SPLENOMEGALY (in adults) DISEASE OVERVIEW ‘ine spleen is loestadtin me «eft side of he abdomen behind bs $2 Y wit bisod cele to hig cptiaes propardin and tute 1d managing the number of Boo ‘defined ty on increase in 2 ‘om or 1000 gis termed massive weight” An increase in se tana by sdorinal Derlrmed dynaaeed neater the saleen may protec ‘CAUSAL CONSIDERATIONS The wide vari nocb5 immune gaat, Table 1 Classification of primary splenomegaly etiologies? Ercan stam suse prt sien sem en, CongerSPLENOMEGALY (in adults) 7 nesasec amatopoiss lasing 9 rlenerassyCivene mi ort of aotactil causes of splenomegaly nay bs river disease, and angmia or 2 issues, Computed tomography Nepatie 1s ther culprits neta Fal rurther investigations can nals shortist the p2ssble ndacarctis. ar malaria may 9# inceative of -y may have petechiae, abnormal mucosal bleeding, + RiRCEas orcas te Slots ie coven fons Roe et tendeessnling or bora ungSPLENOMEGALY (in adults) counts. poripheral blood smear and homogatn marrow biopsy can sass in screening for soterial mavgnaneies, Spine ‘by angiogragny Seusnoprtagropny onables evalua leterative dsarders suen 9s Gouchor ds "3 once al thar nore come Key POINTS: 2 Myeloprolterative Liver sisease causing portal hjgertansion s@ common cause of solenomenaly ntial diagnosis of the underying couse of splanomegaly requires care Sh examination, laboratory ansiyess and magia Common potential couses include nepatie dystunetion, infection, and blood! sisorder ‘The more rare lysosomal storage ciseosvs #9, Gaucher digeace and ASMD con aso and should net be overooked ether clagnoses hove been fled out REFERENCES