss L, Jonas Z, Csernatony Z. Intraosseous
20. Kaneuji A, Sugimori T, Ichiseki T, Yamada K, Fukui K, Matsumoto structural graft technique: a new surgical concept in the treatment
T. Minimum ten-year results of a porous acetabular component of superolateral defects in case of dysplastic acetabulum, during
for Crowe I to III hip dysplasia using an elevated hip center. hip replacement surgery biomechanical and cadaver experimen-
J Arthroplasty. 2009;24:187–194. tations. Eur J Orthop Surg Traumatol. 2014;24:1447–1453.
21. Karakurum G, Gulec A, Buyukbebeci O. Vascularized pedicled 41. Tönnis D. Congenital dysplasia and dislocation of the hip in
iliac crest graft for selected total hip acetabular reconstructions: children and adults. Springer Science & Business Media, 2012.
a cadaver study. Surg Radiol Anat. 2004;26:3–7. 42. Traina F, Giardina F, De Clerico M, Toni A. Structural allograft
22. Kawamura H, Mishima H, Sugaya H, Nishino T, Shimizu Y, Mi- and primary press-fit cup for severe acetabular deficiency. A mi-
yakawa S. The 21- to 27-year results of the Harris-Galante nimum 6-year follow-up study. Int Orthop. 2005;29:135–139.
cementless total hip arthroplasty. J Orthop Sci. 2016;21:342–347. 43. Tsukada S, Wakui M. Bulk femoral head autograft without decor-
23. Kim YL, Nam KW, Yoo JJ, Kim YM, Kim HJ. Cotyloplasty in ce- tication in uncemented total hip arthroplasty: seven- to ten-year
mentless total hip arthroplasty for an insufficient acetabulum. results. J Arthroplasty. 2012;27:437–444.
Clin Orthop Surg. 2010;2:148–153. 44. Tuchman A, Brodke DS, Youssef JA, Meisel HJ, Dettori JR, Park
24. Li H, Wang L, Dai K, Zhu Z. Autogenous impaction grafting in JB, Yoon ST, Wang JC. Iliac Crest Bone Graft versus Local
total hip arthroplasty with developmental dysplasia of the hip. Autograft or Allograft for Lumbar Spinal Fusion: A Systematic
J Arthroplasty. 2013;28:637–643. Review. Global Spine J. 2016;6:592–606.
25. M K. Arthroplastie totale de hanche sur luxation congénitale.
EMCTechniques Chirurgicales–Orthopédie Traumatologie Elsevier
EMC 1996.
26. Makela KT, Matilainen M, Pulkkinen P, Fenstad AM, Havelin LI, Corresponding author:
Engesaeter L, Furnes O, Overgaard S, Pedersen AB, Karrholm J, Lei Zhang
Malchau H, Garellick G, Ranstam J, Eskelinen A. Countrywise Department of Orthopedics
results of total hip replacement. An analysis of 438,733 hips based University of Debrecen
on the Nordic Arthroplasty Register Association database. Acta Medical and Health Science Center
Orthop. 2014;85:107–116. Nagyerdei krt. 98
27. Mendes DG, Said MS, Aslan K. Classification of adult congenital Debrecen 4032, Hungary
hip dysplasia for total hip arthroplasty. Orthopedics. 1996;19:881– E-mail: leizhang@med.unideb.hu
887.