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  • J. Biol. Chem.-1995-Taylor-ENOLASE

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    Damien Vicaire
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    The document analyzes the regulation of expression of the human beta-enolase gene in myoblasts. Through a series of experiments, it identifies a myoblast-specific enhancer located between nucleotides -321 and -292 of the gene that is necessary and sufficient for high-level expression in myoblasts. Deletion or mutation of this region leads to a significant reduction in gene expression. The enhancer interacts specifically with nuclear protein extracts from myoblasts.

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    The document analyzes the regulation of expression of the human beta-enolase gene in myoblasts. Through a series of experiments, it identifies a myoblast-specific enhancer located between nucleotides -321 and -292 of the gene that is necessary and sufficient for high-level expression in myoblasts. Deletion or mutation of this region leads to a significant reduction in gene expression. The enhancer interacts specifically with nuclear protein extracts from myoblasts.

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    © All Rights Reserved
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    3 views7 pages

    J. Biol. Chem.-1995-Taylor-ENOLASE

    Uploaded by

    Damien Vicaire
    The document analyzes the regulation of expression of the human beta-enolase gene in myoblasts. Through a series of experiments, it identifies a myoblast-specific enhancer located between nucleotides -321 and -292 of the gene that is necessary and sufficient for high-level expression in myoblasts. Deletion or mutation of this region leads to a significant reduction in gene expression. The enhancer interacts specifically with nuclear protein extracts from myoblasts.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Downloaded from http://www.jbc.

    org/ by guest on October 21, 2015


    Downloaded from http://www.jbc.org/ by guest on October 21, 2015
    Downloaded from http://www.jbc.org/ by guest on October 21, 2015
    Downloaded from http://www.jbc.org/ by guest on October 21, 2015
    Downloaded from http://www.jbc.org/ by guest on October 21, 2015
    Downloaded from http://www.jbc.org/ by guest on October 21, 2015
    Nucleic Acids, Protein Synthesis, and
    Molecular Genetics:
    Regulation of the Myoblast-specific
    Expression of the Human β-Enolase Gene

    Jane M. Taylor, John D. Davies and Charlotte


    A. Peterson
    J. Biol. Chem. 1995, 270:2535-2540.
    doi: 10.1074/jbc.270.6.2535

    Downloaded from http://www.jbc.org/ by guest on October 21, 2015


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    This article cites 53 references, 28 of which can be accessed free at


    http://www.jbc.org/content/270/6/2535.full.html#ref-list-1

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